<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFG3</accession>
    <name>A0A5C0UFG3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TatD family deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="261" mass="30183" checksum="FCFED4D537958E1E" modified="2019-11-13" version="1">MNGKWTDSHCHLDYEPMFGNVKEKINNMHLNEVGCAMTISTSSNTLDKIYDYTDYNSKIFASVGVHPLDKEVKQIDVIENYLQTWIEKPNVVAIGETGIDYFKDFQNTPKEQKKSFEMHLEFAKKYNKPIVLHMRDAEQDTLDIIKKYPDVVGIAHCFTGTMEFAKKILDLGWYVSFSGIITFKNVSKNILDVAKFIPNERILIETDAPFLAPEPHRGKKNEPAFVRHVGEFLAELRNVDKDFFADITTRNFLDLIQYKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFH7</accession>
    <name>A0A5C0UFH7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4280 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025460">
        <property type="entry name" value="DUF4280"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14107">
        <property type="entry name" value="DUF4280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="130" mass="13528" checksum="A2E4169966F8DB2E" modified="2019-11-13" version="1">MKMISVTSSGCMSCTMGLIPSMLGVLPINRVMTDSKIQSNIMDHMPLVNVMSFGMCKTPTNPAVAAVIIASLGSVTQAPCIPMTMSPWMPGSPTVLVGGKPAVSKDCKLMCAYGGMISITSPGQFTAKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFI8</accession>
    <name>A0A5C0UFI8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsO</name>
        <name evidence="7" type="ORF">FZC36_00210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="86" mass="9871" checksum="0614C5413E563999" modified="2019-11-13" version="1">MKKTKKEIIELFGASEKDTGSSSVQIAILTNDILHLSDHMKSNKQDKHSMRGLMRKVSQRKKLQKFLKSDNPEEYKKVIAKLGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFK9</accession>
    <name>A0A5C0UFK9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_00325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="202"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="423"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="532" mass="60158" checksum="CD3193B5A1A34FBF" modified="2019-11-13" version="1">MILDWFSKPEYHQCFSTPCIIISDDGTIQKVNKDFFERFGDMRGKKISSISSMKYYRSQMICEIENSQWELNYFKTSAKQYHVLFIPYDSTSHMLSQIPSPVAVVGEKGNIISANDSFRGYTPKDKKIKNLNQFFDFSSSMLRKKLNVEDVLWNGIPMEVHFKKGTCSTWIVGLQDKTEIQKIKKQMQKSQHLQNLGQLVGSISHDFNNIFTSIKGLCELLHQSVTEDSVKSDVSEIISNIDNATGLAKELIKFASQKDKAICNPYNTIIECKRLFENISADINVSFDIKQSDALIKISSCSLQRILMNLVINSRDSIKENGEIKISLLEKDLYEKHIKKNVIPSGKYVILSIEDNGSGIPLEIQDKIFSPFFSTKDSGTGLGLSNVISIVENGDGYLDLKSNPNGTSVTLYFPINQKNTKKTVLLIEDEDGIRQIMKKSLERKDYEVISATNGAEGIDIISSDQHIDTVITDAVMHGKKGTEVLEYIKENKPNIKTILMSGYPETQFEKNFDNFLPKPFSISQLVDMVSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFL7</accession>
    <name>A0A5C0UFL7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">recA</name>
        <name evidence="12" type="ORF">FZC36_00320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="203"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="69"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK38885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="347" mass="37558" checksum="477CBA8AAB14C206" modified="2019-11-13" version="1">MNTNLSDEKASALKAAIEQIKKAYGKDSIMNLNQRSSVETEVISTGSLSLDIALGIGGLPVGRVVEIYGPESSGKTTIALQVIANAQKKGGVCVFVDMEHALDKKYAEKLGVDVDNLMFAQPSSGEEALEIVETFARSGSAKVIVLDSVAALVPKSELEGEMGDAHMGLQARLMSQALRKLTGTISKSECMVIFINQIRQKIGVFFGNPETTTGGNALKFYSSLRLDIRRTSSIKKGDEITGNSTKVKVVKNKVAPPFQVAEFDIIFGEGVSKIGELIDLGVKNQIINKSGSWYSYGSDRFQGKDGAKEFFSANKDKMLELENKILEIYGISSRKPNKPSSKENDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFP5</accession>
    <name>A0A5C0UFP5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="5" type="ORF">FZC36_00480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="129" mass="14621" checksum="A9EC90CB23286BC1" modified="2019-11-13" version="1">MINDRISDSFSRVRNALLVGKKHVSVLNSAIVKSVFKVIQEEGFIEDIKENSDRELLIKLKYDKKGIPVIRGISRISKSSKRVYYKCKDFDGMRRKDFSMFIVTTSVGVMSDREALRSGVGGELIGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFQ8</accession>
    <name>A0A5C0UFQ8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplQ</name>
        <name evidence="5" type="ORF">FZC36_00530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="124" mass="14288" checksum="B1EBCB565A5989B0" modified="2019-11-13" version="1">MRHKQNKSKLNMKGGHRKSLFMNLSKSLIKTISDDKKIKTTLAKAKAFKPKVERMITTMKGFDSDEKIASVRRAVSFFGDKEFVMKHISLVSDKYKDRNGGYTRIIKLPRRKSDGSKMCFVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFU7</accession>
    <name>A0A5C0UFU7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ComF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZR_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="240" mass="27450" checksum="1EF1BCB0D519D5B4" modified="2019-11-13" version="1">MINLKSIVDIINPKYCYSCSNEVQEDGLCNSCWKEITFIHNPSCIRCSNPFPHEISEFALCASCINKEFNLDKIKSAMKYDSFSKKIIMLYKNHNATYMAKFFAKILVSCGKPLLDRTDIIVTVPIHFWKMVWRGYNQTSLIAKHVSDISNKTFLKTGILKTKFTQSQSNYNQLQRQKNIKDTFEVNGIHKQEIKGKNILIIDDMITTGATMEECARILKLSGAKKIFGLTIAKSVHKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFV9</accession>
    <name>A0A5C0UFV9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="273" mass="31654" checksum="DD80EB3E5B725671" modified="2019-11-13" version="1">MFILKNIIRISKFIFQTQIIFLFCFKIYSKEVIFNREYEGLSNGFLESMNAQADSYTKQNPESKERYDEFIETLRKSLIISDDNEKIVQLQCTARAFCRVKGNDLVLYLNTHRFIKENANDEIPEEEGSGMTFRSILLPISDARSKGYLGSYDGQVFITVHAFLDNMDKIKKSTVSYTGNNFNTPIIILEKDDSSSGDYKYFTIKNGLLDSLESFKDQEIEIDPFIFVADYSAKDFVTENLFRSDIIRQTIEKDGDYFDYNNAKIKLTNIDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFZ7</accession>
    <name>A0A5C0UFZ7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="181" mass="21068" checksum="13A5519CFDA09421" modified="2019-11-13" version="1">MNYIQYVQPSESKSGDKIFNISNLKSLEKFATYLSEKLFPGCALFIDGPLGIGKTTLIRSILERWNIKSIGSPTFSKVITYQSKLFNKERNSDLQNDSNDSRSTDNESMNNEQPVGSEFFVWHSDAYNMENTEYLKEYLFEFEEGILIVEWSELIPYKDLWDSRIEVNVNEHRIASVKETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG27</accession>
    <name>A0A5C0UG27_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elong-fact-P_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043043">
        <property type="term" value="P:peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elong-fact-P_C" evidence="1">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="198" mass="23165" checksum="8213ED5FCB3220A8" modified="2019-11-13" version="1">MIEKIKASNLKKGHIIDFDNELFEIRDISHVKPGKGRAYFQVEMKSFTGHRKLDRRFGTDDVFNKAIIEEKILRFDYYMNGVYNFFCDTTNEVYEIRNNEQNDKNKKKHNLFDFLQDDVNISAFFYDDNFINFKFRDDVVFEVKEAASYTKGQTAAASYKNAVLSNDVKVSVPTYINSGDKIIIDPYSGDFKEKYKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG35</accession>
    <name>A0A5C0UG35_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">acpS</name>
        <name evidence="10" type="ORF">FZC36_01280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="132" mass="15066" checksum="A0C01A092833574A" modified="2019-11-13" version="1">MIFGIGVDIFNLSRMETVFKRTPNFANRILSQSEKDMKFVNTEMRNEKVGKIFSIKESFSKALGTGIGEHCGWKDISILKNDLGKPIIEIQGKPLESLSTFKRFSIHCSTSDEFINEQKIFISKVIIEIFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG42</accession>
    <name>A0A5C0UG42_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mnmA</name>
        <name evidence="8" type="ORF">FZC36_01275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="394" mass="44401" checksum="FE00E9B67823B606" modified="2019-11-13" version="1">MNLNSKNKSVQPEVAGLEFPVWYRKQRLDLSKYINSMFDKDKVVVAAMSGGVDSSVTAALMCKAGYKVIGLTLKLHDNPSVEQAITDAKKISEFLGIEHRVLDLRKEFDEHVLSKFYEEYEEGKTPNPCIKCNKNIKFEGMVEYSKSIGAGGLVTGHYIKREMRYGEESIVRGADSSKDQSYFLSLIDANYVPFVGFPLGIMNKSTVRRIARIFDLFVAKKAESQDLCFAVSNRYHDVLRIMGSKDRSGEIVNCKTGKVLGEHDGISRFTIGQRKGLNLPYGPWFVNKIDNKTNQVFVGRLKDVQCHEIWINEINLLRDFTKKENVRVKIRGSQTPVPAKLEINGKEGRVILENAEYGISPGQVCGFYYDDILFGGGYIVEKEDLSELSKKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG60</accession>
    <name>A0A5C0UG60_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="152" mass="17483" checksum="BE5E7204BD8AE305" modified="2019-11-13" version="1">MIEIKDLLKDRSEIISGDCSLLLNSNNIRNLEGALMHDSNSCSNKYQIKISGESDLPEIFLNGELLIKSPIRFFQFVNKEEKIMFNRKPAEGSILFSKRDQITKTNVLVEEDYRPGCDGKVNYKPLFNVFVKSISCDFKNLETRWAVVLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG86</accession>
    <name>A0A5C0UG86_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="3 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pdhA</name>
        <name evidence="10" type="ORF">FZC36_01530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 8"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="9">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="325" mass="36400" checksum="22D3D3AEF4FA902F" modified="2019-11-13" version="1">MPTLFVDKDNKYHKIYKQMLLARKFEEATVQLYREGLIRGFCHPYIGQEAVLIGINSKMQSQDSMITGYRCHAHTIIAGCDPKSVMAELTGRSTGCSKGKGGSMHMFSIKNRFYGGHGIVGAWTSLGTGIGFSHKYKEDNGVCVVFLGDGSSNQGQFFESMNMASLWNLPVLYIIENNGYAIGTSVERSAAGGPLHKRGECFGIDSEEVDGMDVEKMSEAADRGLSIARSGKPYIIEAATYRFRPHSMSDPDKHRSKEEIDKYKALDPISSYEQKCLKNKFMTEDEVKQIKKEVKEIVSESVKFAKESPFPENHEMFEDLYTKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-10-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGA0</accession>
    <name>A0A5C0UGA0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminopimelate epimerase</fullName>
            <ecNumber evidence="4">5.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="420" mass="47558" checksum="A1743F85F9A69B43" modified="2019-11-13" version="1">MCRENEDKKLQNKSRFIKAHGLGNDFVIFFSGIGKEMFSGREHCFAMFAQENIIHIADRKLGIGCDQVIYAESIHERSIGNKHGNNISELCNPQTNYIVKFWNSDGSHAAFCGNGIRAVALYIFDNILSNNLICKDNKTYNTNKLVNNDISNANLELSLYTDSGLVKAIYTGGEITYSMPCEFFAEEISEIDNSKQKNPCIPQNKNIALKKKINTKDTSKSEFFNTCEIGLEEISALDAFHVFTVNTGNNHIVVINNREAKWDHDINIFKHLTSMFNIIWIWPNDKSVDKKQKTKNKETSTTESNIITKDNKLDINSDNWNIMPYERGVGPTMACGSGTAAAAFVLWTLQNPVQLTEKASDLKCKVERNTNTECSRTNTKDEYKKLIFHTKLGKIEMSRDSNKIWQKGPAEISFEGEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGB1</accession>
    <name>A0A5C0UGB1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="265" mass="29369" checksum="12DB183C060EA75E" modified="2019-11-13" version="1">MNTELNNKTVINSNSKNNLQKEISEILNQFESGERKAVHKDHKSAKNSWFVDKKAMLELNKLFKLEKSMFEIQNVIKWSDKIPFLTETMNNETLLNKTYRLVAGCWIRRGVNISDDVVVMSNSFINIGAQIGQKTMIDSGVTVGSCAYIGSKCHISSNTVIAGVLEPSNSNPVIIDDNVFVGAQCLISEGAKVPYGCIIASGVKITNSTKLLNREGEILDKIPELSLIVPGFYKSGQVYISCNIVAKTFDSVQDKSKINDILRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGC5</accession>
    <name>A0A5C0UGC5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="164" mass="18595" checksum="A2402116059A9A51" modified="2019-11-13" version="1">MFEKKIPFIVEVLKTKGLKEIEYKEGDKSIRITQDPYSSNNNQIENFNSNEDLNDFVVLNNNPDAKENVSNSENKATSKEDMVNLSDIKSHIVGIMYIAPSPGKDPFVRKGDRVKEGQTLFIIEAMKFMNEVKAEFSGTVEEILVEDSCPVEYGQVLARIKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGC9</accession>
    <name>A0A5C0UGC9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA carboxylase biotin carboxylase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_01835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="6">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="120"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="446" mass="50055" checksum="3159C7FBDE2D9E49" modified="2019-11-13" version="1">MIKKILIANRGEVALRIIRACKALSMETVAIYSEADKDSMHVRVADESVCIGPAKAKDSYNNMQAVMSAALLTHADAIHPGYGFLSENSEFAEMVEKHDIIFIGPSSNHIKQLGDKINSKSMMKKYNIPTIDGSDAVKSLEEAKICAEEIGFPVIIKASNGGGGKGIRICLEPADLEDSYNAVIQESTAIFGEGSIYIEKYLEEPRHIEFQILSDGKNAICLGERECSLQRRRQKIWEEAPSMVLTNAERQEFYKKITNMFSEIGYKGAATLEFLYQNGKLYFMEVNTRLQVEHTVTEEITGVDIVKWQIRVAFGEKLSLQQSDVNLTGHAIECRINAEDPKDFAPSPKIVTNHIPALGPYVRIESAIYNGYQIQPYYDSMISKLIVKGDDRDECIRNLKHALKEYIITGPKHLIPLFIKLVNNADVLSNNIDINWLEKFLNNQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGD5</accession>
    <name>A0A5C0UGD5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmF</name>
        <name evidence="6" type="ORF">FZC36_01890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="61" mass="7063" checksum="DF80D4B71CFA9AE1" modified="2019-11-13" version="1">MAVQKKRVSITKRRQRQSSSYKVTLPELSVCKCGFYKQPHTVCMGCGQYKGRQVLKIKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGD7</accession>
    <name>A0A5C0UGD7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Lactamase_B" evidence="4">
        <location>
            <begin position="43"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="625" mass="69702" checksum="1586A112A1B6D4C4" modified="2019-11-13" version="1">MNIKRKKFNYKRVPRKNTEEQEKINIDRNSLCFLPLGGSGEFGLNMNLYHCNGKWIIVDLGITFDKVPGSDIMVPDISFIKSLDPQDVLGLIITHGHEDHIGAIPYLIDDLNIPVYATPFTSSLINNKLKEANSKGVLKTVDMGSTLNLGPFDIKWINVTHSIPESAMIYIKTPLGNIMHTGDWKFEDNPVIGIPTDYKSMESAAKDGILAAVCDSTNAMVDEETVTEKEVQNTIDQALSEAKSKDSRIVIGCFSSNVARVDSCARLAKKYGRSVVLVGRSIHRIKDAALKHGYFKDLPDFLTEDEGSRIDKSRVMFICTGSQGEMNSGLKRLSENNHPRIKVNKGDTVLISARTIIGKEKEVSQMLNNFAKIDVNIIKYTDSTPVHASGHPMQSDLVKFYKMLKPKISVPVHGEICHQKAHAKLVSNLNIKPFIVSNGDILVLSGKSVGVSQKMISSRMVVDGKALVPEFGSTIRQRYLLEDGCIFVTIFIDNKDYIRTSLSFYGICEKNDTLKDSIKETLKKDIIAMDSNDRKVYKVLTEKVKQSVHHAMFESRGKDPVVLVHLVTSNIPRKKKDSERENGSKEVVKNTVDIDSISLNKSLSSSETQSPERTIDENVDFMEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGF2</accession>
    <name>A0A5C0UGF2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_01725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="275"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="388" mass="44207" checksum="D10717ABE1290B98" modified="2019-11-13" version="1">MTGKRTKKVMWITILSIGFSLGILIKTIAIMRGFQESILQKSLHIYGHMDVVSQKGFKVDFLKKKDWYVRSIKNSEKHGMINHYSSTKGVKIVSADPEDIDYIIQNKWINKKFQKNKTGDVESIAVGQKLAKEFGLRIGSYADLLIPHGFGSNNISIKKIRAKVVGIFSLGFHSFDRNVIFTLGHGLDKYTIGNPEETHTVYTTNPEKIENYKKEVYKENRNALSVWTWKDTNPSLKQMFVMQNLVIGIFIGLFVLCAMVQSTNSLWMLISEKTRDISLLKAFGASKKQIFWLFANLSIIMSISSVLIGTLFGVSMIKIFPYIMSFIKNRMGINIIHGDTFGFTEFFPRIEVLDLVIITFSAFFIMCFILFFAARSATKTDILKGINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGG0</accession>
    <name>A0A5C0UGG0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rpsG</name>
        <name evidence="10" type="ORF">FZC36_00395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="157" mass="18069" checksum="679543BBE826FA21" modified="2019-11-13" version="1">MSRKGKIQKREVRPDSKYSNKRVAMLINKVMQDGKKEIAEKIVYTAMESIAEELNVESVKVVDDVIDNLRPNEEVRQKKVAGHAYTVPFEVDEGRSIMLALRWLVENARKRTGIPMHEKLRREMKDALNSTGGAFKKKEDSHKQADANRAYQHYGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGG2</accession>
    <name>A0A5C0UGG2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proton_antipo_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="106"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="798" mass="92355" checksum="B5ED57B2148247E9" modified="2019-11-13" version="1">MTLNSIFNFMHIEPTEIFFLSLILFCIPIFLYRLFFISKFDFGTRFSGIKILYDKEKLHIIFLFICFSIIFFGSKSITTTFVKKYINTGNMETNIKTELIKNLTFALLFISWEVTTWLSYFLMYKNAEDKKEARIPLITNLLGGLFFMIFVALSFKSKFFLGNEIGDLRSLEAISNFSKFFYNYKYFKYLNLNISDLIGISAAIFVLTKSSQFPFCWLDYAKNASPYVSAFLHSCTLVKMGVFMSMFHLSYLHTNVFFKNTIIFSSMITSLSILKNLNREKLDLKKYLASTTQIYISFLLFYSFVVDSFTIMKMIFVHCVYKSVMFLTCQDLKHAKQVNLQEIIESKSNDNVSIATGSGDSHEDSHENSNKDSNKDSHENSNKNSNDSSASDYPSSGNYIACPEALRKQPFSTLFIWISCFFIMTGFPFIFSSDLYKIEKLKIFSIFIKSLHAAFVVNFLFKTKMISELKFRILNIKSKINHKKGSVPVLEKRHLVILYPVLFLCPSIFISDSVREIFNLGPSSFNFTYNIISFLIVSSTGFLIFKATKYCRIKSILHKIGELSNFNITNYIYKAIARKMYVLRDINIMFFCITLFLLSVVCQVYSSFYESLSFNSEFNKFINGSLFYDLFFVSSFYDKLFFLFVFTGCLCVFSRNKLNIIVGLNFIGLGVTSFFMRYGGSDIAVTNVIADILITIILLNNDKFWKNDHRIVFSSKILKILFYSFLFSAFIVAKNPALWQSVSSGFYFPSETTVNDVVINLRLFDTWGETLVFLISGIVISSQIKNKKYRKNKNQTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGH3</accession>
    <name>A0A5C0UGH3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HU family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_02155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="104" mass="11700" checksum="FFFDEA0F70FE6676" modified="2019-11-13" version="1">MNKTELCKTIGSSLREKASKDPSFSSMTDRQVTQVMEEFMDTILSELKNGNEVSISSFGKFYPLKKEAREGRNPKTGKTIQIPKSIAAKFKAFQAFLSELNDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGI3</accession>
    <name>A0A5C0UGI3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">FZC36_02200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="24"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="263" mass="29133" checksum="778B11C774EBE45D" modified="2019-11-13" version="1">MDNMNKLFELNSKGIKVYNPDCLDKMKKSSAIVLNTLKEVESKIKAGLTTKEVDKICEDYIKSCGARPTCKGYQGYPAASCISVNEVVCHGVPSDRIIKDGDIVNVDVVAEIDGWHSDSSRTFMIGSVSDKRKKLVEVSKKAMEIGIQSVEIGKDLKEIGIAIEKYVLSQGSFKIVKEFCGHGIGMSMHEKPFIYHFDPKHKLGKIVPGMFFTVEPIIVNGEEDFKELKDGWTTVTKDGSDAAQFEHTIYVGYDGKVHILTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGJ0</accession>
    <name>A0A5C0UGJ0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="216" mass="24750" checksum="DE64E63F606204B1" modified="2019-11-13" version="1">MNVKNCNKCINEKNNKQTSLIRSYAICKKIFSSMYKTIMHSSSKAYKVSTAFIVLFLLSGCEKYNYAENSLQAVRFFCNSEMNSGTAIVVDILQVSDNALFDKLKEMKSIDYFSQRKSILQTNINEIKLWSFEPISGNWTDQFLLKGTSCKSSGLLVFMNYKNSSEKNSFSIPLDYKSIDIKMGEKSIIEFSESQKSDEQVKRDPESIERIKNDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGJ3</accession>
    <name>A0A5C0UGJ3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="153" mass="17003" checksum="3CD0CC46DF8BE7E2" modified="2019-11-13" version="1">MNKELIETIKNNIGNKIDSNKCTKKGVKLSNALIFVSVLAISSFALGQYYASLLFKKTEMSSYKDQNLESEIQTSQNNKKQKYEVRLGKFANEIDAKDFSTKFGILSPIVSKDKDGAYVVKVKGTHTIKEAISTANAIKKEMKILASIAETIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGJ8</accession>
    <name>A0A5C0UGJ8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FZC36_02320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="451" mass="51200" checksum="ECDCDA196E2EA8CC" modified="2019-11-13" version="1">MIFSKEIFFKTFGFYPSKQFSGIEIDSRKVKPGNIFFCIKGKINDGHDFAKEALEKGASYIVVSKPISIAFPAPESIQDTHTKLSPHNASFNHGLVYKTELIKENQILTKDTEEVLTRLLINLRNSIKSTILAITGSCGKTSTKEKILCAFKEKDILGTPGNYNTILGLAIFLSSIEKEPEYLALELGINKPNEMDEISAIIKPHYSIITSIGPAHIGNFKNVNHIRSEKLKIAKHTQKITFVPKDTNKAIIETLNCSVIKEEDLKSKTLDSLADQDFTHNAILKISDEEKLKHARKNIKSYSTPKGRNNLVKIKFDDKEITLIDGSYNCNPMSLQFSLSKLESFSIYNCKKENIRKIAIIGEMKELGKHTQKYHELDLNFKGLLILLEETPNLWKTKKGMIFKDWVQICHFLKQNIQDKDVILAKGSNSTDIKKITQWIEDLQKSKYSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGJ9</accession>
    <name>A0A5C0UGJ9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="282" mass="32304" checksum="589DFC9694E3FB40" modified="2019-11-13" version="1">MKLLNNLLNKFYFLSRLLSKNIADFYFKNSIDSINNDKSIVKRTAASFSSLILCCMVFCSSVSKAELYEDLKGSHTLIGLTFAGTSNPKYGFKTKDMGYSDLEKYTERNNPFYGALSLNIVKVYRNIFSLSNCFEIGLMKNRMILALEGDKIEIKHKNFFGSFLISAGLSVVDKMEMYLSTGLNLCRFSNKAWLNGKEYEFSGKNLLLPHLVFRSGIRLMVHKRVTMDLFYIFSTSLEKEIRVRTIANEDIPAFKSNDDFNKKNFKLKSKFGMIGITANYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGL0</accession>
    <name>A0A5C0UGL0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="459" mass="52085" checksum="EFA2BEB232AC5CAE" modified="2019-11-13" version="1">MRVRNKMYTKIRHAITVAYNSSLRNLMPSSFTANNLIIASTTMLSRVLGLLRDILITHWAGIGHITDAYYIASKIPSFFRKVISEGAMNNILIPVLSQMPEEKQSKFLQQFCYKILFTMTFISIIVIIFSKNIISCIAPGLTYETKEWASKFMKIIFPAITLISINSSWSSYLNYKKKFAASSISSSFINIGAMSLILIGMKFNKLIFLGFGILFGVSLQTIWIYFNIPKDVRKIKNNHQFSLDNKILMKKFSHILLSSSSMQITTLISIFVSSFLAPKIITQMSNAEKMSQVPISLIGSSIGTTLISYLSAHIKSSEYKKARKILKQSIIFSLIISTLVIVFVTNFSYQISYSIYSSNKNNLDSIIQISQYLKLYILMVPAYSLVKIFAAVFFSLQMNKVPMYTSIVQCFSYLALLMFFHSSGSQIILCSLISAYVHIFFLLITFIKKKIYSIHFSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGN6</accession>
    <name>A0A5C0UGN6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II/IV secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="473" mass="54531" checksum="14444CBA40B69B33" modified="2019-11-13" version="1">MISTNKIDEFLIDFSLLKEVPIDFCKKNRVLPVSIEDKNLKLICNKESDLHVFEEIKQYIDFNQVKKVNVSEVDMDHYMEMIYPQKLESIERLFSSKEVDGEILVDSVIVEAIKSNASDIHIIPKEGFFYIKYRIDGVLYSRYSFSKEKWNTVCIRIKVMSELDISETRISQDGSFEREFCNKKLDFRVSCHPVMFGESIVIRILNGSEQFFLGSIDYSEKNKQNMEKFIDIPDGLIIFTGPTGSGKTTSLYSILSSINHESNNIITLEDPIEFKIPFARQTDINKYPKMDYINGIKSILRQDPDVILIGEIRDEKTANMAIRAAMTGHKVFTTLHTTNIAGVVDRLMEFNIDKTLIFQYLKGIVAQRLVRKLCSCKTEVKNCYSGQLRKHIDCDYFFKSNGCEKCEGIGFSGRTVVAESVFLKPNDMQEFVNNKTLKKEIFESMCVDGIHKVKNGITSYEELKRCIDMSEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGP8</accession>
    <name>A0A5C0UGP8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="204" mass="23771" checksum="9EA20A629401A984" modified="2019-11-13" version="1">MSLSIEEIVSRIKNSKDGNKRSQDDKSNQKPTYLNPLESDIESQTHDEEKRTEQEYSLELKTESLNDKSINPSLQSSVEKLREIMGDSNHRKSIYVTKEEKISLDSDIIKSLVKPLVQKWTEENMDKIGKYISYSLNENVVKDHHVMDFLQKNIDIVQSIIKESIESYIESYRHYVESKTETMVKNYVEECVKKELSSILKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGP9</accession>
    <name>A0A5C0UGP9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FZC36_02590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="13">
        <location>
            <begin position="15"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="732"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="962"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QEK39296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1034" mass="120462" checksum="A36031D5043EC550" modified="2019-11-13" version="1">MNYSKSVTNMEKNFFSKADPFQKSSKYESKSRMVLPPPNITGKLHIGHALNAFVQDLKVRYERSFNNNKISWIPGTDHAGIATQIMVEKLLLESNIKKEDLGREKFLEKVWEWKEKYQDNIYDQLKKLGLELDWDQAKFTMDEDVQEAVSEAFCKFYKSGLIFKDNRIVHWDTKMQTAISDLEVRNEEVTGYMYYIKYYFENSLSEDSPKNTTEEPISENFVTVATTRPETMFGDKAIAVNPNDERYKNLIGRSAYIPMTDIKIPIISDERCDMEKGSGAVKITPAHDFLDFEIGKDHDLEVQNIIDKYGKLSGDSVPKSLQNIDRLEARKKIIKELKDKELLVKEEKIKHIIPHGDRSGSILEPMATKQWFLDMDSMASEAKEDIQNIAVFPQNYIKIFNHWMNNIQPWCISRQIWWGHQIPVWYFDDNHIYDLEKYNSYKKHGTNYLTSDYGQINKDNEQFSKNANLNHEFLNQVNFEKRFIVAKDIESARKIAKDIGIKNDSLTQETDVLDTWFSSALWPLVNSKEINSIFTNSLNQELNQKSTQELSKGLDPKNEEYPNECIITGSDILFFWVARMIMFCKFFSKKIPFKQIYLHGLVQDSFGKKMSKSKNNAMDPLDIIAEEGIDVLRYALLSSSVPGKNVKFGKQNIEKSRHFCIKIWNVFKFIKSNCSELFDVNIHTPENMEDNLKSGESSQTHDSQEIKKQNIPQEESSYNLPENLHPWNSFIVLKISDIRKTILDFISEWKIHEASNEIYKLIWEDFCSLYIEGCKSMLNSEHSMETKIVITESFKELIRILNPFMPVLSTEIFSLMENINPQTKAYNSNLTNKPCNTSCSFDSILDSILKKKSQKENQENETLIKSKTLDYIKEITEITDSIRYCKGVLGIENSIIYHVNIKQDHVGENIIQGSKSHLESNVEKDEVFYNIIEKLSGFKIHPSKEPKNDMTPYPLQQGVLYINFLDKDLNKLKNKIKKEKEKSYQDLSDAERKIENKQFIENAPTEIKEEIKERIAKLKQIVDNFDKVELMWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGQ3</accession>
    <name>A0A5C0UGQ3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsQ</name>
        <name evidence="2" type="ORF">FZC36_00455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="78" mass="8868" checksum="0DC7121234B6FEFA" modified="2019-11-13" version="1">MSKMLKGKIISKPSLKTIKVSVLRNYTHPVYGKKIKLSKKYLVHDENEEYSVGEDVTIHSCAPVSKRKKYCVRGKDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGQ9</accession>
    <name>A0A5C0UGQ9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="601" mass="69130" checksum="14190A63D8DD18A4" modified="2019-11-13" version="1">MMTSNLDKFTSGASAKQSANANGSTNKASKSSTMSKMRNILKLCTLALTAQHTNTVDIPKLHDTPNEHGCFYHFKYKDAQKPDGTAAKVLDAYHVEFDLDDVDTSDLRRNPEMKFFVVNLLMELEFIIETESDFMTKDNYYKKMHRVESIAESAEDQEDYNLVLSLIKEKGFSEEDYHKNLSRDNLYTAMSFLVNMHSLVNDFNYHDYIDAKDMVDKKSRPEVKSKKELDSKIEYLNNTTNDVEQWVDKDSISRWFSTNRIKSINNGLDYSETPKTVKELDELNLFSVEIFRCNQQIGPLIRLATNLIDLRLRLEYKQNEDLDVLRNLKWIPGLEKLQLKLTLNSKEDINLPYEMGDMENLGSLSVNVDGSGDGFALIPNSVSGLQNLRHLELTRKTKYSNGFSKCSNLQEIDAHVPAELDENFNSLTNLVVASFMADTYLKTDISLPRLEVLRIPNARLKEMPDFSGCSRLEVLDLGSTQRRHLGGSEKRSVGNLLTSMEDVESKLPKNLQRLFIGNWIKKIIPLPSLTELKLLSIGIDYGYKVDKDSVMDWVKNQEIYIMIEQPETEHDMKNNGNWDQIYKYMLKNKRSKLNKNKDNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGR1</accession>
    <name>A0A5C0UGR1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="201" mass="22520" checksum="1BA128F46D7C0261" modified="2019-11-13" version="1">MKSANALAEVHLTLNMSVPKINRGKFKMKTIPVLNPARPPLSSTRVMIFDTLEHMHEIKNVADICCGSGSMGLEAISRGAEFCIFIDNNIPIIRNVCSTIKEWGVNATGLVSNAEKIDKNIVKVKVNVPKIDTVFIDLPFKNEKTNSVLESIKNSEMCSNDCVYVIRSHKKHDFNHESFEAVKEKRKGISKIIILKLKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGR5</accession>
    <name>A0A5C0UGR5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="242" mass="28293" checksum="C315599C19DC8858" modified="2019-11-13" version="1">MGSGNKLNIVDIIDEKINKAEKNMTIINFFKVEARPYAKYDEFLGVQVPILRKIVKEHHKEVSFNEVKHFIMSEFNEKRLIALLFLVSLYKTDPEKVVDFYLENIKQVNNWNLVDLSCYKILGDYLLNKDKKILFDLSKSENMWERRISIISTLNFIKNGHIETTLKIGSTLVDDDHDLIHRALGWMLREVGKINEEALIEFLSSNDVHNTTFNYSVEKLTDAQKKELRANRKKSNRKASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGR6</accession>
    <name>A0A5C0UGR6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IcmF-related_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="2">
        <location>
            <begin position="154"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1292" mass="150108" checksum="36C573A1501764E1" modified="2019-11-13" version="1">MILNEISKIDLQYVTYALYALIAILIILILKFLPGITNIKKMAEKAKNYLLDSFNITLERSCLKSNKDEEAFEEAMQTLKSFIGGRNFKYKLPLTILIGKQSSGKTSLIQSLETEKPFEDIIGETCTWSFFNQGIILDTSSEIFSSSSENTDLKWHNTLNLLNYYRPDSPIDSAVLTVSLKDILTSDENIYKAAEEYYIKIWQMQKNLSISFPIYIVFTNADCIPGFGNFCNSIPEKDKNEIFGWSNSSSNNTIFVDEMFDEIISRIHYISQKLTVGSVDYQNHSGLYVFPFQFMKIKRKIETFLNYIIKSNSYHDNLNIRGIYFTGSATSFSKAQSQINESLRESKFGKLKNVCMRHAVNKIFFSTNLFTNKIFQEKYLTNSIKKIAFSKKRKIMFIQASLIALSILSIFNFIHFIHNIKKIQVDFLANIDSANEILKKSKSLRSLTYAESEDENFSKQVDSLIVTMSKLNAKNLKFVSIPASWNSKLGKNLEKFLGQLFEKVLFDPLQSKFSYKLKSLSNGPLKKVNKSNPDYYDPTNSVDLIRLYSYVKEISEIENIYYRIERLPYLKNIDDLTYVMEKLFNIKLQKIFFDNKKVFIKAINHINIKIESVFKFENKINLIFNKLLERFLKNTFEYENVNPHLTKLENTLWSIEHNKNKFHNIHVLKEIVENFISHFNRQELKWILQDNINFGSKFTSMLFRLKNSSILGEKAHRKTTESLKDSSVKLKKILENHKVPVVGKIIQTKSGKVELSKEFEEFQGYLNILSAKQFMQKETQTLNTNIPAHKTLTWDSVIIRSTVDAISSFESFMSSGLLQKKPKLKPTLESMALEHLIKFIETELEDAKILTDTISSVPNQSEQIVKKNLESNTHSLIKILSTLKENDNNMYQILKTMLMDQCYKSLFRIDKMLENANLYIDFKNKKFFFMNKDKIISKLEREQAELIKICNFAKPVIEMIKKIHEIDYEPQIEIVEKWSKILLEVDKHKKGDDSVIKQIEEIIINGMNYFENPNCDSDATSKVNQSKIFELIGGKVFSNIKTQCKDKNKQNFELEYSKFKKYMEKEASTFPYINNKASAEKLHNKWNEFKNNTKYEQNAEKLNLSKNTLDFLENMERSIKFVAAYFDPKGKATNIKITMRSRNCESMIENISNSKFIFGTQEYSLQSDPFTIPLSSTTLKTLLSLSKENNLLFKNGNKHNKEILNGSIPLLKWINKYISQTKGNIKEIKYEALLKNGEKVSTWIKMEIDGYLKSWPNFKLKAPAVFFKRKTITPKSCKNTKSKPTKKSLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGR7</accession>
    <name>A0A5C0UGR7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">FZC36_00380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="43"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QEK38897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="247" mass="28281" checksum="9323192EF302E5B6" modified="2019-11-13" version="1">MSEHEECKLKKKWEVDVGTIFPGMFPGPLSFSCVGKSIDKFWNINSHDLRKYRIKKDLDDKPFGGGHGMIMRPDCMDSWLSEIYRGQKIIYPSPRGRVFDQSMTSELLENDLIILCGRYEGIDCRVLKHWNIEEVSIGDYILCGGELAAMVMIESCVRTIEGVLGNSKSALEDSFSDGLLENDQYTKPASWVPKNTDLEYNVPHVLRSGNHASISKWILENKENLTENRRSDLWSKYVARKEKNVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGR9</accession>
    <name>A0A5C0UGR9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transket_pyr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_02700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="9">
        <location>
            <begin position="408"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="738" mass="82721" checksum="357912B361BF2DDA" modified="2019-11-13" version="1">MEGKMKKEVLRERKISTNLYRKMASDKLRLLSLEMVEEAQSGHQGIALGMADVFTVLWSKFINYKNKYQLRDRFILSAGHGSALLYSTLYCLGIIKNLNGFRSIDSDLNGHPELSDVIEMTTGPLGQGLGWSVGIAKAAQEHTKLIKKECLRLSKEKEHSVEKQNNEKPDEDQNEEQIDESLNNKINSLLDNSNRVFVVVSDGDLMEGVSHEVSELAANWKLSNLTVLWDDNSITIDGQTDLSKQSATLDVFKAYGWNVFSCDGHDFEDIEHKIEQAVNSEGPSIIGCKTKIGKGSEYEGLCSVHGKIIDRNGLDKLKEDLGFNYSEKDKFELDDEICDFWNLVKNRMDHNFEQLNRVLDGLDKNILKTGSGLDSVLELDKETSPCPSQSQKLINKTPEFMDSLMKDNSTRKISGMVLDGLFDKEKFWIGSADLGESTCTMGMKNYIPFGVREHGMVCITGGICLYGFKAACATFLVFTDYARPAIRLAALMRTPLIIIATHDSISVGEDGPTHQPIEQIESFRAMPNVDVYRPCNGLEVLYSWENALGSKNPSIICLSRQKLKFINQENIEITCNQNYNKISGGYLIKDFSGLDKGSLSSEKDSVHKSDLYRNVHEVNSNENLVVILSSGSEVSLSVDVAEMLLEQGIKSKVFSIVCMEKISDEFEKEITAPYIVSIEASSSKSWYEYLRHASVDSLLIGCLEFGYSGKEHDVRAKMGLEKNIILERIMSMIENNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGS7</accession>
    <name>A0A5C0UGS7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="246" mass="27197" checksum="5A7CBB2C1C0E4547" modified="2019-11-13" version="1">MAVVNQKGGVGKTTTAVNLSTALAQKGKKVLLIDLDPQGNATTGVGLEKNSVSNSYDLFFEKVQESKTFVENLHCIPSSKDLAGIAIELASDPVKNYKLKQSINYPEYDYIIMDSPPTLGLISLNILNACNGIIIPMQCEFYSLEGIAQLMETISSVRENWNKDIKIDGILMTMFDRRNMLSKDVLNEVTMFFKDLVFETKIPRNVKLAEAPSFGKPGVIYSPLSPGAKAYDDLAEEFLSKEKLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGT4</accession>
    <name>A0A5C0UGT4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="349" mass="39684" checksum="4E42FF3AAF31F8AD" modified="2019-11-13" version="1">MSFGVVTKSSPIYRYSYDKPESKVGKILTLSGVWSNDNLSFLLELLPVDKVVLETKVNPNIAYILKKYTKEVIFLESQNSISERIKLQSIDNRSGSLIEKERSFLVSIFKMNTKILRINKFSEPRKEIFRFYFYKAFMKIGNETLPLMFLISSILGIAMVLEGYSQLKYIGVEMLTMQFFVKFAIREMIPVIISMLMASKSGSSIASVFASMNISGEFTMMKIMRIGKMNILKPYFIVFLVLFPLMNILSIFFCLILGMLAYKILLKTTIILAVVRTVEYISLSNFLISEAKSLLFGYWTGLCVCAAGMFYNYGTENVGKSVTKAVVYSVSGILLLDIFVMFVCNVMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGU0</accession>
    <name>A0A5C0UGU0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein FZC36_00300</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="250" mass="28787" checksum="792969E08910828D" modified="2019-11-13" version="1">MVAGHSKFSNIKHKKEANDKKRSKEFTKLAKAIAAIARQCPDPDKNPRLKTAIHAAKSKNMPKENIDRAIKKASDKDCNIEMSYTGYGPHGIAFMIETITDNSNRTVSELRALFKKYGKGLSDLRFIFEKVYEFCFVSDLTEDEVIQLLMESGAEKSLRDIKIVQNNVMSGNESNGVNKITIEFENLDNFDSNFLNKFNDYDQKIVYCPKEKVFLKNDEQKSEIKNFLEILEDNEDVQEIWNNLDMESFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGU3</accession>
    <name>A0A5C0UGU3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Toprim domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FZC36_00665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QEK38950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="273"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK38950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="579" mass="67421" checksum="C6021864FD929E7A" modified="2019-11-13" version="1">MQSWVDEIKGKVRISEVIRRYVSNIKISGDRMYIACPFHNEKTPSCVVSDERGTFHCFGCGESGDSISFVQKIEKIDFKESCKKIASWYGINLVSNKFEKKDKNVDVFHKINNWFKENLHNNLQAYKYLKSRNVDLDLIKNFELGWIPSFKEVKSFCKSENIGDFELNEIGFKEGILKAFQNRISFPIFSSKNVIGFGARYIPSHYEGSGSGFDNSSTNLEKKRSFIGAENVKSFSKNDANAFVRPKYINSPETKYFKKSKNFYGLNQIKKFQPIALVEGYMDVITMSKRSGNALACLGTSVSDDHINMLKNFTNEVIICMDGDEAGNKATKRILEKVMCHIDGRLRFYVFRFPENEDPDSFMNSNENGWKKILESKEDFISSVWRLFMIKRDSPEEYYNDFKMLMNLVKKIPDQELRKIYASKWKNIWSKEMYENNSRQESYKNSYGGYNSGKRSKYDKSEFSSGLKNKTAPNLGLVYEKALISIVLRFPEVFDHIEEEFLDVAFSNEMKIMKESIIDWIRGGKDVDFFTKKGLDSVVDDCVSDKITQILPFMNYKQFDEKIIESWRFIYKQMKARNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGU6</accession>
    <name>A0A5C0UGU6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">DNA polymerase III subunit epsilon</fullName>
            <ecNumber evidence="3 8">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dnaQ</name>
        <name evidence="10" type="ORF">FZC36_02655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3 8"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06131">
        <property type="entry name" value="DNA_pol_III_epsilon_Ecoli_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006309">
        <property type="entry name" value="DnaQ_proteo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01406">
        <property type="entry name" value="dnaQ_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="237" mass="26879" checksum="7606380A503E365E" modified="2019-11-13" version="1">MNLGMESKIEKSNQKSKQDIIILDTETTGLDPQKDKIIEIGCVKISDRKISTDSFQVFINPGIEISEESQNIHGITNEFIKDKPKFESVYSEFSNFIKDSILVAHNASFDMSFLNAEIKRLKHPILKNEVIDTLKVARKKFPGSPANLNALAKRFNISLHERDLHGALIDANILAKVYLCLTKPIASSLFAEQTTTKEVKETKYSYTKHKLTISNEEKNLHLDSLKIINAESDKWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGW2</accession>
    <name>A0A5C0UGW2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">clpX</name>
        <name evidence="8" type="ORF">FZC36_00765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="396" mass="44344" checksum="9FE03585F15A7F64" modified="2019-11-13" version="1">MNKSKVLNKEPIICSFCRKDQFVVEKLIAGPGVFICNECVDLCEKMIKEHKKTEPKDHKILFPGEIKESLDEYVIGQETPKKILSVAIYNHYNRINANEKEDNIEKSNILLIGPTGSGKTFLAKTLAKTIDVPFVIADATTFTEAGYVGEDVESILFNLIQASDMNVNLAERGIIYIDEIDKIARTSENKSISRDVSGEGVQQALLKLVEGTKINIPQKLQEKMRGGIVKNQIDTSNILFICGGAFADLDSLIEEKASIGFQKKNEILDKKIENNHLIKFGLIPELIGRFPIVAKLDKIDKDSLVSIMKDSKNSLIKQYKRLFKLSNVILDVTDGAIELIAEKALEKGSGARGLKSILESIFLDPMFDIKRDIGPMSLNINENNIEKKKFKLEKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGZ0</accession>
    <name>A0A5C0UGZ0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="233" mass="26971" checksum="658202E6863C3185" modified="2019-11-13" version="1">MKILFNITFAQNQILKYIRNSRKSLSFLFLAFSFYMPVYSTQNINYSEVRELYTEYTNIPDEVMASIYVPHLLPQEIIFPDLLDTYHLVAYGLFCDRKTKPIKIDIYENRKECIHPDNKTLIKILDSVKKDLEIRKSAENSQIQTPTQPRLAPKALDIKNIPKKKHKTSQKDSQKIPTLMPRTQFSNGKTNNESRKTAVNEKANKGAGQKSLAKSDNIPEGSRLLIYRKINSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH53</accession>
    <name>A0A5C0UH53_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="141" mass="16682" checksum="B59BDAA0B609D0E1" modified="2019-11-13" version="1">MKIFEIIENIIKLKKSTFNMMKNNNKIINCNELSGMQSIILLFIHRNNISLLELVNDCMLTNVPYNIKQMKNSGYITQKKTEHDKRSYEIKLSKKGLEIVKKLEERLKLYDEAYPNFVNMPQSAIVNSMKQIEDLFKFMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH55</accession>
    <name>A0A5C0UH55_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="195" mass="22516" checksum="717D857D7FDA3F1E" modified="2019-11-13" version="1">MLGLLKIVINIYNVQFIWYSTPVNCSYITKNGDKGKTSTSSGIVPKNSNLISFIGNLDESNSYIGLCLNYCKDKDLLEILLKVQNQIFNIGAKINGANLEITEEYHIWIENKANFFFKKLKPIHNFVLPGGSLFSSHLHICRTILRRTELAFWACEEEHRDVNIGKYLNRISDFFFIIARVYNNEEIQWEVGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH75</accession>
    <name>A0A5C0UH75_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ychF</name>
        <name evidence="6" type="ORF">FZC36_01100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="367" mass="41462" checksum="342AB088A104FEA6" modified="2019-11-13" version="1">MSLSCGFVGLPNVGKSTIFNVIMKKVVAESSNYPFCTIEPNKGSVPIKDDRLNNLSKIENSAKVIFPTLECVDIAGLVKGASKGDGLGNKFLSHIRQIDLIVHVVRCFDSEEIIHVHGKVDPVFDVDLINTELVFADIEVLEKWIKKNKALKTKEIDWAKSYLKHINENKSLDQFKEDNKDKNTEEIMSWLKSIGILSVLPRFYVANMSEDEIKNGNKYFEELKAAYPNEVVIPIAAKLEEELMSMPDDDYREMLREFGVKKIGLDFVLSTAYKFLGLESFFTVGPKEARGWTIKKGYKAPEAAGVIHTDFRDGFICAEVISYEEFISCEGYVPAKEKGKIRKEGKDYVVSDGDVCNFRFNVLKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH88</accession>
    <name>A0A5C0UH88_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="244" mass="28962" checksum="2FCA605B05D3A1C0" modified="2019-11-13" version="1">MIYDIYSDIFGLINKNKLIFIYSEEDSLSASFFDEFIGQNVEFDQFSENIMLSLGLIQNPPVKIKTTLANAKKILKLNVGNWKRECIVCVDKKIEIKKSEKNYSDIAVVDCKIMNKTKFINFYSSLFGYKFDDVKDVLWVENLYDLHYANKINLIDKSLLKTLNTEEKKTFSSLNSKDLESRMRLWQNVDSPWSWIRFLQYHYRMRGKSALYADALHLETWARETTPNDEVFIWMCRQLMEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH90</accession>
    <name>A0A5C0UH90_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsK</name>
        <name evidence="7" type="ORF">FZC36_00520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="129" mass="14101" checksum="DF750CDEAB2B98CD" modified="2019-11-13" version="1">MSKKKRVGVKKKSVHKSGKVYIKATSNNTIMTLVSNETKQVIAWCSPGVVNIKGSRKSTPYAAQTAANKLSEKMHEFGMVEVDIVLVGLGSGRDSAMKAIQGNGFRINSVEDRTSFPHNGCKLPRRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHA3</accession>
    <name>A0A5C0UHA3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="311" mass="36682" checksum="88904ADB74752654" modified="2019-11-13" version="1">MQTYRKKLVTISIALLVFPLLFNLFSKQDQNQIAWVGNRKVSRQDIVSMIRYYNLRNDTKESMQRNISNLMKLLVVDEKFKEMKINFSKKHILQYIYNNEHFFSNGKFDPEKIELILKERKIPYKVFLDIQKLEMQKKILDQVSEHAVNKNIFNSEKIAVDYVSKLREKRSGRFVFIPKRNILKKSDSEKERLKDIVKRYAYLFNAKKVSVSKNRNLLPKRIALISSDKAKNIYQKMLFKTKVGSIIAEELRDGTYLVSVDKSYDPTKGNDLSARDEVNKMKIYINDYLQDLSMESIAGDLLIKHKVEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHB4</accession>
    <name>A0A5C0UHB4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system baseplate subunit TssF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tssF</name>
        <name evidence="1" type="ORF">FZC36_01675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03359">
        <property type="entry name" value="VI_chp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="598" mass="69692" checksum="6F00249C5D51ECEA" modified="2019-11-13" version="1">MILFLNLPMKSTPDLNNLFPHFRKSMDYLLKKGNEFAEKYPSVARELNFAENKVDDPHVQRILESFAFFDARLQWQIDDQLSFLSSFLLDSLYPQFMAPFPSCTIVHFESKKNISNQKNIKIPKHTKISANNKEDILCDFITSQEITVNDFNPKKISYMKTEDTELLESQNYWCLSLETENMKSFKNNSNVVFYINSDLFSAKSLYEHILGYHPTEPTPIYLSDKSGKLLQKSKIGVITPKGFGEDESLIDRPIYTSDSHRLLMEYNIFPHKFLFLNFEINNLNVNLEQIKGDIAFLIPLSKRTKPSLLPMSDNILMNNCCPAVNLFEQKSEPLRLDYEKDSYKIMSDRFDSNSEIHTIKEVFSYKSSFKNNRKVYYPYFSFSDIENGSERSFWYSRREKEDKGSKMMISFIDEDLDVEEYSEETVYADLLCTNRDKAQSINYKTSFQFNKIDNLSCVNILKPTEQVDPQYGGQSQWEIISNLSLNHVDLSINNSDIKPLRKMLEIYNFNFNQKYNEVILGIKHKKTIARMPNSPWTGSVPKIVIDLKIKDEVAEHFMLGKVLSCVISNNVGFNTLLEMRVFGSSNDDVPWKKWEVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHB5</accession>
    <name>A0A5C0UHB5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ParB/RepB/Spo0J family partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="5">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="337" mass="38300" checksum="EBE63C1CDE49906A" modified="2019-11-13" version="1">MNSKNHRPRIGKGLQALLETETSQFKEISIKKLHPSKFQTRTEFKESEIEELSATIKTNGILQPIIVKKTELSSSNTEQKFEIIAGERRFRAAKLAGLENIPCRVVNWSEEEIIEANLLENIQRSQLNGIEEARAYKKLLDKYSITQEELSKKVGKSRSHIANLVRLLKLPENIQNEILKGNLTVGHGKALLQKENTQLMEEELGRILKENLSVRDIENRSNNVPENMNDYNPKNNNKNSRKSDNAQNGKTGKINLGGHNQEKTEEQCINVNEPKSQASKTKNEDLILIESQISQLLDYTTEIEMLSKSSGNIKINFKNSIDLDDILSKLSSIQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHC0</accession>
    <name>A0A5C0UHC0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="602" mass="68103" checksum="98E14964575027C9" modified="2019-11-13" version="1">MKKLLLLTQIITLNSFAMSGGDSASDSSKMSYTHPAPSAMSSKPKGESELVPELVFHPKGTEEHKGLGLYGEEVFKLGKGIFKSEEQMEGFQAKILKIFSDEFGDEDVKSHKNAVSDFVYSLTNPPKESGSFDSYDSDLPREKVLETNPYRSALGNHNYESYVKKVIDLIENIFEKKIKQIKEQGDYNEDQVLDLLLKIQDHEFMKEYYDKYKESEKLKDIRGNSPAFAKKDAKLTRDKNDTEKEHEKKAREYPDIVKNERTKVQEKIFSHFCNEILGSEFSKEMARLCAIAVQLRIQDILQYDISKYKEFVNNCDLSKYNEQNDEIKKLNAELDKSNAELDKSNAYLKKINDLLALKREKKSNKPKDNNLTAELEKELGRETNIRDLIAKQTEIKVTITQNEGCIELLKVDIKEAKQSLAKLNPLSGDVAVAFDRRAGEMNAYLDILVKNHSKKDKHGNLFIGDNGNLSRGYYRIVSHLSNMAKHGIDPYEYPLEVKVSESESEITEEKSKNPSQRTVRRSPGKTSGKNQKKSSGKKTEDKAQTRPRSGSELLTGSQANLESRQKSKNSGEHAKVTGTSPRPKVAKPGSKKGTSPDKSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHC1</accession>
    <name>A0A5C0UHC1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="440" mass="51487" checksum="19F0EC2648C2E590" modified="2019-11-13" version="1">MRIDSELYEQQIEHSNPKDLNEKIEKYKYEKFCTGFSNLIEFFNRVSVKLEIKSGAEYTINYKGLYNSKNNAPLKIIFIKDCLGRSIPFVFDTILKLNYKSIFIGRHSLIVLIHEGKIFEKPLFRISKDHGYLNFILSYGIERNFENSMFFQHESTIEKEKPCLVKNFIKKYKNELFCKKDKMYMFNQITQKMFFDIMELITVTESDIDTAMSLFLDFSEYLAKYEKQNEEELKKAKSISKKAKGKKGKKHKSRKNKSSKIKVTEKLEEQCEEEFVEESEHEIEELTSKEVEIDEKESETHGEDQDKIEIAPLSKDEYENNTEPEEELVIESTEDEKIDFMTEALYSHAENKKSLKKQNMIKLISKWLKHTNLYDEVNKINIKGSHVSFHINNMAVRFALPHGSSKDGASRGVMGKIARQIANIQINKVKDSGIADIKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHC3</accession>
    <name>A0A5C0UHC3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="140" mass="15104" checksum="C94972682B20FA6F" modified="2019-11-13" version="1">MNSLFRLSILSVALILTGCGEKDKSASCSEHVHFANNVSAPSKEESEKVKNFADKVKGGLCKVHVEGHASAVGSKAYNLGISKRRADKVASQLVEHGVDASRIEKRSFGETKMKDDSSEERRVVVLSMGPSESSHESEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHD2</accession>
    <name>A0A5C0UHD2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name evidence="3" type="ORF">FZC36_00730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MraZ" evidence="2">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="158" mass="18225" checksum="F0CC49B290ADFFEC" modified="2019-11-13" version="1">MSVFLSKHSKVIDERGRILTPSSFRGSLSKESFQGFVAFKSNFLPTLDCFSMSKIEKLSFKYENEDPFSKNWNYNENDMFADAEMITFDKAGRIKISEELLNHCKIEKELIFAGRGSSFQIWSPELFADNQNNSRRKIIARQESKENAENGNTDIQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHD9</accession>
    <name>A0A5C0UHD9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022687925" evidence="2">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="155" mass="17031" checksum="2101CA74AF264051" modified="2019-11-13" version="1">MKKFYLSLLLISTSACFAMNERPCSRNGGKNIVMSDFVEKRDMGDDFDFSREATGVSFGSRSNTFVDFGEDGKTGVSPAAEYKAFLNEIGVNSRSGKYDLFGFNGPDCDLSDDLMDEMLSSKTGCSLGSESSESKENEECDSRKVVEQKVPTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHE5</accession>
    <name>A0A5C0UHE5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_01410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="4">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="5">
        <location>
            <begin position="158"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="6">
        <location>
            <begin position="257"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="458" mass="52019" checksum="7A8435C7F672D67D" modified="2019-11-13" version="1">MEFMVSNLFPRNVIGDYDIRGKVGIDFSAEHAYQVGLAFGSIVQQQEGKTVSVGQDRRKTSPMFSSMLIKGLLDSGANVIDLGKTTTPYVSSSYNFIDCDASISVTASHNPAHYNGFKFSLFGNSFFGDDLQKMYERIVNKSFRSGSGKLTKRSFVDNYINYIKRNFNISEKSKVIWDCGHGAAGEFIELAVKDLKGEHKIIRSEPKDVPDYDNSKISFLEKTKEELDKNPGFIAFTFDGDADRLVIVDEKKEVWTGDEVLCFLSLVKRIKSGQKISTVWTSKSSKKITDWLKEFEIESFFSKVGHCYLTNAMNKNLSSIGGEISGHYIFRDNFFTIDDGIFTALRFLDCMSIFPYKLNQIKSIFPKVWVSPSLRIKCGTLKKKEIMEYVENILVISDHSFELKDDSIIVNHPMGWWLIRPSQTENVVSLRCEGWNENGYMEVKNFMETTLANIGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHH0</accession>
    <name>A0A5C0UHH0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="727" mass="83362" checksum="262CDC9BEB69FD0E" modified="2019-11-13" version="1">MKILKNFFRFMAVLSWKFFSTLVFTISCFNYLIIFAIFTSLYRKSFDFLIGTKSEFQEIYFKNNVFGLKGFVSKDFSVKKIEANLNKQNLVMENLTLYGSEFGLLCDYRDGVKIEVSKSNKKISYFYLDDNYVYDFSVLGFNCGGRFLFSESKGLEITFEKNSKGFMLINDNSFLLNFRNESLQLNLSKNIKSSSFGKLARRCLKQTTDFKKNEEVDCSSEGLKSCNTPNTPDLHNTINDRISDNSNSLTNSENSLGSDNIHIDNESKNEECLYYLDEPCVEKLNTSFAEAKEKKYERDNSSKSGNKLKSNSKKHATGKTKLKNCIKNKKVNFVNKYCNFDKVDFSCKDFNGTKVGFKYNDGIGVGFIKSHDFCDHKCYLDLSFTAQFNENGIEITSKNSSKTQEIHLNCLDLHQKHLKWSVALGDKSYVKIDSGNLQVSSKINLRKTDFNFFIDTSQVHMKGSGYFDQSMNMFVKSEGNYFNCNLVDLGMFKGPGLGVSVVIDSFFKEIFVHGNLYLDDAHLIFNTKKTSDSAIVFQAYCDKKPIYLWSKNGLLVNIELFDFGKMISLLSENNLVKNGGHLLGSIDFSNKVIDWDFKIKDMRTKAKLDSIFINLFSITYWTKMMKYSRDTWDLFECSGSLINGQYNIKEFKLSNVFSVFDGEGYLSKDNKIFINGRMQSRTVFNEISGLVNKENHDLNFVVEGDVSDPVIRKNIKMKRIVSSLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHH5</accession>
    <name>A0A5C0UHH5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="3">2.5.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="438" mass="48641" checksum="E4ADB059C04CA0BB" modified="2019-11-13" version="1">MNFCQITGSKNIGGKITCSGSKNFSTKAIIASMLSDQTSFFENVPEIGDIDSLKTLIEDCGGSLIIKNNKAEVIPGKSKSIIKARDNVMYGRLSILFLAVLIHKFDYVEVPNQDGCDFSGRPLNFHEKISEKFGFKLGSKDCSFFAEKSKKLEGQDIKLDFPSVGATEFAIFLAVMAKGFSTIENIAIEPEIKSLITMLQNMGAKIHYLKTRKLFVEGVEELCGIKTEMIGDRVEASSWAVLAACTDSVIEVENINPEHMSGFLGIFRRMGGGFELEKNSIKFFKKEKLHNILVQTDTYPGFSTDYQAMLSVMMTQSEGMGIIHETLFKYRLHHLETLKLFGANTYSSVHCVGDVCRFKDQNYLHSGFIVGPTKLTAPKKTVFAENLRSGMAYVLAACISEGTTSIGNMDFVYRGYSDLYNKLKSVNVNVKLIDNEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHH8</accession>
    <name>A0A5C0UHH8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="242" mass="28533" checksum="279A3C146DDE28E8" modified="2019-11-13" version="1">MNSKKIIEIENILIENYTKIQMPVLVYGNNVDLLNLMSERVANYIYKDNCADFLFSSCNKDLSIREIENFLNKTPMYDNTKLLVLQSAHKWTDKNFSSLLKILEDMLPFNRIIITSSSKMPPTIMSRCLSFYAYTPILKDSEIIKCILEKDFILLKQKLNESEEGIDVKLDSVFLWVKEYIYSKIKLFVGDQKSNSADYIYYLLNVWDNFEKTYKWYKKGVMSLKQATEIMLQTLKNCFQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHI4</accession>
    <name>A0A5C0UHI4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">FZC36_01960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="99" mass="11540" checksum="44456ADEDF82FA33" modified="2019-11-13" version="1">MDFAIVKSGSHQYVVEAGQKIICDKIDLEPGSTLNLDCVMGWDESEFTRDVEVKAEIVKSFRGDKIPVFKKKRRHNYRRSKNHRQDFTLVKIIELNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHI9</accession>
    <name>A0A5C0UHI9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="676" mass="77360" checksum="51DF5A9BB150521C" modified="2019-11-13" version="1">MYVFYRGTHFNTNVTDNDINRIVNDSKKRNLHGIDCTSKYSAENKLDESACEQLSNDFAELSYKGSIKFQTGKSKSTNKDFRSPMHAVQEMHVQNCDLFQEKLKDRTSELSKMLLETTGEYIDKKFLISTSLNPYVALKFCTGRAGCPEGQVRKPEKVNNELFINPLLGYLDIFVVPLDEIKSLNPFFVTEEFSTLGITLFNGASNPRHEQEEVTFPFHIPGKYHKLRYFLDVSKEPSFNKVENCAFKTFNKGNENPNRLTPIAQNIETMVSGFLLKNKFVQTFSGPTLQMLNKVEHFTPSDLKLFRKAVEEARIVLIAPHHGSESNNNKSSLINLFNPSNYIKPHHGSSNSQEHCFHVNLKKVFKENYDPSQSLQTDMFIKFQAIKYLGDFWDYNKNAPLHGHFNLHIDLSDFCLNSPEKRKLIPIILSAKNVKAIKILGMDELIYWGNIDRRGIEGSLDIEGKKRFCEEKLFPWKKLKDFPEIIKLLEFVGTSIHPKATFTLDLTGNSFSEDESHRAFEIIDNHKPGSYIEIIDENLDANQAEEFEFEEMKERLQELIEEEEEESEPSETYSEYLERRSRCTDSESNQCTSIDESSLDQTKSDFSEYEEEIEEEEESEIVSESGEENSDLDERSSGYTDSESDDTKGSGNGSDSSNPSYGHDSSESGNANNCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHJ9</accession>
    <name>A0A5C0UHJ9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="13"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="293" mass="33247" checksum="3546EACFE5134311" modified="2019-11-13" version="1">MFILFAIAIVVNLTKTNFVKLKKFHGTEFFFKSIDSTQKFARELIKENLDEYFEDNKFITVRATKQEVGVGQYERVWNSPEGNLYLTSIIPVPNDKEAQDLINLSQMISLLIHQILKDYRIDTEIKWINDVMYCGKKISGNLSELYDYNGSNSGKISKVAIIGIGLNINLSPLGRSTCMKEAFMLNNFINNNGMVSLNCVQNISVEDFSDHIACRLGKFFRDFLQTGIKPHLDYINSNLAYAGQNVILNSREETFKGALKGINDNGMAVLTIDEKEKEFSSGSMFLDLNDTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHK4</accession>
    <name>A0A5C0UHK4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="7">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">gltX</name>
        <name evidence="11" type="ORF">FZC36_02395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="9">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c" evidence="9">
        <location>
            <begin position="73"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="10">
        <location>
            <begin position="360"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="506" mass="58685" checksum="898876B53803E8A6" modified="2019-11-13" version="1">MLVKIVTRFAPSPTGFLHIGGVRTAIFNWLIVKASILKEINGNKEISNSFEINNKNRLDLESNNFNEINENTNKSYKSNFLLRIEDTDIQRSDEKYIKAILEGLSWLGLDFDGEIFFQSKQKEIHIKIAHELLEKGLAYKCYLSKSEVEEISKTGDKSLLRKWRDCKEIESSPKESRKYVIRFKMPVSGKAILNDSVRGKVEVNYEELYDFVILREDMTPTYLFACVIDDHKMGITNVVRGDDHLINTFSQNEIYKSMQWDIPKYSHIPLIHDEDGKKLSKRNSAVDINDYKRMGILPEAMFNYLIRLGWSHGNDEIISVEQAIEWFSLNGIGKSPARLNMDKLLHINSHYIKKSDDDKLVDLIKDYLNDKEKSGIVPKNWLMIKNAISELKIRSKTVQELKEMCVNYFGYNLPIYKKETISMSEEVHRFLQNWNAFDEEGLRREIKESGLKLKEVAHAIRYAFTGSQVSPSIFHIMSILGPELSKSRVSNFLTMSDNIEIQRKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHL0</accession>
    <name>A0A5C0UHL0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="5" type="ORF">FZC36_02160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="183" mass="20463" checksum="8C213A03DCDDE9B9" modified="2019-11-13" version="1">MILNDSQIKELSKNGMISNFSEKNVCKGVISFGLSSFGYDARLSNDYKICTNTYSTIIDPKNFDEKTFIHHSGETCLIPPGGFVLCMTMEKFKIPNDVLVICVGKSTYARCGLIVNVTPLEPGWEGYVTLELSNTSTVPIKVYSGEGICQFLFFKGDKCSNSYKDKSGKYMHQEEITFPKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-10-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHL1</accession>
    <name>A0A5C0UHL1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="77"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="261"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="391" mass="45457" checksum="85AC6B64874B935B" modified="2019-11-13" version="1">MMFKYVYIFNNQKTLGYIDAKNKAEVFDFLSSKQTNGNNIDLVCVKRSYIAFINKFLFRKMFKYKDMYIMFGFLHKFLSKGLSLDKSLKCISECKIKMSSFCLDVYEIIKNGKSFSHCFKSKSEHFPRNALYPLLLIDKVGDLDLYCQNLSDYYKNISEKKEKINKAMRYPLGLLSFFVFIFVFLVKFFIPSIVDIFNDMSLEIPMFLNCIHCIGNNLGSIGLVLLVIMTLLYYFNYKLDYIIDRLPIVGAYRRYRDFSFFYKSISLFINNGVHLTDAIKNTGNVFSNKKMVEKINSITSSLLSGYSLHKSFERADLDYMDVIMIDLYEKSGDIKLGFEFLAKANEDNMIEIIDLIKDYAQPLVLIFTGVLLGLIAYVVLSPIQYIISDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHL7</accession>
    <name>A0A5C0UHL7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">FZC36_01985</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="344"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QEK39191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="462" mass="50758" checksum="526A5F96B1F76E70" modified="2019-11-13" version="1">MRKYDLVVIGGGPGGYTAALEAQKLGAHVAIVEKKTHVGGICLNSGCIPTKTLLESAELYQKIKDSSALGIECKDAKPDIKKIIERSKDVINQLSTGLYALLKNKIDFIEGYGKISSDKYPFEVEVNNETISAENLIIATGARNRQIPSMPFDGKKILSCKDAMNMKSIPKSISIIGSGAIGMEFASFFNALDSNVTVFEMQDKILPFADEEVSIAAKNKFESLGIEFKLSTSINSCEIKNNQVVLNKNFESDVCLVAIGIQGNHENLGLENFPKIEIEGTFIKTNPLNETGEKGIYAIGDISSRTPWLAHKAIHEGIRCVHRIFNNTSIENNISERPIKDEDVPVCVYTIPQIAQIGLTEKQAIEKGHSVVIGKQNLKFNGKALTKNENEGFIKTIFDKDNQEFLGAHMFGKNVTELVHGFSILQNMEGLLWDIKNTIFPHPTLAESIHDAVSDAEAKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHM7</accession>
    <name>A0A5C0UHM7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022729783" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1471" mass="164600" checksum="22E2E698C1D5E8ED" modified="2019-11-13" version="1">MTRYKNNKTNTKLMSALLLLSVANISAGDIDILSTGLFYTESSSKKTKYPVILESDVRGIAGKLDQKTKYEFKNKHKLINDKGQITSNALNITFENGTIPAIDFTGSQNQPAVDLRNKFIALHSFAYGLGMGSIGSYDGRFVLVSRQSNGNQSLYDISKADGVWGLNLTAQVGENPLSLYDLFAVSTDSEKKVSDVIMFLNSTYSMDLLEASTKEEFDLTNLNIDISIADEKLLRFSADAAPGFAQRFGYSDVSIHDSYDEIRNKVVQELDLPEGSLSFKIGDQNLQSYEPYRIKRAINDAFFYSDSKADKAKSVKEAQEMINAVRWFVDKMNVLRKEKMDSKNTADGKETISKRVIEVTELCLRAFESRNFSTESYQSFFADLFSSGFINKAADKLYSQNLHNFLFLADSDRTFESFKTELLDVRLDTESDVQVFIGNYVTKGLESNSLISLIKELNNSYKNADGTNSVLGKFEYLYSDSDVSAKEYVSISLALKEATHFIEEIGKTYSDMLSYKGIKLSSYDVNAVVYPIRVVLHDKSSDLATLDGRVSGAIAKSRGVFLEKFAAAEAEIVKAYYSDLEFEGTKLSDVKDEQNNVLFNDLDINVSNYKAFSEVFTKLENLESEIVDYLGLSGNDARRDELLVHILSVTDQGKSLEEIGSKVDFIGDIINNNNNKRIYNTVNSGSDEALKDSFRSALFHSIMEKSDLSLEIFEKIAQLYAENPKVVDLLKADLEKIELENKDKAIGFKLTDMNTVYDLAVEYGKKIHEITQEYKLGQAEDLDNTVDAVLEMLLKDRESSTVGEILSSGYNTELLEAVFKSYLNEKINSSYFSEQNAKDAFVGRLNAITENIIKNSKDSNTIKLGMNALNDTLSESFDLFDRIYSVEKSHNVDSLGGDNLFSFYSLIEILEQASKIISNTFPDGSKSELSFEISKTLFAPLKALGVNGSEPGVILNIENRFLPLLESNSNDKEGILVYKLLFNVWDKDGVKDQLDSYEAIKDRLNSISTLSSILKNPEARVFGRYVNEFFGDENARLVNVGGSGDFANLVDGVKDYLIAYERFEGLGISAQSLFRFDSLVLKITKPGAAHGSNRMLIGTASDDNDLTKVSGVLSDFVEGFSKLSSDIKIIAESYLNNNLESGNTSSIVDVEGLKTLLDDALTVNIAKLFDSVEKSSKSSAFKKAFMVKVVDLEKGITHSEKNNDSILIKTTDYLTSIDELESSDNLVKDSDLFERYDEDSSDNNLTELKPIYDPKWTGDQKLHAVVRQTHAKYQDMDLTTNAFARAVTNGDKKEIELHVNLYDLKFSKGDINANRDIDKNKFYRINVPQSVCATYLKKNRDGIIIIDGAMFNEANFKTVLKRAFGEGQAQIHLSNDDSEISLERVEYKDESQKTFKYYLNVAKNADGNVSLRNLSSLKETERFEKFASYSNLPSGAESNNALDAFKKIEIIFNTVNREINDEHFIAQNNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHQ1</accession>
    <name>A0A5C0UHQ1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="174" mass="21211" checksum="5C4F2002CE2A0415" modified="2019-11-13" version="1">MIFSNRYLNDFLKFISQTWKYLLTVFVFMVISLFYSIYVSYISNKKNTDLVFSTFIETKSEDRASYVKRIISDKSLSKNRMEKSFQLFYLFNFMETLLEKRNVKNDFNSYIDVVLENTENKKERRRLEKLIQTETFLRNYLEFMFVSKREESFGRFLSVGSPWKRFAEFLNKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHQ3</accession>
    <name>A0A5C0UHQ3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall polymerase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_01370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="367" mass="42177" checksum="DCA196B16F354A1A" modified="2019-11-13" version="1">MNARIFRNEHRFKIFNTKLPIYASLLQVIGFFALWSMSENKKALSHLVRLIAMIPISYLIRKVRPSLIFSFSDFFYFICVLLLLFTFLYSKKHMGAYRWLNLFFIKIQTSDLMKVGVLLYLSKFLHISSSSFKSFAYVLCIVFIPFFFVMKQPDLGTSLIILVTAICMIYMHNFWWFLSIFLSGVSFVPFVWKFLHSYQKNRIMAFLNPSLDTKGIGYHSNQSIISIGSGGFWGKGVGKSTQSTMGFLPEKHTDFIISHIAEELGLIGIFIIILLFFLILLEIYKLIKNVKIKYYRMLLIGISSYILFQAYMNIAMSVGLCPVVGITLPFTSYGGSSLLSIWICIGLVENIASNQNYVLPGSDFYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHS6</accession>
    <name>A0A5C0UHS6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="174" mass="20192" checksum="25965B976121B3F1" modified="2019-11-13" version="1">MKLNDLYSFSPNLLKNINCKVKWFKAKRGYGFVVNEQIKEDIFIHSSVLLLFKKDLVLSPSSNIVCDINLNGHMQKPQVIAVHEVLGSKSEKMDLQECKGYIKWFNEIDDYGFVRVDNYDVFLPGKAIRENKINFYDLNPGTEVDISYFIDENEKKIVQDIKESNKQNVQSANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHT6</accession>
    <name>A0A5C0UHT6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="463" mass="52848" checksum="A5BF4537DDE2BD0C" modified="2019-11-13" version="1">MNIFKKIISILMLYNGFYIKGGNSLSESNPGSATPICIEDILEDMFLKNDNQTNIDSTTSSENETQTQRLNAENLAQLELADPSVRDGEEGEAINLNGINFANWDLASESTNLTFATSQQDLRRKIEQVSADLELAKKNRDLVIQNGNLTEQGMSLAKQQVKLSTQNLSLLSEQQNLVNEKHKLSLENINLKSEKTVLEKKLEIAEQKLKVLEISSIGKTKELKLRYEALEKALEVSKLRNEQKDLSIELSKKQIEELTKLNQSYEKDKIRLTELNKTQEDLTKSEKECSALSSKQLKLQIDILEKQHKSSEESLRLSQKSNEKKDLEIESMKDRIANLVKIRTVNGTEIEALNGTTKELREKLIYALNILGPEGALYMKKFSIFRILCNDQEQARIIVIHKSGESRNVLISGKTENYTMVFERQDGKIKTHYEKMCLQEDNIHYSKLAYLAQRFVIISLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHU5</accession>
    <name>A0A5C0UHU5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="671" mass="76670" checksum="E58CDBF64EA40FEC" modified="2019-11-13" version="1">MMTSNLDKFTSGASAKQSANANGSTNKASKSSTMSKMRSILKLCTLALTAQHTNTVDIPKLHDIPNEHGCFYHLKYTKNGTLDLYESGLPKYESGLVDLLDGMVEMHKFSKSDIEFVAFLRHEIEKILEVDYNKGLENDFLLKFPKIKGIIGDGELEEEVLAEHGYSKEDYDSTITGYNVRDSLDCLIRAKRIWGKMIDQYGEEDLNKIKDSVKNANHEYELGKKTHLNLKVMHNLVGYGLRQREAAGMPDESTFLQRWYSGRHAYADDKKSKVSIKLDNSAFIYQVIPTKDSGTDYEKKPCERHSNIMSVSYFDANTKTDNLVWAGDERELKERTCKVVQYNSFPDLRNLDRIGPIFQYALALRYVHLDITSPDHLYWMRFAQDLEYVKLRVTESDHLKHLGLLKNTQYLGITNINVDDAIILPEEIGTLSKLRCLHLSGVEGYPNQIHGIKGLREIKFVESEGKIDKSLSDLDKLVHLELSGKVELPETIELWGLESLVAPSADIEKMPRFICPELRYLDLGSARLDHALEPGAKLPIFAGGNEMTKAVDLSECPELREVWVGNRINEVDVSVFKSCKKLMYIGLGVDFKYSIKSGLTEYVKKNELFFELLHPLNAGEKLQYNCKIPGEDGEWLKLKRYQENQKRNWVRNKNARYKHMAKILKENGQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI24</accession>
    <name>A0A5C0UI24_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="622" mass="70564" checksum="68C8C3138F25A954" modified="2019-11-13" version="1">MKLKSSLLILSSIICCDLSCRSLALEKAAVDFLSKGEKYDGAIGYCEKIDSEYVLCLETGESVSSKNKSFAKLFKNNPFGGKHLELSPIWRSIVSKEADLEFVIDSEIGYAVSQKLVGKSEKDASIAMLDKMKLISSDYFKSGILKGLEKHSAELSVEDKDKFASYRTEVDLDAKKLQEEYDLAVKLKSKLEGVDSFSDQDRVLLNELKVEYEKARQGYEVSENLEKIKKHATGLYEGKVNDYKKEISDFNEIIESRFPDSDLDLSFLKSVASADFEKFVISKYAQNIKSLLNIFIQKLIKIHDIKKDFEKLRGIKNSETLEKIRKSSDLEDNSYMNTFWNLTNVQSLTKILENTSSLSIDSAYDLLVKHSQVENATLAEKYAKKDLSMNEVLKETKEQIFERFKIYLNTKLISNSISKNIFEYSVNQYKSLLGKINSAIEKNKKEARKEKITEALSNIQKYLVMENENIVKSIENLSAAVNSVDISHRLNDSDLKSIENKSAYGKFANSSSSFGFSADNLGFNIYSKEGKKDLNIDKFLVEQSVSYLQAKNSTDSFEEEMHEIFSKMESLIGKEKGNDYLKGQNSSLNMLSKSPEELEQNLKDGMSSIKQKHIDEISKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI32</accession>
    <name>A0A5C0UI32_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="194" mass="22662" checksum="7BC8D9E83D360A68" modified="2019-11-13" version="1">MDSNFDNISEEFSKIWDFVLYQKKNFNDMEKKLSGLFAKIGSVVDQKMDKTNENVDSGNERDTGVNLIVRESSLSQGMKKDFEEEDDYYIEKQSDEIVIYSKSENSKCSINLDRLYGEAFNMKFDENKPKSFTGHRDKIEIKKLVSESELESLRRSLESGGVENKEESACVYIFDGKAYFYYKEEKELSYESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI56</accession>
    <name>A0A5C0UI56_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--N-acetylmuramyl-(Pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="4">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="201"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="399" mass="45308" checksum="AC7E103CBBC67AE1" modified="2019-11-13" version="1">MEISTIVFSGGGTAGHVFTANGTAFFAKARNIKRIMITDQRGYKYVDKTLFDEIYVIPILPNILLHPIKFFKSIFKSMKIIKNNPNSCVIGFGAYISLPACIAAKLKRKKMYIYQGDQIMGKANRALGYFCNKIFLSSFNIKANKQKSSIVGLIPRHSIKSYPIKINSGIKLLVIGSSINTPFWKFILPSAFSKLPKEVLSQISIRQQVGKDYEYFDKIYKNIGFKEVSLEKFIDTNTSLPWSNLVFARAGFSTICDLTASMRPAMLVPWSKSKDNHQLRNALWFESSTGGWCVKEEMCTPDYVSNLIMKVYKYINNSEGLNNEINTSEDNTTNIKKDTLTKSNQTNEVKIAEEKKEKMKNEEFNLESKSMNLSKWMPVHGGLIIVNEIVEDHKKTNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI97</accession>
    <name>A0A5C0UI97_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_02670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="325" mass="37740" checksum="6BA36457999995AF" modified="2019-11-13" version="1">MTSISYIIIFSYFLNIISFVFLAFIIAYILSPCFDFLMRLGFGRFFSSFIVTFLVFCMLVYSIIILVPKLYIQGIEFVKMFEKYVIYLKEHSWMTNYSSDVYSRIESIFNRKKFLDKVFILVSNYGYDFLNIIFQGFGLTMTIFYILRDWGLWTERILSIFSESKKVIINTLIQDINNSLRSWIYGQMIVTLCLFIFYFIFFNLMNVPFVFFISLLFGLLAILPYVGDMISFCVIVSVLIAGGNLFCQRSIAIFIITFVGFFLENTVLIPSFIGRRTGIHPLFLIISFLVFGKLLGILGVILSVPLSVILAVVLKTWSQKRDKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIB2</accession>
    <name>A0A5C0UIB2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FZC36_02450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="13">
        <location>
            <begin position="65"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QEK39331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="465" mass="52302" checksum="94806EE6D0A6852D" modified="2019-11-13" version="1">MDNEKNNQRDTQDNLYGDNFVKEEVVNQKNTKQKNVSQKKTRFEDFSSDKSFDSVYREESFGDGVYLDYSATTPCDPSVVDVMSQSYKIFANPHSITHMYGWNATDLVESSRAKFASIIGAESKEIVFTSGATEANNLALKGVISNRRRNGLENPHIITTNIEHKATLETCHTLEKQGVEVTYLEVEKKTGLLDIEKLKKSIKSNTVIISISWVNSEIGVIQPIEEIGNICEEKNIYFHIDAAQALGRIDVDVKKCKATMVSFSAHKFYGPKGIGALYIKKRTRVDSIIDGGKQERGVRSGTISPQLCLGLAKAAEFSTKDLESENIRMKEMQDYLLSNLNNSISDIFINGDMNSRIPHNVNISFACVEGESLMMKMEKYAMSSASACSSQTLQPSYVLSAIGVDEDLIHTSLRMVMGRYTTMEDMKNFTNDLIESVNFLRNISPLWDMKKKGIDLKTVEWHDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UID4</accession>
    <name>A0A5C0UID4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="308" mass="36232" checksum="F14D42CC4E94CE77" modified="2019-11-13" version="1">MLLCITFESNSYFAEYAKMDGFTSEAKELIGKMDEAMALPDQCTAGAFCVYRGNNLVDLVYGSVFDELYKKTEVIKSVSLNEIQKWLIINDGSLKGISYEFFLDKEEKHKYGKRTELVDLGPFIHFRSEMSEKESEKVSRSVCMLLCDYDGKYIQNGYVQSIVNQYRDSVLFVYDEENKSVLEKKSNIDDVLYENLYSHRLYSIDSEVFEIRTKNKLGGWLQVNYNRIDPESFNLEFYNRLSSLLKRTSYINSEKIPEYSTEEEFTYEKYVKDISLNLLFYITEEEFNSKESKYDALKFYYTNMNEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIE4</accession>
    <name>A0A5C0UIE4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="148" mass="17123" checksum="8A6CD0B19F45C483" modified="2019-11-13" version="1">MECVLSKLSKVLMMEIKDKDKKSFEQDLENILQLIEKVKQITSNSTESQNSNLLECSHTNRIHKYEMSPTQEDEINPVAFDAFLNKYNSLSNCINNQNLINDSVSISTINIENDFYSPDYETPIKDIEKLKEQESMETKNFFITDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIG3</accession>
    <name>A0A5C0UIG3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="6" type="ORF">FZC36_02055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="188" mass="21930" checksum="34582DC57FFCD137" modified="2019-11-13" version="1">MRKYSIIKSSHTFLSMKKSKGFFTDIFSIRYRKNSNIPNINTQNLKHNSCNSAEDKNMSCYGVLERNSLLDSNIDLNLDNTCKDFGNHNLDSLMPCDFNNINSNLQIKEYVQIGIIVKKKIGKAHSRNKIKRRIKSALDEIFNSNELEKTEQIILFLVKKEIVQSTYQEIKSEIEKFFLTRKIIKVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIH5</accession>
    <name>A0A5C0UIH5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="3">NDK</shortName>
            <shortName evidence="3">NDP kinase</shortName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndk</name>
        <name evidence="6" type="ORF">FZC36_02680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="5">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="134" mass="14885" checksum="EC97606A26C1E74F" modified="2019-11-13" version="1">MYQKTLSIIKPDAVKKKAIGNIINIFETNGFTISDIKMLKLSMEEAREFYKEHAARPFFNGLCEFMCSGPIVAMCLEGEGAILKNREVMGATNPSEAEAGTIRKMYGDSIDNNAVHGSDSTESAERELNFFFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIH8</accession>
    <name>A0A5C0UIH8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
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    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="114"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="416" mass="48143" checksum="B15418DCFE004E92" modified="2019-11-13" version="1">MKLRFLVTKDKITLRQWFREHFINMQFGDLQKNIRLKNIRLTNRKTTQDSILSREDSIEIWDQIVKKHRTGKDDLKTTANNTVIHQKTEHIINKPSQLKNTNLDKLIMFKSKDFCVIDKPYGICTQGQNPSIYSILKEALPEHPYIVHRLDKNTTGTLLVGLNREFANHCRENISSFTKKYITIIPTAYSDNQFSIRENTGHKIDVEIEPIHAKSGKSSKPNKHITPNLHTLSNLDINKYYLIKSDNSALLTKIKIVRKFTEKTYISKKNQQNDKGESNKNNKYTKDIKEIHIAIDSPSNRKNGFSKHLGKHFNAEFAVLEIELITGKKHQIRRHLSALGHPVLGDSKYGSKYNSKLALHCTEINFFSPQNNVEKSLESVSINETNLDKEKPLLFKSKIPNHIGVFLDKNYIKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UII5</accession>
    <name>A0A5C0UII5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplK</name>
        <name evidence="7" type="ORF">FZC36_02235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11" evidence="6">
        <location>
            <begin position="81"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="151" mass="16383" checksum="5C43A9C25C5402B4" modified="2019-11-13" version="1">MSANKRINKSKFGVVININLPTGGKVTPGNVGAVLSQHKVKNMKAIVDKINEIGKKISNAEKVPFRIYLNGDKFEVQSLGPSVTDLIKQEINLSKGSDKPGRGDFVAEITEAQLEEVAKKKMQYVSFHSIDSAKKIIAGSARSAGIKVIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIJ2</accession>
    <name>A0A5C0UIJ2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="623" mass="69202" checksum="ED880E033250E137" modified="2019-11-13" version="1">MKSINFLLLCLCANLTNPINCSGIGSEMPGLQQSTRDPSSETSASSISGRAAGIELESSEFKAKKLLEANESKVIFDGKIFRLEIDTADGRFASVTGGAPSYDLELLTVGGLNELQSSALGKFFTNFFKALTEIVTDHGKSLDKNTKTFEINPETFQAVSQKALESGSFTEAEKELIERTLKDSSESGESKFKTKANVLYQEPTKGSLNTEANLQMSLSFPMEQFLGILNKDLSQNIEQRIREQVVKTEDLENISDRLKLMNLNPLVVNPFAVANSELKTLDDTGAAAFVNRANAFKTLFTKKDELSLDEKIKKLNEDIKSLEKEQESFMKKNNFDKYDEKGAEITEARKALESLSTETDPREDLLKQSALLSEQDIDSSAPIKDKIKSIINKTGFSIESSKKIQEFIAQPLTVSEDIFKQSNNPADNLFALFSLYVSDLFLALPRESKEIGPKSMIAVMSRMPFSDMYRSLNETDKDKFQDLYTKHFAKFGGLLINPYNLGKDASEANLISSNKLITLDTWFDSIITKPIVWAADGPYVNNNVIDILHPPADLYPGYGMGAIRPEEGNGLQGKALVEIRTVHDRVSKIWEAYSHQVKDLDISEKMISLVLKGFFGTTAEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJ92</accession>
    <name>A0A5C0UJ92_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hflB</name>
        <name evidence="7" type="synonym">ftsH</name>
        <name evidence="10" type="ORF">FZC36_00255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="189"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="597" mass="65511" checksum="6FF03D0764E6367E" modified="2019-11-13" version="1">MFKNKNLILTFIIFFLSLGIVNLYLSNGEQERKNIPFSDFVQDTSKGEVSHVLIKGFEVNGSYKNGSKFSTMVPYQDNMLIKRLMENKVHISVSYSNQSTAGSIVSLILSAAPSVLILILIVYSLRQIQSGSGKAMKFGKSNARLIDQKNNGKVTFKDVSGLEEAKRDLAEIVDFLKNPKKYEELGSVIPKGVLLYGMPGTGKTLLARSVAGEAGVPFLSAAGSSFIEMFAGVGASRMRDLFAQAKKNAPCIIFIDEIDTIGKERGSGLGGGYEEREQTLNELLVGMDGFEKNEGVVIIGATNRFDVLDKALLRPGRFDRKIPLHLPLTKEREEILNIYIKKIKTKGQGIDAESLAKGTPGFSGADLRNLVNEASLVAGRKNKKSVTMQDFEDAKDKIIMGSEIKSLSLSEDERKLIAYHESGHAITSIHSESSDPIHKATIIPRGSALGVVVRLPERDEVSIRKSKLLDDLVVSMGGRVAEELIFGPENITTGAYSDIQFATKIARSMVTKWGMGKSGRVNYEMDPYSGAKVSEDMIKQNDLEARELIDSAYERAKNILKDNLDDLHLLASELLEKETLTGKEISDLLSVSQEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJB4</accession>
    <name>A0A5C0UJB4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="916"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114330" checksum="88EFA97C33AD9E3A" modified="2019-11-13" version="1">MKLNLSKFFISRPVLSWVINILIALSGYIGLRNSVLRENPQVDFPVIEVRMEYPGANPKVVESQIANPMEEEFASLEGLKGMSTTISKEGEAKINMTFDSGRSIDSISSDVDSTLRRVRGVFPPNLKDPQVRKSSSNNGSFITLAVFGDKYTSSELSDIAYRHAKNSLESVNGVSSVKVAGMTGEGKTYRIDVWLDPYKLKSFNLTAMDVYYAISKQTYLYPAGNIESNNIRYSVTLANELSTVSEFEEIVIQEKNRNVVKIKEVAKVEMQNADHDVRTRYDGKVCSLVNIDAQSRANQIQIASEIKNRLPDINKALPSGVRIEVALDRSESIKVSVNRVVQSIFEAVILVVIVMILFLKSWKASLIPVITIPICLLSGFTIIYLLGYTINLITLLSMVLAVGLVVDDAIVAIEIIHKRLKKESAKEAAINGMNEIQFSIIAMTLTLVAVYAPIGFSTGIVGSLFKEFSVTLAGMVLVSGLVAIILAPVMSSYLLVNDSGIKAYPVVKFEKYFKKLESGYEKYLSRAVEYRNIVIFFGFLFGLSGLVIGKFFLRSEVMPIQDQGMLSLEIRAPSGANVKYMEYPISKAEEIIKKHPGVRSTFSSFYSGEGKASITILLKSFSDRESAFKISKSLNDAIRKQIPNLSASVSVPSGSIGGKANQLEFSIKSSKSYDELEKFANKVSKIVHSSPAVESVQVSRISPEKTYDIKINRDRALSLGVDLGFLKENIAMIMRGNPPAYRYEREGKRYPVSVWADQKFRSDPEGIKQFYVKTNVSEEDQRSIPKLVSLKDIVVVEETKNRPFILHEDGVRAFNFVLGLKPNNDVIETYNEIKEGIYKIIPQGYVVSPGRDVRTIIEEGNNFLFIIGLSLLFVFFIMAAQFESFAYPAIIMLSVPLALSGAIFTIFLFSGSSFNVYSQIGLITLIGLITKHGILIVEFFKKELEQSKDPVVSVIKASSLRLKPIVMTTFAMVLGAVPLLIPGSFGYEVRSSIGLVIVGGLSIGTLFTIFIVPCLCVLFIDLRNKSTGYKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-10-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJQ0</accession>
    <name>A0A5C0UJQ0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_01115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.65" evidence="10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="214" mass="24322" checksum="D140E9D81D95C588" modified="2019-11-13" version="1">MINKYLLNKIRSEGYPIIIVSFFLSIGLFYFHYIAGFIALSFNIFSIWFFRDPNRVVPSLDGIVVSPADGIVVAIDNHPCPDFDLEEDKFTRIGIFLRVTDVHVNRAPISGNIEKIVYKEGSFDFAWKKEVFMTNERLSMKINGFIDCVVSQIAGFVARRIICDVNEKENLKIGQTYGMIKFGSRTEVYIPKSMKVCIKKGQTLVAGETIIAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJT7</accession>
    <name>A0A5C0UJT7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="442" mass="51795" checksum="1269F47937AC2F9F" modified="2019-11-13" version="1">MNLIIRLFNYFSFLFLLSRSDLRADLNTDVQQICRGLVISKAVDPNRENLIGFVQKTSDKKLIFVKKEELKFNFFEINEHNSIDFITNSKLKNNELIVKKDFVSSLLSKLDKTSVEEKITDFLKDVFEKRNESDYYINHEKGLERKLEELILDIKHLSKDKPSVVNTAFGNRLYFGGEKYQIINVPGDGLCVIRAFIASLKDYFDRLKEAGTPEDELYANVNYEEEVKKLLSIDHNKTGKLDSENMKNAYYSLFKKYLEKDLTEEESNYIFNSFFNSAFADHKVNFKINKISFPSQYLKQSTFSDVSDFFKNNSDEMSDGLILKFVDYFKSKNQFDGKYDSTVLPEKYIEPLIRFAHEMHEEKKWNIKGIMNMYLDSGSGFTWFNYDFIIMTGNIIGLKTFLVRNDNSKIFLYSHEYSQKDNIFIYSSGGHAQYLRKINSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJW2</accession>
    <name>A0A5C0UJW2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="404" mass="45228" checksum="7C0E6BBC016FED7D" modified="2019-11-13" version="1">MIFLFVRKKINFLSLNSFIIGNIIGSGVLLLPSSLARFGSFGIYAYFLSALAMFSIGMVFFKLQTWTGCQGVHGPIKSMFGEKAGAVAAFVYWLSVVFGNGSMIATLFSYMGLYSISFSKVFFYSFLIMSLITLANSFDIRMVEIIEIAVAFIKVIPLLVIPMMCFYKAYFSEIPFPPVYDFNQAIYKGIPIALWAFLGIETAVIISKKVENPEKNIPRALTLSLCIISLIYMLGFWVMVKLIPNLSSSTSPYADLLCFILPNSYSCYVGYFIRALSVMLILGTIYGWVFTSGIIIQDSANEGLMPRIFAKQNKFGSPAIGLWISSVLSTLFITLTYQESILSHFELMTEILVLMTFSIYLFANFAFFSVVLKQNKKTFTNLAYGAVSLFSIIFAMFSIIKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK01</accession>
    <name>A0A5C0UK01_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="5" type="ORF">FZC36_01885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="323" mass="35683" checksum="D0495B2777A3D6F5" modified="2019-11-13" version="1">MSLTLSIDCMGGDLGPQMVFDSVKIFLEENKDLSVSLYTTILPEENFFRNFEGRVELVKCSDFVDPKKNILDSLKYYKKSTMGLALKSVKDGASQGVITLGSTGPYMILSRKILGFFEGFSKTPLAVFIPGYKKSKVLTDIGANLTCSAKDLHSFGVLGSILAKCYLGVDKPKVSLINVGHENIKGTPEVREAGDMMEKDGNFDGFIDSDKIFSCDADVIVTDGFSGNCISKSCEGTFRFLRSKLEKNFITRMLVKVLNRWSEDKYNGAIMMGIKGLSIKAHGSSSEKSFLQSLRTASKFIRSYEKLKQETNDASLIEQKIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK52</accession>
    <name>A0A5C0UK52_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Preprotein translocase subunit SecE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">secE</name>
        <name evidence="8" type="ORF">FZC36_02245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="65" mass="7649" checksum="F912679EDFB492E0" modified="2019-11-13" version="1">MKFSSIYDFFSKIKSESKHFTFPKISEVIFNFFYVVIFASLIAVIFYSIDSGFSKIVRWILGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK61</accession>
    <name>A0A5C0UK61_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="6" type="ORF">FZC36_02305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="273" mass="32258" checksum="31F9A653A1136F3E" modified="2019-11-13" version="1">MKFKKVYIIAGSTASGKSAYAENFIKEKKAIINSDSKQFYNIIPTLSDIPKNLEDHYMYGSYDYSEQINVMKWIRDLKNLLGNLDKQPVIVGGTGLYLKILTEGIIPIPEIENDPLLSSMSNEDLYAKCISLDDSFKFFIGDRFRMIRYLNIMISTGKSISWWHKQKRTKLIDDVEFYKIMISSDKEKTLQKAKKRIEFMFPRAIEEVIEAQRLQENMPHHIESIIGFREIRSYLNKEIGLDEVKDRMLVRTMQYAKRQRTWFRWQMTFDEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UKD6</accession>
    <name>A0A5C0UKD6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor 4</fullName>
            <shortName evidence="7">EF-4</shortName>
            <ecNumber evidence="7">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">lepA</name>
        <name evidence="9" type="ORF">FZC36_01070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="622" mass="69575" checksum="8D36833F14A18B95" modified="2019-11-13" version="1">MDKKINNKEKTINNKEVVFQNKYIRNFAIIAHIDHGKSTLSDRIIEKCGGLSEREMKSQVLDSLDVEKERGITVKAQCVSLKYTLDNQEYIINLIDTPGHVDFSYEVKRSLAACEGAVVLVDASQGVQAQTMANVYNAIDEDLFMMPVLNKVDLPSADAEACTDQIRNLLGIEMEPLQVSAKTGKGVEKVIESIIENIPSPIGDINKETRAVLVDGWYDKYAGVVLLVKIIDGSLRPKQGIKMINTGSNYTIENVGIFTPKRVELKELTSGMVGFMIANIRDLSDCKLGDTIVLKDSTITESLPGFKEMRPVVFCGIYPADSSDYETLKASLEKLKLNDGSLLIEKINMPSLGSGFRCGFLGLLHLEVTQQRLDQEFDINVIMTSPSVEYKIIKKDGEVLFLNHPSEMPEVNKIDFIEEPWIKASVIVDEEFLGNTIVLCEEKRGRQESMEYMSGINEASKRIILKYRFPLSDIIFDFNDKLKSATKGYGSFEYEDDGYEVSNIVAVSILVDGIKVDALSTLIYRDHAESYGRNACEILRDNIKRHLFPIAVQAAIGGKIIARETVKPLRKDVTAKCYGGDATRKRKLLEKQKKGKKKMKELMAGKVSIPQKAITNVLKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-10-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFG2</accession>
    <name>A0A5C0UFG2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="126"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="332" mass="37554" checksum="EACD8FB1102F6948" modified="2019-11-13" version="1">MHNLVILSGGWEEKEASIGLKNLFYPALKDKYSVFVIDPADYISEEEANRCFEIKRFDENGRIFSEAENCIRSEILKINPVLVVNLMPGLWGEDGRAQMLLNNIGVQYTGPSACDAYITFDKYKTIQIVKKLGVKCPESHMMNLEEYKKVDLYPHIVKNPKSGSSNQVYYVDSESAKQEVVDGWSADFVVENVLPGLEYAFAVLSGSVIGGIEIKHEKPIYSKECKQTGNGVSFRDATEVLKDDVLEKVKDYCSKIYIELNMSGICRIDFKIEYDCVYFLEVNSIPGNTLVPRIFNYADLDLENMVNMHINNANTPALSKCESADSEKRRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFH6</accession>
    <name>A0A5C0UFH6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 19">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="6 19">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">murB</name>
        <name evidence="21" type="ORF">FZC36_00080</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 19">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="6 19"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 19" id="KW-0132">Cell division</keyword>
    <keyword evidence="13 19" id="KW-0133">Cell shape</keyword>
    <keyword evidence="17 19" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0274">FAD</keyword>
    <keyword evidence="10 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 19" id="KW-0521">NADP</keyword>
    <keyword evidence="15 19 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14 19" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="20">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QEK38845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="279" mass="31166" checksum="AF989D8203C229A1" modified="2019-11-13" version="1">MDLSYKTTKEMGSNLTWIRTGGEVEVFRPDSILELKSFVKSGVDYFPLGMGSNTIIKDTNLDKVILKLDNLYKEIELEYPYIIVGSGVPNFTVSRFCIQNFLGGLEFLHTIPGSIGGGVFMNAGAYGSCFSDNLEWVEVMDIFGSVSKLYKKEIKFSYRKCHVPKTFIFLRACFKVFKDEKIKEKVDGYVVSRNLTQPRFLTLGSTFKNPEGKKAWELIDQAGCRGFAIGGAKMSEKHCNFIVNTGGATSGDIVKLINSVQSFVFSKTGILLDREIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFJ9</accession>
    <name>A0A5C0UFJ9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FZC36_00040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="7">
        <location>
            <begin position="280"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="297"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="602" mass="67271" checksum="15B2DE68B3ABFF7D" modified="2019-11-13" version="1">MISLSLRFALSIIIAFLFSSNLNNDYWLVSLFSFFKSFFHIQFIFIPFAFRNALSIVLFFSNSVLLNNFGIGKGMFGEINSRYIPTYAAFIPYGILIVFLLYKKIKQRNLKTLSNKPKNKKPANSSNNQDIPAKKLNVHEKVSGNEKSNKFNMPSISFLSSIRNKTAETISKDVLARVLKEFKVEGRLLDKHTGPVVTVFEFEPAPGVKASRIINLAYDIARSTESLSARIAPIPGKNLLGIELANKVRNMVTLKEVLASNNFMNTSASLPLALGCDIAGRAVVVDLVQMPHLLVSGTTGSGKSVSMHSMMLSLLYSKTPDECKFILIDPKMLELSIYNDIPHLLSPVVTDPKEAIQVLKWVVQEMERRYKLLSKAEVRNVHSYNQKAKQNKETEIPFLVVVVDEFADLMLTAGKEVEISVQRLAQMARASGIHIIMATQRPSVDVVTGTMKSNFPTRITFQLASSTDSRTIMGYNSGAEQLLGKGDMLYLSPGQPTIRMQGPFVSDDEVQKIIGHLKASGKPEYIKLHVIEDLSNLDNGNSEDLTYKMALRIVLEEKKVSISYLQRRLSIGYNKSAKIVEEMEKQGIVSTPDRTGKREVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFM0</accession>
    <name>A0A5C0UFM0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="198" mass="21960" checksum="0D43E88263BB98D2" modified="2019-11-13" version="1">MIGKILKLHGFKGSFKAILYQTPLGKLFIENSDIEVLEYSLMKKTGSGCFMYVLRTNSSDLDELKGLLGFSILSKDESELISDKQNSAKSDLNSKDLDLNPDNNNSDNICLNDNIDLNKSSENVHVYLLGMMGKDSCKMEICDSAGNFICFSKQVLNFGSGPVLDTEKDFMISYVHINGFCKDSGKVYIADNIAMSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFM9</accession>
    <name>A0A5C0UFM9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="113" mass="12345" checksum="4F9987276F362427" modified="2019-11-13" version="1">MINKEIISYAKSSMHGKAFKLSLIAKRVRRGNANLASARLAYYPGKYALALKKTIDSAVANAKQKGASSDLIIDSIDVGIGTYAKRIEIKGRGRVGSKYKAHCNFIVRLVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFS6</accession>
    <name>A0A5C0UFS6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rplP</name>
        <name evidence="10" type="ORF">FZC36_00445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="143" mass="15956" checksum="A4DFA5D416D80CA4" modified="2019-11-13" version="1">MFPSKTKYKYHFEMVPKGNAQRGFVPVGEFALKALEPGRITTRQIEACRSAIRREMKRAGQLVIRIFPHFPISGKPSEVRMGSGKGAVNKWVAKVRPGTIIFEVSGVEESIARKSLKLASDKLGIKTTFVARGRFSTYKIDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFT6</accession>
    <name>A0A5C0UFT6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="8">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="169" mass="18121" checksum="3C70E371817EFC04" modified="2019-11-13" version="1">MTKQYHSSTSKLKKNVLSLNWVSATTKGGKRQRICAFVVVGDGAGSVGYALGKAKEVPEAVKKAIDKATANMFKVHLRDNKTFHHDINTKYCGTKICIRSAKSGSGIIANETVRSALNALGVKSATVKVIGSSNPYNVIRALFKGLEIIQPPKLIAARRGISVKQVIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFV3</accession>
    <name>A0A5C0UFV3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="521" mass="57527" checksum="ADBCF3E5DB11CC64" modified="2019-11-13" version="1">MMKNKSTFIVLSLLILSQIEGMPTETPSLSPSSSGSLVDRTNKASPSSSGSVLSSPRNLNKEHIAALSSNTKPLRSSTHSLKSIGSSFSLKSESSEIKKQLLGSANVLQFYAWNRILKENGFESEILFAPEGYYSDLDEDKQPIVMHVIGDKYEFLLDPLNDIDGAFLSKIPSSDWLKFRHKITFDKGRHKESQDSEVTVSTKTSSRQEYLKISNIVGKMSKKEKSVRLSYEKTLAETYMKSQNQLVSKGLSSEQNENFNKSIPKDKKNNEKFILLLIEFYKKQITPLINKVGFLTSMEDLDPDKTSDILGSIITIESLKSSRQYLKVGTALDSAKDLDHARRKVQRKNSIVSRRSSMANSEVRSEIGTAFSANGDDSLLDGLMQDLDLHNSSPSVNGSPRSALLSPEGSVLGDDKSPKRSKTPVQFDLSNNSIHHIGNSGNNSDEDGSEKSLYSAGSNLSSKMLKIPRNEDDLDCFSDSSKKEEQFDESEVLFSQMESLKSSAVIALISGSAEGESEDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFW9</accession>
    <name>A0A5C0UFW9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023071581" evidence="1">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="305" mass="35344" checksum="81AF83AF4D91D0DC" modified="2019-11-13" version="1">MYIKIRNKIKKFFQILTIFLSFTNRAIAAVQEKELLTEIEHSNMLEEKELEFSFFGDFDPNQAPLHEKQLQSTVLQVKDYTSISKYFADPISKPDLEEIEYQLMHTAKIQTGHEQIAKDFTETVLESLKSPFQSSTSFFARKQGDKVILFYTDASVTYASIDLKNAIKFIKSIDGTYVISEEAFFKNSADLYLQEQQDRPALMNYNIPALYLKGENKTLTKEVDALNTNTEAEEKMSLYVLLNFSTLYNSSALSIEQILEEFEMEITDQSKKFFKESFEKLKPYSTKDVFNPEKLKKIKAMAKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFX0</accession>
    <name>A0A5C0UFX0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="13" type="ORF">FZC36_00655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="164"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEK38948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="489" mass="53402" checksum="A43A0972AC6F7857" modified="2019-11-13" version="1">MPDSLAKDDFVKKNELIEKNSNSEKNIGTIVAIRGVVVDVLFKVSVPAIKNALIIEADSKKIYLEVFSHLGNGVIRAISMSDTMGLKRGIKVIDLKEGISVPVGSNTLGRVLNVVGDPIDGRGPVEGYKQEIHKAPPKFEDQSIKSEILITGIKVIDLLAPYVKGGKIGLFGGAGVGKTVLIMELINNMAQEHGGRAVFTGVGERIREGHELYNEMIRENLIDLEGGMSKVCLMYGQMNEPPGARARVALSGVTVAEHFRDVENQDVFLFIDNLFRFSQAGAELSILLERLPSAVGYQPTLDAEMGILQERITSTKKNSITSIQAIYLPADDTTDPAPASAFSHLDAITVLDRSIAAKGIFPAINPLSSSSNTLIPEIVGDEHYDIATRVLICLQKYDELKDTIAALGMDELSEEDKSTVLKARKIQNFFSQPMFMAQSFSSTPGKYVELEETIEGCKKILDGELDHLPDSAFYMVGNIHEAIEKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG02</accession>
    <name>A0A5C0UG02_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FZC36_01065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="13">
        <location>
            <begin position="61"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="12">
        <location>
            <begin position="330"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QEK39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="648" mass="73836" checksum="63211D52B8626C63" modified="2019-11-13" version="1">MTKLSGKVFMKKLLNFMLTSIITFCVIFFYINLTLPQINDLSILKIDPFVVIEDENKNLVSTYGSLKYQHLSINEIPKHIPHALISLEDRKFYSHIGIDFASIARALSKNLQSSRIVEGGSTITQQLAKNILQENLGGKIPPKSYFRKIREAFLSLKLEHKYSKDQILEYYLNRVYFGSGTYGIEAASWKYFGKTCKELSVSESAILISMLKSPSTYASKPEKLAERKEHVLNSMLKMGFINQEKMELALATPHKLKHTQSNSSIYFYSDWILTQIPTWIKEMKRNLKIICTIDLDLQNKADQASKEIIEKYKNKWDFENLALLAMSTKGHVKAIIGGSNYSSGAFNRATQSLRQSGSIFKFFVYSTALENNMGINTLIEDSPPQIMGWSPSNYYHQEKGYVTLAEGFFKSINSVTVRIAQKIGIKKILLKARDLGLNIDGAKNNLSISLGSLESTLLELVQCFGSVANLGHKVEYKGIVKIIDNDTNEVIWDPEEAYDMSFNDNEIYETEEYINESDKCKNELTEQVFEEKTNKKIFKLLYSVTQKGTARSIGALNFPVAGKTGSSQKYRDFWFVGFSPKIVLGTWCGNDNYSKPMRKNLGPNPAVMLCKTFLQKIKHDKTENEKWLKLFELNDKNKNESEEEILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG05</accession>
    <name>A0A5C0UG05_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xseB</name>
        <name evidence="5" type="ORF">FZC36_01125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="135" mass="15650" checksum="9A68EC130442AE7E" modified="2019-11-13" version="1">MNLNKKELSFEDKIKELENIKNKLESGDLPLNKAVSTYEKGIYLAKEAENELRNAEIKVDSIKEEESEFSEIKKQISSEFKKAQSKIFESLDSSLTDLNLSEENDTKNKINEILDKTLDKIKKISLEFFNVKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG26</accession>
    <name>A0A5C0UG26_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mutL</name>
        <name evidence="6" type="ORF">FZC36_00975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="5">
        <location>
            <begin position="202"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="666" mass="76886" checksum="AC1971C19222673D" modified="2019-11-13" version="1">MNIKLLSDTIVRQIAAGEVVIRPISIVKELVENSIDSGASQISIFIEDGGKSSITVEDNGSGISKEDLLLCIQNHASSKTESLSQIKTLGFRGEALYSISSVTNFTIHSSKNSESHGLEVFNTVPTDPFPIKDRVGTKVTVKDIFFNFPARLKFLRSESREWSIILEYLQKMCIAYPDIDWIWSNGKSSKKNYKNVEYSERLTDVFGSNFTNSADLDYEQSNYKISGKIFFNKIQNSTNNLMIFVNGRGIRDRGLITCIRNSFENQFECKGYPSGFIRIALPFNEVDVNIHPSKEEVRFLRWNFLRNAIESTFYKSKYGFKSNNEQNNQDQYSYKDTSLDYKDESNNHNQFAKNKLSYEENSRESESKSYTDIRKNLNLGSNKNQSKEPLLDKEYNSALNLNEPESNTSLNEPTHSMYNKRHSEHGLNFSNKHKDTNNENLSRIHNQKPTTLEYKPQQTEEKKRNNISIVARLQSIDCTIVCKNASNEENSTSLFQKNEQKGKFFIINHKFYFGRFIYRKLNHILTLDKNSDINKKNTEISKNLLIPFRTDISDKSISNLNKLKETLENIGLQFENNILISVPIFLPIDYEKQIFIEFADSLENFNIESKNKEYWSNILADIASQKLLKNLEISEIENILSESDLLTSKEYCKELSKESVRIFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG32</accession>
    <name>A0A5C0UG32_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">FZC36_01220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="215"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="429" mass="46956" checksum="ACAE842AE884010A" modified="2019-11-13" version="1">MDCYLRRSFVKRDLSPRIVIFGVGGAGSNAVKNMMEDMKRRGHDQVEFAISNTDAQALESSPCEKKIKLGPKITKGLGAGAIPEIGRKAAEESIDDVMEYLKDSNMVIIVAGMGGGTGTGAAPVIAEACKKEGILTLGVVIKPFLFEGSPRIMAAKEGIEKLKDQVDTFLVFDNQNLQRAESGNTPFLQAFSMPDKFLSECVSGIVSIIKSNGLINVDFADLCTVVRDRKSKAMMGIGNSVGENKGSSASSEAMFDNVLLDCSDMSWKNVDHILVCINGGEELSSEDVFQAVGKIHESISPNAKVIFGAAFDKSMGDSMRVFMFGTTTESKNLEEDLRSESSKKDNNEFKGVGEDISYMTEDESFIGSHHDLNDSESENSYEPSLKTSQNKKNKKGIWSRLSGFWSVEEDIKIEEEKSEDIPEFFKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG51</accession>
    <name>A0A5C0UG51_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="130" mass="15353" checksum="7390244FFBE7B86A" modified="2019-11-13" version="1">MNKFFINKCFCLTVLYSKHIDSGNLCSRINNFPKYIVGNVCCFKKNESSFSDIPEDIIQYVCKFCDFKAHLQFSNVNKYMHKIRVRDLLVRKYIYDHILAKTSSPYKALCESKGILGMKKSDMLMRKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG56</accession>
    <name>A0A5C0UG56_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="429" mass="50501" checksum="D870D14CC307DFAA" modified="2019-11-13" version="1">MIKIVFRKFSLLKHLFISSISIFLQIKYAYSKNLGYLFAIHFWYFICFENVSNFKLKSDFFVEISKTAVFGVVAFFASKYFNVSVYFASYSVMYFYVSYLGYKRNSKLIPDVIIISEKIMHKWPVFAKYKIIGELILDSDNIENIKNTIKKAKPSIILWNCRAGNYFADFLGWSIKNNIYINYLRKDKPIPPSIEHCMEDFLVTNKIDITNKEKTTKKVVIFSHDIGLLTALYREFKKNNLECFVFLDAKSSIAFKIKLYRQFGKQVLNKSMIRKVGDFLFIDCSGIISFKEECRDIKLLEKIKERICLVSRNKGDFFFLSTKTYNSEDLIFNQLTLASENIVKFYNGKVIKTPYLANYSRKLCNYEKNSYINMDSGWITKKFLISSISNIVLHNHIKLIESEHFLTKKDMKSICNNLKKAWFMWSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG69</accession>
    <name>A0A5C0UG69_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="450" mass="51306" checksum="C681B93ADF9D2F32" modified="2019-11-13" version="1">MFSSGPTKKHCDFDIKSLGNFLKQRNHVSDQGIEKIKELSDKVRESLKIPHDYKIGFVNGSCTGALEAVFWNALGDRSVFVLDYGLFGKRWADDILLNIKMPGKRLDLSQIELIKKAASNNGSYNSSYDTSKGSELRVSEKEIEYETPIIYDNDFVFTMTETATGEKWFDKEFLRKVKGLRIADLTSAVFCEEIEWDFLDCAAFSFQKALGAEAGLGCIVMNPKGFRRVLEREKISNKSVCAKFPIPRFMKITENLFKNIMPNTPSFIVVEDIIQSINSFMKLGGIKNSIKECTNNRECLLKNICYLENVNKACLFDNESSDGGYAMNNIHTCNETIENNDNDVKNLKSEFIAKSGNELDTLRSIQQSNYVLCLKPSYKKWNYLSKNEKWNFINLVAEKLEGYDVLGIVGHSMSEPCFRFCTGPTIFVNKQYIKYFMQTFINVAEDKDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG81</accession>
    <name>A0A5C0UG81_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3 6">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FZC36_01535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="326" mass="35490" checksum="F87F56E7E026E948" modified="2019-11-13" version="1">MNSEKVPVRVALRDAMAECMREDETVFVMGEDVAHYGGSYKVTEGLHKEFGDKRVIDTPISEMGFGGIGVGAALSGLRPVVEFMTFNFAMQAIDHIINSAAKSSYMSGGEAVCPIVFRGPNGMAAGTGAQHSQCFASWYAHCPGLKVISPYDSHSAKELLKASIKDPDPVVFLEQELMYGEGFALTNEKVEIGKAAVIRKGTDVTLVSFSRMVGFALKAAEECEKLGISCEVVDLRTLRPIDEKTIISSVKKTNRVLAIEEGWAYSGIASEVISIVNEKAWDSLDAEPLRVTAENTLLPYAKNLEELAVPTVEKIINKIKYLTNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGB8</accession>
    <name>A0A5C0UGB8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022880522" evidence="2">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="311" mass="33815" checksum="ED0F068EDC65F4DC" modified="2019-11-13" version="1">MNKVKSLLSLAVLSAAYSNAKPTLSLGLGAALVKQGMDIELTKTKQIMPESKAIGDIKSEASSFVIKNEDSETKGIFNLFGAYAYLNAGLLKTGPVCHEIRAAFGLRDGNRTLVDTKSTKYAEFMGIATAASTAKADDDNTKEENKQENKSAQLSEERPFNIDLHYILNFKPTCRFGIYAGGGVSMIKTKIISSLSDNNSDTEDNDSINGYAVKLNKKYNDVSESFFAFVPQAILGFSMNFTKRIAMNLEGFVGFPVGGKKENINMYNGTYSFKGVEGAAAQADLHDSISIKTRKQALSYGGRLMVSFKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGD1</accession>
    <name>A0A5C0UGD1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Acyl carrier protein</fullName>
            <shortName evidence="8">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">acpP</name>
        <name evidence="12" type="ORF">FZC36_00225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="UniPathway" id="UPA00360"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036104">
        <property type="term" value="P:Kdo2-lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 8 9" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8 9">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK38869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="85" mass="9632" checksum="E043E9936333D6E4" modified="2019-11-13" version="1">MSEQKVENFEKLKEIISDFVKSDKKIEIKEDSNLEKDLGLDSLDSVELVMAIEDSFGLEIPQEVSQKITNVKQILDYISQAKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGE3</accession>
    <name>A0A5C0UGE3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="10" type="ORF">FZC36_01950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="403" mass="44227" checksum="A747B4B83231AD68" modified="2019-11-13" version="1">MAKEKFERNKPHINIGTIGHVDHGKTTTTAAITTILANESKSNEAKSFAEIDNSPEEKKRGITISTTHVEYETEARHYAHVDCPGHADYVKNMITGAAQMDGAILVVSATDGPMPQTREHILLAKQVNVPYIVVFLNKVDLVDDEELLELVEAEVRELLNKYDFPGDDIPIVRGSALHAINPDSSAEQKSKSAESILNLMKAVDDYIPNPERPIDKPFLAPIEDVFTITGRGTVVTGRVETGNVKVGDEVEIVGIVEKTQRTTVTGIEAFRKVLDDARAGDNAGFLLRGINKEDVQRGQVLAKPGHVTPHTEFQATVYILKKEEGGRSTPFFGNYRPQFYFRTTDVTGKIELPEGVEMASPGDDIKDIKITLISPIAMEDNLRFAIREGGKTVGSGVITKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGE5</accession>
    <name>A0A5C0UGE5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="83" mass="9066" checksum="E28FD441F30CD4E1" modified="2019-11-13" version="1">MAYHGSGGSTRNGRDSAGKRLGFKIFGDQKVRSGAIILRQRGTRFFSGENTGIGRDHTVFSKVDGLVKISTKRGRKIISVNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGF1</accession>
    <name>A0A5C0UGF1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FZC36_02020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="217" mass="24101" checksum="1FEE67CF7F9B4893" modified="2019-11-13" version="1">MYSLFKLLADNTLEIFFILNSIMNAFFIVSLTAENSYLERKKIIQKAIIVVTFSIFAFIFIGNFMLESLGVVFYAMQITGGILVCPSAYDMISGKASEDIGTDSSDVSLYPIGVPIIAGPGAFTTSLNLFKEATLFHEKLITIIAIFLGIFLTYLVLVFGAKIGNKIKKMHMRILSVFFGTILMALGVQFFINGARGFANEYINTKPRTLTYKQNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGG3</accession>
    <name>A0A5C0UGG3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tryptophan-rich sensory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_02090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="195" mass="22661" checksum="1CE0D1C59F2DE41A" modified="2019-11-13" version="1">MIIKKLTEKIHQYKYELIGIAISLLIGIFYSYLIKHSAIYTHNPSYSMSKCYLKCIFKLSTYIVTGIAFGKMIKKSYEIPCLTRLLLVQLTLTIAWAPTFFLAKRTGLSLIISLLMLITLFRLLCKSRKSKKILILMTPYLIWSLFMFFMNFKIWMSKSKICKYGCGKNAIVINLQKNGILPEKKNNSGFLSRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGH0</accession>
    <name>A0A5C0UGH0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsU</name>
        <name evidence="5" type="ORF">FZC36_02150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="77" mass="9255" checksum="75EFFF0386F17024" modified="2019-11-13" version="1">MKLQIKKRKSIMSIIVPTPNGLPEALKRLRKILATEQYYTEYKKRRHWEPKSVKKAKQKAEKEKKIKKFKRNQSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGH9</accession>
    <name>A0A5C0UGH9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosome biogenesis GTP-binding protein YsxC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ysxC</name>
        <name evidence="9" type="ORF">FZC36_01905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="171" mass="19719" checksum="832E67A1F7166DF1" modified="2019-11-13" version="1">MVKKIYDFKNLPVKEKYEIAIMGRSNVGKSSFLNCILGEKISRVAKKPGCTRWLGFHETSYSVNFVDLPGYGYANMGRQRKNFMVDMARDYLFSGRVDEIFILIDSRRGVMDLDREVIDFCRENNVPFKIVGTKSDKKDSLDFESNFLTSSHTKKGYDKIAKYLRSVSSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGJ5</accession>
    <name>A0A5C0UGJ5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCLP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCLP" evidence="1">
        <location>
            <begin position="192"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="444" mass="50168" checksum="90CB87A5C1CDD0C7" modified="2019-11-13" version="1">MEKMENRKSNSISNSKILSGVQSSNIFAEFITPKLFMRMLPWIDLETGIFRINRVYKNKSYASDMDLESISKIPIFNGLAQEKINFLKENCVVKDCSLGDEIIDDKKSLYVILSGEYQLNTLNQNNRKVVVANLASGKFFKKKNSCSHSVMLKTFMPGKLMIVPEEVVNKIFDASHKDNYLEKPISCKYDYETGEQVCSLISSYEGEPEIPRGFTKYSENPKEIELDVIQAVTGLHTRVHELYNNPNPQLESQLRIVIANILEREEWEIFNNSNHGLINQVSMDRIMTTRTGPATPEDLDDLLALLWKEPSVIVAHPKAIASFGRECTKRGVPPVVEEVFGSKVITWRGVPIIPCDKMPIKTNGLGYKTTSMMAIRLGYEKQGVVGLHKKEVSYGGVPSLSVKKMGIDENSVMNYLVSKYYNVVALVDDSMAMLTNIEIGHYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGK8</accession>
    <name>A0A5C0UGK8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmB</name>
        <name evidence="6" type="ORF">FZC36_02380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="119" mass="13595" checksum="28C7A24F313D93B9" modified="2019-11-13" version="1">MEILLTYFNLRSIISFMSYCAILGKKKMRGNNVSHANNKTKRDFLGNIHVLTTKNPLIGKFRLKVSAHGMRTIEKKGGIINFLITSKKRNLTEECQRYKKRIIKSMEKAEQKASASTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGL4</accession>
    <name>A0A5C0UGL4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="43"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="226" mass="26800" checksum="BC84B2AE07E481D2" modified="2019-11-13" version="1">MFRNYAFGERRLISSEEKKLLYATNNNNYIIMHFPEEEKNDVWRNYLSGFSWEILDNFGIKTHYIQKLNIREQLVKSTHPYPFSLKVTNISSPEINKLIGVPEGTKFDKPLVEWYLTQDSSKNLISQEHIVHFEVTTKEEAEQIKNISLRVNDVISSYFLSWKLYISEITLKFGKNEENLVLIDEISPETCKFWNKELDTEIPKDEAYEKMKEIYKKTNNHNKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGL8</accession>
    <name>A0A5C0UGL8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YifB family Mg chelatase-like AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Mg_chelatase_C" evidence="2">
        <location>
            <begin position="403"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="506" mass="55749" checksum="BD074E49F9EBD7A6" modified="2019-11-13" version="1">MSVIKAHTVSFQGVDAVNIEVQIHISRGLPAFNIVGLPDKTIGESKERIRAALQSIGFALPAKRIIINMSPADIPKEGNHYDLPITIGIMAALEIIPEHVCSNWIIMGELGLDGSIINVKGSIIASLHAKSNNKGIICPAECGPECKFATDIPVIAAGHLIQIINHFNGTQVCKEPEKMQILETENSLDFKDVKGHESIKRALEIAAAGRHHALLIGSPGAGKSMLSSRISTILPDMEISEAIEVYKIYSMSNISNQSFSLKNRPFRSPHHNSSLSAMVGGGYKCKPGEISLAHNGVLFMDELSLWKSDVLNGIREALESGKINISRANSKIEYPSSFHLIAAMNPCSCGNAYDIKNICSKFPKCHQDYISKIPGPIWDRFGIIISVPKLAPWELSSSKSKSKSSFEMKESIKKAIDFQKSRYKDCKFKFNHDINSSEIKMLNITESAIDCLNIISEKRGVSSRRYYNTLKIARTIADLDQSESVETLHMKESISYCLVNQVVNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGN4</accession>
    <name>A0A5C0UGN4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="5" type="ORF">FZC36_00760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 4">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="202" mass="22892" checksum="F7566910EE5234EA" modified="2019-11-13" version="1">MNVIPSVIDQTIKGERSYDIFSRLLKDRIIFLTGEINDEVATLICAQILFLESQSSEDIYIYINSPGGSITSALAIYDTMQFVSINVNTVCMGQACSAGSMLLCAGKKRFILKNARVLLHQPLGQMKGQAKDLDIYVTEINRLKDIVLEIYYSHTGIDRKKLESFFDRDTFFRADESKKLGIIDEIMEKDSKKTLKRSITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGN9</accession>
    <name>A0A5C0UGN9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsT</name>
        <name evidence="10" type="ORF">FZC36_02540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="96" mass="10680" checksum="B3EBE5963A4813FA" modified="2019-11-13" version="1">MANHASTKKSAKKQTILRSVNKSSRSKMKTFMKKVTGNKKQAVNEALNPVSNEEFSKIQGLISKCGQKGVVHKNKASRTVSRLAKIRNNQLKQNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGP3</accession>
    <name>A0A5C0UGP3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsJ</name>
        <name evidence="7" type="synonym">nusE</name>
        <name evidence="7" type="ORF">FZC36_00405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="6">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="129" mass="14699" checksum="80B97A6405B0839D" modified="2019-11-13" version="1">MIDSNSEREMDKKKVSRKPSKKIKEGMSIVFKSCDGAALDSCVAYIVEIARSLGLSIKGPVPMPTTRKVFTVLKSPHIDKRAMDQFELRYMKRVLFLKEYSKPILDLLESKMVAGNYSIPRNVEIEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGQ1</accession>
    <name>A0A5C0UGQ1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="246" mass="28610" checksum="AB41E1BF41FDAB9A" modified="2019-11-13" version="1">MSIFLCFTLNIKSEITFDEEFGSSVSSFVQDLQQKTDKKDVNDPKKKSYEDFIDTVEKTIGSKSDELSKKLHCTGNAFCRVNSGNKVTLYVNFMNHNENSDIPSSNDGYKPNFKYISLDMEAIKPYLKVIEGKTCIMLDAFINNLEKLFECTEEIILQDKYNYIFIDQGTKIFLYANEYAIDDMANKLGDDYYLFIDPLYNLAEYSESINKLKEFSRTKLYEQKNIKDNIDLRSEETEEMQEEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGQ2</accession>
    <name>A0A5C0UGQ2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_02390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="466"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="609" mass="70984" checksum="E052BE7C6CF1D626" modified="2019-11-13" version="1">MKILLFFKNIFNSVYFKFIGKSNLGKEPKKLDKRSKRTVDSEINKTILKFFLKKKVLFTLLANLICIFLYIYIRKLLNEWYLGFYSILGSGSSTNIYKYIFWYLFYSLSSDTILSSIEFSKMRLSLNWRESIVINSIRKMSPLNFKNVEYASQKISQDSEEFTTLFMNLAIDLTLNILFLVVFMFILFDLINKSIFLIISIVICHLFFSKMLSILMKKLNYYGDLNESYEADLREKTHNLHNRLDGLYNFRKKKIYIIFHNLKENYKKFILQKTKSILTRKNIDNIGTILPYLFIPFFRKDNYGEIMRTINAITMLQFSFLFFVNNFDKFSQCIVGYRRLKSYLMAFYLDTNVIKVYNTEDDAGLGNVPISDSEMHIRIDAFSPDYQDNLDLLRNSMGFRNQESAITSSKGSSVDKYRKINKECVESLLRKDGSNKPLNSFLEYKQGLKLFSGRKIFDEFCLNVSKKEFVCLYGKSGSGKTTFAKIISTVYEAEGYMSFKGKIRVLISANSDYLDGISDYSYGREKMGLSENCYSKGEEHKHIAAALISEQPDWVIWDEFGSGLSSADKEYVFCKLKENLKNSGVILLCQDKFNLCDKFKKLSTKNCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGQ6</accession>
    <name>A0A5C0UGQ6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_00110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="176"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="550" mass="61170" checksum="5A156CFD0F09936F" modified="2019-11-13" version="1">MTELSFKFSKVKSIVESEKENAKVVKVSVKETARENFDIRADFRNLNNNLNNESDVESAVNESNTDIMKNTKNSKLNESNYISTKSSLMKNKIQSDSCVEFCNSYAYGSNFINNNNLHNSFDRSDQHGHESDQHGYRSINHGKSSVSKKTHYDFFGRSVRNDFPILSRVVNGNKIVWLDNAATTQKPAKVIESLVHYYSVHNSNVHRGVHTLSQEASQLFDESREVVRNFINAEKSDDIIFTKGATEGFNLISNAYLLPSLNPGDEIIISNLEHHSNILPWKVVAEKTGAVLKVVKMDQSANFLIEDYERLLSSRTKLVSVTQVSNAVGTSVPIRDVVEMAHRVGAKVVVDGAQSISHMPVDMQDLGCDFFVFSGHKMFAPTGTGVVFAKHGLLGNPYQVGGGMIRNVTYNEVEYANSPFRYEAGTPNLADIEGLKAAINYLEGIGMENVYDYEHGLMEYAMQKILQVQKIRLVGDPDSRIGIIPFVMNGLENDYVGKMLDKKGVAVRTGHHCAQPAMNSLGFSGTVRASLALYNTHEDIDKMVSILSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGR4</accession>
    <name>A0A5C0UGR4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secY</name>
        <name evidence="11" type="ORF">FZC36_00505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK38920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="445" mass="49401" checksum="269E5907AAF72C9D" modified="2019-11-13" version="1">MAAKFKQGSRNFVIRNKSKNKGSVFGNLKDLKAKIIFTFSILCIYRFLTHIPIPGVDLSALQALYSKYSSKMLDSIDSFSGGSLQKASIMALGLAPYISSSIIMQLLGSTSEYLKSLKKDSDGNLKIKQYTRYLTVVICSIQSYGLSWGLEYFNDSVNSLVILPGIFFKLSTVASFLGGTILVMWLAEQISSKGLGNGSSWIIFVNISISGFAYFLRLLSRLSDGSLSYIHFLVFVAMICLIVFAIIFFEKTARFIKIIIPSQRGLMSNIESRNRIPIKLNVSGVLPPMFAEIFVGFLAALGNISWKSLGVPEILISFISSEFFYIVLKMFAIVLFAFVYSTVAMNPKTMSQDLASSGRFVPGHKTGDQTEKFFERVIFRVTAYGALYLIFIAFVPDIFIKKLNPCLSISGTSFLILAGVSMEFAEQVQVHGMSYFMSKIASIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGS0</accession>
    <name>A0A5C0UGS0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hflK</name>
        <name evidence="7" type="ORF">FZC36_02495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="6">
        <location>
            <begin position="111"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="447" mass="50837" checksum="2264053BAABADDDA" modified="2019-11-13" version="1">MYKGGMLIYNLNVFFKAFAIPILVYYFFKFFPFILFIIVFLLISNNAGLFSGTKKSDQYIDIDDVKEKKFGFNSDIFNFLGSDIQNRLSSILSSKNIFRAFCAVFVIWISSGFFMVKMNEKAVVMRFGKVINEVGPGLHWKFPKPIEETLKRDVTILHKINTSSDLKDNLMITKDENLLLVDMVIFWRISNLKNYLFKAKRPDEIINAAASSIIRYVISLYNTEQCLTLDRDEIGNKVTDLLNRAIISYDIGIDIVDVQMGKIDPPSSVISSYRDVLKAKLEKETKINEAQSYANFVIPSAKGEAEKIINNAKSYYVEKIEKAKGLSGAFLKKYEEIKNNRDLSLFFMNLECISDVLHDKTVYVVPGSAMNNNFISVGMDSSKLDSLKLLNTEKFSEYDKSRKLMHKKLITKNADNKSTKKVLSSKSNSVDFGSHGFVSQNYNGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGS8</accession>
    <name>A0A5C0UGS8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rpsC</name>
        <name evidence="11" type="ORF">FZC36_00440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK38907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="209" mass="23232" checksum="9DD4144D977F0D9D" modified="2019-11-13" version="1">MGNKSPWFRIRSGSFLSQWYPSKKSADYVVSDYKIRSLILKNKYWEVSEIFISRVESKINIDIRSAKPGSIIGKQGSSLSVLKDKISNIFDKKFDISIQVTPVKDSEKDAQIIASRIASEMEKRRSYKAAAKRAVQDALRSSKGIKIKCSGRLGGAEIARDFKLSSGSVPANTIRADIRYGFAEANTNSGKCGVKVWVNLGLEEKKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGU9</accession>
    <name>A0A5C0UGU9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="213" mass="24825" checksum="B69821DDD9FA3006" modified="2019-11-13" version="1">MNSEINFTNYKKNITKIDIDLLKNVDFVFCDLDGTLVRQNTIFSTFKKTLFYKPFTFLKITLNWILGKKLENIKIINSNHSLLKMEELDFNKDVISFLKDVKRQYKSIKIVLATGSTQNIAKKISLKLDVFDNEIYSTHNNNCIGENKLKEIISFNKNKPFMYIGNSKQDIIIWQSSEICGAVCNKISQNQIQTLNLQNLIYFPDKWSKLNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGV1</accession>
    <name>A0A5C0UGV1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FZC36_00540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="39"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="326"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="748"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QEK38927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="927" mass="107493" checksum="94195E865EEAD860" modified="2019-11-13" version="1">MYRNKLKEIENKSTDFWNKLQINKSEISNKEPYVILDFFPYPSGFGLHVGHTLGYISTDVKARFERMNDKNVLYAMGFDSFGLPAEQYAIQTNQHPEITTQQNISNMKKQLKALALSHDESRTFNTSDSDYYKWTQWMFLKMYDSFFDNIEGKAKPISDLVEMLDSGKFTVENGKLYKASNSVKSINKDKEEIISSMRLAFLEEVEVNWCPKLGTVLSNEEVKNGLSERGNYPVEKRPMKQWMIRITSYAERLNKQLDILDWPQNIVSMQKNWIGEQEGTEIVFSTKKGDIKIFTTKPQTLYGVTFLAISSKHPVLGGMKVDENKFTNIYAKHPITNEEIPIWTADYVYSDYGTGAVMAVPAHDQRDFEFAKENDIKIKSVLKPDYKWLEENYLGSVKQSEIMLEWENNPDKFSSAFEGRGNLIDIEQFDVNEFLSINKEKNKVLEHLLDKGFAKQVKMFKLRDWLFSRQRYWGEPFPIVYDSSGKVFPICEEELPVELPKQHDFSPREGNDPEAPLGRSADWKSVKGSIVNGKFTSKVGNEEFTREINTMPNWAGSCWYYLRYMDPTNKMEFISKEAMEYWSSSKVGAIDMYVGGAEHAVLHLLYARFWHMFLFDLGYVKNKEPFDKLLNPGMITADAYKNGNDVYIDINDVEIRNKKAYQISTGELLVIEPGKMGKRYKNGIDPQDMCDKYGIDVFRLHVMYMAPITQTRNWNSDNIIGMERFLSKVYSKISSIKLLDTDSDENLIHKTIKFVTKEMEEFRFNTAIATLIKFVNDSDSISLSTGLSFLKMLFPFAPHLSEYLYQLHRNNLSIFDEVPDQHKEGLDSDLIDEIKNKSICMSKWPEYDDSKTKNLYMEMPITINGRLRDKINVPVDLDESEIEKLVMDREKIKSFVAGKNIRKSIVIKKKDPKDPDRLISMICNLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGV3</accession>
    <name>A0A5C0UGV3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_00715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="72"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="227"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="546" mass="62437" checksum="8FD33325451DF1B2" modified="2019-11-13" version="1">MNSGKQNHNKMYYKKKDKYHQYKTFILKIVRKLKPNLEKILVIFLISILSLRILYINKFTTKNRISRSSIVRSSILDCNGNPIAITRNTYSVYISPRKIHADMLRKIEENLNTKIEKEKSFFWIKRHVTKQEANKLMKEWKSKYKNIKGLFVRNDHKRDYPQSEITSHVVGFCDKNLKGKAGAELAFDSELQTNNVELTIDTRLQYILHQTLNEIKETFDSEDAFGLITEIESGEIKALSSVPSPDSRVPITFLSKQNRNHNLDPVEAGSILKIHNAAMLLENEIVDLDSMVDAQGSLKIGKFEINDFFGKNRKMTFLESVRFSSNIATGRLALQAGAETQKRFFKSIGFLDKIEWLPNQNAYPLVPSSWGKSTVVTASYGYGIGLTSLHIVQGLIRILSGKDRKVSMYKSKNPIQENQIINKKTTEPIQEIMRESVRSSYRSINTAEYDIGGKTGTANICENGKYIEGENRVSYLVAFPMHSPKYVVIIQSTNPKKSKLKTGRYLTASNVLTNSVKKLISYIAQISDIQPNQHKFIQQRSQQITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGW5</accession>
    <name>A0A5C0UGW5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="508" mass="59988" checksum="9DF99BC2F802E9DF" modified="2019-11-13" version="1">MNCFCVYLTSNSDLSKFNSSDVRKIDDTTKVKIVQSKFDYVEAEIYVSSFISDLNKYPFLIITNDHGVMFFGSYEYINKQNNSYKISFKSKASSEKKQKCLDKEFLNNGLSNALDPKGNVVNSLVYSDSLMGCESIFDDKEDSYSIDSMSILSRNDFLKKEYNSVESEESFSVTFCFSWDDHIFRQSDVFEEVYKNFKENELSKWPQKFSKHGQYTISNSFIKKEYGNVYGALVLDWMELIKRREKWCFNIFGANVSKDLNLNIDLNKVFSGCDEWKEKQFYKKNDSVSYEKSIFICAVDHFSGLVFDLEYWIESDKKPEILQKNKDNIFDSEAGKLLLYQIKNMLFAYTRAYQYDYILEVKINLTNSLDLCFVQLMDKVRFKSVEDGKIYTGVVFEYEKTISDKESILFLKIKSLTKVKSFDSDIIYYFRDEYCKSYCFEYEHKRLKDLYFKRIFDKSSIKSHSDLLKNLNMVIDFIEDEEKFLGIKINSVQKKLPDLCLNYEVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGW8</accession>
    <name>A0A5C0UGW8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="114" mass="12428" checksum="B1877139090C438C" modified="2019-11-13" version="1">MSLSKFFILCALRSKSMHGYDVAKVVESQSGGCCSPTEGAVYPILREFEEGGYATCKSETVSGRGRKVYTITDRGLEAFQIGLSAWLKIAKCLGKCDTSEKIQDKCKNDLCNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGX4</accession>
    <name>A0A5C0UGX4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FZC36_00830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="206"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="390" mass="44931" checksum="C144EBADC1FF3FB3" modified="2019-11-13" version="1">MNYLVFNRNNVDFFNSYMNERNLSKNTIDAYTSDLVLFICWLEFVSKTDQSSSLEEDFYEYDLSNSMKKEHSQLIEKYGNLREKLSVVGYVQFLKGCNYFEKGLSKSCSAENENNNSNSYKNTPENIFLEKKLVERDDLQESCNSIGDNKSTDEDCTNKPNKRAILDSTLFRKINSIKQLFLFCKEQIEGCNDVEVDFPKIKLKRSNLKVINDEEVNEILEDLNKSNTKFSIKLHAMLSMLYSTGLRASEIICITLNDLENVINGSEKSFRIIGKGGKERQVFMNRKAIESLKRYLLSNSRKIASYIWPSTNGHITRQTLFLWVKKIGLSPHDLRHKLGSNLVKKGMNLLEVRKVMGHSSVKTTSIYTHASNSSSSIKKHHPMYNKSKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGX5</accession>
    <name>A0A5C0UGX5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="302" mass="34896" checksum="665EE85135A556B2" modified="2019-11-13" version="1">MLQKTKILHKFLSSVLVGYNFKQNLYKIFSKTVPEKYYENESDLKNLSLKISKGKEYSYKPYESRKLKINNSKIKEVDLKELNGNFSRNHSRIEKYLEEIGMKGDVNPKDSSYTSYDGIVVIFDSIETFRLKIDFINKLNIRNKKLHVIVDDSGKNYSYEQTLLIKGSKDILDFSYHKKVEKIEKLNSIPKTDKEAAQIIIEKTLGSNQNLSIEYLEFSNDKNRFIKDYIWSNSGRKLLFIEVNPYIPFYSLLVKSYATLDGNVEVAGDRGITGHIGTLDYEKNAPVYINAIMKISNIVGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH00</accession>
    <name>A0A5C0UH00_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="13">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgsA</name>
        <name evidence="13" type="ORF">FZC36_01350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="13"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
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        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEK39079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="175" mass="20050" checksum="DD40A74CF150B162" modified="2019-11-13" version="1">MISPNLLTIFRIFVTPFICLLIIFKMKLLSAVLFLIACISDFLDGFIARKYKSKTSIGQHLDPMADKILLTSILVTLIQTGHIKGIHTTTVYLIIVRNIFVYFLRNYMNAIKKRNIYVNNFGKTTTISQMVSMGMLLLDIKGGMLLLWLSMLFSFFSLFVYLHKSLLNNNPNKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH12</accession>
    <name>A0A5C0UH12_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="294" mass="34384" checksum="6DD8E2D41B0FFF77" modified="2019-11-13" version="1">MILSSKVMCLKTQVGNNFYNSNLEKISDSKYDICLIDETLSYMKIERIPQGFNFLDRIKWILNLEKKLFLNKSFKRIFYNKELCVWIYSNIKVNKKIKWSVVEKVELLKKLCRNVNISEVWVIREGDRNVCVSLLKGKIVFFKVMDSNVGAEVAEISDYMSDKYSFKPYIRTFGDDVEINSDYSYSNSEVEVKTKLSIGMLAFSYLKSFKMDFYCYVTNSIALSLLILFSSYISINNKILKKDILINQKQILDLNNKLSNIPNVNHIKQLMSFKSNVFSFTQKHNKLSDKNVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH13</accession>
    <name>A0A5C0UH13_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_00865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
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        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="224"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="546" mass="63689" checksum="5136954E2C72F126" modified="2019-11-13" version="1">MEKNYKLKVFFIFHSLLIFCLFIRFFYVQVSKGKKYFDMSMKNFTVERKIEPPRAIFCDRNNTIIADNIHKFDLIISTNKRKRYLEITNKIKEFIPDIKINKYNFSHILKRNINWEELCLIERLDIPEVYTKQDYKRVYIFKSVANLIGNLVTENRKLSSGLESFLLNKIKGKEGIEQMKVNAFGEILSRKATLNPEQNPPVQLSICMSMQNKAYELISETRIGCVLVTDLKTGEILVSASHPSVDTNNFNQDWNDHIKNRDNPLLNRVSSGLYPIGSIMKIFATLYLLENNIVDENTTVNCDGEFTLGNHTFKCWKSHGQNINLQKAISESCDIYFYTMSKKVDLIDYLNFLRKLGFQSKIDVMHNEKKGFFIEKKRYYLYEKLLTLIGQGFFQCTPLELTLMMNRFLSNSNLDLKILKNENSEMKFENNDENEKPLFSVKNIEMLGLAMKNVLQKSKGTAHYAWIINKKPDMGGKTGTAQVCRLSKEEYGLSIHKKKWERREHSLFCGYLPSDNPRYCITVVTEHDNLAKSIAIRLSKYIESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH21</accession>
    <name>A0A5C0UH21_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="221" mass="25122" checksum="D7BB6DEE502171D3" modified="2019-11-13" version="1">MQVLSIKDLTTRFGDKCVHDNLSFGIRKGQIFSLMGSSGSGKSTLLNLILGIKKIQLGEVFWFGEKSDPEKIRKMIGFQPQSGNLIRDYNVIENVALPIRINADLEWDICYELAAMKIKMVGLDECDFFKYPHMLSGGMTKRAALARAIALDPDLVILDEPLSGLDFESAKKFQSLIWDLVPEFTIMCVTHDYIKSHEYAVLENKKIRLLEENDLKENFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH35</accession>
    <name>A0A5C0UH35_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="144" mass="17437" checksum="8C94BD4BE2E44D80" modified="2019-11-13" version="1">MQFGLFLSVKIRFFDSYKKGILYEVFSIIYLKLRGFKILAWRYKTPVGEIDIIAFKKNTVFAFEVKYRKEMESCAWVVADLVQQKRIEKALSWFLNSKEAENKLSYYHLSKNRKSLSNNSYINKLNPKIEYIFWYKAFRMYRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH77</accession>
    <name>A0A5C0UH77_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="278" mass="32375" checksum="A543D941D8088A3F" modified="2019-11-13" version="1">MISGKKTLLKKISNKVTSLILYTHACLFFNNKLRAANNEINLRINQSSNINKSSSVMEKSKKKHQELCKQIFQESHKKYKIESENDKSKECIRVFSKQKKCIKTYNGLEDSLENETNENTTSSAEHKKSEAPKELPYKFIIIKGDNINMPTSFKKLTKENVKQIISSYFIPNLKINYNESVFNEEIKKDLMCILTGKNEKSKASCKNNSLYIHIQDVSVILFDKKAYFNVFLKFYSGKNFIYEIKITKNIDKITENSVEKELHEISKHISKKLLEFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH99</accession>
    <name>A0A5C0UH99_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="301" mass="35031" checksum="E67F2A595636226F" modified="2019-11-13" version="1">MYLLLFFITLLNTVFISGESNSRAESKNEITKTKNITPLKNSVSKKENKNSVNKKSKYVQIGNLNYTKSDLDGISKFLDSAYSELMKVPNFMPAQSLRKFNVVDFLVECEAVLVGTEQNLSKMSNKEELEKYLGSIISSEHEIKQKFIRMIIGQMSILSVNNNQGNESKVELNHSKLIKSFNVILIKSKKKLDLERFKGRVAKIEKEQYFSEVIKMDYSVFTVPIHEYQLNSKNTKVIKDTFLGEFSEIVFEEGYYKIFFVIDSNYLNIELINKIRNSQEAENLYRRVVRFNKPLVYVKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHA5</accession>
    <name>A0A5C0UHA5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">FZC36_01620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42732"/>
            <dbReference type="Rhea" id="RHEA-COMP:10209"/>
            <dbReference type="Rhea" id="RHEA-COMP:10210"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.170"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.170" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="248" mass="28759" checksum="ABF1F6E271E6444B" modified="2019-11-13" version="1">MVLKLREGVILNKSGKEKISRIFDKDQQTKLDIYMQMILDWQPMLHLVSTNALQNLRKHILDSAYLLKFMDSELTSAKSENESFFGIKNITEQDQLNEPKSPELCKYILDFGSGNGFPGVILAILGLDVILVEIHKKKCIFLDEVKIKLELNNLQVYNSDIRNFNLQSSNSCKYKEIKYIVTKGFGKVDKCIEYTEHIWSEDTVGLFIKSNDVESELEQALTKWNFNHKILSRYMPGFVLELKNLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHA6</accession>
    <name>A0A5C0UHA6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="232" mass="27278" checksum="99E3572FDB67D0FB" modified="2019-11-13" version="1">MTYINLVFGFKIKFLETGMMDYIKTDHANIEKDKIMIVEDSDNFFSIAFFYNSKSYVESFLITILALREYFSKIGSIQFKCPNILMLNGKKVCYLHFHEIGDKKFIRIFVQKNYFCYGFINNLCQFLEKWINLSKMCGFDYLVSSANKIETESCSDDKKQEIFLQQKNYDNSGDIHFDSSEINLVNSNSEGGSLVEKGLFIFDKFNENGHFSIRGYDYIKYTFEVEDLMCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHB7</accession>
    <name>A0A5C0UHB7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_01305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="8">
        <location>
            <begin position="128"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="7">
        <location>
            <begin position="371"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="545" mass="62075" checksum="BE53B522A4FA7FD1" modified="2019-11-13" version="1">MGAGGKGISAIKEWATKIGYEFTGSDDSSSGLHQNNELSTNQLNESKSYNKHFNNKKFESMKEEKNKSNWINIPENSTDFEADCIVTTGVIKKTHPQYIHAISKKIPIFHRADFLKQIIPENAISICVSGSHGKTTTSGMITWLLKTAKENPSYALGDKILEVGKLSELNKSKFAVIESDESDGSMQKLSGNWNILTNIDGEHMDYYETQENLNKAFNKFAVNNVISHISCFDKIFSEEKEADKFSHKEKSNAQLNNQLNNMHKINRTLHSYGIDSKEPILKSIKSNIYAENISINKDSMIFDVKGFFTEKSSGDRVYFNIENIMMNNIGKHNIENALSVILLAKNLINEGTYINDSTILKSMKTFPGMSNRMEGYSDSKNTYIMDYAHHPVEIKALLNCIKNREYKNVKIILEIHKYSRLFNNLDSFVKCLEGFENIIVAPIHSAGEIKDKQLDIKFFNMLNNFMKEQFDGSYNLTKVDKYNELEIYLDQTLKAEKDNKKENIRNLHKSGSKTEPNTFIFIGAGEICKFYRKIVDQLKSSSVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHD4</accession>
    <name>A0A5C0UHD4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
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        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
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        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
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        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SpoU_sub_bind"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="4">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="249" mass="27722" checksum="6EA98E578D751CF4" modified="2019-11-13" version="1">MRTIRIWGRHAVFSALSNKQRQVESIICIKKYAEEVKQIRRVSIKIVDRRHLDDILPGVQHQGILLMCSSLNTCKLSTCDHINPDDNILALDQLQDPQNIGAIMRSMAAFNFKHLLVTKDRCPELDGVAAKASCGGIDRVHILKAVNLADSLIRLKKNGFWCFGLEGNEKDEYKKYSGNITKGVVLVVGSEGFGIRDRIKSECDGFISIDTNPEFPVLNASVAASLGMHIINNGDKYVPKKLEKDTSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHE3</accession>
    <name>A0A5C0UHE3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="193" mass="22719" checksum="9C34FE4EA7071580" modified="2019-11-13" version="1">MYNINMREIYVPIWEKDLLGSKTSSLENKICTENITINQISHKAETKTESCIIWTPEIETNIPPTQFIDQVFPESNKAQNTNSAFLISFFAIGRRLFFPDKEIINSSFIDLCQGRRVRIYYSIKLNDKANNNIYYTYEWFVMKRLTPTEKDYVKSELCNKNYKHFLKDSGNHLIIKSGVNKNYKNMLYNHGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHF2</accession>
    <name>A0A5C0UHF2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FZC36_00845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="TSPc" evidence="11">
        <location>
            <begin position="784"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="919"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="977"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer; via amide nitrogen" evidence="9">
        <location>
            <position position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK38983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1015" mass="116895" checksum="F3419A2928A5461E" modified="2019-11-13" version="1">MISQYYRYPVGFGDTVYMVSHETLWKWSEKTGLNRWILLKSDAKDLSISKDGQCIAFTGSEESESDVYTIDLKTHKIIRRTFYGNGTYVVGWDSSDNIIFATNHGMPFKRNVCLNKLNLETGKITKLKTGLSNWISWNSKGSAVVQRFGYGYSTWRDYQGGTAGQLWMDSRGEFEKIPFEKHNALRPTFVNDELFFLSDASGCGNVCKYDFNTKNWKTITKHEDFYVKDLSRYGNNLIYSKSGEIFLYDTEKKEERKLEIKSANYAFEKSNFVCEDNSKFLTSFDINNEGDNVSCCIRGQAFSIPLWNKGYLQKTTSIRHRVALWSDNEKFLSIKDDKEDAVLFMDGQEFHRFSGIGRISDCKISKNNIIAAQNNRNEIWLLDLNSRTEKKILDNSEQVFGFDWSPDGKWFVFSSGKYNEYSSLKIYDSETEKCTEITEGTFKDISPKFDSSGKYLYFLSFRTFKTEYDPFSFNLFFRKGFKPYAVCLEKDSLNPFEPWLADDEEGDSKNVSSDSKNKNEDCKDEDLDPKDIVVNIDFENINKRIFECPVKASDYVDIEVIEDKLLLLESNKKLKSFTPGSKKLELVSDGISSFEVSRNKKWLLVFKDEKLRLCNSGLKFEESDSYKNNGWISLDSIDVIVEPEKEWKQMFEEVLWLTKVHFWDKSNEIDWDGIRKKYSKILESVQSRNELNILFYDMIGELKTSHAYVLEPGDILCEKHNNTGYLGATFKWNGEHYEINEIIEGDSWGVHSPIHQFSKGDVLISVNGRKLNENVPPESIVFEGKKTSLEIKKKENDSIKMIHVNPLKDVNRLAYQKWISERVDIIKSKTDKIGYVHIPNMVSSGYNEFYKRYIFEHRKAGLIVDARNNSGGHLSSLIIDKLQRKPNSYTIPRYGAPEHYPSESPMGPMVLICNENTGSDGDIFTRVFKDLNLGTVIGKRTWGGVVGIMPRYFLIDGGLTSQPEFATKMINGGYDIENIGVDPDIDVDNTIEDFDNGVDRQLEKAIELIMNKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHG9</accession>
    <name>A0A5C0UHG9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="178" mass="20065" checksum="92B8B5DF11641F30" modified="2019-11-13" version="1">MNIRNKYFALCVLFSFVSRSNTSSLELETGFINTDLYNTNKIGNNISIEKLKLTKSAGIVFDTAGMKNRFKAGIRVETGVVRFEDELKNMLSGFKGFVGLSLNFRPFSSFEKLYFRVYPGLSMINISSNNSVSFKIGASVGYELSKNLYSFVSFERIIEDQLSAFNCFKLGIAIRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHH2</accession>
    <name>A0A5C0UHH2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="239" mass="27041" checksum="63BD2B2F47733A66" modified="2019-11-13" version="1">MIQFRMDSNSIYSNISRFKISLSKLSTKLSKYFRPKGFSFFEIGIVIFLISILLGYVIKKGSTIMEKTKMFEVSNKIRDTKMSIESFKISHGFLPGDCPHKNMYKPGNGNNIIEGKGLEKDSESYVFWDHLYMHENTKIPKSHFISVMGGGIITVEQNPDGLEDAWLIIGKPVTSTNRANGPLFSYTNIIELIKNLSDSIDDGELMIKTANEGSAKKPEEISNENKQSSKKIFTAYIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHI8</accession>
    <name>A0A5C0UHI8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_02275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="356"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="594" mass="68420" checksum="077788F38A5F1E42" modified="2019-11-13" version="1">MRLFQNSLREGKKNTKEKSNLKETSFTNHRIFLKISLENIRKFWLRSLFLFLALFANGILSGLFVKLIKDLLQNQNKEVIFLLVIRSYQNISIGHIKNIILYPILNSIIMDSKTYSLESFLNRSSNKSTKDQLGKQERISSNIYSVINVYTSAFVTIISLIVQVKLMYKTNSAYILFLGLFIYYAAFLKTVKTWSSVLSSAYKASDDVSYSSLSAMEYKRNFEGNTKLFDSEIKKKMSKENKIYILKNKYIRYKSIILNIEPYVFLLLWIKFISSTSTTKEIIAYSTSGVFLIETCIRLANQGRFAFQLMRSFNLAENSLSKKKEELVIKSIYLNRVSIEKEKTLILKDFNLEIPNNSWIVVSGSNGSGKTTLCEIISGQLLPTSGEIIADIETSGIEKNISKDKGNDQGKIKLNNENKYLWSSNFIIKEGKLKLFDSEKKLLKQSEIINLHFSSLLDNSSFLDKKKYSTGEENFLSIVSSIFNTNNLYKPKALQNIQKPNMQNKENTKVQRKPNIQAYHNNANHEPSSSKSTIQTKHMIILDECLEFLDENLAKEVIKFLMLHYNSGIIISRRFEKMLSSELGFKKVTLHKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHJ3</accession>
    <name>A0A5C0UHJ3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylcholine/phosphatidylserine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="260" mass="29396" checksum="55991F3C9011E372" modified="2019-11-13" version="1">MNQRIKKYRKKLFINKGINYIANIVTSLSICLSLKAIKLSYNGKVNEAVILIIICAFIDGIDGKIARYLKSDSEFGKTLDSLADFLSFGIAPILIIFFYKTHNWLNLGWSIGVFFSLCMAFRLARFSDKSFSNCEPYDTNTSKEKHSETFEGIPAPAGGLLLFMPIVVENVLQIKLNHWVFCINTLLISMGLISKIRTIAINKIKLNKSQYHIFFGILSLLSTLVFAYIWIASLIIGSAYILYVITLLIKDNSKNKKLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHJ5</accession>
    <name>A0A5C0UHJ5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AmpG family muropeptide MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_02340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="PTHR12778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="417" mass="47645" checksum="43B136518EDD03F5" modified="2019-11-13" version="1">MVLYNFSVFSLAMVSAMVYTLPGHTLGYWLADLKVSKKALGLLSISYFIHASKILWVPFFERIKVPFLNKILDIRSSWIFLMMIIPSIGFFILSFRNPLQNQYIFVSVVLLSVFCMSTMDPLLRAHFYKLSNDQNIKKILTLGNIGFRTGLYLALNIYVLISNFVSWNVIYRISSLFMIVASFTIFLLPREKEEEESNFSFKEMFIEPYRDFVSKHKQYLVSVIAIMFLFRLQDKLISPVFYCYFVELGESLRGTISAQHMKYLFSASKIIGGFTAIAGSLASNYYLNKYSYKYNFFISAILHSLSCLPLLLLNNFLQSQYLIVGAILIEKTIRGFASNTFYVYQTSLCSKKYASSQLALLSLSESFGSALIGSCSGYAAEYLGWNYFFILAALISLPVLLFLKALPKNLVVKKSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHK1</accession>
    <name>A0A5C0UHK1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">FZC36_02095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="454" mass="50899" checksum="71F9DD372001BDF8" modified="2019-11-13" version="1">MSYLVLTKNRYDDSQRRTALVIHSINNNLEGDIRGIFSHLHASEAANIMHYLSVSQRSKLIKFLGDDFDYYILAFLEDAVREEILHKWANDKLGKALANLDEHYALEILSDLHPEHRKAILKLINHDDRVFLEKSLSYPEKSAGRLMSYQIVALPLNWTLEKTIKFLKNAKHLPEDFYYIFVVDLQNRPVGHISLSNVYKFDKYSTLSDCMSDEDISISSYSDQEEVALIFKQYSLVSAPVVNNNGKLIGVIDSHIVIDIIYREREEDFLHLAGVEDDGLHSNTIDTTKSRFKWLFMSSCTAMLSSSVIAQFQSVISKNAALAIVMPITASIGGNAGMQVVAVIIRALSNQQISKLNAARVLRKEITVALSNGVFFASLFGLISYFYISPKISLVFSLAILVNIVWSGFVGMMIPMILTKFRFDPALSAGSFLTASTDIVGNAAILIAASYFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHM1</accession>
    <name>A0A5C0UHM1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">dnaX</name>
        <name evidence="7" type="ORF">FZC36_00060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="35"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="475" mass="53230" checksum="9EE27D6CD98D1A3E" modified="2019-11-13" version="1">MCSLPNKMRPRKFSEVVGQEMAVKLLHEGLKKNIIGSVCLLNGPAGTGKTTLARLIAQWNCCENIKDKITKSNSENEASPNTINVEENDLCGQCTGCKDLINGSHPDVLELDGASKTSVDDIRQLLEGYIYRPVKAKKRTYIIDEVHMLSRSAISALLKTLEEPKEYAQFVLATTEIEKLPKTLVSRCFKINLESINKNKISEHIKNVSDKQGYYIEDDAVNKIVFSSKGSMRQALSILEQAAIVFENKIKSENLDQMLGLASSDQVENMVQMILDYNLEGIKNTIDKILENGADPLNFISQILTFIRKKKADKKSITIGFMLAQSCVDLNKSPYPAELLDMYILKAALCLKVFPEDSTTQNDCQNNLSSSKNEQNFSENDQPVNSHDFGNSKKTQTKTKDSQAFVNNSNRSEKSEKQSLSQLKDEKHTTNNKAYQIDQESKVVSNNTQNNSQANDTSNTDLRNKALDMFNKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHM6</accession>
    <name>A0A5C0UHM6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_01260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="216" mass="24641" checksum="759E7D6BF501FF3B" modified="2019-11-13" version="1">MTKMMFFLNWLKNPIKTGTFREIPKKAGKHILHFSQNLSQNDIILEIGGGSGSLTKYINNKAYSSAQSICIEINDSFCKVLRKKFENVKIIQGNAADLSEIISPEEMSRVRLIISSIPFLLINKAERNKILNQCSDIMESNLCPMLHFSYTSFYSNVFKNRGVVDFLSKKIKSFPTVHVNHYSYKNCSEAFSSIVKGMDFSEENSQKKEIKEGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHS7</accession>
    <name>A0A5C0UHS7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsM</name>
        <name evidence="7" type="ORF">FZC36_00515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="120" mass="13523" checksum="C024C975D524A6BB" modified="2019-11-13" version="1">MGGFLVRIAGESLKENKAIECALTYVYGIGKYTAFVICEELGILGKKVKELGDKHMVQIQSLIEELDIPIGSELQKRKRNAIMRLVNMRCYRGIRLQKGLPVRGQRTHSNAKTASRVRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHT3</accession>
    <name>A0A5C0UHT3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_01645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="242" mass="28598" checksum="B70D31CEB7F753EF" modified="2019-11-13" version="1">MYIDECRKWMSFVIELALKTKNHEEVPVACVILNKTLTNQSSSSLNKLQLKSTEPDRKTFHNNKNQKYSECISQINSNEYKNTNEYNNEYKYELVSKSSNQVQLKQNPLKHAELIALELALKKLNTKYLTNCILITNLEPCDMCMKAIELCKIKRVIFGAYRNNLNQNKLDNDLQENHKERHISNMQNNSQKHNTNYHSCKSHNNYHDYHYKNHSSHHIGGVMETECKKILQNFFKKIRERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHT7</accession>
    <name>A0A5C0UHT7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mutS</name>
        <name evidence="11" type="ORF">FZC36_02560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="802" mass="90067" checksum="6DF2A3456CCCE7D9" modified="2019-11-13" version="1">MTTPLIEQYLHLKEQYKDCILFFRVGDFYEMFFDDAKISASELNITLTKHGKKHPMCGIPFHASDSYINRLVNAGHNVALCEQTETPDTKVGKKGPLKRDVVRVITPGTITETSMLDPKSHNFLLACSPVSNEQIGFAVVDLSTGDFFVEDVFKKDFSSIISKWNPKELIIPQSFLSDEDSWMQVLEWQDKARIIPDLKYNLQECQENLKKLYKIHTLDSFGFMSNNSVIAAGSIARHIFYTQKSNSLSLKSISKLNNSNFMMLDQFTRNNLEIVKTIQGEKKGSLVNTLDKTLTSSGARLLQMRLSSPSKEEKTIRNRIESVDFFVKFSNRSAVSDLLRNYGDIERSSGRLFLKRGGPRDLLEIANSLQSAAMIYQILKNEDLSDELKREVSELKDLDKIYPIIYSAIDSEPPLKISDGGFIKKGYSEQLDSIRGLEQKALCDIEMLEESYKQATEINTLKVRKNSSIGFCIEVPASQSSKVPYSYIKKQTLTNIIRYVTPEIQDLNERMVSSTLLALSEEIKIFQDICDHIKKYRNRISLAAKAISVIDVSLGLADYSLQYDYCKPLIAQGKKFNISKGRNPVIENILMKSNEDFTANDCDFDKNKFMLMTGPNMAGKSTFLRQNALIVLMAQAGCFVPAESAELGIFDGIFVRIGASDNLGKGMSTFMTEMVETAIILNSSTENSFVVVDEIGRGTSVEEGEAIAFSVMKSLSEKRCCTLFATHYHSLADISANDSNIDCYTMEVQSWGEKLIFKHKLVKGASDSSYALYVCGMAGIPSSVIEDAKRFIVDRDKTQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHU6</accession>
    <name>A0A5C0UHU6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="6" type="ORF">FZC36_02180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPBB_1" evidence="5">
        <location>
            <begin position="53"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="178" mass="20255" checksum="1636F0F4209F7877" modified="2019-11-13" version="1">MHYIVFFALFLFGCSVKEWNEVPHPREFAKPYKIKNTQGSFKITPQKHYSLKEKGIASFYGDKFHGRKTASGVCFNQWDMTCAHPRLPLPSIVKVSIPGTKKEVVLIATDRGPFVKKGDRRIIDLSRGAARILGIEKQGVANVEIKCLEKESAELKSKWPSYRKKGTLPFGLVNRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHV8</accession>
    <name>A0A5C0UHV8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ppx-GppA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="299" mass="34119" checksum="8BC46F6F324414BB" modified="2019-11-13" version="1">MERSRNYACIDLGSNLCRMLIGYKNEKHGVTVLKSLISQVKLGEDIYKNGFVKEEAIDRCVNFLKKCMKVAKNYKVRRIESVVTAACRLASNKKTLLHRIKNETGLSFRMINPDEEIYFSALGCLDVMPYKDCYVIDMGGCSTEVGLFSKRNNRIYLQKWVSLPIGILKFQESGNEQHLTDDLKDIMKNFSDSQTEKLPLILSKSGIMSNISKHISQNSNVDPEVFHGKIISNSRTEQILDEIISKYKNEGLKNRNHSTYGSCKFMKDLLHTIQSTEAIVMSTKGLREGLLYKLCNNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHX9</accession>
    <name>A0A5C0UHX9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="10">Glu-ADT subunit A</shortName>
            <ecNumber evidence="4 10">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gatA</name>
        <name evidence="13" type="ORF">FZC36_01930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="4 10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEK39183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="509" mass="56865" checksum="DAB7BCCA8F0DA77C" modified="2019-11-13" version="1">MSEIWKLTLKEVKDLLHNGEVSPLTLVHEMFERIESQSHLNNFITITRERAFKSAEESWERIKQGNARALEGIPIGVKDLYCVKNERMTSASNVLRDFIAPYESHVTQKLWNQGAICLGKLNMDEFAMGSSNNTSAFGPSFNPWNYDQKLSPGGSSGGSASAVASGSCFAALGSDTGGSVRQPASFCGIVGFKPSYGRCSRFGMTAYASSFDQAGVFARNVEDTAIMMNNMMGYDPKDSMSCSEKPPTLDINKSIKGKVFAYPKNWMENLDKHIIKNWENCLQYLRDAGAIVKPIELMDFDFYLSTYYLLTTSEAASNLSRYTGVCYGSKKQESNPKYNATFELFGKEVKRRILMGVHSLSSKNECGYKLGLKARSIIKNDFMKIFEEFDAIVYPCSPREAFPVNKVFENPTESYKEDVFTVIPNLIGSPAMSVPSGYGGNGLPIGIHLMSKPFDEQILISTAIEIEKRANFVNYIKKFENDMNENNNSKSENSNLSNKTDSQYKKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHY4</accession>
    <name>A0A5C0UHY4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="520" mass="58320" checksum="6DAB145E815F67BC" modified="2019-11-13" version="1">MTEIKNREQFRYKYKYILDRVLVFLSVFLLGCDEKNFNAKPISFLNRNALKEVKSKYKHKSLEVPKNWSKKISINISNGSSVLDIIKSIGVSNGLNIKFAKDLKDKELNYFCKEKPVLEAIKDISESSGFIIRVSNHGILIDSDEPYDHVHEVMFLSSTRKSNSSTSVNGSGSKGSMSMDIGSSVEVRSESISDTWKELEENLSFFLRSKKYTINKQAGLMIVNAKQSDHRRIARFLLDLHKRISTQVLIEAKVIFVKLYKEFRTGIDWSTLQISNFFTSPDKVFDISSKSVADNALSVLIGKDSQTASSIISLLEKYGELETISNPTTSVLNNQHAIFKVAENKVYFKIYQKTISIGGKSIDGVSTIFGSNLHTVPVGTILSVQPSVDFRNRTITMSIHPTISEVHDEKEDPSVAIMLKDNKVPDNIKSQVPVISTQEMDSTIRVNDGDLVVVGGLIKSSRSNNSSGPLGTKKLKFLRKNEKKSDQQEVVIMIKATILDPPENLLVRSLADYEIFPIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHZ1</accession>
    <name>A0A5C0UHZ1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="Pentatricopeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="382" mass="45333" checksum="F562F0441FC4E7E0" modified="2019-11-13" version="1">MFFKIIYKLFKPLLVLTFFGYIFYPLKNLDIQFLSEENIALTVWDVFMYIVLFSMLSIYLTKMMFFIKNFFKSIGKSREKKYQIKEHNKLANHVVLKILGNKPAPLLQMKDPDQAYLISRFLLSDCKDLDIASKIDKTLKTKALRTFVKANETYEDKNYEESLKHFEYLVMNFKVGKYIYDYFINCLIINKNFDKAIEILKEMLRDNLIVKNAYLQKKSLVLLEHYKTTKDVQKIEHAFEINPNNEDIVNELILTKRNKNQKLEIIEAFWRKNHSIKLGIYYLKLIDKIDSKQFSMVENLVSKFENELSSLVILTKASIDFGIFNSAKNYASEIFKKDPILGHIFEMLICIKKEKNIDITLLESLEREILHKLENIKHIKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI49</accession>
    <name>A0A5C0UI49_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="272" mass="30930" checksum="AB45CF58CE5DC76A" modified="2019-11-13" version="1">MEDQIKDSSRVLVSRKDKFHEMFMSSEGLKDSEICVLCIPDLFGDCSDFIGLKEKLSIDFKVISFDFLGHGLSSKALEYSYNDFLNDTLHIISKLDSRNIFIVGMGVGASISCDLISMHNNPFIGCVLLDADKIFDPEFKFKLPDIGEFTNFKDAKNSLDLSKHCSEETIGKIVCQKYKVQENKFRRALDDKLGKCLGQFSGFSFVEKTKNIKTPVLFMGDSVNFDSELIQYEISKNISDLYDPENIDIVSKWIKNIALDPCTVLKCWKNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI61</accession>
    <name>A0A5C0UI61_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ORF">FZC36_02060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="44" mass="5167" checksum="A7D6248138379270" modified="2019-11-13" version="1">MKRTFQPSNLVRKRRHGFRSRMATANGRKVLSRRRAKGRKVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI72</accession>
    <name>A0A5C0UI72_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="101" mass="11432" checksum="AA9E1D706023B3C3" modified="2019-11-13" version="1">MIRISDSAANEMKRRNKTAIQVRTFFGGCSGYKYELSFPNTFPDNAEILESNGITVITDIFSAKKLKDSIIDFKSTLMNSKFEIKSKTFKRNCHCGTSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI77</accession>
    <name>A0A5C0UI77_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="628" mass="71742" checksum="432760A1BF7ED4E1" modified="2019-11-13" version="1">MQFLRKFKEKYILNTRKSFSVRKIFCKHSGRYSEVYSGDSYSNNRKYSCNYASKNKPRYKVFLSYIFNKSRKIFKSSIFVFIFILQGCENEEVLFEKQLEDLVKNYRWRDASRVINRGLNMNPNYTQLHLLNGFIYERLAESEPAYSGLSLVAYKKSLSIDPNNVKVLIALGRHYSMNHNYSKSMDLFSRVIMQDEYNIEALYGLANASYALRYISVSKNAIDRLLNFDSSERVCRLAALIYASYGDKKCYEFIRKFSEKTSNKEDVSYLYGRAEEWLELNSKLKNINYAKIQREESRKKEIKKDHPIDNFVVECIVLSFSENSRFSRGNNILEALQNFGDEETKGLGMRVSNGNLLNRHVNKGYANVDGKWILDENNTTKSITKGFSIGFEDIRYNLNIANSSSSLVDIMARPLIQITRNGRGHFYSGDKVFVSAGGDVGSALSSIPTGIKIDIQSRDVNKDSIFLNVKVDLSKNSFKNSAGSANDRANVMTATMESDITAKIGKTYAIGGLYSHISEYGNTGIPGLKSVPMVDLFSAKKSSLDDKKSVVILLTIKDPKEKAQGRSVDLSGTIGMLRKSRRFLFKGIHPKSDLILMSHQMYQRNDIKEMNVDFMENDINYILRSLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI78</accession>
    <name>A0A5C0UI78_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TraR/DksA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="106" mass="12178" checksum="7E7A60B9A5B83CD9" modified="2019-11-13" version="1">MFLKNSEIRYFRKVLLGMKEELSSIITDELEFEKSADSYDAALNEKSSNTRVIEKTKAMEMLKQVNMALSRIETNKFGICMRTGDPIDIRRLKVNPVAVCNINIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI84</accession>
    <name>A0A5C0UI84_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PCRF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="369" mass="42220" checksum="0F0DC219682D51BD" modified="2019-11-13" version="1">MNIKSGNISKNTLKILSKIDEAKQNNWWKEIIEEYAFLEKKSEDMFLSGAEKADVYKRMGMIFKELEISKKAELAFDTILQIEELSKFEQEDEFANELRKEQSDLLNDLEKLKTDFSDLKNKTQESDQSIIMEIKPGVGGDEAALFSSLLLSMYANYCTNRKFKFEIINQNITDIGGLKEVIINISGENAFNLLKNESGVHRVQRVPKTESSGRIHTSTSAVSVMQEKENVDIKIDENYLRVDVYRSSGPGGQSVNTTDSAVRLTYSDPDLDTITVCIQDEKSQHKNKEKGMKVLKTRLVDMVERKEQENLASIKKEQIGSADRSEKIRTYNFPQNRITDHRSKVTIHSINDSNLMTFESMEKIIKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI90</accession>
    <name>A0A5C0UI90_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="642" mass="74736" checksum="D5A210067BE58504" modified="2019-11-13" version="1">MITNKYKMGNMSKMRNILKLCTLALTAQHTNTVDIPKLHDTPNEHGCFYHFKYVEGTFSIEKNETFELLEQMYEQSKYSIEDIKLIAFLRHELEKILEIDYKKGLENDFLLKFPKIEEVMGDGEWEEEVFLGHGYSKEEYRQTDIVCNVRDAISYMEYTKRIWGKIIKQEDEETAKEIKDSVKNTNHECELGQKTYLNLGAMLNSIGYGLRQRKEARMPGESTFLQRWYSGRHAYEDDKKSKVSIKLDNSKFIYQGIPTKDSGTDYEKKPIEYNNSTDLMYLSYFDANTKTDNLVWCGDERELKERTCKVVQYNSFPDLRNLDRIGPIFQYALALRYVHLDITSPDHLYWMRFAQDLEYVKLRVKESDHLTHLGLLKNTQYLGITNINVDEAIVLPEEIGTLSKLRCLHLSGVEGYPNQIHGIKGLREIKFVESEGKIDKSLSNLDKLVHLELSGKVELPETIELWELQSLVAPSADIEKMPKFICPELRYLDLGSARLEHALEPGAKLPIFAGGNEITSVSDLSECPELREVWVGNRINEVDVEVFKNCKKLMYIGLGVDFKYNIKQGLTEYVKKNELFLELLHPLNAGEKLQYSCKIPGEDGEWLKLKRYQENQKRNWVRNKNARYKHMAKILKENGQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI92</accession>
    <name>A0A5C0UI92_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-packaging protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035421">
        <property type="entry name" value="Terminase_6C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17289">
        <property type="entry name" value="Terminase_6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_6C" evidence="1">
        <location>
            <begin position="315"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="475" mass="54850" checksum="5006CD940E8ADEC2" modified="2019-11-13" version="1">MITTEEYERTKILNETKNESKQELINKQNNLTVSEELSMSEKLSSISRKLCMPRRLSSKLSKLRNMLTSFSHKKKKQYDWNNLARESQRIPQSNWDTWLIMAGRGFGKTRTGAESIKLLIEQGYKRVCLLGRTIDEVKKIMINGNSGLLNIYPEGNKPKFLESKNIIKWKNGAVAEIHSSESYESLRGPQFDLAWVDELAKFSNVDQVWDQLMMTMRLGNPKTIITTTPRNLSLLDKLMKQENVFVTKGKTLENKENLSETFLKNVYGQYSSTNFGLQELDGEIVKEFEFWNQSMFVYESLDNLDIRMSEKIVISIDPAITSKDNSDETGIIVGMKLNNGKIYILEDCSGKWGVNQWPALCVDLYKKYKEKCRNVRIIAENNQGGDMIEQLIRSELRDVDFLSKRSYQSKKNRAAPISCLYQKNKVIHVNKFEKLEQQMIDFPSKKSPDRLDALCMSVNELQVSDSSSYSKIMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIA8</accession>
    <name>A0A5C0UIA8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="258" mass="30284" checksum="F1EC5F35AAD1E0EA" modified="2019-11-13" version="1">MLTKYRQTRLWLVQSIFQHLINKNPYKLGKNNSEQVKSEKIRNEEIKPESDFINNEDGTLVFESEQTTETTLNEENEDNEIVKEDEDDTLQDLQEKSDEFNDVILNDINLNTNELETESTELIEDLETKEFENINEHIDINYKMREFEEIIFDNLGDKVEFKKLFSGVLHNEQEVTEKVSKYLTSSCKWKNMQLVLKSIFLSAGYEIIFANLDNGEDLEKTKQHIIKNYISIARVLGEEKGVDVIFSVLHKIKHKINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIB4</accession>
    <name>A0A5C0UIB4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ORF">FZC36_01745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="56"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="335"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="439" mass="48334" checksum="254362D17D6F61AA" modified="2019-11-13" version="1">MSKTPKFTCASCGTNYSKWQGKCDSCNTWNSVMENIVRKSSIKPLELKVLSDEADEVIRFKTNISEFDHVCGGGLVAGSVTLVGGDPGIGKSTMLLQISGSFPGKVVYVSGEESLNQIKVRADRLNINLENMECAYGTNVDQIIETLNDAKPSLAMIDSVQTLYDPFSDTTPGSIAQVRICGNKLIQWAKDKNIPILIVSHVNKDGMIAGPKVLEHMVDTVLYFEGNNSMRIIRAIKNRFGSTNSMGIFEMRDKGLIPIVDASKSFLKNRSLTYGSCIFPAVEGNRPLLVEVQALVSNSYLQNPRRAVVGWDVQRLAMICAVLENHCKVPLSGKDIYLNIVGGIKVFEPSSDLSVAIVLMSAWYMIPVPQDHFVFGEIGLSGEIRPVSQVDQRLGEGEKLGFKSACIPDKSEVTSSKMDLIQFKHVQEVQQWLRSKAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIC0</accession>
    <name>A0A5C0UIC0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="10">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">secA</name>
        <name evidence="14" type="ORF">FZC36_02365</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 10 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="13">
        <location>
            <begin position="16"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="100"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QEK39253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="824" mass="94247" checksum="9AE6FE966334D774" modified="2019-11-13" version="1">MFSFVKIVKKIINWVSRVLYRIVFWFRSNEIDNLKSIAKEIDKKNYSDLSDEELALKTQEFKSRFENGESLDSLLVEAFAVSREASKRVLNERPYFVQLLGGIALHKGMIAEMKTGEGKTLVAVAPAYLNALAGKGVHVITVNDYLAERDSTWMGKVFNFLGMSVGCIHNNMRDEERKVAYNCDITYGTNNEFAFDYLKNNMKMSEEEIYQRDLNCAIVDEIDNILIDEARTPLIISGSSNHSSDLYAWINTLTKNLNESDYQKDEKHGTCHLTSDGVKKIEKMLTDDGVIDSGDTMFESRNATLIHHLNQSMKAHFLFKKDKDYMVKDGQVFIIDEFTGRIMSGRRYSDGLHQALEAKENVKIQDETRTQASITFQRFFRLYNKLSGMTGTAMTEAEEFDKVYDLKIVSIPTNKPISRTDLPDEIHATLSEKIKAVISLVKKCSEKKQPVLIGTSSVEKSMIFSNALREEKIAHKVLNAKNHANEARIIADAGKLGSVTVVTNMAGRGTDIMLGGNAKIIVSEKIKDLENESEIDSITKQTIQEIKEEKEKVKNTGGLFVIGTERHESRRIDNQLRGRAGRQGDPGKSKFFLSLEDDLVRIYAGKVNTLSSRMKSEGPITGRIVTRLIAKVQKNIESHNFDLRQHVKKYSDVQEEQMDSIYRYRMELLKNYSKNIWLDLVKNSIEKMIHDFLLKDEDLSALSKAIKDHFKLDINFDEIESNEITEEFLVDYIFTKVEKSFEDYISEDEKILKMSKIIALTILDEHWIDHVEKLNYIKQGIGLRAYGQKDPLVEYKKEGIHAFEEMLGNFYLDSVKAFFHELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIC3</accession>
    <name>A0A5C0UIC3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="651" mass="75237" checksum="93ACD0E04F8827E5" modified="2019-11-13" version="1">MLKNQNLLGFVKKPDRFAAKHVCKFIYLTCLAVSAAPNEVYVFFRGFHFNTSFTEDNINKIVRESKQRNFQGIDCLSKYSAENELDENACSRLSNDFAKLYEQGSMKFQTGNSNSTKRDFRSPMHAVQEMYVQHHDLFQEKLEDRTSELSQMLLETTDITTGEYINSNFLVSTSLDPCSALKFCAGSCSDQARKPEKRNGRFINSLLGYLDIFVVPLDEIKILNPFFVAEEFATLGITINNASRKPYHKYAEVNFPFHIPGKYHRYRYFLDVSKESSFNKSENCKFTDLDKRLESITEKLNAIVSFILCTNGYSRIFSGSIMRSLSKITHFMPDKLKEFRKTIEHLRDSLKTNNPRCNSIQINLNEFCININAFCERFYNPTLDSQEGMFTAFQAVRYLGDFLDYNTNSPLPGYFNLHINLSNLNLNDPEIEKFIPIILSAKNVKAIKILGGDESIYWYDIDYRGIEKDLGIEDKKQLCEEEFPWTEIKDCPTMIKLLKLVGESIHPEADFSLDLTGNSFSEDDLHSASETINNHKPNSYIEVIDDNLSENEAEEEAFKVMKEHLQELIEEEEESEPSETYSEYCERNSDADSEESNVPVHTNNYESSSDKTESNSSEYEEETEEESEKSEEELEESEEETEEYEEDQLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UID7</accession>
    <name>A0A5C0UID7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endolytic transglycosylase MltG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mltG</name>
        <name evidence="8" type="ORF">FZC36_02470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="312" mass="36569" checksum="2E168E296D43CBC8" modified="2019-11-13" version="1">MKFSKKLPLFVSTSFYCTFFLTALLCFSKPKKTTFIIPNSKNLSDRYRKTKKNLSFPIITNIFISTFHIKRGEYSGGSNLQLLLNMLLNKQVMRKITFPEGMSSVQIYDTLKEREDLTGEIKHTPEEGTLYNSTYVYTLHSDRNQLIRKMEEEFVKASEDIFKNSYSIWKNKKDWITFASIIEKEGKEKEEKEKIASVFLNRIKRGMKFESCATVLYFKTQGKYNLNKLMFKDLLEKNPFNTYRNKGLPPKPITNPSVESLLIALNPKPTENLFFFIRDNKTIFSKRFSNHVKKKSKQNSKNIKTNKQNITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIK7</accession>
    <name>A0A5C0UIK7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="221" mass="24641" checksum="3602479320DA4E50" modified="2019-11-13" version="1">MFFSNITPSKSGAMASYFGTRFSMNFTEIAPIGQIKLDTENLNIKSLLKDINTSGIKSKINTSFSHQLSQGLGLFAIGVSSDVGLSGNKKDVVNLSDIKNTKLNLKTGNFVLSHHVFFGLNFGIARALFVTGVTGRYYEIDSDSEERIKSGDFQKSWNWNKNVGVAVQFILFKLLAEIRLMRSVGQNVFSKAKIEEEPKSNNQLFYEDKGLKLSFAVLFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIL4</accession>
    <name>A0A5C0UIL4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">smpB</name>
        <name evidence="3" type="ORF">FZC36_02465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="141" mass="16571" checksum="97CE4F073D633FEE" modified="2019-11-13" version="1">MLNNRKAFFNYEILDKYDAGISLKGSEVKRLREGSGDISCSHIMIKNEEAFILGMNINNLSKNDCFDSKRDRKLLLRKKEIRSLFSKSREKQFTIIPIKVFFMKGFAKIQIALAKGLKKYDKRKKIIDKEIIREKRNQTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIQ1</accession>
    <name>A0A5C0UIQ1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FZC36_02675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEK39312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="184" mass="21336" checksum="4CE048B44AD37244" modified="2019-11-13" version="1">MMRQVPNFLSVVRVFIGFAFFFTFPSFLSKVLFYIALFTDLIDGYIARKFNFQSRAGEVLDPLADKTFFGLVLIKLYMAGILEQWFFYLVSIQYSVYVVIVALYLKKHFDFKANICGKITGTMIALVSFLAINNADPLYLNLACFVYVLSMSVSTYVYWKNFLTQKKAKLMVAKKHLYRDSKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJ57</accession>
    <name>A0A5C0UJ57_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCA tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="47"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="5">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="407" mass="47590" checksum="19511C02FEDDCB1D" modified="2019-11-13" version="1">MLSMNGKEDISKESDLFENYKIASKSSALWLQEHNLQNLLSALEPAMVVGGAVRNHLLGIQIGDIDIATELTPEEVIKKARENKFQVIPTGLQHGTVTCVKNGFSYEVTTLRVDVKSYGRYADVRFSKSWKEDAERRDLTINALYLDKNGNIFDFVNGLKDIKSRTIKFIGNPAQRIQEDYLRILRFFRFSSFYGEQYDNLSFSECKKQIENLIKISRERCTSELLKILSSNKFLETVKLIDEIRIWDYCDFPKPNLEILNKLNISEKQKNRKTSEICRLSCFYGDFTKMKLSNKQYKNVITLKDLVLENKYNHIRWLHESTDELFWDGIILKSNLNNFDFLEKWRKYPFPLSGKQIMDITKINPGPKLGELIENLKSFYYSQEEPSKDALLEYLSKVYLAYKSWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJ66</accession>
    <name>A0A5C0UJ66_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="215" mass="25432" checksum="4BAB0BA3F8645690" modified="2019-11-13" version="1">MKFDHLIFASVNLFLAFYTFLLFKKNHSYKSDNKNKQLVQRNLEKEFNFIASNQDSWSKFAIKQDRSISKWFMQNDIEVKRIQKESYENILIYTIFLEIDEGKINRIKEIPFGCVKIVEMQKLNKKVELKIDLILSKIIKTNEEEAQTETTLNLSCILDNEDDWLICINGIWYAKNDKIPDIKVIKTSYDHVVIQYQTMNGQKTDKLFVGKPKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJG7</accession>
    <name>A0A5C0UJG7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="439"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="684" mass="78969" checksum="CDD00B0EF676F741" modified="2019-11-13" version="1">MNKIFLLTQIIAWNVFAMGNDDIIEMHKDPVAVVSVVYAGAVAAQNSESRLLNPVNHEEDIVPEIVVNANEDVETGFVIPANTNEDEHREPFSKEVQGLDPKLLEDKDRVDRIRKGLMGVLNTELGQYVNENYINENYTWEVEDLIDALKRSSTLGKTYPSVSIEEREKALGKGSYRVGYNNEDYSFYIHKVVELVNELFPEYVLTENCILVGSKRDWESSLHGVVVNVLDIEGKNPLLSNEYDESQVSIKETNTLSSEYVENLLYLTSHINELLELEEKKNDKDPNNMRKLLDIKIDTVYLLSEKFIKKSGKLVDKSVYKLLSVKNDEFMRRYISRARKTEEGEAFFEGIELSYNSLSIGDDSTYKTKVQERIFTHFCENVLAQKREESMKRFVFGEERARVCAIAAQLRVHDFIQNHVGESESFMENSMSELDLEKYTELSNKLVMLEDELYELKETIKELEIEKTSLVLALKDKGLPKQEKQRLATEKNAKQDLLKEKNTEKEVKICLINEKKELMKNLCPLKEGVNDSFQERAGQLHTYLNILEKNHNIRDTEENLFIKDNGFLSRGYFRILSYLGNMAKHALDPYEYELKKENDSGSTIKGTLQKILKFEKKLGKVFESPVPGTDLLKLRDKNENPRKKMKYSSDMEKPEDPPQINRTVNPNKDLSNSLNVLKENKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJL7</accession>
    <name>A0A5C0UJL7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">FZC36_00955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="347" mass="36983" checksum="D9118D5934322E87" modified="2019-11-13" version="1">MIRKFFSKFINKMSKSLAIDLGTANTLILTHDGKLINEPSVVAIQENNGSKKVLCVGSEAKKMLGRTPENTYAIRPMRDGVISDFIIAEEMIKHFMRLANSDKGLINPKVIIGVPAGATIVERRAIQDAAKSAGARYVQLVKEPMAAAIGAGLPVSDPMGSMVVDIGGGTTEIAILSLGGIVIAESCRVGGDRMDSAIAEYVKNEFQISIGESTAELIKTRIGAATLPPGAEDKSFIINGFDRVSGAPKRIEIKSSDVVKSIETPLIEICSRIKAVLDQAPPELASDIAESGICLSGGGALIKNIDVFFNSRLGLKFFPADDALMCVVKGAAKILYEMDDLKLESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK86</accession>
    <name>A0A5C0UK86_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FZC36_02475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="entry name" value="PTHR31187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00769">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="510" mass="57969" checksum="A0D83E236AA9916E" modified="2019-11-13" version="1">MNDYYKGKGVTGFFQSINKVLLGFVKIFFPIEKSEIKKYLPLAMMMFIVLFNYTILRTLKDGFFVTHVTSGAETLNYLKGVVVLPCSILFVIFYSVLMNSVKKKQNVFYYTIAPFIIFNLVFIFFLYPNRDFLHPSMDTIVRLQTSYPMFKWLMPIYGLWIFSMFYFFSELWGSFGMSMLFWQFANKITKTSQSKRFYVSFGVLGNIGFSMASYILSRSMSGKISDDVFDLRFKYIIVSVTILMVVLAGIYWGINKYIVSSDPELAEKKPVNSSKKKKKPSLRESFRVVFSSKYLGLIMLLIFCYNSMMNLVEVTWKSQMRSLYPIKSDYTAAYAGVQLATGVSSIIMFALGNYIVSKFSWSVAASITPVVMVSTGVLFFFFVVFESYLSPLASLFSVGPGFLAFIFGAIQNVSSKSTKYSLFDPTKEMTYIPLDEDLKSQGKAAVDVAGSRISKSFGGWLQSALLMIVPGSSQFAIAPYLMVVILLISVLWFVSIKMLSKEYSEKVQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFJ5</accession>
    <name>A0A5C0UFJ5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="2">
        <location>
            <begin position="33"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH" evidence="2">
        <location>
            <begin position="307"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="802" mass="90096" checksum="A2CE97DA42674776" modified="2019-11-13" version="1">MHFQTENLNQKPKTNKIITFRNEEENQKITLDFSTFDSRSDSSVLVKKGNTAILCKVCIGSWDEAFSSVPLQINYQERSYSANRIPGGFIKKEPRKESDMLISRSIDRSIRPCIAPSFKYEIQIFCTVMSHDKNNSNEELATIGASAALYESGVPFEPISACKITFKDGVWKKSANNEKNGLLFCSNVNGLTMVDYYGEPASRKQILKGIIEFSGKNNEVLEAIYSVKRKAAQVAPMSESRDSVVDHKKILSLLQNDQDLSGEKLKFLSNWNNKSIGSDEWNKSVKQIIRKYIIWSKKRLDGRSFLESRKMNVMTNVIPVDKNALYSKGKTKVFSKITFGNPEDNQMVESLEGNYRDRFMVQYIFEPHACGSVKRNLSVTRREIGHGNLVKRSLKPLISDKRVMRVVCDVISSDGSSSMGSLCSAYLAMTDAGVNITNPVAGISIGMVSDGFESYILSDITELEDFAGDMDLKVSGTVNGFTSIQLDIKPSSISVSNLNSGLIAGQEEIIQIIKNLYPQNESSKNVKTDHEIDNRQVSSKNFNSKSNEHKNPKDDESEPNTKRPESENLRRSKKSYSKEDSEKSSAQPQSDNNNKSEYVKKDRKSDNISLTESGKHKNPKDDAEDFRNKKKDNNKKRSSVVEDLDQKKSVNPKDSQSNKKADGKNPNFVESHLIKLSSELKSNVLQKLNAVITDNFSGSVGFTLNKEQNEIKIHGINKQLLSDAVDRMITIIHSKPRSKTKLKYVLFVSETETSISAKAIDGTLIEIEKNEDFRNSNISLSENYSFIVKVGRFGKLFFFGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFL0</accession>
    <name>A0A5C0UFL0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="173" mass="19558" checksum="5F34C8FB41C07984" modified="2019-11-13" version="1">MKGLGERFPDFILDAVTGSKGEVKKINSKSYPDHWLVVFFWPFDFTFVCPTEISEFSDKEGEFTKRNTKVLGVSADSAWSHSTWKNIDPNMGKITFPMLSDFNKTLSSDLGILNVDGAPERATYIVDRDMIIRNVVVYDRNVGRNVDETIRVLDALQNGNLCPVNWKKGDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFN9</accession>
    <name>A0A5C0UFN9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplF</name>
        <name evidence="6" type="ORF">FZC36_00485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="5">
        <location>
            <begin position="93"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="177" mass="19674" checksum="267B9E6F0EB8FF0E" modified="2019-11-13" version="1">MSINALKPIKLEKEVTVVLDGDSASMKSSAGEHVMQIPSFLNLEMYEEEDQKFLKFSTEDKKHIPMLGTIKAILKSFIVGLTKGHVKTLKLEGVGHKAEVSGDILKLSLGYSHPINADIPNGVNVSVSKNELKITGIDKQKVNQFSATVQSFRAFKPYKGPKILDSDKIYIMKERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFQ2</accession>
    <name>A0A5C0UFQ2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_00335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK38888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="117" mass="13023" checksum="A7C835AF2498EEDD" modified="2019-11-13" version="1">MCEKKSVEIIFVYPDGSKKVCNANVGDNMLQVIRKNHIPMACSCGGALACGSCHGTLDQPFFDKIEDSDQAMSETEEETMEYFVNDDATDTSRLCCQVDVREELNGMHIYIPKNTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFR8</accession>
    <name>A0A5C0UFR8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022927716" evidence="2">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="332" mass="38092" checksum="9B7C12423F0340C1" modified="2019-11-13" version="1">MRKIRKYITLISICSSLSAMPSGNGSIPSMSSSPNSLASVQMKSELTAQNLSKLHNELFELTRNWDLDSTSTNLTSDALQKDLQNALNHQKESSDLLAQNVNDLSKLQKLENENHKLNMENTDLKTENDLLHIKLKNAQEKVKYLEEENSVKTRELKERYNSLERSLSTSTKRHETKDLSIAEMREKLEKQTSLKELHEIKAESLQAELNILESKYNQQSSEARKNDELLKFELKIANSEAYVNKTACELYKVSLSDLSNISIDLFMEYLKEKSLDSKIDNDKEKTIKSFLKLIKESKTYDKLINSFNLFKVKQLMAENPSAVKLFSSQNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFT7</accession>
    <name>A0A5C0UFT7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">dnaJ</name>
        <name evidence="12" type="ORF">FZC36_00690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="11">
        <location>
            <begin position="130"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="9">
        <location>
            <begin position="130"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK38955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="364" mass="39464" checksum="C4091F2C0E551A0F" modified="2019-11-13" version="1">MSENFYDILGVSKNATDSEIKTAYLKKAKKYHPDSNKGNETCANQFKKVSEAYETLKDPKKRSMYDAGGSDPFGSGFGGHGNQYSQGNGSFDFEDIFSSFFGGQGGRQRQKRGEDLRFRVKLTLEQAFSGTKMTIKIPKTSSCKTCSGKGSSGPIEACSACNGKGTILMRHGFFHVESECSACKGRGKTSKNLCSTCKGSGIVKENKEISIEIPAGIENGEELRVPGEGNSIGSEGPNGDLFIQVGVSEHKLFSRERLNLHCTIKVSPVTLVMGGEAEVVSIDGKKISVKIPAGTQSESLLRIKKLGMQSRGRIGDLYIKVSTKIPSTSSMSSKEKALWKELSEMSDSTATSLLDSIKSMFKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFW0</accession>
    <name>A0A5C0UFW0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="166" mass="18943" checksum="9DA5355519A03AA4" modified="2019-11-13" version="1">MKFLSCLLCCFSGDVLQNSPKEQDSDYIVNYIVNDKVFFSSRYDSDTARSNIPLKEIKKSDSSTQTDSAAEINKTSQSLINTLIQEVSLLKARNTSIITSAMHIEQDRDILKLERNKIERACRTLYKANAKLSGQIDHLVSERILLMQELEVYVEDKPKTKEESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFX5</accession>
    <name>A0A5C0UFX5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dprA</name>
        <name evidence="4" type="ORF">FZC36_00910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="3">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK38995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="511" mass="56571" checksum="E795531E57C14E6B" modified="2019-11-13" version="1">MNKSFDIEISIEEKVKWIQVIRSRNIGPVTCNYLFRRYKSINDVAKSLLSDKKELILESEARAELENVEKIGGNIITFNDPKYPALLRNLRDAPPVLSVKGDLSLLEKNDKFFAVVGSRNPSIQTQAITERLSKGLGEKGYITVSGLARGVDTAAHKASIRSGTIAVIANGIDQVYPSENMHLSDMISKKGLLVSEVKFGTTPSQHLFPARNRIIAGISLGVLVVEAGLKSGSLITVDFALENGREVFAVPGCPLDPRSRGTNKMLKEGAVLVENIYDIVDNIPTEDDVENKNVFLDSEKNERKILETDLTNKSNHEINSVKGSSVKSVKNIFSENNSFEKKDNINEPKGCDSENIDSELLINNLNKKNLENIPNSDGLDVPDLENKSDSNESRCGIDVKHNISEEESKDSKVNKGNMQNHIFKNITLPFSTEDVNEDALSFNKKGCEILSCSKIDLKNYILSLIGSSAISIESIVEKMELPPSEIRSILVELELEDKIMHLVGDKISRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFX9</accession>
    <name>A0A5C0UFX9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ybeY</name>
        <name evidence="8" type="ORF">FZC36_00705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="171" mass="20375" checksum="642B086F76CE7991" modified="2019-11-13" version="1">MFEVKPLPDYTKLWKISRSNVPTDLFLISDFIIKKALTFKKELANREVHVDLTCVKNRYIKYLNKKHRNKNKTTNVLSFPLEFTEEKEEFLQILEENPEMPLNLGDIFVSTDYIKTESAKLDREFSYHFLHMICHGALHLVGYNHENDKEESIMNDIEEKIMTFFNMPKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFZ4</accession>
    <name>A0A5C0UFZ4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="92" mass="11006" checksum="1A54EBE042CB010A" modified="2019-11-13" version="1">MFKVLYKILSRLLYLSILFFCLFSITKISFAIKEINKDIEFANVSKNKLHEKIRIYDYGVKYLDKKIDIDLLEEVSMWMLGYIPKGFKIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG90</accession>
    <name>A0A5C0UG90_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP nucleosidase</fullName>
            <ecNumber evidence="3">3.2.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037109">
        <property type="entry name" value="AMP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011271">
        <property type="entry name" value="AMP_nucleosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018953">
        <property type="entry name" value="AMP_nucleoside_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF6">
        <property type="entry name" value="PTHR43691:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10423">
        <property type="entry name" value="AMNp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01717">
        <property type="entry name" value="AMP-nucleosdse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMNp_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="481" mass="54753" checksum="9D480923375960D7" modified="2019-11-13" version="1">MKDTYHSIVHKLTDYSNIPKDIPSKLKEIITDPKCFTSPEEAYNYCLYLYDQSADLLKEMSKQKNFDDSVCESDITYPYIGCEIKSKKKNASSLELGFYGTTITKPKIFKDFYINKMKEITSSGGDIWVGKSSYPMSLAFVSEDLFNELNLEKRMKFNSPCINRIQTGLSEIHKQESIINISTFHAEHVDYSLNRLHHYCGTNAETFQNNIVFTNYQSYVDFFLEDGKKLIEEGKYESMTGPNFHISKNESCVKANTNPQMPAYHLSLPNRRGITLINIGVGPSNAKNITDHLAVLKPNSWTMLGHCAGLHSSQEVGDYVLAQNYSRHDHVLDPYIANRIPIPASKELTECLEESVLRNNHNGEKLHKGTIATTGDRNWELNGEMVKEFSESNAIAVDMESATIATNGFRFSVPCLTFLCISDMPLHRKLKLKGMAQNFYETRIRTHFNTGMEAVKNINKKLNYSIRTNSSKKGKKLVPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG93</accession>
    <name>A0A5C0UG93_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1373" mass="153008" checksum="89E878716A7A7843" modified="2019-11-13" version="1">MCTSIVNADFDLNNGFVIKNENALASFNEDFGKLSKSHKNLVGFIKREDNGTFFYHKDGVRFDYKKGTKGLSFNSRHNVADKCFLRGSDFNRVLNAVNFNLKNNVRTSNSVKLNERLLETVTNEGVELENSIKEQDVLESKIVELEEKLALKEKCVAELEVSFRKTQNALECRMDVLVKEKNALEGKLGTAGKELTANNDSLEESVKNNEALQSELKTLKESKENLEKDLENKQKLEKELTNLKTELSEKATNLSLIQKELDELKESSEKSTTIKKNEEILKEAEVEKMANELKTTLEIEQKKKLDLEAELNAKAENLQAELKTLQESKDELLNDIKEKTVKIEQLENDIKTKDFDISENMTKSSETKAKLNKEVSEAKEKLNTELNSLRLASLIEQGNMKRAFIVQEERSSLEKMLSDFKYVKLSLENKKELLDKNTEIEKVTKESVAADLEKRLNLIIDKEELVRDLLERDSELNGILVDFYKSSLEMNSARKISSNDAGIQTELGFSSVSVNTDSEGILRSFPRKRFEEGFENEVDLSLNSDNHNIAGNDFVRGLSDSGSQRRRARSVSYSRNDWDGEFYPKRSILEKGSLKNASDAARKSFSRPELNKNISEDLGNGARLASRFSDDIIQISRDNLDNVASVDLFEQSHVLSTLASIPLTNEGLLVEDLREMIRGCNLSDTEIKSVKDELENSEAKVLDSILDESNKTQGSGSAVFLDDLAASVSNARLSDAAYEPERKILNAILSCRTSFAGSPARASEFALSRETSKIRSGSPEPRIPVQTTERGTQSSPPLNPSQSPVPTLPLGSVDRNYSYATASPESINSTNRGDMLETQRGINLTSSFNSTIGQGQQNPLLDPSNTDGYIMSDRNGKVTDRSARQVDSVDQEERDQVQSHLKTNAEAETIAASPQRGVLPQTPRDSMDGGKNSERTIEGFKSNSDKTDSNINKSKSGAETHRTEELLQKAQAELEKSGSNGTVTPKSSKTDSLNGSGNSSFVAVESKSSSGKSGDESEELNVKLNSEVNELKLSKISEGFLKEIETAEENFALQGLSVKELNSKKLTDKQKSTLKNQMIALENKKEELKDEYLKNAINRLKIENSKSHSYTAFSNDQKALQSTEEYKSLFNEKNFEMLNKISLNGKFEDFKKQFAVPSLKNIWKKAIFVKFILTENSSEYKKEDYSAELLIQNIVDSKVFGKMVKSVDNKNISTDLNINLANQAIKYAESNPNAFLKLRKKVVRKQSGSDLSRKGSNVSGVLFGRKSSMQSFGTPVSASLSRSTSVTPEKVTRLFSNSPEVSRNQAIGSVSKNKKSVKNTVKTAEANNTENKKSTSRRSKNQQNVAPKPATKLSRKSSASDKNKSNPVKITNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG98</accession>
    <name>A0A5C0UG98_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_01395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="729" mass="85020" checksum="216D44786C9C7B60" modified="2019-11-13" version="1">MIPEHISGNKTSKTKRFIYGNLKTFKKMINKLNIFKSPAIFFKKLNLFFLILSSVSISLHANKSIIGKIDLIQKQSSVIENEIEKINKEISEIKTNVLKGNNYSEYHGSGLLNVGSFSGIWKFLEKIYQNWVDIFLNIKKSLEFMIQHKKTREVFYKSIQSIFYIVLYNCMIFGFLKTIVFFIKKRLDSAYLKSIVSIIPKVFLYLSLLFSIHIWCGNLPQETYWMSNLIKKIVFYLLVFDLFKFSFYDLNILNNYKICKKSLVVFSKNILSILLIYFIFGSLTEFIKIPLIQNKDFFEKDIIDNISFIFNIFFTIIMINFVLSFRTIISELILRLNKKNVIRQLTGPVALNLLILLIILFLWVEWHDTSNKLTRMIASFMIWPIIYFSSLYVRVSISKKIRSINYNQRKYIISFYFVFEKLTKFLFFPVSILATLKIWNIPFEGFLYRVINPNFLHLLYKMFLLWFFSYFLFKFSKYVLHYWIFHKSKKDDCKRLKVIFKITSSITSGVIWLGAFLFGLSLLGLEISPIIPALGFLTAGLTVSVSSIIKDFLNGILILLDNTITVGDIILINGSNAIIEDVHLRYMRARLDNGTLITIPFHKVEEVFNKSREFIGIVLNVAVTYETDIKEATAAIEEAFFRVRTSAEFEHKIILPIEKRGVSEVTGLYMTLMFKCKAKIGSQFKIHRAMNEMIKIVFDERGIKIPSYVSLDQISKAASTNTSPPALFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG99</accession>
    <name>A0A5C0UG99_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (NAD(+))</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_01660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIGANc" evidence="8">
        <location>
            <begin position="49"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="653" mass="73964" checksum="231EE1160AF7C3FF" modified="2019-11-13" version="1">MGSLFDEIDESSVLKKDKNLENTSKVSKFVEDKPIGKITEEGLGGDLGKLKQEWKEVSKKVKFYDKKYAYGKPLIADTSYDLLKYRLQEIEEKIGKQKNSPLNKIGHIEDKEVKHKFPMLSLDHGYGTDSMEKFYKKILNSIKLEPEMVLEHKIDGISASLSYTKGKLSLCVTRGDGTYGMDITKQAKYIENIPQEIPVKIEALVEIVESAEEDKNIDINKDTKDESSGAVSVNIMDTEEITMPDEFEIRGEIFMDFESFNKVNNSIEKEFKNPRNATAGILRNKEMDFIANYKLKFIPHGFVQNLRSKYSNQIDLISKLGFNTMKYVICDDLCEAKEAFQKTELSRNDIPYPVDGVVLKVNSLKSWDELGFHSTAPRFCFACKFFPRNSSTTIVDIVMQIGKSGAISPVAILDPIFIDGVEVKKVSLHNVQEVINKDYRIGDEVIIARAGDVIPHVMSKKNTGKEKFILPVICPSCNSELVRESVMLKCINPQCSEQKILQIEHFVSKKALNISNLGEKNIRKLFEIGLVNNQEDVIKKLRELILQNNSQVKNILGSKVAINILNSINSQSRIELNRWIFALCIPNVGYGQSTLLAKNLITLENFIETFTDKEKLANINIKGIGPSVIDSISNYLKENTWVLNSYNYLKNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGA6</accession>
    <name>A0A5C0UGA6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Lon protease</fullName>
            <ecNumber evidence="7 8">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 15" type="primary">lon</name>
        <name evidence="15" type="ORF">FZC36_01445</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="7">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="7 8"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="595"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 9 11">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 9 11">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QEK39098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="775" mass="87259" checksum="C33294262539E441" modified="2019-11-13" version="1">MTLEEKNSEIHLDKSERSIAVIPLKNSVMIPGSVLPIFIGRKISAKAIEYKKGKEVVFLTQKDPLVESPTFDDLYKIGTLGEIAYVFELSDGTLKIFVEGKKRVKIKKELKTDPFLEATFEILQEEKNEFKSESISIRSLIKSFGQYLKIVGQYPSDLLVSISSMSDAGRISDIITENTFLKLHQKQEILEELNLEKRVNLINQLIESEIEAVELEDKIRKRIKKQVAKTQRDYILQEQIKAIQKELNSGEENEISNYKKKIKTLKLSKEAKEKLNQEIKKLSTMSPLSSEASIVRNYLEVVLELPWNKKQKLNESFRKAKKILDNNHYGLEKIKEIIFELLALQKRSKSVKNSVLCFLGPPGVGKTSLAKNIAEAMGRSFVRIPLGGVQDEAEIRGHRRTYVGAMPGKIIQGLKKANFSNPLVLLDEIGSINYSYRGDPASALLEVLDPEQNSHFQDHYLELEYDLSDCMFIATANELNLPPALLDRLDVINLSGYTEQEKVKIAEKHLIPKQKELHHLKNDEITFSEGSIEEVIRKHTREAGVRNLDREIAKISRKVLKKIESESINSIEIHKENVKDFCGIEKYSSDAAELVDRTGVTTGMGWTPMGGDIMYVEATIYKGSGKIVTTGKLGDVMKESIQIALSLLKSKAEEFKIDQDLLKNSDIHVHFPEGAISKDGPSAGITTCCSILSALTSKKIKSNLAMTGEISLRGRLLKIGGVREKVLAAHRSGIRNIILPEENKCSVEEIPENVRKTLNIMLCDKVEEVLEYAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGC0</accession>
    <name>A0A5C0UGC0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpH family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_00165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022899181" evidence="3">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK38859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="168" mass="18855" checksum="0C8276D438FC97CD" modified="2019-11-13" version="1">MFTSRILSVFLMALCMLGFEMNAEADKAKFAFIDTVQIASKSNKIKNKIEKTNEMKKSIEKEFKGKLKTLQDEMEKYNSFKKSDPSKAEVLAKSIEKKRQALAEEYSKAQETFKKQQYADLTEITKSIENASAAISKKHGVVIIDSSVILSGKGLLKDLTEETSKLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGC6</accession>
    <name>A0A5C0UGC6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-clamp processivity factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">DNA polymerase III beta sliding clamp subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dnaN</name>
        <name evidence="15" type="ORF">FZC36_01545</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="12">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="13">
        <location>
            <begin position="134"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="14">
        <location>
            <begin position="263"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QEK39118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="377" mass="43230" checksum="5CB6951D280A394E" modified="2019-11-13" version="1">MFRVVIEKSELIKSLRVHQQIIDKKPTQIIFSYIKLEAKDNSLVIESTDGDTLLNHKTKVDIIGEGVITLPGNMFYNLVRKISDTKIEISQTSTQSACVKYKKGSFDLEVINHEKWPKLTQQEHQKCFSGKSAELIKILRVSKTSISSNEAIRSSFNGVLLECNGEDVVFASTDSFRMSIYSRDIISNEDLQKNNTSLEVFNKFKFMISKKLVEIILILLEDSTELSFYKNEQHVKIESSNFSLTSRLLPENFPKDYQNLVLKNEESSFECSLEDLKEVLDRVSTISMDSLKNISVNLKSKMNLECYNDNYGSSKEDIDGIHLGDESSFKIQFQTWMDFLRAFNSGNIKVEYHGKNKPIILKSMQEPNFVYITSPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGD6</accession>
    <name>A0A5C0UGD6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">era</name>
        <name evidence="7" type="ORF">FZC36_01615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="297" mass="33923" checksum="824A041BE8F6ADBA" modified="2019-11-13" version="1">MMYTHFMNQKCSLVAIVGPPNAGKSSLLNNWLNKKISIVSSKPHTTRNNVFGSVTKEDTQVVFVDTPGFAKKHGVWGKHLQKSMYESLKDVDTILLVIDSLSPFKLGTEILFDVAKKTDANLLVTVHKTDRPKKSKLYEIGRWLKESKSYEDPIFLTSTNTKTGTEKLLDKIVSLAKEGPWLFDKDQDTNLTKEWIGAEYVREKVFQSIHQEVPFNIAVQPTEWDFNSEKWVLRVRLLVRTLSHKKIIIGKKGFKLQQIGSAARAELMSLWGPGQLFVEVVKDNQFEETIKELYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGE2</accession>
    <name>A0A5C0UGE2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YMF19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FZC36_00290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003319">
        <property type="entry name" value="YMF19-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02326">
        <property type="entry name" value="YMF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="YMF19" evidence="7">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="143" mass="17322" checksum="D3AF2EDDDC26452A" modified="2019-11-13" version="1">MIPQFNSHWFLSQLFWFCMVFLSSFLILDKFYFPRMKSVIRSRKLKRIELEENIDKLQKASKQISEELDYYKEKVDNVFNKALERIRVDIKKKYDCKATELEKSHQVLIKDTDLKISKWKADFINEFKAKSKDLIEEIINKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGE4</accession>
    <name>A0A5C0UGE4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system baseplate subunit TssG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010732">
        <property type="entry name" value="T6SS_TssG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35564">
        <property type="entry name" value="PTHR35564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06996">
        <property type="entry name" value="T6SS_TssG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="394" mass="45886" checksum="BA5A80F60A16915A" modified="2019-11-13" version="1">MSSEDIKYLNVTKLKLLESKLESELEMEQNKLNSESKFYLDKLDSGIDSGMDSKNELKTYHYFDSQFVLYNLIKSPWNFSVHQAIFLLESYQKKNPKDIKEIVFKGSVEMSVNSSDIKSISYDKKRKRIEMIVNNVSMLGIQGALPLFYIHKFINDGKEKDHVFKDFLDIFNNKIIENTYKIAQRGNVSICNPQNKRDHVINKVLESIGSTKPYVNSYINNISRYVSAAFWKQKHNKFQLKRIILSFLNYKCDVAVFQFKGKWEYINDEDVFSFDKVTRRHVENKGYCLGYSDAPGRSFGTTFLGKRFLDNTYGIDILITIHSLDLYKKLMHGKRLRSQIIKLIKSYVPFDLNFSIKLNLKKESRPDALLGEDCILGELSWLNSKNGYCKVNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGF3</accession>
    <name>A0A5C0UGF3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M23 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="290"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="420" mass="47838" checksum="853DB3A27D786E94" modified="2019-11-13" version="1">MIPIFFRFLFEEMNFWVSSLIKLSVIRRFLSISFISFSRFFSLFRLSIFLFGSMFFVYFIKEDISPDPLLKKEDLGEIFCKNGKIDYEGVGIALSKHGVPLMDLHKIIPEIKSMIPGEWIRNATISTKLEDHKDKMVFKECTLKHSGYEVLIKNENNIITSKWKQESKKQFISIRSGNFPAENLSKHFPDPMVSEIVRNFGKLNLKNKVINISYDTSSRKGCMPVIKFIGIKDSNGGYASCLMRVSGSDKLYNPIKECAHNEPINFIRPVDGRVSSPYGMRLHPVFKILRFHQGIDYASKKGTPIRATAEGVVNKVVFSNSGYGNMVEIIHFTNKGKIISIYGHLHSIKVSKNQKIASGQNIGCVGDTGVATAPHLHFGLKIDNKFVNPSSLKVFYKSLNSDVLKKLRNEFRFCKSKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-10-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGG1</accession>
    <name>A0A5C0UGG1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="147" mass="17540" checksum="2BF721EBCC5433A6" modified="2019-11-13" version="1">MRIWSIEPKYLDSKGLIALWRESLLAQNVLFGHTKGYKHHPQLIRFKEHKNPTQAMSKYLHYVSEEARNRSYNFNASKIKHELDSIIDIDLITVSTKQIQYEWSHLLHKIKNRDCTHYEKIKQIKEVEPNPLFKIVSGEIEKWEKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGH2</accession>
    <name>A0A5C0UGH2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="224" mass="25417" checksum="8AA403E2468F5DC1" modified="2019-11-13" version="1">MNIINKCFALCVLFSFVNKPNASSLELELGALNKVIRKEAYHYAENYAENSKEFKLGNTLGIAFDSNGMNENKLNTGIRLGIDICKIYAKEARYNHITNEYDSDDKSDYEKTGYDKSDYEKIGFVAIFFAGTSLNFRPFSSVGKLRLRVYPGICLSQNILNNNNFFLKIGLSVCYDISKNLYSFISLEKNVFFASESYGKGFDYDAKSSFSFLKFGIAINRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGI0</accession>
    <name>A0A5C0UGI0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplO</name>
        <name evidence="8" type="ORF">FZC36_00500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="148" mass="15953" checksum="42961EAFD277D3F7" modified="2019-11-13" version="1">MSLNNLSRPVYVKSRKRVGRGIGSTKGKTAGKGHKGQKARAGASIKGEGGQTTLIRRLPKVGFTSRKKIRSNVHVCTLRTISELIKSGRILETDVIDDNLFRNKGIIAKHKVLKIIGNDLLNSPIKTSVKKISAGARKAIESSGGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGK4</accession>
    <name>A0A5C0UGK4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxyacyl-ACP dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ</name>
        <name evidence="1" type="ORF">FZC36_00170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="165" mass="18402" checksum="9AB86FE24D01C5DA" modified="2019-11-13" version="1">MCNVEVKKVSLGVKDIFELIPHRFPFLLVDKVSEIAELESAKGIKAFSYNEYFFQGHFPESPVVPGVLLVESLAQLAVCCVSYSLKYFKQMQFESVALMTVDSAKFRVAVVPGDLVNMSVRKVNEKMLSNKDGKITTVYTFSGYGLVGDKKAFEASFKAIAVFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGL9</accession>
    <name>A0A5C0UGL9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FZC36_02425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="entry name" value="PTHR31187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="540" mass="63350" checksum="786269F786255B7A" modified="2019-11-13" version="1">MISKLLLRTKFNFRFIHVFIGFIKTNFYKKVVRFIKHYLNKFIKNPNKFIKNPNFDCKAKRRIFSSLSNLSKNLFPVKKSEFKKFFPMAFMMFFMLFSTTILKNVKDTLIITHKGSGAEVINFLKFFVVIFSILFMSAYGKLSQFFESKNMFYVTISFFLLFFLFFNIVLYPNRETLHPNMLEIKQIKALYPRLKWILPMYSLWIYSIFYAFADLWCSMCISFLFWQFANQVVTLEESKRFYGSFAAIGYIGLIIGSKSIKYIINSKLGSFDQKLRLVIYLVCIACCFIMFFYFLFNKIFHSQVNFKSKKSKFSLRQSIKIIFQNKTITYIMAIVFCYNFSISMVELTWKSELRNFTKSKEAFVNYYAFVNESVGYSTIFFAFFSNILFKKINWFGSALITPVVMLVSSLLFFSAIILKIIGFKTFLGASIVVISVLTGTIHNITSKSMKYSLFDQTKEMAYIPLDKELKTKGKAAIDVVGSRFSKSLSGQIQAFLLILIPQSSQINIAPYLLFLIIIVFYAWFWSLNKLNLERSKDLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGM3</accession>
    <name>A0A5C0UGM3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FZC36_00710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="7">
        <location>
            <begin position="118"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="6">
        <location>
            <begin position="383"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="581" mass="66854" checksum="6E7D5FB9E7D9F381" modified="2019-11-13" version="1">MKLEVNLNSKDMRTFYGSKDFHIKNITKHTDFVNNETWFICEDINYLQKAIDKNPAGLIIPEEHEEYEKYEEHEKHKKYKRIQLQQSLKTLFSKNIKKVWPEFCSIKFPLKPDFICLVTGTNGKTSVSWITSKAINNLNISINSNHSKHDSNHLLKSGYIGTLGIIYPNTKTTNLLTTPDALDLHFHLNKMKKEGVNFVIIEASSIGLDQERLAFVKADICVFTNFSQDHLDYHITMDKYLKSKLKIKELFKSDCKFITHASLLDTKTTDIKKVKNCNKIEIKGDIVYGECPEACISYKVDSPTLDQEYLFHYQNRFKRALHKKTQENKKNISEIYSSEVHGFKRENINAAFVIIKNFIDRNASIQNYTDYKIIEEILKSAHVPGRFQKINSNLLDVYVDFAHTPDALEIILKEAKKEYRKVGLVFGCGGDRDISKRSKMGEIAEQFSDWFILTNDNPRSEDPISIAKDVISTLSEKAILIPTNNTNLSGIHNNESGNSKEIKSNQECNQTQNFSQYKIKIVLDRRKAIKEGILRSISEKTPLLIAGKGDERTQETNGVKVHFHDPSIITEILEEIEESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGM8</accession>
    <name>A0A5C0UGM8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S1 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="120"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="213" mass="24023" checksum="C466682228E23880" modified="2019-11-13" version="1">MIVNIKQRKYERDVETSAEDIANLQKIAQGMSMPQERAIVQGTVISVTKDHVWVDIGVKSEGKISIEEFSMNGHGEVPREGDMIELWLDKLEGHKGLSISYSKVKHINSWKALDQIFRTGSLIDGIISNQGKGGFTVNLLPWGVKAFLPISQTDLKIRNLANTDPKLLSKEKFTFVIIKMERKWNIVVSRKNIRGSEEEISEQTEEKTEPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGN1</accession>
    <name>A0A5C0UGN1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">truB</name>
        <name evidence="6" type="ORF">FZC36_00215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="57"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="454" mass="51293" checksum="8C6A5CAC2E1DB5F2" modified="2019-11-13" version="1">MSVMNVGSKTTSLDIKKTLNETSRKKLEDRAEIKQNCILKVNKPKGVSSSDVIRIIKSTFKSKKIGHGGTLDPMAEGVLPILFNEATKLSDIMHLLPKTYFFSVDFGYTTDTMDLEGNVTDKNNEIPNESDLKNVLKDLIGINFQVPQKFSACKVNGKRAYELSREGKEVILKPKEINIFTIDLLEYSCANHDHSRSLDYDQSLDSDTNSDKTIQTSECKAKACFRVSCSSGTYVRSLAAEIASKLGCLCCVTKIYRENHSFFNYEDCLDLSEYITTKDFSSENTKEHLKEKTNSRNIKNGGQKWIKSSKRKTNPYRIEDKKLFSVEMLKFCVNIDDIDFNRSNTKINTCTEQNPDLSSLDIEQKLVTLEISTEHANSLKNGIPIYLSEVVSLELESPEKQSLDNILKKITENNIDNNDTNYTLKNIIIKSNNKIIGIGYISGSTLFSQRMLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGN3</accession>
    <name>A0A5C0UGN3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="123" mass="14554" checksum="30C33AC36F689FB2" modified="2019-11-13" version="1">MKAALFERLKKNPSSYSSYEDLYESIKEEIYCILDRQSLFAESMSGISNYIPDLSPYDQEKIYLLEVYLKKNIERYEPRLKKPSVKVQKFIENIQSLAIEINGYVVFEEKIELMQISILHSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGP2</accession>
    <name>A0A5C0UGP2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">FZC36_00280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEK38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="239" mass="27218" checksum="A798D98EB7D7741A" modified="2019-11-13" version="1">MYVFEQFKILEIIPINVFGYVISFTNSTLFMAITALSLGLLSFIGLKKVRFVPGFFQSINEIIFNFVKGICKEHLGKEYKNYQPLIMSLFLFIVFGNLLGLFPMSFTITSHLSVTMALSLIVFCMVVFVGIRKHGFKFFKLFIPNGVPLVMSPLIFLIEFAIFLVKPLILSLRLCVNMVAGHIMLKVFLGFAVKMKLFSFIPVFACSILLIFEFFVAIFQAYIFTVLACISLKDALYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGP7</accession>
    <name>A0A5C0UGP7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="180" mass="20324" checksum="B2C1B4B32367CDB4" modified="2019-11-13" version="1">MPKSKNIHEVSKLIEKGEAVILPTETVYGIGCRYDCQDSIDRIFYLKERNINKPITLHITKAMLSIFDIDKKILELAYRIFPGPFTLIVKSNKKAGFHSKSEYTGKIGIRIPENKIFQNVIEKVGVPFCMSSANISNQETPILFENIPFDIEGINDDRNIRGSSSLIIDASQESASCKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGQ7</accession>
    <name>A0A5C0UGQ7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type VI secretion system tip protein VgrG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tssI</name>
        <name evidence="4" type="ORF">FZC36_02635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="3">
        <location>
            <begin position="523"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="857" mass="96616" checksum="D074BE6FC75E8163" modified="2019-11-13" version="1">MIKQNKEKKKTKDGEVSAQKSAESQTTDPDIGSICQIYDEKWGETVRNVNAGTYQKLMTLTNFGTIEELEIEEELSEPYTIKGKCFFWEEIYGDVVGMEPKVTLATEGKTRYWHGVITEWIEGGTDLKDERYYYEFEMRPKLWYRMQSRQNKIHVSDKGMRVKELASKLIEDAMQNNKNTKVKFEQKYDVNFAKVKSAQNNPNGPLIEYAVQYEETTYEFFQRLLSNHGIFYYYKHAKDGSKIIFKDNTSKMEPITGIRKIEIGDNDKVEANYDNLFLSKQGSDEINSPFVDTWGKVNRYAIGKQKARGRNYEKAGIEVEFDKLGKVEEKKHEGNAEEGFENNEYFETLTDPDAAEDHAKHITDSSESVKTQYKSVTSNFLISPGYLFELKSALDLYQHTKVYKTEKKSKIKKIKSDVKAASKRDLPDQVKEVIDNKYYARKTKHKLFLKNPEMAEESLTDPLYKQQNIKSKAGQVSGFEYSYVNESIFLKENTVFKVLPKVKRQILGYQSAIVVGPDNAEINTDDLGRVKIKFNWDNDDTLSYSERSCWVRVAQWGGSGAGFGGSYIPRVGQEVIVTYENGNPDNPIVIGTVFNSINSNPYDLPDDSHKTGLRTKTIDDEKEDFGFNEITISDKAEEEQIYIHAQKDLLTEIENDKILLVKQGDIDTQVNNGNIEISTLAEDDEKQGDYKITLEKGSKEISLLSKGDEKSHHKIEISKGDLIEKITEGNISNEIEKGNLDMKLASGNLSTTLEKGDLSISLSSGDFKSDIKGNKSISIKSGDYTISISGGAIKISADGINMESSKSVEISSNANISLKSSGQVSIEGKAGVSIKGAKLDLKADTIANIKGSMVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGS2</accession>
    <name>A0A5C0UGS2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lipA</name>
        <name evidence="9" type="ORF">FZC36_00560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="64"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="312" mass="35384" checksum="7EA7A0034FD624F6" modified="2019-11-13" version="1">MISHIKITDPNEETKSNQDNQLSKRYKPRIKITQMSAELQEMLRTKKLHTVCEEAACPNILECWSKKHAAILAMGNVCTRACAFCNIATGRPLKLDPEEPENIANTVFNMKLKHIVVTSVTRDDLPDGGANHYKKIIHAIRAKNPETTVEILVPDFLRKKGALEIVMQAKPDVFNHNLETVPSLYPTVRIGANYYNSLRLLDEAKKLDPNTFTKSGIMLGLGETMSEVIQLMDDLRAANVDFMTIGQYLQPSPKHHVVKEYISEEIFKEYKSIALQKGFLVVSSSPLTRSSYHADEDFEKLRKIREIENSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGS3</accession>
    <name>A0A5C0UGS3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lspA</name>
        <name evidence="9" type="ORF">FZC36_00980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="146" mass="16548" checksum="241F60747007B62E" modified="2019-11-13" version="1">MIRKILATISILAVDQISKRIAIQYGSRIIYENFLNIHVMWNKGISFGMGKSFHSTFLKFTVFLSCLAVVISWYKTKNKFDSKAYSFILGGGISNFIDRLTSDSGAVLDFISIKLFGINMPVFNIADISISIGFLMLFWKIILNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGS6</accession>
    <name>A0A5C0UGS6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HemK family protein methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_00235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="4">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="277" mass="31765" checksum="13671F5D3A16A6DF" modified="2019-11-13" version="1">MAKLSHLIQEYSKYLLDQNESIAYISAITNLSRTEIWLNKHRELDEVLGEINLEKCKKAINYVKYGVPLSRITKTRGFWNHDFHVSPYTLDPRPETEKIVELAISLSKKNKSKNILDLGTGTGCIILSILLANPLISGAGVDISKYALLTAKQNAKSLKVNNCTFMHTSEIEENKDQFDIIVCNPPYIHNPNPANLDNPKEPENYCVDYATKFDPTKALFDQDGIQMLNNLPLSENGILLCEVPTYQKQLMEEKFKKNYKWHNTSHREIVILEYLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGU4</accession>
    <name>A0A5C0UGU4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpmI</name>
        <name evidence="6" type="ORF">FZC36_01090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="67" mass="7746" checksum="445B73469696D146" modified="2019-11-13" version="1">MKLKTKKSAWKRLRTNANGKILRGNACKRHGLRKRRNEMKKQTRGLTEVHSSHAKLIKKIMPNGLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGW3</accession>
    <name>A0A5C0UGW3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="9" type="ORF">FZC36_00595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="177"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="419" mass="46570" checksum="F50429A5C65B913F" modified="2019-11-13" version="1">MQNDIEFSVYNKFYLGIETSCDDTTVAIFNNEKCICNKTITHDYSDFGGVIPEYASRDHMTKLPGMVRECLKESNIKPNDLHCIGATVGPGLLGSLTVGVTFAKTLAWSLNIPFVSVNHLEAHLLVAKWKHAYNSINVQNEHINSNKQSAGKTLNNNNNLQNGSDNNFSKNESISFTGLDFPYGVILASGGHTLLAIATDLGKYSVLGTSLDDAVGEILDKFGRKIGLKNPAGKHIEQLALQSEFSKNPNSFSLKNPNFNLPVPLKNDKSCNFSFSGLKTAVIRKWESSDKSEKYKQNLCYALQYAISESLIERLRNALGSKFHNNKEQEINNSNNTSENCKIKNWVFVGGVASNMFIKNKLRDFAEKNGKKIFVPKPEFCSDNAAMVTYATYLYDQKNMHSGYKTEAKASYSLEDISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGY0</accession>
    <name>A0A5C0UGY0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Adenylate kinase</fullName>
            <shortName evidence="4">AK</shortName>
            <ecNumber evidence="4 6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adk</name>
        <name evidence="7" type="ORF">FZC36_00510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="4 6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="4">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="210" mass="23983" checksum="2524A1DF3B17330F" modified="2019-11-13" version="1">MKRIAFIGPPGSGKGTQSEIISDLFDINVFSIGLALRREIEKKTDLGFKAQEYISKGELVPMDILKCFFKDFFKENEEFIVDGLPRTVDQAKFLQTFFKNNMPLEMVIEFVVPEESVVGRLSKRIVCSKCGSLISCVNEKICSECGSVEFEKRQDDLSEQAIRKRISIFGEEIKEIREFYKKSGVFYSFDASGDVLEIKSRLIELIQKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGZ1</accession>
    <name>A0A5C0UGZ1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="10" type="ORF">FZC36_00750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="207" mass="23695" checksum="6AAFF8ECAED77C57" modified="2019-11-13" version="1">MPSSNAKYKKDRSYGVNIWGRAKSPLNGKRNSRPGQHGSKRMKKLSNYALQLRAKQMFRVYHNLREKQFVRLFKNAMNAKGDTGLNMVRILERTLVTFVYRMKLASTIFAARQLVVHHHVLVNGKRVDKPSYLLAVGDVVTLAEKSKNIGNIRAATESEERDVPGYYEVTEDGIVGKLLKFPDNLDEVPYPSQMNMDLVVEYYSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGZ8</accession>
    <name>A0A5C0UGZ8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ComEC/Rec2 family competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_00615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="9">
        <location>
            <begin position="319"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="774" mass="88396" checksum="5CCDA6BD4D4CF85B" modified="2019-11-13" version="1">MIFRSFLVGQILGILTYLSNKNLMISIVSLLFFGIIYDIAKCIQSKFNNNPKQVSDFNTKNKIQSNNIYLYTRISLYLGFSLGFISIMIKTFYIAMNMPVIEKRGADSYIKGNVISVEGSEKYTKILIQAETLNKSTISNKIRLVLKNESVNESTNNLEKHNLLNEKLENKYSYIESTYNDIENTDTTKHNKRHCNNDSFINVGDLLSIKASIYNVPAPCIKGGMDSRYSEFFENVFAHGEVISYTKLESRKAESLKEKIICFLEKSLKNTQINKKDQSSETEKPNISITSTQTSKESEPCKNPYKQRISDSSALILALVFGDRSYLSNETVEAFQKSGIAHSIAISGLHIGCISFLFYIIFKSLICLLYPKLGLSFSIISLSSVISGLFTLTYLKFIKIQLSVIRACIMLIAPLAGYILNRKTDSFRNIEIACLIILAVWPESILYPGFQLSFFASLSLIYLNKVSSKSSIMKSLMINSNRKTISNFLKRIMKYVALSVIYSSFVSFITLPYVTYWFQQITLQPILANIICVPIVLITVCLGIVLMLFMLFNIKIIFLAKSILFLSNLTINLAFFFKDFLNNTIQVHQISHNVIIFWSIGILYIFYINTSHVNSAHRDSGPTIEVSKINTLNTKTSLHTIFSNTVFSKITKLSFTITNFITINSFMNSFLIYLIFFLPFCISIIKKPRRMLIISSKNYAIYENGKLFTKEENYLTHSWARTLGSKMIVTNHVNTYPLEIKSNNSVYYLGRALAYKKTFPCLIYLDKIEVVRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH18</accession>
    <name>A0A5C0UH18_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="92" mass="10655" checksum="0B01FB6CE5FEE1B8" modified="2019-11-13" version="1">MKKNYTNSILRVSAFTAMIALAIAHYKKSKTIIKLEKTKQELFIMKRHLKNQKAKFAELTNPGRLNLIISSHTNLVPTKVKDFLHNKEQEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH27</accession>
    <name>A0A5C0UH27_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trigger factor</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tig</name>
        <name evidence="13" type="ORF">FZC36_00770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="11">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="12">
        <location>
            <begin position="279"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEK38971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="505" mass="58861" checksum="56ECB9F43B1151BE" modified="2019-11-13" version="1">MNNPINSENKSMQTDTKVNLISKNDLKCKYELTIPHSKFKEHVDFYLSATQKNYKMDGFRPGKVPLSLIRKNSKIKEESENYAFQNEFSKIMKNFEHAPLTNPKKDFESSFDYEKDSEVKVNIEFETSPETPEVDLTKINIENPKVEVSKADVKKEMELWIEKNEYTVPLESARPCKEGDTLNVSVKFYGSKDGDKLQIKLGAGVLLPDLEKKVLGKNEGDVIEYTSTVPENVKHGPHAEEFAKLAGKEVSTFLTIEKIMDTKKYEINEHMAKSWGLATVEALENKFHEMITDKLKININSYRKFLLSEKSVQGLKFNVPESYLDAEYMNTFYDILKKMDSQMVHNFSMDNLETYFESVKEKGFFESKTLDKVKEEVLENSNKRIMFLFLIRKWIRDWDVKITQQDIDSYIFEESKKYRGGLSEVQKYYKENADELEKARAYILEEKAIADALSRVVSVDKEMKIKDLNEKMLEIRQKVFYEKSDNKLTKDKKTSSKETKTSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH28</accession>
    <name>A0A5C0UH28_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FZC36_00135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="320"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK38853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="546" mass="61254" checksum="CF6636289257C086" modified="2019-11-13" version="1">MTELNKNNKKNQSKVSTIFITGGVMSSLGKGITASSIALLLKSRGYNVCLRKLEPYLNVDAGTLSPEQHGEVFVTEDGTETDMDIGNYERFANVKCNKHDYITSGRIFSEVITAERRGDYLGKTVQIIPHITEKISEIINSNIPEGTDFLICEIGGTVGDIEGLPFLEAIKKQAGLQNQKGQKNDRNSLFIHLALMPYIESANELKTKPVQHSVRELQRSGIQPDMIICRSERNTNSDWKKKISMFANVDESNIFGAWTQKSLYEVVNQYHEDGLDAQICDFFQKNQNASSIGEILEVVRKEPIREKELKIAIITKYQNIKDSYFSVTEAVKHAALFHRTKFTLEAIDTSEVSNYSGLKDFDACIVPGGFGARGTKEKISALKFARENNIPCLGICLGMQLMIVEALQNICNIDTNSSEFVKSKNPAVGLIDEWTESQKGGTMRLGSYPCTLTGVLKDIYDQGLISERHRHRYEVNHSFYKKNLEAIFELGAWSPDKSLLEGVAIKEHPFFVGVQFHPEFQSSMTNPHPLFRKLVEAGLKRSDSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH51</accession>
    <name>A0A5C0UH51_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ORF">FZC36_00940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="32"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="344" mass="37335" checksum="AEB2F6988476272F" modified="2019-11-13" version="1">MSINHKDVNSKANTNSEYSINSDILKSKEVSDVAIIGSGPAGLSAAIYAVRAGLSVTVFMGDDPKGQLMTTTDIENYPGFIGSAPDLMHAMEKQAVSLGCVMENKTVSNVFFDKKTNQKKIISGKHEYNFKSCILATGAKAKYLGLQSEYEYLGYGVSTCATCDGFFFKDLEIAVVGGGNTAIEEAIYLSKIAKKVHLIHRRQEFRAEKIMQERMLSMKNIYLHLDCILEEVLGNSEEIKSSGSGIKAVSGARIKNVKTGSTEDLNLQGVFIAIGHSPQSSIVSDLLDLDTEGYVITDGVKTKIPGFFVAGDVMDKVYRQAVTASGQGCMAAMETIKYFQEHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH52</accession>
    <name>A0A5C0UH52_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rplM</name>
        <name evidence="5" type="ORF">FZC36_00310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="162" mass="18009" checksum="3B67A37AF60E2B55" modified="2019-11-13" version="1">MSKSFVSKKEHIKNKKSYIMDAKGKVLGRICVEIANVLRGKHLRTFTKGADCGDRVIVLNAQEVVLTGKKYKNKKYYRHTGYPGGLKTRTAEDIMTSDPSEIIKKAVKGMLSRGPLGRTQLGNLKVFSQGEHDLGSLRPEVWAPKSGYMNPESEVKAEKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH61</accession>
    <name>A0A5C0UH61_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux RND transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_00360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="67"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="355" mass="39322" checksum="AA5EB7ADCE6063CC" modified="2019-11-13" version="1">MLKRKSNVFYLLTLVVIFGSVSFFYYQYVNKVNPKFNFIETIDVEAERVKIGDMYERRTYSGSLKAQKSISLINERGTGIIKYIRKDGEVLKKGDYIFKLNDSSEQNAAESAKAVLEENKLQRDRAEDLNEQGIVSDSELETRKNAYNKALAEYNRTVSELEKTKFIAPFDGILGLVKYTEGAVLYPNQEISTFRSVGPLVSIFSVPESDANSISIGTEIYIISESSSILPQLAKIDAIDAVSDSTHNIAFKATLINENVRLIPGQFVKVDVPLGIKKNVLMVPESAVKISYGSSYVYKVEDGVTYNIPVEIGIRDEGYVEILKGLEQGNVVVTEAGDGVSDGQKVKANIAGESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH67</accession>
    <name>A0A5C0UH67_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MCE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="247" mass="28522" checksum="FC86C2071B9531AC" modified="2019-11-13" version="1">MKNYNYFNRKTVGIFFAPMIPIVFGLLFYFCSYGFNNKKYVVFFEESVLGLENGSNVLFKGINVGHVTKKSIKGEDVLVFVKINKDFEIKNKVAQIESKGITGHKNIVMINSPEPYEETKVLGYTRIPSKMSSLSKMFESADEVTNHTTGFFRKISKVNVKKIDDFILKLDYVIQNLEKTALEVSQISSRFNKITKTNEKNISMIFKDTLPILNKNMLVFNDFLIDSTSILKKFKTKPMKFLLDWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH68</accession>
    <name>A0A5C0UH68_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplW</name>
        <name evidence="5" type="ORF">FZC36_00420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="108" mass="12430" checksum="D4DC732F1CA2F01A" modified="2019-11-13" version="1">MSDNNNLNEKALDLSFFKFKGVFSSEKSSFLSRTSSYIVLKMIPSTTKVEMKVIFESLFGFSPQKIKSTNYKGKSKVFKGTKGTRKAWKKFFVKIDKENMKKFVEGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH78</accession>
    <name>A0A5C0UH78_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplE</name>
        <name evidence="8" type="ORF">FZC36_00470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="6">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="7">
        <location>
            <begin position="87"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="192" mass="21416" checksum="3D9B2CF09E6A1AFD" modified="2019-11-13" version="1">MSEFKQKFNTEIRPVLRNIMKLDNILAVPTLEKVVLSASFGRSMKDSANMNFIFKEMKMISGQVPVIAKAKKSVSSFSVREGMDSSAFVTLRSDRMFDFIYEFVNITLPRVVGFEGLSSKSFDGQGNYNFGLKDHLPFIESTETGFTFGMNVAIVTTADTDYNSKILMQALNFPFKGEVNDVIKKVKGGVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH84</accession>
    <name>A0A5C0UH84_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006427">
        <property type="entry name" value="Portal_HK97"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01537">
        <property type="entry name" value="portal_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="352" mass="40195" checksum="C2778A6FFB92CAB0" modified="2019-11-13" version="1">MNLIHRVFPYLQRKDKNTKCDFIPNLMNVNSFSGGSMCKQDFKNIIVYRCISLISRNIANIKCFLYDSENNKVSNNYVSNLLIKPNGYETWFEFVENLVTNLCLHGNAYTYLESGEHGYEMYNLNPENVEILKNKYGHAESYKIKEEKNKYNVYNSSEIMHIKFNNPYCPWVGLSPMGCIKESVRFYDSVTKHNQSILDNGGRPSGAFILKNKVDDYEFEKLKNSIALSHKGKGNAGSIILLQSDVDWKDLSISSKDMDFNVGKNIAAREICQAFGVPPVMLGLQDASFSNYKEARLHFWEDTLLPMANKILQKINDLVWVNLSEKDSSLEKFSIKPDFSSVPALSAKSENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH95</accession>
    <name>A0A5C0UH95_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="187" mass="21745" checksum="602515685CABC0CA" modified="2019-11-13" version="1">MLKKILKKYTTFIALLVFIPVIYIFWFKDCKICRRGMKVYGENKKVIDIRKMKDPSIIAFLSIDFKNLPISRENYLMIFQMNNVHDLMDKNNIKQIIVIDGRNIKQEQEESIISGLNKIKRGNKSDLEFYIDRNGSVINLLKLKSFPSLIMIKNGKQLFKTSEVSDLNIFNMFSNISSYLGISIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHC5</accession>
    <name>A0A5C0UHC5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="2 5">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FZC36_01680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2 5"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="7">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="342" mass="38099" checksum="DB6943943941380B" modified="2019-11-13" version="1">MKYAFVFPGQGSQKQNMASDFYSCSKLLDTSKNIYPNIENIFKLPDPELSQTENSQPAIFVACSMIWEEINKMYSFSSLSNNAGNNNEHSIQNGHINQADKLQTSDQTTVNKNDTKMIPAPSFFAGHSLGEYSACFASNAINFESGLELIKLRSRLMSKSKGTMFACIGKFDDVQNLCQFVSEKTNKICQIANDNNDTQVVISCENDCIDLINKSYKNFNVKRCIQLKVSGGFHSPLVESVKSELSKGINEVMFNDVEIPVISNKTALPEKIGQKIKDNLMDHVVSGVKWRETIMFMKENGVEKIVEVGGNVLSKISAKLGVDSFSISNKNELLDLESFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHC9</accession>
    <name>A0A5C0UHC9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="460" mass="53162" checksum="8047C6EB3CB9CAC4" modified="2019-11-13" version="1">MIKKRMNFTKENLSNHKKRQWFGRFNLKNFIAFSATAVEYYDYILFMEMSFFTAVIFFPEKFNSLFYFFSMGYGVRLVGSFLMSVFKNKIEKLTGMKIMTFALFSVSFITFFICLIPPYKQVGIVSTYLFIICRIVQSFFYGTQIPSAISFVRSGKDTESLKGMEYRKDNSSSSSSEKAGLVISGASLGTLACSLVVFLLSKLFSKESIVSFYWKFPFLFGSILGSVILYFSKPRKVDSELSSEEDLENNSENGLDVDQENKSKYDKKSKSVFMIYKNLNVDDFLDFFFSVSMMLMPAVLIITYIYFANFFSTKCSYDFNVVSAYRLIGYISALFMNIFAYKIVKLLDNMRSLDILKIFVFIWVVFLILATKISFFLFCLLMFTQLSITYTMNHALQNMYKHNSHSLNTLSYNVSFFIASLSVSMMNSLVKVMLIPVIFSVFFYFGKSSIEKKNVSKHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHE1</accession>
    <name>A0A5C0UHE1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="233" mass="26914" checksum="438BDCF151A28F13" modified="2019-11-13" version="1">MNEKMKLDLYASLLAFETINFEDEIKKIENSFAGIHLDYIDGNFINKFGIPPYFIKFIKKFFKKPIQVHIMGYVDNFIDEILSQDALPDSIFFHIDSSNNPELVIEKVKSKNIKIGISIENFGTKEMSIFDKIDEILIMTVKPGKCGQKFIEKNLLILDKIDSFCKEKATNDFYHTKNIFVDGGVNLETIQAVYKYNNDHEKITENTITNQHHKIKGCVVGSAYKDFLYNKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHE8</accession>
    <name>A0A5C0UHE8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">alaS</name>
        <name evidence="14" type="ORF">FZC36_01910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="1"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QEK39179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="873" mass="99356" checksum="6969D8A47BD65236" modified="2019-11-13" version="1">MTLMNQFLNFFENKNHKKIKSFSLIPERDDSILFINSGMAPMKSFFLGQQVPPAKSVVNCQKCLRAGGKHNDLDEVGFTKRHHTFFQMLGNFSFGDYFKEKAIHMSWDFIKSINLDISKIYVTVHPSDLESRKIWSKFVDKSRIIDEKTNEWSAGEEGPCGICTEIFYDHGNHIKGDFHSGDRFIEIWNMVFMTHTVENGIKLKLPNPCVDAGMGLERLEATVSGTNDNYEAPFFKNMLKIITELDFDNKHKSLSETDKRVIADHSRAITFIVSDGIETSSEGRGYVLRRIMRRAMRRIVDKGLENKGIIEACVDYTVQNMSEFYPEILHNKQKVIQSIKAEQEQFGRIYETGMCRLNKYVELEKVSAQNVFELYDTYGFPYDLSFDILREKGIEVEKNEFDRILANRKKDSKKKYDLGICDKNSEFIGYELKETSSKIIDLKCLDITKCKEANDVIKVDKELCGKVFVLLDKTTFYTESGGQASDSGVISTDTGVFVVEEMFKDKNSIWHVGYLKEGELEIGQDAKSSIDIEKRKGLEKHHTSTHILLHVLRKKFGDTVLQKGSSVKHDSLRLDFSKPENITKDELEEITLEINKLIQKNHEVKIESKTFEEAMKENVLITEKGYPSKVRVVRIGQFSAELCCGTHVERVGEIGSFYIRSCKSVSAGVKRIEALTGIAAIKNGLENIKNLENYKNADNYKSKNGSSGDNISKKINSNKADLRNKSGFDGDCAGFDSKNLEELDKNLNVIKSKRGDLGYIECVNLPKSKMKELSDKLIKRCDLLIIINKESADFNDRKVDSNNVNNNTIQDKRKNDKNNSIVIRVNKISKHDFLSAKEYLKEINATGGGREDLVQGSINNPDILGLVNIIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHF1</accession>
    <name>A0A5C0UHF1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="472" mass="54200" checksum="23FB63AFB61B6CA1" modified="2019-11-13" version="1">MGVRGTKDWVQNYKKYREIINVFEAHTKTHGFDQINPSILENASLFSRSVGEDSDIMNKEMFYVISKESNSMDTVLRPEFTTSVIRALLESNSIQNKKVSYYGPVFRHNRPQKGRLREFTQLGCEVLEDSPYVDADVILCAYKIVKDLDINISIKINTLGSKETLNTYIKEIESLFYKLKHEDCTDFVNLKENSASKNTKDFEEGPRKSEKLTEIINKIKSFDIKNPIRILDKMSSKEKVLLNIPKISDFLDKESLDRFSKVCIALKEMKVPFEVDPYLVRGLDYYKHTVFEFEDESESLGKSILGGGCYQGLVKSLGGPDINGVGWSFGLERMALLINTDKLSEENIIAVIPINKTSKAEKEISIEGENLEKSKQNNPEESEAEKEHILNNIYVMKVAEKIRKNINKNSDIKLILFHDEWKKSMKKLSKINPSMIVFCGKEERNEMKITIKNCSTKEQKNISYDDIETVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHJ2</accession>
    <name>A0A5C0UHJ2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_02030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="3">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="192" mass="21687" checksum="22F174B6DAE8E4CE" modified="2019-11-13" version="1">MQDLNSIENIEEQMNLECSTVIKKLQDYVSGLRTDVVSPKMLQNVKIKTKNGFLPINALANLSLKDSRTILIEVRNSTDVKDVERSIMDSKLGLNPATAGNSMFLKVPSLTTEDKVRLVKTAKSTCDDFKISLRNVRKSFMDKVKGMKKNKEISEDASKKYQKKIDAILDKFSKNIDSILSEKEKEILGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHJ6</accession>
    <name>A0A5C0UHJ6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_01870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="8">
        <location>
            <begin position="11"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c" evidence="8">
        <location>
            <begin position="274"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="487" mass="57245" checksum="0B7B1C82329D57C7" modified="2019-11-13" version="1">MNNTNSNNILCTRFAPSPTGLMHIGNIRSALITYLWARKNNAKFILRFDDTDTERSKQEFSNNIKEDLLWLGINPDKTIFQSKRNEIYCNWFSICLNANLVYECDETPEELEDLREKLKSQGKAPVFKFYSIKTSLESEQSSTTSDKKITKSEKPKYWRFKLPDLKITWKDLIKGEISINLRNVSDPVIRKSDSSFTYTFTSVIDDISEEVTHVIRGEDHTINTAVQQYMIETIKQKIISKPETDGNSKPTEQSTFDRESSQNIESLGNKSEIKWAHLPIILDNSGKVLSKRNGAKSIKEIREEGFLPETLISYITNLGKSQYIIGNMKEVLKAFDINYSSSQARFNQKEFLKTQQKILRNKIKEQNAYFQNKYKMSEKTLSLVREEIDFEHELEEWHDIFYKKIHFYRSDNENNTEKTDKIIFLEKEENEIWKNWIERNCEGRNRRDILKELRFVLTGRKFGPTLTDLLENIDIEVVNFRLFNRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHK2</accession>
    <name>A0A5C0UHK2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HK97 family phage prohead protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006433">
        <property type="entry name" value="Prohead_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04586">
        <property type="entry name" value="Peptidase_S78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01543">
        <property type="entry name" value="proheadase_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1188">Viral release from host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="140" mass="16075" checksum="B4D1F219F1B456FF" modified="2019-11-13" version="1">MRALSSGLNENEFIVQGYASTFNFKDGQSDIIKPGAFDSKKIDIPKIKMLWKHDIMKPIGYWYEMFEDECGLFVKGKVFRNLSFGEQICNFIKHSFVKGLSIGYIPTSFQTFKNCRIISKLKLYEISVVTNPANEKAKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHM3</accession>
    <name>A0A5C0UHM3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Signal peptidase I</fullName>
            <ecNumber evidence="4">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lepB</name>
        <name evidence="6" type="ORF">FZC36_02500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="5">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="271" mass="31478" checksum="4F78AD7D4B73EFB7" modified="2019-11-13" version="1">MILTSNFSKTEFTRNNNKKKTSLSFYIISILIFLRVFVIEHYIVPSESMSRTMENGDIVLAKKYHGFSRMSIPFIGGMLPFLKNPIFAQEPKRGEVICFSLESEPQKLYTKRIIGVGGDLVQVKEGIIYINDTPLKMTQKGTYNLLHDNGTTTTMNVFEVEISENKKYEVLRKQELNDTDRASDNTPVFKVPKDHVFCIGDNMHYSHDFRFFTFTSFLHKNRIIAKPFIIIFGSKYRNNANVSWSQWIIRLPYSILMSIVNVRFNRVGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHN2</accession>
    <name>A0A5C0UHN2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Choline phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_02555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a virulence factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="209" mass="24228" checksum="05F305000B67355D" modified="2019-11-13" version="1">MRMNKKLKYLKSLPYLVVTILSLSFSVLKKHEPEMQLGNVCVRFTPGSQCIPFISSAIRGAKRTLHIQAYSWTSEELTHEVNRAKQRGVRVFILLDKSHMKINNCIKSFMRNGIDVLIDRVPGIAHNKIIIADDDTVITGSFNFSNAAEHKNVENVLKIKDKEIAKAYLRNWYSRRSFSKDIRDPYNAELNRHPWKEKTNSRNYFNSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHN4</accession>
    <name>A0A5C0UHN4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation initiation factor IF-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">infC</name>
        <name evidence="6" type="ORF">FZC36_02115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="4">
        <location>
            <begin position="83"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="167" mass="19465" checksum="A530CF5FA5331908" modified="2019-11-13" version="1">MKSKKKQKKDLINKEIRAERVVVIHGGDNLGEMPFFSALQYAKDKGLDLVKMSDSDVPICKVMDYNQEKYKQKKQKKEKVQALKEIQIRPNIGENDLMTKINRARKFLEQRHKVKIVLKFRGRELIHLDDNVKNVLNKFIENLNDVGKADSRVPKERARVSVIINPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHN6</accession>
    <name>A0A5C0UHN6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_02325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="373" mass="41813" checksum="FBC7E988B44D484F" modified="2019-11-13" version="1">MFLYSSFIIELTNEITKAAKRLMPFKVSADSAMNFFISFSIYLIPIIFSYLLTRYSISAFLSNKSNNAKFSQPISKFIEAHNKKNVPIFGGVFMLISLLISTLLIIIMKNLLHTFCPSFFIIFRKLTIFSMQSLFPVCLAVSFAAIGFIDDLQKVKYRKNSAMSAKTKFLLQIITASICVILFRKVNPLSNLSYIDKISTTSSSDLNFLSLAWQVFVIVGTANAVNLTDGIDGLAGNVSKICIILLGFISNKNAYLCFCMVSIINAFLRFNNNPAKIFMGDTGSLLLGSFMSGVALESGVEWTFAISGGVFIMETLSVILQIASVKLFKKRIFPITPIHHYFEKHYTEKEIVYYAKKITLFLSFIALMISLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHN7</accession>
    <name>A0A5C0UHN7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">thrS</name>
        <name evidence="12" type="ORF">FZC36_02120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="261"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="633" mass="72201" checksum="E02C3672DB71740B" modified="2019-11-13" version="1">MIEVCLENGSQEFGSGISALAIVESLGDQGKGIVGFRSVDEGDIYDLHSILTGHISVKPIKKGSEYHLIILRQDAANVLSKSIKEIYEDDAEIIETGVLENGFYLEFYSENPVSQNDFEKIEKQMNVITGKSTAISKSVYSKEEALEIFDQEDNSFARGFISLLGEEPINICSIGDYKVVCSKACGNNTKNVGNNYKLVSISGVSSKYDYQNVQRIVGTFWHNKQDLKKYLDELEENAKWDHRNICKNMDICFVDHDVSNGMINWLPNGTKVINKMKTFIREMWDKYGYSEVQTPVLMASDLWKKSGHEEMFKENMMFVNLDKLTYALKPMSCPAHINMFKFRNRSYRDLPFRLAEFGYCHRYEPSGSLYGLMRTRAFTQDDAHVFCMEDQITDVIVSFCEMLKEIYRKFGFEELKVKLSTRPEKYIGNDDSWSEAESALQEAANKCDLECEINPGEGAFYGPKLEFSICDKRKHVWQCGTVQVDFSLAERLGATYTDSDSSQKTPIIVHHAALGSLERFLGILIENTKGLLPAWVHPAPFVVLPLVKEAEDFSKQIKKILKGLDLECLEDYDHSEKLGYRIRKYIEKRVPNLIVIGKKEMEKGLVTLRDIEGNQEQLSLEDLVIKLKGKNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHN8</accession>
    <name>A0A5C0UHN8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DotU family type IV/VI secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DotU" evidence="2">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="279" mass="33051" checksum="956D7D29EB43A5AA" modified="2019-11-13" version="1">MINLIARSFLLKHFQNYYIEVLKFKEQALIEPEKINQEEIKNVLIRLLKDQKELFDNEGSLMSNAYEEYSYICCAFADEIFINVNWNQKKEWQKSLMEQKFFSTYYAGSKIFENINSFLKRNSHNKYELGSIYITLLGSGFRGQYRSINDNGTIHKLKQDLFDFVNKTSYDYLSDEHLFPQAEKHNMIGRPRNTYKNTRRIISIMTMGILIYIGSTYILWNYFTHDINSAISKTSEMHLMKKKIMNARINKEESSDQNSCSANNRKLNLINNTFNWSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHN9</accession>
    <name>A0A5C0UHN9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit omega</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="11" type="ORF">FZC36_02605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="91" mass="10619" checksum="F31AF3419220DC1E" modified="2019-11-13" version="1">MLKDRKYTKYELVSALTQRAKQLFAGDDPRVETKHSEKLSYIALKEYMQGLLDIESLLNEAKMIYTDQAVAFEDDEDDDNYAFDANEEDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHQ4</accession>
    <name>A0A5C0UHQ4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="131" mass="14712" checksum="BB2B89937A982E58" modified="2019-11-13" version="1">MSCSTENTYNQNIPFKREDFVAPEFTANAIKAIKDNFDNYYKEKNVMPLGIKIMTERGGCSGLEYKMEYIFEESEDKVKEIDGVGIFIPNDSMGHLNGSQIDFEETAISAGFIFKNPNEKCKCACGSSFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHR0</accession>
    <name>A0A5C0UHR0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_02490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="38"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="299" mass="34573" checksum="C56DC66290ACE2F6" modified="2019-11-13" version="1">MTKLQWRCFVNKIKSFFTKIILVPFISFLITLCFILFFCTFSLQESNQAIVNSFGKYVKTVQESGLHFILPWQSVETYEKRVLSCDVSELEMTLGDQKRIIIDIFARYYIKDPVRFYESLRTYESASKRLGVIIAGEVRDVLGKYNLKDVISSRRAETISKIKNKLLESVDLLGIGVMEVRVKKIAFPKENNDSVFKRMITERLKEAQEWRGEALRSYKRIKSKADLDSMSIISKAERESASIIGKADSEYIKIVNSAYVVDPEVAKKLMEYNNYRKALSGKKTFLISSKSKYMESLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHS1</accession>
    <name>A0A5C0UHS1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall polymerase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_01520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="361" mass="41723" checksum="B188800A17BAA3F9" modified="2019-11-13" version="1">MIKKLEIMFRRLDLRTFFPFVMFFLISTFFMAAYIPWNISIFRHIIIWVVGFFLINFITKKGYDSYIEISRILFFISVFLIIFTFFKGTVTKGSKRWISIAGLSIQPSELLKSSCIAICANYIYENNLKHFFLSYFVSFILLITQPDFGSTLLLGSVMIIQLLYSDFKKEKLYPLFWLGLVFCIFVIIYFPHVRIRIKNFFLGNENILEGGYQGFRSVQAIKNGGLLGLGLGKGVFKKYIPDAYSDFIFSVIAEELGMVGCFLILYCFGYIVLSNVRKSKILKPYPEYYLILSSVFVIFIQAWINMASALWIIPTKGITLPFISHGGTSLLISFWTIIPIFISNKKYKKAKLSQCFGMECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHS2</accession>
    <name>A0A5C0UHS2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="164" mass="18867" checksum="FF7B73ECC505B06C" modified="2019-11-13" version="1">MIFIKKATSFIKNLTKTIVNKINTKNLFYSTNSKQNIFTKLLLISSLVFILQGCEEEKHMNCPKGKLIGMTKTEFISKYGEGAIKHPLDNNTWFYVDLIYINSLFSKTAKGNWMSVRISNNKIVELRKGKLPKKMKMKEHKKETLVKKKIAEELFGYVGSASSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHT4</accession>
    <name>A0A5C0UHT4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_02705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="99"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="267"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="KH_dom-like" evidence="5">
        <location>
            <begin position="437"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="522" mass="60197" checksum="96A21C33AE53A26B" modified="2019-11-13" version="1">MFKNAKRSKNFKGVSKFGRDKLVRKGTVSKDKKPVEKPVGENKRPIKTRLNTKVRLNGNRLHRRADKSSEKGRSKEINKKVLNFKEKLEKKPYAVGMPKVLILGEKNVGKSSLFNKITGVRTSIVADVEGLTRDVIINKSHNYDYGFIDSPGTDCMDEVKRIIEKTNGVDGFCLVIKEFNKVAKDFLKFMKQTNLPYVLVVNYFEDSPKLKITKDESFFEISVRKNKTDKLERLIKNWFNAEIYKKALGVESEKEKRVDFINDQKWAFVGRSNVGKSTILNKIIGKDRFVVEDEIGTTQEVHGSNLEIKDKNVLLVDTPGYRKNNKLSELDRASQYRLENIMGENISVFVVLMDIREGIKRSDLVLIERFWSKMKPVVVAIGMEDLIKDKSIISKAKEIIRKRFNSIPCVAVSGQTGFGLGNLKQEISEAHRMYGLKFPTNKLNKWMEEMKKYDIFNLAGIKYVTQFSDLNLAFAFFTNKRIKHEELKFLKKKLAKHLKIEGFPIKLIVKHKQDSVRNSIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHU0</accession>
    <name>A0A5C0UHU0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rpsF</name>
        <name evidence="7" type="ORF">FZC36_01695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="171" mass="20240" checksum="CD7B0D4AF95B90F0" modified="2019-11-13" version="1">MRNYRLNCVLKQNISEEEAEKVVDQISKEIDSLGGKEVSRKNFGLNKLKYEIQRNIRGHYILMDFNLPSEQSKKLVNTLKLNKDLIRYMIRLLDKKERPLTEVQSLFDPIRDPRNRFAENKIDYLRDTSRMTTPHGRILAPKILGFSAKEMRRLSKAIKERRFLALMPYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHW1</accession>
    <name>A0A5C0UHW1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_02080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="173" mass="19316" checksum="1D2C46F100A39712" modified="2019-11-13" version="1">MNLNTNSLTIAYIDTPLGKMCAISDNKSLFLLEFIDKKNLKQEIEKIKKQSKLSLGSTTPIKGITKELNLYFSGNLQSFTTTVSFTGSKFQTKAWQELSKIPYGKTISYSTQAQSMKKEKAFRAVANANGANTLVIIIPCHRVIGSNGKMGGYSCGLQRKQWLLDHEKKYSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHW4</accession>
    <name>A0A5C0UHW4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rsmH</name>
        <name evidence="7" type="ORF">FZC36_00725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="341" mass="39241" checksum="4C498CF37074B317" modified="2019-11-13" version="1">MAREIMDFLKPTPSKKFIDFTFGFGGHAKLLLSFGAKVTGIDRDKESFLYGKKLEKQNSRFKIIRAKFSDIYEQHEKSRLKNQNNGKELDSEHFMTLNPEKNLCTYTNANEIRNTKWSNKNYEADANKDMDKKTYFKEDFSKIISEADGILLDFGVSSEQIDNQEKGFSFTNEGPLKMQMGLNNVSAYDVVNLYDQHVLADIIYHYGDEVKSRQIASKIMEKRKEKKIETTKELSDIVNSCFRGFSKKPHSAKTFQAIRMFVNDEVNEIVKILHVLKSKMKAGAKLATITFHSGEDKIIKKEFKGCFLTTKPKFLQPSLEETLFNSRSRSAKLRLGAKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHX6</accession>
    <name>A0A5C0UHX6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022834522" evidence="2">
        <location>
            <begin position="25"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="550" mass="58363" checksum="3EA31F072CB7C6FF" modified="2019-11-13" version="1">MKSSKFRSLALLSFLCFLSNEINCGNQDRNFLESSIDADLVASTYGSESSSECSDSTPQSLSDGTGTSYSGEAFYVNENIEALLNDKEIGLSADLSKKIMREFLDERTKIDSEYNTETSVILNDLSDKLEMTMSFEDTKAELSSFFVAHNLTSEDVMQDFETRSNASSFANQSVEESKTNVCKTRPRRNSALKQEGSPKKSYPVSFLGSDGSRSPVSDQAMTPENRSPSGKSEPFVFGKQTSESRKVSSSSKTESVKPLKKSVKKPGSKLSPVSKKSGISKQSLSGVKSKKLSENPVKSTSASKKAKPMLASIAPAESKQETEVGSGFGISFGGFQVGIQGQGQSTNDPFEPASISTPLGKLNLSQEGLSLDGSFGSIGTKLDENGKPVIEGSVNTPLGKFGADQKRLSFDGKNGSKVNISAKDGLSGTVKTEAGEFGVDASGNPIAKTNINGTNVKHDKNGTSISRKGSKLNISKDGKASGSLKNDHTNLNLDQNGNVTGSVNAGPVSVNSQGNRKSSNTNSIPQFKNPKRQSSVKQANKGGCQCCTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI00</accession>
    <name>A0A5C0UI00_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="222" mass="25818" checksum="2C86BA4EAA2B72CE" modified="2019-11-13" version="1">MYFFALVLLFFKNILFFITNFLYDGNLINIKEIECQIEQYKTQYRNLLEKNATMKKILQISTSENANDDFFVAELKTPLTMNGNVVIQLKSNRLSSEKDLENALLIHNGRLVGFYNKGLCIPITKKNVSIPAVDEYGNKFILQGNITNLKIIKSEKEHKLKENSNIYLAHNDYKNILIGNYNSKNIVNVNRDWHKIQFVWVGKQNQANIEKHDNQANKVNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI50</accession>
    <name>A0A5C0UI50_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_01255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="184" mass="21344" checksum="78E1C4ED90B72F46" modified="2019-11-13" version="1">MKKVFFKQYIKNPKLTGSVIPSSSHLSKAFIKNMDLNSGTILEVGAGTGTITEHVYNKMENKSKLISFEIQEEFCNDLRKRFPESTFINKDICDIYDILDLKTIKDIKYILSTVPLLSLGKKKSLEIIETYKKIMLQTGATYLQLTYTPFSPFKYKNFDMTCKRIETVWRNFPPGNILKYKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI69</accession>
    <name>A0A5C0UI69_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_01365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="336"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="574" mass="64502" checksum="B42F5055240DD041" modified="2019-11-13" version="1">MTITKFVLDSIKPFRGAIFLMGAVVALISIAISGFHVVSKYLVDGFDVYSKTGNLDKVYISLLFLIANVIIYQIALRAREYLEIRFVPKLKKNVVDILSSKILFYPYVFFKDFDASKFVFSVFQVSESVSDLIIDYLSDFFKGFLNLVLAVVLMFSVHFTIGVIGLAWVISWIILSIFLAKRANKLAYNLADSRSTLSSKWNDTFKNVDSVFIYNGSNYESSKNMKFSHDTMIQEKKMNVFILNINIIQGTVFILVTIVSIFTLLNLFKQGQVTAGDFILITETIHSIGANLWDFAQDFSWFISDLGKISQGLDMTKTPLKQALLTSNVQIKSHDILFNDVSFRYSGSRDVFSNNGEIAIKQGEKIGLVGASGSGKSTFIKLMLGLMHPKFGSVKVGGVDTKEVCSDSLRKSFALIPQDNSLFEDTIMNNIKYGSFGSTEEDVINAAKRANIHNFISSLPDKYETIAKNNNFSGGQKQRIGIARGFLRDAKIFIFDESTSALDTVTEKDILASINDIESSKTKIIIAHRLYNVFDADRIFVFDKGRIVQIGSHEELKEQNGIYKTFFDIQTRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI95</accession>
    <name>A0A5C0UI95_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="7">2.1.1.182</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmA</name>
        <name evidence="7" type="ORF">FZC36_01570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="6">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="280" mass="31967" checksum="B6DF2CDBD2F0CEEA" modified="2019-11-13" version="1">MNSKIRTKKSLGQHFLTNKFALNRIAESALLPVLLNDVNALCQIVEIGPGTGNLTKFLIKHGAKKLLAIEKDQRFIEIIESIFESETGKEKNLEDCKKDYKIILRDILDFDWKDLHNKNTVVGNLPYNISVKIIINWLKFSNNSNFGIFMVQKEIAQKIISKNKNTFGRLSIVTDFLSSSKETLLEISPNSFSPPPKVMSQVIKITPKKNFNSMVLEELDYITKLCFSKPRKTLKNNISPDKLLTEIFAKVVDIDKVRPSEVTSIQYQRVAEIYLNESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIA2</accession>
    <name>A0A5C0UIA2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="577" mass="67225" checksum="6C8A782AD33AAE39" modified="2019-11-13" version="1">MTKRVSLNSIYNIAKHLMFGLVFTNIQNIKCGDDTDRFCKSLSTAAQCGRVVEFAQMSEYDQRIYTKMSSRIGFSKYSKEACKSSFLGLKRETTDSGLNEENVCKTLRFLIDEVKVDSRFALKDGEKRKQFESSSSEPEDVSDLAADELLRKYQESEPHERSDMKKRYLIYKYLEAYKLHIRKNRDFRDSDHKDLTTIFRNMDLSIQRHMTSLSVCAKEANEKQTLLTLEKMNTSVQERLNKFLRNYFTESLEAFKENIEKNKNIGSELKLLDERYKVDLENIEYIESTKQVIKNLEIQINTSEHRKTYAILKANFLTFRKSLEKLPTLKDKLEFNSEMDLESIIDLKKELSSKIELNLLDYSAKLSEMYTHKWTAQIFLKGLESKEKKDEYTLDLFKDWEEKFWNMINSKQSEKNEDSRSNKRTSTYKNNTLLNMFQNSNEPSSSSTEESPKSKPLVKLSLKAENEAILKSYKSLKEANVKLETTNKILDIYFMLHSRNDSEDASDGKEMTTSLEQKTYSSSDIKSESMPKASTDEAKITIEDLLNELDLLDIKFEGKKYVQNYAALAANYAKVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIF6</accession>
    <name>A0A5C0UIF6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_02575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="8">
        <location>
            <begin position="99"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="9">
        <location>
            <begin position="203"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="318" mass="36022" checksum="0775CB424F631E7C" modified="2019-11-13" version="1">MTKYINMHMSENILKISILGANGRMGSAIALKALKDTYSSLNLINSKEENKTRNNTTQCNQINNNKNAMIHSLIARKTEDINELNNLIQGFVRDLTAEYNLTAEYESTKESIKYKENLVNESKILNIIQEIKEIKISTDINCTKGCDVLLDFSHYESTPSHCKFAASNNIPILIGTTGNHEPEDYNSYSKSTPIMWAPNTSLIWNLFSIAMKVLSSEDKDISFVAGDVHHENKKDKPSGTMKKLNRDINLESIWSIRKGDMVSWNQILGVSSSENVRIEHQVLNRESYAIGAINAAIWLTKQKKNGIYSMHDFIKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIN2</accession>
    <name>A0A5C0UIN2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FZC36_02570</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QEK39292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="279" mass="31448" checksum="5D5D7FA507C23BC1" modified="2019-11-13" version="1">MSVLVEKMNYIIQGFLEAFPISSSIHLKMLGISEHSVAFMHGFTGLAALIFFRKRILEMVLNFFSNPILHGKPALIIAPKILLGLFLSKVMKLKIIPINEIFSITLFSALFFVSDVFCAKNRKLEELSYKEVLFAGIVGLFAFFPGASNLGTSYTSFRMLKCTKKESLMYSYIFSIIPSIGAFVLSISDVNSLSHLNSMFDTNFCSYISKVSVLGVNITAGVSMSEIFCIISSVLYVFAQSSLFYIFGIRLCFKLINYLYFFSIYRVLVLVIYAIFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIN9</accession>
    <name>A0A5C0UIN9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="635" mass="73919" checksum="5F390D1A457066F8" modified="2019-11-13" version="1">MITNKYKMGNMSKMRNILKLCTLALTAQHTNTVDIPKLHDTPNEHGCFYHFKYVEGTLNLEQNETYELLEGMYEQSKYSSEDIKLIAFLRHELEKILEVDYKKGLENDFLLKFPKIEEVMGDGEWEEEVLLGHGYSKEDYRQTVITCNVRDSFDCLIRSKRIWGKMIDQYGEEDLNKIKDSIKNANHEHEFGKKTHLNLKVMHNLVGYGLRQREAAKMPDESTFLQRWYSGRHAYEDDKKSKVSIKLDNSAFIYQGIPTKDSETDYENKPCERDSNIMYVSYFDANTKTDNLVWAGDERELKERTCKVVQYNSFPDLRNLDRIGPIFQYALALRYVHLDITSPDHLYWMRFAQDLEYVKLRVTESDHLKHLGLLKNTQYLGITNINVDDAIVLPEEIGSLSKLRCLHLSGVEGYPNQIHGIKGLREIKFVESEGKIDKSLSNLDKLVHLELSGKVELPETIELWELQSLVAPSADIEKMPQFICPELRYLDLGSARLEHALEPGAKLPIFAGGNEITSVSDLSECPELREVWVGNRINEVDVSVFKSCKKLMYIGLGVDFKYSIKSGLTEYVKKNELFFELLHPLNAGEKLQYNCKIPGEDGEWLKLKRYQENQKRSWMRKEHPRYKRMEKIFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJD9</accession>
    <name>A0A5C0UJD9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_00525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="9">
        <location>
            <begin position="46"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="354" mass="39223" checksum="70503CBB8CF216E7" modified="2019-11-13" version="1">MSEDKILSPDSFNNVEAFVDSASVWDSSMSAGGSDDSIPLEQGELRGVFEHGPLKPGYSVTLGNPLRRVLMSSIEGVALCGIKIKDVHTELSSKKGAKEDVAEIIINMKNIVFKADIELFTFDLIVEKSGKVFAKDLDLPNGIEILNKDAYLFTLDDSASLEISLVLKKGIGYSQANDITLPDESYIKLDAVFSPIKRVVFSSASTMVGQNTEYEILVVEIVTNGFVEPGKAYKQASEILVNEFGRMHKVFDEVKETEEELEEVNESLFDLISADHFPLRAVKVMHESGMTFVGDIVVKNKEDLMKMGKVGSVTINKVINVLESKYGFSLETEIENWESLRNKRIEETEEEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJF9</accession>
    <name>A0A5C0UJF9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="223" mass="26292" checksum="BF6E70644247F1E1" modified="2019-11-13" version="1">MNFTMLVSILFLSFLSDIKAKPTNSLKKQAGFSEKEYKFIFNPKGHFHYLATKDMFIKFYLLKYEDFKDSFGLQNLYEFLSSSFDKSVAFFDFSKQENINHLAVIKDGNIVGYSAFVEKIKPSKKEKVPSTYLFLLQFVFSNDYVKERMFKEIAIKYGHAKKIVTFIRPVMKSSYNFIKSKKIVPLSTEEAKEFNLSKDMYQKLIFKPRIFKQQLESNKKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJH8</accession>
    <name>A0A5C0UJH8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">FZC36_00735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="726" mass="78755" checksum="096BEB7F5EC73AE9" modified="2019-11-13" version="1">MSIASNELIMYLFYIIDWRIKLFNCTFQSIAIFSGLFLFFRSYVYYKKIKNIKVSEDVNRIGSYIKDASYAYLKKQYLYVFVVSCVIALFLFFFSEFNVCLGFIVGAFLSSVCGIAGMHVAVVSNMRTAQKAESGVSDAFEVSFGAGKVTGLLIGGIIIFSVVFALWNECGTRVISEYDSNIMKKVTKSVNFSDFSYNRILKILLGMSFGASVVSVFARLGGGIFTKAADVGADLVGKIEKNIPEDDPRNPAVIADNVGDNVGDCAGTSADIFETYIVGFMAACYISSQYYVDPILFLIISLSSMLGSYIATEMFSRTTNPFKTMFKFMIFSLCAACMFNLVGISCYLNYMGSFSYNMLFYFFKPCAVGILSSFVIVVLTNYYTSYSCSPVKRIAKASESGHAMNIMTGLAVSLESCFGIIVCMVSAILGSYYFADTLGIAICIVSMLSIVITVMTLDAYGPITDNAGGIAEMSKMPASARENTDTLDALGNTTKALTKGYSIGSAALAASAVFFSYSHDLLSYTGENFVFCLTNPFVVSGMLIGGAIVYLYASMSIESVSEVGQEVVKEVQNQFAEDPLIIEGKSTPNYSRTVEMLTERSIQKMFYPVLVAVGVPLICFASVYLFFGSSAAFTILGGLISGVTIVGIFSAISMTNGGGAWDNAKKYIELGFYGGKGSYAHKAAVTGDTVGDPYKDTAGPAINPMMKMVNIIAIVIILLFNKYGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJP0</accession>
    <name>A0A5C0UJP0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="296" mass="33675" checksum="BFBF32BC6D62045F" modified="2019-11-13" version="1">MFLKFFENKKNNYIIGAFYFSMSILCGLLNDFIVRYMSFGEMGLAQIMFLRFLFSALSMLPFMIKNKYSTDNYTVHLIRSFLFFVPIVLWNYGVSNGGLIIATFMELSIPVVLLVMAKIFLGEDLKGRILSTILGIASVCFVMFKQLEFGVSVYVVLAFAVAVLCFSSLDIINKKLLNKDNDPLYAFLFYSALGTSLFSLPFAVCTWVSVSYQSIVLCMIQGVSSNLILFFILKAYKKTDVSSLQPIRFISLPISALLSAVFFKERMSWYLVLGFMFLVVSIMMNIKNEVIKKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJR1</accession>
    <name>A0A5C0UJR1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage major capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
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    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="370" mass="41941" checksum="97CE6485D262A711" modified="2019-11-13" version="1">MNILNNKNSLKKNVNTFGGMSFDGGRFEGSNLEKQLDSEKQPKSEEIPSNIEKKSYGAPQTWGSSETESVSSIAKYIAGNFSDIETKSMSNSFFNSISTNRNGHYVPDESGEILLENDYYFSPIRSRARTIFSDRTTCTVNKFNSPEVTETDPSTPYQIGTKKLELSKETLSMHALQICIPVSQNSDEIHSIVDFEEAVNRKMCTELSERERNLFISGVDGKIDSIIPSESQTMTGKLDDNYISLRKMLTKLELKYHKNAVWFMTPETYYEKVLGLSDANKRPILNMDQISSDCNSIFGKEVVFVEELRGSGCDIILADLESGYLICENKNIFYQEDPFSEKPMVLHYMRKYMCSKVIDEKAFVGFKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJR8</accession>
    <name>A0A5C0UJR8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="398" mass="47746" checksum="2F76080505C57D2B" modified="2019-11-13" version="1">MKRILLIEIEELTVKGFLLDLQNKSILLEEKTDKSDFRNKKIQNKSSINIPHIMKDLEFVSNLERNNYIKFLKEITVLESCIRYLLKNLSDRVESLPESSVILMNGYIYSHDFLIKQNGKEEHKHKNDYIKRSMKNKMLSKNSFIFLIKSIKQKESTQKIRKFKCFCFSNEYKKYLEKILNMEGFDNLSIIPVSFLKFKDSTKDTIFNEFCFVNIYYEKTFLYFVENKEIVSIKVLDIGYELLDKNISKELSISIDSAINIRKKNKSIKFSKTNLEKYIKIKTQDYMDISVSKEDLRNKTIKSIGHIYDFIERFILDLKYNGTIFVKDEFSNEIKGIDSFLKERSFFCNLSSNKIKLHHIYFLINKMHEEYKKTRIMHKLRNWVNFRLKKIYDIIKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-10-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJU4</accession>
    <name>A0A5C0UJU4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_01425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="138" mass="16049" checksum="9444AFB8AB441BEA" modified="2019-11-13" version="1">MSMLRKIGNFVYLKINEIFCKNAILCKTFCFSRFFFLFFYFIVKSLYLFIKNGFLGEFYESVINLDISMLSDFDAELLSTWVTLTPGTIAFDTINFESKNGNSKKIIMIHSIVKDPENDIQKMISCIIDIRQTKIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJW9</accession>
    <name>A0A5C0UJW9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type VI secretion system contractile sheath large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tssC</name>
        <name evidence="4" type="ORF">FZC36_01650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008312">
        <property type="entry name" value="T6SS_TssB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010269">
        <property type="entry name" value="T6SS_TssC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044032">
        <property type="entry name" value="TssC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044031">
        <property type="entry name" value="TssC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35565">
        <property type="entry name" value="PTHR35565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05591">
        <property type="entry name" value="T6SS_VipA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05943">
        <property type="entry name" value="VipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18945">
        <property type="entry name" value="VipB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03355">
        <property type="entry name" value="VI_chp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VipB" evidence="2">
        <location>
            <begin position="250"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="VipB_2" evidence="3">
        <location>
            <begin position="559"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="672" mass="76008" checksum="B190FC44A2D37668" modified="2019-11-13" version="1">MTESIQKTLSRIRPPRVKITYDVETGGAIVKKELPFIMGVISDLYGHQEEKIDLKDRRFIFIDRDNFNDVMSSIKPMLKIRVKDTLAKKAPDSKKAKKSDGKEEKDSKKAKSNDAASEDAMIPLEIKFESIDDFHPVSIVNKIPELNSMIKDHVSLVDLLSKVDGNEDLDKILCDVVKSEDKAKLIAESADISKATPEIEKIIKEGKMILQEGETVDPDKLLKAKEIVAAFVRSLDEAKELSNSYPYIMNRISNIDQQISLQLDEIIHNPEFQKLEASWRGLHYLVMNSETGERLKIRVLSITRDELQSDLENAIEFDQSKLFKKVYEEEYGTLGGMPYSCLLGDFYVGRSPVDVSLIDHISTVAAAAHTPFLAAADPSMFDLSAFTELHYPRDLKKIFESSEMIKWNSFRDKEDSRYVNLFLPRVLVRLPYGDDTIPVKEFSYNEKVDGLDNSKFCWGNPAFAMASRITDAFAKFGWTAAIRGVEGGGLVENLPAYTFKTQYGDIALKCPTETIITDRREKELSDLGFITICHNKGTDKAVFFGSQSTQKPKEYNLPEATSNALISSRLPYMLNVSRFAHYIKMIMREKIGSFASAEDIETYLNTWIAQYVFLSDTGSQGIKSRYPLREANIKIKTNESDPGSYSAIIYMKPHFQLEELTVSLRLVAKIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJX7</accession>
    <name>A0A5C0UJX7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FZC36_01700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="51"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="399" mass="45306" checksum="C6FAEA8CF6814D9B" modified="2019-11-13" version="1">MIMNTSKNDNYSSNCESLGKFFIPTKKDSDEFSETAKLMMKSGMIHKLSSGIYAWLPLGYKILSIVEKIISDKFEDIGFNRMCLPTLHPASLWIETGRYEVYGKEMLKIKDRNESDLVFGPTAEEACVDMVRNKIKLHDLPVKVFNIQWKFRDELRPRYGIVRCREFLMCDGYSFHETEKDALDFYDNVSEAYKEVFDELGLDVISKPAETGEIGGSKSHEFLIESEIGEDTAVVDGVEKSFMELGHIFLLGTRYSEPMNLKVTNSENKTNALVMSCYGIGVSRLVGALVEKYSVENGINWPKNIAPFKITILNMCKDSEKADKTCEKIRRKFSKTTYIVSGKKSPGEKFAVSDLIGSPIKIIIGNKQLESDSVEVRVISDKTHYIKIDEIIDFLDKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJY5</accession>
    <name>A0A5C0UJY5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ORF">FZC36_01755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="241" mass="28156" checksum="3CA4F84AEBE144D5" modified="2019-11-13" version="1">MNIFIDPVLFNFFGLQIKWYGVAYLLGYFTCRFYLLQNLKKDYSIELLDKLISLIFLFGLIGGRLGYIFFYSKDKITFLNIISFWKGGMSFFGGFLLSGIYLFYASQIFNIDFFKISNEIIKKLPIGLGLGRFANFINGEISGRVFIYKGILYRHPVQLYSLLLEGIVLYLLLNSKRKQNATKYFFIYYGIIRIILDFFRDTESSMFLQNSLIEITYGQVFGLISLVIGLIIKRDLQTKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK15</accession>
    <name>A0A5C0UK15_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_02000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="247" mass="27884" checksum="C1DC55AC4462C8A9" modified="2019-11-13" version="1">MKILIIEDDSSVASSIISFLQSHNMVCEHVDSAFEGLKYARIFEYDAIIMDVVMPDMSGYDLLNRLRKCKVSTPVAMVSFMKEVGDKLKGFNAGADDYITKPFDKDELLARVNAMVRRSNGQSSSLVDLGQLVLDTTKKMVFVNDQEIRLTNKEYLILELLAVRKDSILTKDVFLSHLYDSGCDEPTKKIIDVFICKLRSKISEFSKDYLDNIPTIKTVWGRGYKLSVEPAVKSSDESEKANKQVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK34</accession>
    <name>A0A5C0UK34_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_02135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="90"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="246" mass="28272" checksum="D211164ECC20A52D" modified="2019-11-13" version="1">MNKMKNRNIFFSLVNGSNLSPKQKYIPVKNYSNVLSEEINIQENKQNQDTILSEKNNDDDLEFSSINELRTSMAKNIDLEFKKDATTMVFADGDPNSKIMIVGEAPGEEEDKKGKPFIGDSGKLLEAMFEAAHIKRKHMYITNVIPWRPPANRTPTKEEISKSQPYLLEHIRIINPKILVLVGSIAMKAFTNTSEAITKSRGIFKEHRNCLYIPIFHPSYLLRSPSKKKISWNDILQIKEKYKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK70</accession>
    <name>A0A5C0UK70_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Na_H_Exchanger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_02370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="389" mass="42933" checksum="649D2C3D0038863E" modified="2019-11-13" version="1">MYYKSMGFVALDKISLILTFCAVIGLFLAASNQPPVIGYILTGIALGPHMLKLITETEPIRIIGDFGMILMLFTVGLKLDVYEFKKVWKTSLICVFVQILSSFLAAKLLGSLLGMDTGMTALFTCFFALSSTAVAVKLLENKNEVNNQVGSLVISILIAQDLALAPMIITLKSIIFKSSIYVLFSKLFFSLFIMIVCVIFVSRSNLKFLNKFFNSAFLKNPEINALATIAICFGFAQVSELVGLSGVYGAFICGFILGNLGPKNALLSFSMPLSGILMMSFFVYIGTLFDTVFIAKNIFNILAVVIFITLFKILINYVVLINLKWRRIHSMLASALLSQVSEFSFVLLSLYSTSENFICLKNWIVSVTVVSLSVGSIIVIMIQDFLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UKC6</accession>
    <name>A0A5C0UKC6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008565">
        <property type="entry name" value="DUF847"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05838">
        <property type="entry name" value="Glyco_hydro_108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="209" mass="24645" checksum="8E339904C7533710" modified="2019-11-13" version="1">MQCKEKIYLCNLDLTEEEKSKCKKDKLKQTCLDETSQNPKFLKAIKKTLQFEGGYVNNPKDPGMETNFGITKKYYPDLNIKELTIKEAGEIYFHDYWLKNNLHIIQNATIAGKLFDIAVNSGFGSMIRILRKSTQSMLFPNQSNNQELSTQCYLHIYGRINTLQNVDCKNLFEEIKNFRRNYYLALTKRNNKLNIFLKGWLRRNDSFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFJ1</accession>
    <name>A0A5C0UFJ1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="139" mass="16112" checksum="481EAD31F6AF0222" modified="2019-11-13" version="1">MCIFCVFWFLPFLTNANLFVFFALAGLFVISLFKPKVLPIFVGATLFTFLFKITYANPYSLLVTIPVIALFHKNMKKIYYKMFVEKTCSSTSNVFFSSSIVFVIAMFVGHGLFYFIPVNPYIKFLIMSLVSFFGYKYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFM6</accession>
    <name>A0A5C0UFM6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpsP</name>
        <name evidence="4" type="ORF">FZC36_00370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK38895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="104" mass="12022" checksum="EF7450B962D60C63" modified="2019-11-13" version="1">MLKIRLAVGGKKGKRFYPIVLAESQSPRNGKFIEKLGYYDPFAKEKKLNCDEKKVKESLSKGAQPTDRVHRLLHEAGIMDTHPFHSRKDLDRVVFKNAKKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFN2</accession>
    <name>A0A5C0UFN2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 11">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fabF</name>
        <name evidence="15" type="ORF">FZC36_00220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 11"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="14">
        <location>
            <begin position="4"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QEK38868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="417" mass="44186" checksum="375F339DEE51D05F" modified="2019-11-13" version="1">MKRVVITGIGIVSPLGSGLDFVWDRLLQGKSGISNLPEQYNDYDSRVAGLVPRGTEKGEFDISKFMDSKEQRRNGLFISYAIGAASEAVQDGKLDEIEDRTKIGVNISSGIGGLPEIGEVNTKLNARGIRSVNPFFIPSVLSNLAAGYVSMRFKANGPNYSLTSACASASHSISNAAMLIRSGHADIMISGGAEASICPIGVAGFSALTALSTKFNDNPSKASRPFDKDRDGFVIAEGSAVLIMESLEHALKRGAKIYGEYLDCGMTGDASHVTKPEKEHCKRAMSIAIERSGLKPEDINYVNVHATSTPVGDESEMEAIKGIFGDHAKSKNFAVSATKSATGHALGAAGALESAFTLMALKNQVLPPTINVENAMDSIEGINFVPKSVAAPLNYALCNSFGFGGTNISLIFKKYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFN6</accession>
    <name>A0A5C0UFN6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsS</name>
        <name evidence="7" type="ORF">FZC36_00430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="111" mass="12517" checksum="131D991E45A5E2BF" modified="2019-11-13" version="1">MSLLTEEKKKIIQRRLSISLRDTVPVKPPFIKHCVIKKIESSISNNSKKPIKIWSRSSTIPPKAVGQTFLIHSGKKFVSFIPRESDVGHKFGEFAPTRTFTGHSGNKRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFP7</accession>
    <name>A0A5C0UFP7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="177" mass="20556" checksum="8CE9547B0EE74A47" modified="2019-11-13" version="1">MYSIVLFYINKDFVIEIFLNHTKKYSKKISNARTNLVQEISNALQEEKITLSEINRISFLRGPGSFSSIRIAFATVMAIKTSHPNIICNNVSVDEIIPSPIIIKLNKATILHYFENWQVKKNEELNKDITYNSMDKNDTFKTNVIENIGYTILIKALKLKEPLYIYEPYLKPDFKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFQ4</accession>
    <name>A0A5C0UFQ4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="653" mass="72346" checksum="BDD4C68B9BCDC391" modified="2019-11-13" version="1">MQKKFLILSILCSSIYASIEADIETNSIQSEHDSSTSCELRSESEKIEQVPENGPTSSRSSTSTDLYTETQASQTRSQLSRAGSAILSVASSTAHKVGSAAYSTASTFVTMSETSDVGNRAEIPVEPEAPTASLGNARELVLAPNANRSSVKSVSSSSVKSGSVSSSVQDNIAQLQMQMQQMQMQMQMQQANLTERTKSSRRSGTSVASSRTGIALPQMDWDALSHKSSLSRISQRSMEALYSSKRIRCWLERCNNPEETELVTEIIQFSNKRFGKKDRYIESLKQFIAGQQIAINANSEATVKLADMAAKSQENASKAQEEERKRAAELSEEKTSRLIDKENLMAEKKKLADAREDLADKNANLKYSTEARAKAESDIEKLERSINSKESELEAVKSAKHSMELDLTKESTANECNTRNMNEKNSYLQKLLEEANSTIASLSKDKESADETILKTVTKLSGLESKCMSQESEIDMLKAELNEYKAKNTKLEAEVAKIPSIAPALKEENKTLKSRLLEIQKKLTNKKEKVSLYDKLLETAENSQPSYAFQKVKEIYENSSYSKKDCVASKFIRSFNLNLDKKGEINKSIYRSVTLMLVCKSLDQCTGENIVGHILFLKEIFGSSQDILFKANAKPGEKFTTADLSQVAGLIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFR2</accession>
    <name>A0A5C0UFR2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsL</name>
        <name evidence="8" type="ORF">FZC36_00390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK38898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="123" mass="13688" checksum="FCF56BAF6A5C9038" modified="2019-11-13" version="1">MVTLQQLCRGKSRKPKRNRKSYPALAGAPQRGGTCVRVFTKTPRKPNSAQRRVAKVRLSTGFEITASIPGEKHSLQEHSIVLVRGARRPDLPGVRFIVVRGIRDLKGVEGRKQGRSKYGTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFS7</accession>
    <name>A0A5C0UFS7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dnaK</name>
        <name evidence="11" type="ORF">FZC36_00695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK38956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="631" mass="68887" checksum="11C4817C0D4EF130" modified="2019-11-13" version="1">MNKIIGIDLGTTNSCVGVFEGGKTTVITNKEGNRTTPSVVLFKSGEQIVGQAAYRQSVTHPQNTIHSAKRLMGLDFNSEMTREHMKHVQYKVVEEKGRAYIEVDGKTMSPQEISSIILRSLKSDAEAYLGAKVTEAVITVPAHFNDAQRAATKEAGQLAGLEVKRIINEPTAAALAYGLDKKSGKVAIYDLGGGTFDVSILEMNDGVFQVLSTNGDTFLGGADFDQRIVSYLAEEFMKMEGIDLTKDSQALQRLRDSAEQVKKELSTTLEREVNLPFITMFNGAPKHLNVKITRAKFESLVQDLIERSMDPCKEALKDANLSTSEISEVVLVGGMTRMPKIVESVEKFFGKKPHQGVNPDEVVAIGASIQAGVLQGSVNDVLLLDVTPLSLGIETVGGIFTKLIEKNTTIPTKKSQTFSTAEDNQTSVTIMVYQGEREIAQHNKLLGQFNLTGISAAPRGIPQIEVTFDIDSDGLVHVSAKDKATNQEQKITIKNSGGLSKEEIEEKIKEAEMFAEEDKKKAKLVESKNKAESLIYSTQKALTDHGDKISAEEKTKVEASLEELKTAKDSEDSQQIENAVSALSAAAAKLGEVVYKAEQEKNAKEAQEPKSNDSEQSEEVKDAEFETEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFT8</accession>
    <name>A0A5C0UFT8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="373"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="752" mass="86650" checksum="E70378E37E416556" modified="2019-11-13" version="1">MITWINASAGSGKTYYIIQKIKEIKQSNTNKSKSILCLSYSNAAASEMSERVDSESRKNTSFHTVHSFCNLALKDKSISVINEKESEALINKAVDISLKSNKFLEVVSSFYDESNSLFQSVYEAIKKNIEFKKEFLTKEFPEWNGIKIDKKIIDSLSDGGKLEINLMNSLLYEKCHMGGAPIKSLLTDSGQIRKRLYSSAWKIRNPFSAYFIDEYCIKVFEYVQKKKTFDAYQKSVAITSWVNCIKDNYENLKKESSVLDFNDLINNGIKFISESIYSDNIDVLGLDYIFVDEAQDLSEKQWEFIYALFVKVFNSNPNVKLYVVGDSKQSIYGFQGSSVYVYEGMYKKMQYFAEENKIKFATEVLNKSYRTSPVLLDYIDSTISSTSCKSKHSPVHEFSGRVEIHEYESEKATYGWNIKKANESEYLNKCLRKVIDLQGCNLFSENRGISFNDIMVLTRRRNSELFKFVEMCKSNNIPVKKSLFKFGSEEIVQELVSILKFAIYNDDFSLASILKGPFFKWAERDLLEVCSRRKGSIFDSLNKKNDKHSKVIKTCSRWKKLSFNPVDFYGNLLFSDEYGKFLLQSSFYEIVIEFWNKVVEFTKNNIGSPMMFIEWINGLSESFCSKGEGISISTIHGSKGLESKIVILLLNDSDIKKQKIIFQDGMMVWPVDNPLYMTSKNQRMFDENLENERLLYVALTRPVEQLYIFVKKGSSAFYSDIIMSSSREFKNDNGVLYSGSELTKRNKDCIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFU5</accession>
    <name>A0A5C0UFU5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PD-(D/E)XK nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="520"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="756" mass="86639" checksum="4CBB2AEC50945F20" modified="2019-11-13" version="1">MVFSSIIEKIEGAYKSGKVVFVSNLASAEFLHHRGLNVFVLENILSKFSDPGVKSKNTYKNIKLNERKSDKKISFGYVCSYILEKCKQSDLLFVLSDSGEFKKHENLINDFLLLVNEGITKKKKHEIIKIKEKSLLNEKCKVFENVFEEASYMLKKLRTSKNAVISSSDTTLNTTLLSMDKSLKSFSCQNKYYNSNHCFLLICSAKIKFGKALGLEISEFSATSESNYKGGYLEANEFYKYDQFKEKKTFYEFSEMHLDFMKKNMNYKIPEKIMQIVFFKKPALSDDLSLESKLNLIRNSSVHKKSLGDIVNAYSLKIDQADLNLSVKDLDPSRNSNLSVNDGDYSSENTCRASLSDDCEVYSDVHRVENGSNFLREKIYDMNFNSALFDYIEGLELESKEIDCEMYISILENMLKKIDFDARVDRSNFDIVPLESVPFLKDKTEIIVGGICSADLEQCSLLTNVNLNSKISLSSYGNNANSSLNVASFDKVTKSKKGKLHKPKDKYTDKEIDFSYMPKTFSISEISKLCIDPYSFYVKSVLGLIEKHYSFLNIVGMSVHKALENYAKNLNKEECEQIISESGLSNWGNLIAGQKIKKMLYYIDRFFLNLKTSNQEYEIFTEKESYLNIEMENEIYKIYGRIDFVYRLSNGSCGVVEYKTGSVPSISSVLRGEMPQIIYELAMLNNIDFSGHVNEIGDSGFMSPKGFLPFTYVHFVPEAIESTKKLLDRFLIKDRVFFSTKSNENYKLKNLMRDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFW8</accession>
    <name>A0A5C0UFW8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cgtA</name>
        <name evidence="6" type="synonym">obg</name>
        <name evidence="10" type="ORF">FZC36_00855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="9">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="161"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="308"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="369" mass="41051" checksum="21693B19589D4AA9" modified="2019-11-13" version="1">MYSMTVFVDKVNIVVESGNGGNGCVSFRRESKEPNGGPDGGDGGRGGDLYFYGDHNLNNLIDFRYKKHWKSENGKNGSSCNCTGKSGKDLKIAVPFGTQIYEDGILKYEIMNPKEVLVAKGGKRGLGNTRFAKPDLQAPRICTDGAKGVKFELELVLKQIADVGIIGLPNAGKSTLLHIISGANVIIGDYPFSTIVPKLGAVKHKDQSILFIDIPGLIKDAHKGKGLGHEFLRHIERCKILLHLVDCSDADVEKNIDSIVSELEQYNPKLLEKTKCICLSKCDLVEKDYLEDLLKKVSSKHEKIFCISSFEKNSLNDLLDYVCDLNIEYKKNEEQELKELSEDKKENVDQSENDDNDLESCDETFDYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFY3</accession>
    <name>A0A5C0UFY3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FZC36_00960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="10">
        <location>
            <begin position="344"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="402" mass="46214" checksum="AB8BF63E42FA53D6" modified="2019-11-13" version="1">MNITEEKLNKGIEEIKERGLVYQQTDDVRKSEITFYMGVDLTAESLHIGHLVPLKIVDILSKHGNKPIILLGEGTTMIGDPSMRNNERPMLEKSSIKRNMEFIKNQIKKISPNAIYVNNLDWISKTNFIDFLRDVASKFSVNQMVNLETFKNRLNNNLPLSFLEFSYPLLQSFDFLELYKKYDCELQIGGSDQWGNIINGVNLLKKSGAKSAYGITTPLLLRGGKKMGKTTSNPIWLDKNLTSCFDFWQFWRSIPDSDVESYMLKFTDLKKDQILEKIRNNINEAKKHLADCVTCWVHGKEISEEVRNKAEKIFEQGSEDAYLDLVCDFDGNNVSENGELLLYNLLFKKGLAKSLSDAKRKISDKSVKINGKVEMDYKYEINPEQDSILEIGKKLKFKLKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFY6</accession>
    <name>A0A5C0UFY6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">FZC36_00755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="52" mass="6161" checksum="3279A2A39B866C69" modified="2019-11-13" version="1">MAKKKNKAPFVLLRNGGEFYITNKSRTMEGKLSLMKYSKKQRKHVLFTEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFZ6</accession>
    <name>A0A5C0UFZ6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FZC36_01075</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="15">
        <location>
            <begin position="80"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="16">
        <location>
            <begin position="517"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QEK39026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="972" mass="112259" checksum="153B0C4FD495FEB7" modified="2019-11-13" version="1">MKFTLEWALSYFNLTKNDNNSENSYKNEKNLDSISLYFSKLKDFAKFEGKNYFSKDSNGISELQDLLVERGFEIESCTEIHKLNNLEIVEIIKIEKHPNADKLNLCTVRIIDKDIYKPKEKIQSDKALDSHNTLNEETFTIVCGANNVYVGMKTVLAKLGAIIPSNNMEIKKAKIRGIESSGMLCSSYELGLSDSDIDGILDLNIETIKDLNSIIEKEQNKANDYIFDIEVTPNRKDVTNVFGIAREITAGLGIGYAVKSKDLEELDTFFSSNNSLNIKTNDKMQEINKLHKNSTNEFSEPIEMQTYTLPKEHESEISRVYKSVFKISIRTKATQHINPNDANNDANSGNMNSSYVDFKPISFTPFWMQQRLRNVGIKITNNPLENLSNYVLHSYGYELFFTENHEDWNMILISGQNNSYDKKSSDNGSDIKKQKHFINKDNFGKLGINAFLCIAKYNHTDSKTFNDESHAQNAINFVTDFFMTYSNESFVEKFDLYHNSSTHIDVSKYKENRTEPKSSQIVFLNSTEVEDVTGFKLNASYIEKALRSFGFNIIKQSTSEQNNTLFEVEIPSWRSEDIKDDACLIEEIMRYKGVDSIEPKPMNYIPSKYNQYEDLISNFWTTKGFFEVFNNNFMESRDSSLTSEDHLVEIDNPMTSKQTYLRDSLYYDVLKIAKSYENNNMKCKGIFEIGKTFTLKETKENEKRNNNEHPANDTLSYINTKNKLCIAWLDTEINWANKKTTFHECNQNIENFFNFLGVNHKKTFSEDRKVLWNADHDSYDQTTNKATEKNNQRNNLENNGNNIDNYGIQTLGCLQEITTKHKKHFKIKSDVFFAEICLDSIGLLLNKNKRQNKVTYNTNIYKDFSFKLNSDTPVKMLLDTATELVGRNIKLTVFDIHPTINLNSEKKVGIRLNWINDFVDNDDHTNLNELGNSSEKLINKKTSFRKNISSEEQKVFSDNFIKSMKEKGFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG07</accession>
    <name>A0A5C0UG07_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="9">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">ileS</name>
        <name evidence="13" type="ORF">FZC36_00875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="9"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
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        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <location>
            <begin position="24"/>
            <end position="623"/>
        </location>
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        <location>
            <begin position="665"/>
            <end position="817"/>
        </location>
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        <location>
            <begin position="50"/>
            <end position="60"/>
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    <sequence length="900" mass="104598" checksum="3DFA2E3DE9B89EFE" modified="2019-11-13" version="1">MSYPVLLPKTKFSLIPRDYNLSIDFWNKIDLYKILNEVNEEPFILHDGPPFANGNPHMGHAVNKIMKDIFNKMMIMNGKKLVFVPGWDCHGLPIESAVESDLKKQGKRRSDISIKKFRELCKDFANKWIDVQMDGFKKMGVTADFENPYKTMDKSSQMSILDEFHKFVEQDYVYRENKPVMWSCDEGTTLAEAEIEYMNKKSNAIYVAFKVLETSVKELKDSEIIIWTTTPWTLPANRAISYGDFDYSILEINLSNKKRKVVVAESICDDFLKKTNITEYSKITTIKSSDLKNCICAHPMNDIGFDYNIPLIFGEHVTLDQGTGLVHTAPSHGEEDFHAGKKYNLLIENLIDEKGFFTKTHFKGKNIKEVEKLSIEHLQNNGQLIFHENIVHSYPHSWRSRTPLIYRLAPQWFLKIKDLRERALDSIDSARWIPESGKQRFVSMLKNRPDWCISRQRVWGIPICIMYNPDTGEILKNKKVLEKIRSYVSENGLDSWWTNAEEISKEYPGYIPAYDILDVWFESGASQAYVLKKNIGFPADMYFEGSDQHRGWFQSSTLQSCRDEAVLPFKNLVTHGFVTDKQGRKMSKSLGNGVDPMDIIEKYGPDALRLWVADHDYTEDLKWNNSHLNRVKDIEKRLRNSIKFLIGNIIYVDKIADYSEMAFLEKWILSKVYEIDQSFDKSCKNFSIHKFLKEVYLFCTVDLSAFYFDIRKDTLYCDDPTETLPNSVRNVLSIILQFILKWLSPFIPFATEEAWAELGYDSSFFESKKIKAETRWLNKDLLSQMKRIRDIRSVVTGAIEILREKKEINSSLESDVTVYFRDSDMRFIDHITEICIISKMQCSRINDDVDESLFSLEGIDDVKVSVKRAEGSKCGRCKKILKEVDEICLRCKKVLEKQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG21</accession>
    <name>A0A5C0UG21_9PROT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">FZC36_01170</name>
    </gene>
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        <name type="scientific">Candidatus Nesciobacter abundans</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
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                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39045.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="174" mass="20280" checksum="E0FEF106ADDE518A" modified="2019-11-13" version="1">MLLDLHCEKKYDSIPINIQFVRKCFNVHEDLEDSYIEKLLKIACEKLESITGSSVIEKDWVLTAKRVEIKLFKGPVRNVSSISVKTRNGTYKTIPVEDYYQKINLGNRIIILSEKYMDKIIKVNYSAGYRVNELPGDLESYILRMFGDLYNGNMESKAEEYKVSKSYTMNEIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG53</accession>
    <name>A0A5C0UG53_9PROT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01135</name>
    </gene>
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        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
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                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
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    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
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            <begin position="46"/>
            <end position="64"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="160" mass="18817" checksum="51F7E83DFE33142B" modified="2019-11-13" version="1">MYEFNFLESTIFIVTAIYISIYDVIYKKIPLEGIILLLFFSKKNGYIYESCLESAAFLFLTFLAQKITKSYMGLGDYFLFFTYSLIVPYESITTFYTFSGLFQIVFSLILLGIKFTKNKPKNIRNFILFTNYKNYIYEHRKLRFSMAPAISLSALIVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG70</accession>
    <name>A0A5C0UG70_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Alphaproteobacteria</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="244" mass="27460" checksum="A47111850351B4A5" modified="2019-11-13" version="1">MNSNLYQIQNIFKRYGKKDILKDVSFSIPEKSIVGLVGLNGSGKTTLSSIVSGLKPCTSGDVLLNGKTAYKNIDEYKRTIGLCPQRTNLDNRFTVRENLINDAVFFGISDERININLKKVIKKFNLEKYLDFKPAALSGGYKQRVSIARALMHEASLIILDEPTLGLDPNTRKSLWDVVKNLKEEGCSVLITTHYMDEIEGLIDKLCILSKGKIFFDGTVDELKKNKNSDLDKIFNKLAEEECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG87</accession>
    <name>A0A5C0UG87_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dUTP diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_01345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="143" mass="16006" checksum="F7073619AF4F49B5" modified="2019-11-13" version="1">MIFKIKLLDEKCTPQRMTERSAGLDLRAKITSEIIIHPREKVLVPVGFCMEIPEGYEAQIRCRSGIALKHGIVVLNSPGTIDCDYRDEVKVILSNLGEAAYALQPYTRIAQMVISKYESPEFQLTDKLTESERKGGFGSTGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGA2</accession>
    <name>A0A5C0UGA2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="209" mass="23025" checksum="A79F3EBAB612347A" modified="2019-11-13" version="1">MIAQNNNMGSNLGKLENNRIQYGDGSSVDGINQLERQDSGSDLLIRMGEDTKKEVSNIEKYTCFHPMKSYHESFTGSVNKDMSNPNKTLSGKVISSYIEVVVPVGVFAMSMEETGLTNTGIKFIEVVRTQIVKKERVISESRIFVQSFVLGSAGQLGDHVWLQLGFNEVHKHINQYDSAGNPTGSFGYAYSNEKGTLLADGKLDPYSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGH1</accession>
    <name>A0A5C0UGH1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="5" type="ORF">FZC36_00450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="50" mass="5838" checksum="0E901C5C36DBA651" modified="2019-11-13" version="1">MYLMSKIIELKSSRLEQKMAFLSGQQKNTSKLRALRRKIAKLLSEEVKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGI1</accession>
    <name>A0A5C0UGI1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="176" mass="20188" checksum="05CC688CA48B1E38" modified="2019-11-13" version="1">MYSYNLSANSYVCKKVQKGRPKKNITPLSNQVFKPNEASRCENLSTLEFIYRVGKINKEEYEAGLFYEKLARKSIYLTGGPCVANFSSCKLSEKSSSNIKTSDNVQSFEVKILKKWKKIKQILICESNAVEMTVFKVIVENKMRKELLSIGNKDIKLLKQGLSVIFDYWSKINHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGI4</accession>
    <name>A0A5C0UGI4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="4 10">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FZC36_00050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="4 10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK38840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="230" mass="26623" checksum="94AD3E9E0EA17D36" modified="2019-11-13" version="1">MIRLYIEGCKPGKVHLKLDQIHYLKNVMRKKNTDKLEVFYNGKSWVAEIEFPNINVTEELNNANKTTKPILGIASIRKNKIEMAIEKATELGAREVFILKTDRTNHYFDDLPRLNKIAIEACEQSRNNLVPKINKLTTLQSFLELHTNPNVCHAFDRCFLENNNYINNVVKNEFNINPILIGPEGGWSDKEIDLFMQYNVNFVKIHENVLRAETAAISALTLWNEHNNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGI8</accession>
    <name>A0A5C0UGI8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="213" mass="24683" checksum="4C78D20B81DA72B7" modified="2019-11-13" version="1">MHKFHSIHNTTILVHKRDLPDDLIFGNSVAIDTETTGLHIYRDRICLIQICFNDGFCHLVQIEKGQKEAKNIQRLLKDENIEKLFHFGRFDMAMLYNAFGVMANPIYCTKLASKLARTYTERHGLKTICREFLAIDIPKEKQSSDWGADILTEAQKQYAAGDVLYLHQIQENLNEILVREGRIELAKKCFDFLESIVRLDCAGWHDMDIFAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGJ1</accession>
    <name>A0A5C0UGJ1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-erythrulose-1-phosphate isomerase</fullName>
            <ecNumber evidence="2">5.3.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-erythrulose 1-phosphate = D-erythrulose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:49588"/>
            <dbReference type="ChEBI" id="CHEBI:58002"/>
            <dbReference type="ChEBI" id="CHEBI:90796"/>
            <dbReference type="EC" id="5.3.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.3.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="303" mass="34906" checksum="01C6735FCAEF4F0C" modified="2019-11-13" version="1">MHLVFFVISNWKGFLRPNFEQDLNVFLKQNKIDNITNIFAVPFVSLNMLNEVFSYHKKSIYTYSEQKNNPTAEDSNIFLSAQNSNYVGKNSTGNISSSMLKDLCTHILCGHSETRSEKYSLSEHAIDIITNNLIPIIFVENHLELYKLIENKSFIKSLSDKQINKLTVILEPKHYIGKASAAPIHELEEDFKQIKNLLKERNIEGKVCYGGSLNKENIWPYVDLFDGICFGRFSLSTDFFPTIYEISSYLKNNKYQNSNKSLDSNTYKNKQDLLNDNSLTKENHNTAKNLTNNKSQNTEARDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGK2</accession>
    <name>A0A5C0UGK2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="426" mass="48589" checksum="32D66FF0D074C011" modified="2019-11-13" version="1">MQNKGIEESMDGKKIIFLIFVASYNIKSTLENDKNSCINSATYKETLVDQKQGPLASVLSVENLAKMDEQATHLTSLSSKNNPDTIEKTSKTSTEAYTSTESSQHNSLSSNSADSSKSSTKLESQSKDEKALHDSYDSKKDTKDNETKSRSDCMLSDIESVSETKTPEITSAEPTRTSQQVTIFSQGTSSDRSQNQEIILVGEHFLKEQLYTLMEKERMVLETQKKVYDMYDSLYEKMNNARKEGKAEFREDMKDLKEEHKNDKKELNDDHKVNMENLKNSLSGRIRDLENDVKKLALQITSLQDDKLKLSIDLARYKTKYDDFSDKKEEETSLLEKIKKERDTLLLEGKDKENSITRMKLEMEIFGEKMKNQLEKKNEQIDKLKIEEMDLSRKAFNLDQRASVLGNPIGSFFNTVTLGLVGAVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGK5</accession>
    <name>A0A5C0UGK5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_02100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="4">
        <location>
            <begin position="44"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="3">
        <location>
            <begin position="188"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="590" mass="64854" checksum="0E1BF1B600DA2B42" modified="2019-11-13" version="1">MEVRVFSTVLFTKRGCFMSKKDFDSKKISSLEDRAREYHSSFPNGKFGMHSTKPLSHVDMSLAYSPGVAVVCSDIKENPKMVMEYTSKQNTVAVISNGTAVLGLGNIGPLASKPVMEGKCVLMNGMAGLYGVDIEVSESNADKIIECVAKIGDSFGAINLEDIKAPECFVVEKELQKRLDIPVFHDDQHGTAIVACAGLENALHLVDKKWSDIKIIVSGAGAAALACLDAMVNLGLKKENVYLFDSKGLVSESRDDLNEYKKAYMQKESVEFKDAFKGTDVFLGLSVAGKLKKDMVADMNKNPIIFGLANPVPEIMPDEAHSVRSDCIVATGRSDLPNQVNNVLCFPYIFRGALDSESKKMNWEMKKACIDGISKIARISDKFGKDFIIPGPLNELLSQKVSQAVAQAAFETGVGKKVDDHGVLIEKRLNPNSEYIFNSKGKSAISLKGNSSETSFIISELFKCWDLNLDIDIESHNTLLPISNSCNAERLLWVFGLNDKPWIALSETGSEKSKVIKDLFKSIFGKDLLIVPVVESSQCRDLERRKDFCGRLSMTINQINMEFNNKSSVRNAAYLGILLTRIADVLSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGL2</accession>
    <name>A0A5C0UGL2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007459">
        <property type="entry name" value="DNA_pol3_chi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036768">
        <property type="entry name" value="PolIII_chi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04364">
        <property type="entry name" value="DNA_pol3_chi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102400">
        <property type="entry name" value="SSF102400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="166" mass="19605" checksum="3099E15334CF25EB" modified="2019-11-13" version="1">MKITSYYTENENDVKYIFSLMHKLYKLGKRIYLKTNNVVEQEVLSELFWKFRTFLPHGTTEDQYQELQPVLVSGMEFEDYIAEKPKAAESNKDCNQEHQAFSTLIIYRHPNQYTESMINKVSGKDISGSLSEVIFWNPDQHKNRMMLVGKVWIQQGINWVELKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGM4</accession>
    <name>A0A5C0UGM4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="177" mass="21090" checksum="EC7C68082318A1BC" modified="2019-11-13" version="1">MIFNKIFYEFCSFLVSFLIMKKFLFPFIKRYVFIYSESIENSVKDRSDKINNLELELSSMKSKIDELKEEYKIKASKLPQKEKELIEKLIERHSKILDSKSKFLETEINNMWSTSSSRMKDECKKIIFNEVKSKILKMNLDFSSNLDTIKRVLNDFSENKDSDVVFEKSQDDLSRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGM9</accession>
    <name>A0A5C0UGM9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="15"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="467" mass="52347" checksum="2E9A93255AEF1A6C" modified="2019-11-13" version="1">MILKNLVINGKEILPLVEGGKGIYATNGESAGAWAACGGIGTISAVYSDIIRNHITISKGIDGFSGATRADRSQQLADHSIEATISQVKIARERSNGNGLININILWELAKTKEILHGVLSKVGDLIHGVTCGAGIPYQLGEIAAKYKVMFYPIVSSAKVFEVLWKRAYKKYKDYLGAVVYENPWRSGGHLGISNREDPNNPEDSLGRVRKLRETMNDLDLKHIPIILAGGVWNLKEFEKDWINDPFMNPIMFQFGTRPLLTQESPISEEWKQQLFDLKQGDIKINKFSPTGFYSSAVNNDFLQDLQGISDRQVVYSKEINEEFNTPYKNIRRTIYIRESDLEKVTSWIESGHDKMLYTPDSTIVFVNSEKAKQIKEDQINCVGCLSRCRFSNWDNEAGTSGEKPDPRSFCIYKTLHNVSHGDSVDNNLMFGGDNAYRFAGDPLYKKNGNKYIPTVKELIDAIKSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGP1</accession>
    <name>A0A5C0UGP1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="251" mass="29692" checksum="E38051A0ACB31429" modified="2019-11-13" version="1">MILNFTFLKFTFLFLVYIIPVLNLYRAFYAIKILENPSYKKNKILLITIKDYFKNSDVTDSRFKSLKCDLDHFFQYEPSLIMLFSFPMILNYFYKEYFSNTLVIVSEIFFFCILITILLCRRNFFARVFNYIKRNLSDTKSHESLSLSIDKKISDALKGKNLNFNSLINKLDVLELKNLEIILEKVQKIDQLASSLEKMNEENMALKNELKEAVEHNMQILQSLDYNKDLMIKIGEGFIDLKKKIDSKDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGQ5</accession>
    <name>A0A5C0UGQ5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="193" mass="22021" checksum="F7199C038F58F4C4" modified="2019-11-13" version="1">MGSSEILKPKLVCWDWSGTIIKSDNLNYFINNYLFWKNELDVFPFSQKEKMKKAWFSFDKSMKSKIQREYKNVEERVEPCINPYALGLIDFFADHEIKQGVVSLASSKQIKVHLGLLGLMQFDFILGSDSGKSPKPDPSTLIDIAESLKIDPRNIWVIGDSELDMDLAKNSGGFGIRVESGLKPVWDMIDKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGR3</accession>
    <name>A0A5C0UGR3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022998516" evidence="1">
        <location>
            <begin position="28"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="295" mass="33292" checksum="D76B75076B1ABEE7" modified="2019-11-13" version="1">MNKKLKKILSKTLLCFSMIGITSISGASNDNPIPAKVISQTGFDFDPSQAMRNKQELEEYFSNIPEQDKSKYNSLEEHNTLHDLILSAHATKAQCTTSTYCKVDGENLSVYQKLFSVSETSSSGNQFERNFAKFSVPLSEISKWLVYINDTKSYGISYKYFLQKDFNLTEETKPFIDQLHIGKLIYIQESSKRGAFNALSEDGENSLLSAAIQINPINKDVVNLAISTLSNFSYTDLLFFDPFIDFASNFEGSISDDEEFQEHLKILHKSHSGIDNLRGFYNGLLAKVEQSELNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGT0</accession>
    <name>A0A5C0UGT0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FtsQ-type POTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_02550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35851">
        <property type="entry name" value="PTHR35851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA_1" evidence="3">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="307" mass="35999" checksum="1795D1732ED17971" modified="2019-11-13" version="1">MKQLGMLKKKLHNIFFSVFCAVSVIFYTIELRKYDIKNLKVSGNMISKESYIKSLIFRGCKHSKVMLKDQNKCIELNDKNLEFSEKGIITKNTAYSEKENFLSLGKLKLLDLSAKKTRKCIEKNKWIEKCTIEKIWPDTLKVSIQEYVPYAHSESAYFTLQGNKIDKDSKDTSLNINKDSNAFDNLGKLSKNHELCENHLIKMLGNFTQEDMLSLFRILEKYHDFRKIVKSANMIRPKRWNIVTNENKVIKLRTNEIERSIKRYMEFPMKNEYKIIDLRHPQRVIISNSNPTTKAITIIDAPALMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGT7</accession>
    <name>A0A5C0UGT7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_02600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="41" mass="4896" checksum="35C65D4BD95A5969" modified="2019-11-13" version="1">MKVFSSLKGLVSRNKYSKMIRRRGKIRIINKRFPRFKAVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGV5</accession>
    <name>A0A5C0UGV5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">yidC</name>
        <name evidence="16" type="ORF">FZC36_01140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="65"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QEK39039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="540" mass="62313" checksum="F2F1D19E5191A2CC" modified="2019-11-13" version="1">MDKKFNLKSLPRFVTFMMVAYLSYFTTDILVSKVFKNKSENKVINQKKPVTKIDEPYASGDYKPIENNKISGKVFKKGAIISEVSLKDYKKTIDSESLIQTIPKSSFFRAYWDLEGNTQAPNKNTEWSMENSLSSKQPSVMTWKNKTGDIFVQNSQIIDDYLIKFEYSMFNSKKEENIEGNLKVELKSKDFSYVSGIDQKIRRSNRSRTDNGYGWAGLEKDYWCSIIHSSQPVSVDYNKDKSNLTLTFPNIKLSPNTSQTASFYLFTGPKKLEMLEQYKKQYNIGKMDDVIHFGVMKSLKKLIMKSLLFISKKLNNSMVFASFVLSTLFVLVFSPLSYKSYMSIKKIKKLKPKLDRLSEIYGEDKVSIQKETLSLYRKENINPFGNILPMIIQILVLFSFSTVWSIIIEPRHQAFLWIKDLTSSDPTSITNLFGLLPFDLANGIQYLFDKVWIPFSYILGNVSIDITKFFKIGILPIISSSLILLQTPGEDSSESANNRKVMIFILSLFFLSNVSAMLMIHTIWYFFLTFIQNKIFKHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGV6</accession>
    <name>A0A5C0UGV6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplC</name>
        <name evidence="7" type="ORF">FZC36_00410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="230" mass="25503" checksum="86F4ABFFABEE8489" modified="2019-11-13" version="1">MSIERKRYGFIAIKQGMTQIAVDSESNVPDYVAGTLLWIQDTIVVDKKTKDRDGYESLILGVGRSKEKNWNNPQLKMFEGLDFIPKYMKEFKFENIDNFSKGQFVDVEDFLKIGSLVDIQGKTLGKGFSGGMKRHGFAGLRATHGVSKAHRSCGSTGSRKPGRVFKGKKMPGRYGNETVTCQNLEVLYISKEKLFEKFNGSLILVKGAVPGYKGSACNIYSSFDPKGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGW0</accession>
    <name>A0A5C0UGW0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="352" mass="40558" checksum="E953F77D51F74066" modified="2019-11-13" version="1">MFTKVFRFLTCFLVCVLISSCEEKDKWKEVGSDSRLSTIKIASSDYHNTRKPFRNKFKVFKSLDEHCDYSDCKSDFIYKDSYLSFKNKWKIKTELKDNVSVFDVKNYIVLGDFSSHVYFFDKRNGKLVKKDDINAPLSSVVCSSDRIVLSNAKSSLRAYSIDLKKMWDFKSGSTSVEFMRKALVRSGSTLVSLNSEGDLLGISTINGEVEWSHLSSKLSKRYALFTFSNKFLFMNNEKVSLMDYKGNLIKELYINKLKNIIVLRNSIFLICEKEVMETDLNNLLEGKFLLNYSTTNEHFFILDECLCSVNKNGNVKYYNSEGIHDFVNLNINIIGVKNNKVVTGSGWLEFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH08</accession>
    <name>A0A5C0UH08_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor RpoD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Sigma-70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rpoD</name>
        <name evidence="10" type="ORF">FZC36_00670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="348"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="427"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="516"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="585" mass="67395" checksum="D9DAB4BFE1DB2D0F" modified="2019-11-13" version="1">MSKETEDKVVKDSSSYNFDEIVEAEDKSSNFSFSDDPVRMYLREMGNVPLLSRNEEIEVAKAIEDGKKIMIDSVCEMPVTILRIMDWFGKVKEKSMDMSDFIDAEYPDDGTGACFAFDEDEDESYEELEKKILELEGLYKDFNDLRLKIKEERRKGIEDQDQKEKNSKNEKTTAPENSKDDLSLLKSKSDKKIAKLLDKYKDSHEKIISKINDLSISYFCIDKLINEVYSLKKAIQKIESDLIKEIESKGINRISFINYLNIFYKGKRNNYFNDSSINKDTAKEKKNESKLSLDVIKKIEEHKPTIDDYMSNAQEIINPLNMDLGEFDRVVKDMKAGEQKMSKNKETMVSANLRLVISIAKKYTNRGLNFLDLIQEGNIGLMKAVDKFEYQRGYKFSTYATWWIRQAITRAIADQARTIRIPVHMIETINKVVRTSRKLLHEHGKEPSPEEIAKEIGMPVDKVVKVLKISKEPVSLEMPVGSGEDGQLGDFIEDKKAVSPFDIMVQNSLKSAIEKAFSTLLTSREERLLRYRFGLGTKSDHTLEEVGKIFNVTRERIRQIEAKAMRKLSKSKELISFLSGIKTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH10</accession>
    <name>A0A5C0UH10_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022874550" evidence="2">
        <location>
            <begin position="21"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="451" mass="51529" checksum="E3C6ED9E76F738B5" modified="2019-11-13" version="1">MNIKQTLTYLILSGSMLVGAMNPIYEDSLNKGRQSVSQPEYEYPGSDQQPSLTRNLNPRNHTNKSRTSEAESDRVLERFAKMQVTELNSDQMYKNAQVANDLFFLRSTKNPAARIIVDAAKKDMDEQKIPQVDLTGFSHRTRILMIRELHLYSLNKYICLCKMFNIDPYNNNANWGLKFLIMNQDQSKCVVSLLLLPSVNQAGNAKVLEEGKYSDVFEKLKALQENKKLKKIIDGFYNARKTPEHHQRFKQDYGNYTGERYALDFLLDFEVSRRLLTSSIGVNGLITYEDKVGYDSNPIGVCISEILKFEPDDFWQVFMQTTNKNIIKAVNSPQKDTYKTSQNSGGNDNVYLSETNIFSGYKNKLRSNAAKKVLEKGLQSKLESATEIPAGSPEYYHQQLLEAFGGASESESDESDSNGDRVIFSRNYNELDYDAAMHMHQPKKYRKTTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH17</accession>
    <name>A0A5C0UH17_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="14" type="ORF">FZC36_01450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="13">
        <location>
            <begin position="61"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1e" evidence="13">
        <location>
            <begin position="242"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="365"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QEK39099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="558" mass="64412" checksum="B2ECC4381C058B9B" modified="2019-11-13" version="1">MITESRTIQKNKLSNNLGDILKNLNEKNIHIEQNAKKSTARNEKKPEIKLFNTASKSKEIFNPISKKNVKIYACGPTVYRSPHVGNARSFVVFDCLFRLMKFYYPKVSYVRNVTDIDDKIIIEAKKLNIEFKDLTKNVFKNFKKDCADLNVLDPTHEPFATNFIDKIIEDIEILIKNGFAYVSDDNLELNSNGSENTQGNSLEYKTEHSSKNKNENKDESNDQNAFIKSQDLCKSSSIDLKSQHVFFEISKYEEYLKFSGKSDLLSGARIEKNDLKKSDQDFVLWKPSEDVYWESPWGRGRPGWHIECTTMSKSILGFPFDIHCGGQDLIFPHHTNEIAQTWGMCQKKCANYWIHNNFVNMNNEKMSKSIGNTLLLKDVLENHNPMVVRLFLLMAHYRHPMNWTESGLDEASNIYKKWSKKLIGIQPGNPTEEFIEIISDDLNTTTAIKKISKDLKSLQNEINKSGLNDQKEIDSARRTESNYVSEKLCRIAANCSLIGIIFEANDQILTEEIEILIEKRKMFKKEKMYAKADEIRDKLKENGISIKDTKNGTEWEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH20</accession>
    <name>A0A5C0UH20_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">priA</name>
        <name evidence="12" type="ORF">FZC36_00065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="216"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="434"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK38843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="716" mass="82139" checksum="D00DC8251EF2D62B" modified="2019-11-13" version="1">MTNKIDIIKSMNTVDVLLTYSWSADNLYTYKTEGNIEPGTLVKVEAGSKESIGVVWNSPSRNTQTSLKNIEIKNIKTVLPYKITESSMEWIDLVSNYTLISKSLVLKMVLGSFSEKPGYFCSSHDLENINEILNTQTSKTSSQNSNKATIDIETNMENINPKQTYKFTISDTELNLIKIKKLLKENHISSIKFPILQKKQNPFEFSEDQKSCVAELSKLNGFNPVLLEGQTGSGKTDVYFELVKKVLKQNKQVLIILPEIALAKQIKQRFINSFGYSPYVWHNKSKDSVWKWACEEEYGVLIGVRSAIWIPFKNLGLIIVDEEHSNTYKQENGPRYNAKDLAILKAKKENCPIVLVSATPSLETVWNVQNKIYKHIKLTRQIKHELDIEIVKTKTWMSQKLKTNIEKTLEKKEQVMLFLNKRGFAPFVICEYCNYRLLCSECSTGVVCHKNFYTHCTYCAKKEKLQKICPSCKEEANWKMYGIAIQKIHQEMQNMFPDKNIQMLSSDESNEVDVAIKNILSGKIDIIIGTQILAQGCHFPNLTLVGIVQGDVGMHTGDIRHTERMYQTITQVKGRCGRADKKGKVIIQTQDDESILLKSIAENKTDIWVKEEMEMRQNHDLPPFSRMIRIVFGSSSEASIEKFVHSIKKPKISAEILGPAPTQLTKYKNQYRWSFLIKYKKGQFVQKQVKLWIDSIKSKLPRNIQIIIDVDPQSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH39</accession>
    <name>A0A5C0UH39_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="72" mass="7628" checksum="0AE7E480C69A22A2" modified="2019-11-13" version="1">MIILSAFLIVLTGIFMLFMGKIRSVIGVGLIGQGVNLLIISVNKPGNVLVQSIVLTSIVISLGFMAVLLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH46</accession>
    <name>A0A5C0UH46_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheS</name>
        <name evidence="10" type="ORF">FZC36_01080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="122"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="347" mass="40594" checksum="9816D80896D8937E" modified="2019-11-13" version="1">MGMIMDIQKIKKFIDSLFDPEYLKEVNTLEKLEKIKIDFLGKKGIFTSEISKLKNLSKEEKITNAKELNALKNKFLEFYEKYKDELDSNKKPTPTKSDITLPVYDEVGKIHPLRSCRSRAIKIMKDLGFEFEDGPSVENCYYNFDALNIPKDHPSRNERDTFYIKESADSKEKRNILRTHTTAVQIRALESGKYSDNFKVFSIGDVYRRDDDTTHLPMFHQIEGFVVSEEASLATLKHFLLSFLKMFFEKEDLEIRFRPGFFPFTEPSVEVDIKFKSGNWLELLGAGMIRKNIMEKYNMKKGFAFGIGLERITMIKLGLNNMNDFVKNDLYWLKTYGYSSFEHICYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH59</accession>
    <name>A0A5C0UH59_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_01300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="618" mass="71255" checksum="70573290C7B8628D" modified="2019-11-13" version="1">MKSILIDASDEKNLQVAIKEEERLVHFFYESNDKKSIIGNIYLGQVDHVEHSLQAYFINYGNEKNGFLPFSHAFKVLRKGEFIAVQVTKDEKDNKGVTLTSFVEIKTLLMIFVANKVKNMGISKKITSLEKREILQNWFNEKGFKESLNVIFRKESEDENLEALDQDCVNVQKILNTIEESYSKKEIHLIREEFNLAEKIIRDYYKKNTEIHIEGHLKIKDIIKNRIKIKPHKDKQPIFEKHEIMDQIEALYSDRINLPCGGYIKISYTEALTAIDINSGSCKKVKNIDENSLLVNLEAAEEIAHQIQLRDIGGLIVIDFIDMNSSSNEQMLEETIKLRLENDKAKFNVGNIDKFGLLSMSRQQIRTNILRSTHSKCSSCKGIGFLKLPSIIVSSIIKNIRIVAVKDGITKIIVGTRQEILTHILNSYKEQIFDIERSFNINIEFVQSNHNFQINYLQNGKLIEHDHEVIRKINEGKFALKPITYKKHATENLIKTNEFNRDNNILKEDLGLGLEGIDLENLDHANNPNKIEKISDIFDIASLSPMQDLYFEKNSNTIKKSSREKSQHINQSIKITQIKRLNKNPNEANVYDGSYYKDTNALIESLDSASNLQLKRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH62</accession>
    <name>A0A5C0UH62_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="112" mass="13267" checksum="D6D017D15A503BC6" modified="2019-11-13" version="1">MGEKMYELLEDVWKEIRKEIGNVYLGDKVCEFDKSCSVSIKSFVKNLDYINVKISCCFNFKKKDSEYYEQMINLESNIHNLKNNILIKDLKTKIDLEKSKVDIFIIKEIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH69</accession>
    <name>A0A5C0UH69_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="268" mass="29654" checksum="3D3D7C223DE0E440" modified="2019-11-13" version="1">MTLKKNTKEINQMLDLNIEEISSPIKSGKINLMLGVLQKIEGMACRDFKQNSMILDKNKLDFVDRFEKRVEKKIAEFFLNKVKGDGIIGKHYNIDSTNENNWVINPLDGRANFLRNIPIFCISVAFMTGNIVKSCVVINPLLGEIYQAEVESGAYLNDAKISVSKEVKENKLFGSCTNEEVCIDTANTRSLGCSTLSMCYVASGRFDFSVDLGKELVDVAAGALMVTEAKGFVSKSGVTCNNILGFGKQSLVSSSKMSKKYIQNNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH72</accession>
    <name>A0A5C0UH72_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpS</name>
        <name evidence="10" type="ORF">FZC36_01355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="376" mass="42989" checksum="B5642DD3669FC1AE" modified="2019-11-13" version="1">MHNSFSEQNIGFSAKNKEKTDKNNQPESFLGQNSSTQDLLDKSHTKQSIKKKRILTGDRPSGKLHLGHYVGSLQNRVKMQNSHEQYVMIADLQSLTDESFKSENILEIMKDYISVGIDPEKTTFLLQSQINSLYELTFYYMNLVTLGRLERNPTIKEEILQKGYKDSIKAGFLCYPVSQSADITGIQADVVPAGKDQIPMIEQTNEIVRKFSQQYNSNCLREAEILLSDQPKLVGIDGKSKASKSLNNAIYLSDNEKTLREKVFSMYTDPDHIHVHQPGKIEGNVVFSYLDSFYEDKEHLSELKENYKKGGLGDIKIKQILFESLRAFLTPIQNIRLQLKDEDMISILKNGTYNANIEYEKTIQEVRKSIGIYSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH87</accession>
    <name>A0A5C0UH87_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hemW</name>
        <name evidence="12" type="ORF">FZC36_01340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="460" mass="53753" checksum="DCC2080E924E1ABE" modified="2019-11-13" version="1">MPELDSIIDKKKLRKGVYLYIHWPFCRKKCSYCDLNSHVRDSVDQEVWIEAILSEINYWKENLPYDFVQTIFFGGGTPSLIKPKYIRKIINHIKSLWEYPDYLEITLETNPSHLETNSLKEFRDSGINRISFGVQSLNDEILESINRTHSGQEALDHIKEGLQIFNNISVDVMYGLPNQSIEVLEDTLERLISTGIHHISIYELTVQKGTLLHFQIKENHLTLPDDDKVFMFYKKIMQICKKHGFEKYEISNFAKKLVVKVCDQKVVLENNDVDRICEIDSEITKSENYNKDIKDKLFSKDKFLENINSFSGSSNESNKSFCDYRCKHNLAYWTSKPFLGIGPGACSRVEIDGKLYGLENSKIPEEWILNVQEKGSSLVDKEHINFEKDFLENIMMGLRNVDGIDLDELENRFKSKYESLFNKEKLQQLINSKYLIIFDKRMKLTESGLMRYNAVCKYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH91</accession>
    <name>A0A5C0UH91_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_01500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="3">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="267" mass="31091" checksum="2D392365F9597633" modified="2019-11-13" version="1">MSKVNSNLKKIAHVISLKGFTSRRKAEKLINEGKVFVNDTKVESCAIRISEDDSIKINGVHLEKAEFEFYILYKPIMYICSHNGQNKFKTIFDYVKRKNLPYLTFIGRLDYMSEGLIFLTNNSTLVDKFSKLYKRVYELRVNKVPQSFIEDIKNPIVDFMNLKPIKLLKNEIFMQKVGRVDKDINKNNTVNEHKSNNCFIRKENVITLELSEGKNREIRKLCEKHGMTIFMLKRISYGPFSLADLGRNSIKKISKDSFLKKVPSCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH94</accession>
    <name>A0A5C0UH94_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AA_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_kinase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="358" mass="40090" checksum="37521CA2B1482ECE" modified="2019-11-13" version="1">MCNIINPMSNVVIKFGGSVLSNLDNIGIVAKKIATEFKKPPIIVVSAMSGVTNKIESVIDSVYNSRDLQKDFVFSTGEMFSAGIFSMFLEKFGRKSEPLCGWQVPIETNSSHGNADIKAVHKERISSLLERDIIPVVAGFQGICDGRITTLGRGGTDLSAVSLAVEFGFECCLYKDVSGIFEVDPSIIKSKKLDFISYESMHNASLRGSNVVSHKAVKYASEKNIKVIVKSIFDESECTVISKKEGDSKNLIALQKAFCIKLTGLDIPEIENSIISFNKKWCIFLSESDYLKNKNNFMIEKMYKVNLMHEKPINIGIFIRIAKKYSEMYGNMDTYSWICVSKDKRKELTRELYECFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHA1</accession>
    <name>A0A5C0UHA1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023106637" evidence="2">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="427" mass="50154" checksum="C428E765E658F12D" modified="2019-11-13" version="1">MKKTIYIFTLIMLCNGLHAMFGGSEFEKLSDTNEFEKLSIPKVSKAAEASPVPDLPTKTSPMLTAAKLKQLNSCGLDELSGMNMLDEIDLDLVDWDLESASTNPMYAELQQELQKIIKEQEENNTLLSKLQDSENKVCELDIKNCKLQSENTSLKNQLEVFKRQYEELKEANKEKSTELKQGYSSLEKALYISSQRHEQKDLSTEEMKQNLKSLTEQNKSREIEVEKLKIELKSLTERYNQRTSEHDETLQSLSRNHDREIKMLKFNSFQDALKLKQKEAEYSAYKTKTQSEAESHSERMRYMEIKLEGLIKRFIYRYVSLSNQYKSLSSENKKHRKSLFILLESLYSMKWQTYECRNERLMYFESLIDECIRKFSGLTKRNKFEKLQDKKNTQQLESKEIFEEFIKNYKEITGHGLGLITRSCKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHB0</accession>
    <name>A0A5C0UHB0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="2">FNR</shortName>
            <shortName evidence="2">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_00625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="12"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK38943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="336" mass="37432" checksum="981ABD7F1A95CB9D" modified="2019-11-13" version="1">MCNSYPNAIYTDVLVIGGGPVGLFSVFMLGQVKLDSILVDSFAELGGQCKAVYPAKYIYDIPGFSKVLGKDLIKGLKDQAEYYSKEFILSSPVKSVEKIGDEFFAKIGDKVIKSKAVVISTGGGSLKHKKPKVENIDKFEKVIYKLDNLEQFRGKKVAVIGGGDSAMDWICALSKYTSDIYVIHRRNFTARNLSTVETVYNLVKRNVCKIFTPCEVVDLKEKNNFKDIDYVSIKNRETGEIKEIEIDYLVPCFGLDNKNDLPYNINGLETECHKIVIDPKNGSTSVDGIYAVGDASYYKGRPNLIVCGFSEAALCAFNIRETIFSDSGFIYKHRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHB3</accession>
    <name>A0A5C0UHB3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="209" mass="23245" checksum="6685561FD5BE6647" modified="2019-11-13" version="1">MISYVEKDWIIDGNGDVVICLHGYGSSSPDLESLGTRIKSEIPNSCVLGINAPLQLEQGGYSWFKMGKNINNWISGMRNSFDYIKERINHHGILDRKIIFTGFSQGGIVSAYSAFLGKESFDNCQNIVGAISLSGGALLEKKPSLESKFCMIHGTEDSVIPLLWSAQTIFTLKSWNIDHDFHVIEGMNHEINSEACKKTVQTLKKWING</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHG2</accession>
    <name>A0A5C0UHG2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tsf</name>
        <name evidence="7" type="ORF">FZC36_02040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="6">
        <location>
            <begin position="73"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="274" mass="30857" checksum="B55EC9F97E493EFD" modified="2019-11-13" version="1">MSEEKSLLEKIKSVRGRTFAPMGDCKKALMESSQDEEKAIDWLKKKGIASYAKRAGREASEGVAAFEIKDNAGVLLSLQCETDFVAKNEKFYSIAKFLATELLDKELEDIKIDSVSVSDYLMQQSSSLGENIKLGEVIKFDKKDNSYVYGYAHNKYAENVGRIATLVRVSKEDSEFGNNIALNIVGMGAQYLEFSDIPSEEKDRELEILKDSVASLDKSEEDKSKILQGKLEKKLRPSVLMDQVYVKDTKLTVRQYALQSSNEILEFKKISIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHH4</accession>
    <name>A0A5C0UHH4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="375" mass="43821" checksum="9E8ECAA49FFA65ED" modified="2019-11-13" version="1">MLKISMLTIMYIVLAIKPNAKNLSKEFMHNEAKNYESILQKQDNPTKEILDLPNIIRKTFDKPEAFDRIGEIISPSIFIKITKIVTNKSNPYLLSDVYTLSPDIGPFNVESKIILKQNYKINYQDIKHNRSENIFYIKSSDLNIQDAFNPESNEIFHKEYVAYSPIFNYDRNFYFFSNLDNSSDTKSPISFSIYCMDPENPEEEEKSSVTFKEIHEFTAIGNLFAVIELSKMSLEGILDPVTMNKFVPKELSAEQSKEEQNKHINQHYLDLYIGHSYTSAESFLLLKDNIKLESDNQSQNQHDYKNDEFWNIYGILYKHFSLTVNLNYLKESKIDQDLITLILKTLEDEIEEYKLQELVGEEYKAPDPYPLINPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHI1</accession>
    <name>A0A5C0UHI1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L7/L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_02220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="5">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="4">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="152" mass="16451" checksum="10C2877908250BA9" modified="2019-11-13" version="1">MLDKIIWRIFVNKKDILNSFSGLDSEEKKGTILEILNSLTLKESADIVTELKEAWGVSDAPVAQVQAQAADSENSGEAKEEKKDFELKLNEFPADKKAKVIKAIKSINASLGLGEIMGLVKDLPASLGTFPKDDANKHKAALEAEGAKVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHI6</accession>
    <name>A0A5C0UHI6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="111" mass="13049" checksum="6965A9779D04E0E7" modified="2019-11-13" version="1">MFVLSLLFALTKNSIDKQISQLLYSFKNHEWPYNVIMNDFIRSQCNEAYKEFAMSMIFSDLKKKNLITSKQFDEQEAKTKTCCLRCLVAIHVSSDESMYADYSNYLVRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHL3</accession>
    <name>A0A5C0UHL3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly scaffold IscU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="137" mass="14694" checksum="4DC52B07191B5BAF" modified="2019-11-13" version="1">MHKYNTKINTEFQNPANTGSMDENDPAVGMGFVGSPSCGDVLKLFIRIENDPNKSLEDQVIVDSSFQIFGCGSAIASGSHLTKLVKGKTLSEAEKITNKSIASNLELPPIKTHCSVLAEGAIRGAIENIKEKKSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHL8</accession>
    <name>A0A5C0UHL8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">FZC36_01980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="160" mass="18149" checksum="9749ECBEA935838C" modified="2019-11-13" version="1">MSQKEPITKTGLLKLKLELNELIETVKPKIMKELQYARGLGDLSENAEYSAAKEKQIEISKRIEKLHNMILNSRVVDTANIDKDFARFGAKVTLTDCDTGKEVSYTLVGKYESDIQKKLISIDSPLGKSILGKQVDQEFEFRAPGGHKTFLIKEIRYEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHM8</accession>
    <name>A0A5C0UHM8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="432" mass="49824" checksum="10E28444EBCF1BB2" modified="2019-11-13" version="1">MIVSKFKFTPYKVQWYEGMPLSPHHFQQSDLTNEKMMGYLISKTSPYHWGLIDMEVDSSKITEGIISINTIEAIMPDRSIIFYPIHDQETLHIKLEEEDFKTSNDLDIFLVKPESRNTYDSQTVSQGYESVTEKDVLDQNNEDHPACILKLKPKYQLAIGEIPNKHIGIQIMKIKNGISGIQIAEFDPPCINISKTKNTTSKIQELIKVLRKKTYYMQNNLKLNSDNNAEVMHSIFMQGIIPLDHILNSNYAHPYTLFTSLINLLAHISGLDKTILLQDIPKYNHKNIFKSFKPLFKFINSILDSIKEPYSLKQFINKDGIFFIDLPKETGNALFVLVKDYSMNFSETMQWIENAVISTQSMLEEALETRVLGLKREYEKTQEDSHVIIKINTDDRFFVKGEKLCIYNRSADKKPSEISIVSFANSSNELPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHP1</accession>
    <name>A0A5C0UHP1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ORF">FZC36_01315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="160"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="545"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="598" mass="68585" checksum="C700E62D895FDC17" modified="2019-11-13" version="1">MVKSNKSQIDEYISEFNLDYNKRVLSSSMTKDKINKNISISGWLAKKRDHGNMIFIDVRDHKGIIQCIIDKNHEKFEEIEKLNVESVIWINGLATARPKESINEKIDSGYIEIKVDSFVILSKSETLPFALHQEDIGEEIRLKHRYIDLRREDLKNRIILRSNVISEMRSALEEKGFIEIHTPILTSSSPEGARDYLVPSRANKGKFYALPQAPQQFKQLLMVGGFNKYYQVAPCFRDEDSRADRTPGAFYQLDLEMSFVSQEDIFEIMEGLLYRIFSKFRSDVFSSKPPFKRIKYQDSLMLYGTDKPDLRIDLQYLDFTEFFVENTPKIFEQVLQDGGKILCLPVNNLSSKSRKFFDGMNDFARELGAKGLGYICLSPEKKGSMSKFLSDEVCNKIKEKADGAFFLAGKFSEIVKCMDPIIKKISKEMDLIKKDRYEFCWIIDYPMYEMDDNGKWDFSHNPFSMPQGGMSAFDLDPSEIKAYQYDIVCNGIELSSGAIRNHDLDIMYKAFDVAGYTKSEVDEKFSAITEAFKYGAPPHGGSAPGIDRIVMLLSDMQNIREVIPFPLNQSGQDLMMNAPSEIEESQLKDLGLQSIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHP3</accession>
    <name>A0A5C0UHP3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thymidylate kinase</fullName>
            <ecNumber evidence="3 6">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tmk</name>
        <name evidence="8" type="ORF">FZC36_02175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3 6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="7">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="212" mass="24762" checksum="F76F638729725828" modified="2019-11-13" version="1">MLLFKKVLGLFIVFEGIDGVGKTSHINSLKDFLMNEGLDVIVTSEFSEPEIGKDLKQIFVQKKLANLEELLLVNALRSWHYRKVIQPALNNGKCVIMDRFIDSTWAYQINEDKNLAELFSIILTEIGMQEYDMVFWLTGKNHRNSNLISNNVSDRFDSNDSDFFEKVHRNYEAVFKNIPSEKLFKYENINFDSVQEMIRADVLKVYNRKLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHQ7</accession>
    <name>A0A5C0UHQ7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_02280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="270" mass="30731" checksum="88938A50E6B9B056" modified="2019-11-13" version="1">MSLETNKKKNLFSINMNSNFFSRVFTSVFYSAFWISLNRVAFYYKDIKNIQTKCLDLFGEIPPETWKVILFKYNVVVLTPLIVFLILLFVLNAEHLVQVFKSKVSVTQKICISLYLFVYSSLGSFFVANSYFIHVFLASLSDTFGYIFGKIFKGPKLTKISPSKTISGLIGTMFGAWVFFLLVDLKSFNKLIYVESYFRKINEFSPCAKIALSCLVGLVGQAGDISVSFIKRKLSIKDFSNIFPGHGGLWDRMDSVFAIAIVMSILRCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHQ9</accession>
    <name>A0A5C0UHQ9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="91" mass="10423" checksum="4B7EE1B5F885DF98" modified="2019-11-13" version="1">MKTIILQAIIISTFLSKFSLMLSVSFYLFSVVLLRLFSYEIWPKNIINLIYSISTGVLFAHISRNILKGFDSYSLGILVFLLFFAMSQKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHR3</accession>
    <name>A0A5C0UHR3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplD</name>
        <name evidence="6" type="ORF">FZC36_00415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="211" mass="23668" checksum="D5F3788FF5F607D6" modified="2019-11-13" version="1">MNLKINVHSWNLEKTEEISISDAVFGLEDNSSLIYEIVRWSLMKKRQGTACTKGVSEVSGSTKKKHPQKESGKSRIGDGREPGNRGGGVSGGPKPRDHSFKMNKKQRMKAKFISLSQKYRNNLLFVVDGDLSVKKTSEMKKIFESLKEINKSKKVLFVYSDIDSSVKNAASNLVGFNVLDFKGLNALDVLKNDLLIMDKKSINTLNERLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHR4</accession>
    <name>A0A5C0UHR4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">FZC36_01470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="12"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="408" mass="45017" checksum="138CDCA25D0C5BB3" modified="2019-11-13" version="1">MNAENKEYTNKESIFQLIKEEEKRQKETLSLIASENITSKDVMIAQGSCLTNKYAEGYSGKRYYGGCTVVDKIEERAIENACALFGAKHANVQPHSGSQANMGVFFGLLNPGDTILGMSLQSGGHLTHGFKVNFSGQFYNSISYGVNNDGIIDMNEVRDLAIKHKPKMIIAGISSYSRILDWKKFRSICDEVGAILLCDIAHVSGLIAAKEYPNPIHEADVVTSTTHKTLRGPRGGLILTNNSDIFNKINKGTFPAVQGGPMMHSIAAKAICFESANQENFKNYIKDVIKNAQLMADELSTDFEIISGGTDTHMFVVKLNDCSGKEAQKWLEESGIIVNKNTVPNDKKSPAETSGIRIGTPSCSSRKVDKSTIIEISRYIKEIINSKGKNNFKSEIEKICYKFPILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHR6</accession>
    <name>A0A5C0UHR6_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_02545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="655" mass="75274" checksum="D3BE6AB887F8EDA5" modified="2019-11-13" version="1">MLSNLNPSQREAVDCRKNLLIVAGAGTGKTKTIVSKICHYISLGIVMPDEIIATTFTNKATQEMHSRIKSEIGDDVDLISIGTFHRLSLKIVQNHAKLLNIEGCNLIAYEDQAQVMRKVLSNIKNKDIKPSHALETVQRAKEKNDYASLNHTYANIAYAYNDMLREMNALDFADLISKTIELWRNHKDILDHYRKKYKLICVDEYQDINDAQYEWISLLSCDDNQICCVGDPDQSIYSFRGSNMSHILNFTRDFKNSEKIVLEENYRSTDKIISNSNHLISKNKNRIEKFLVSTLKSDELVDIFVGMHGKEEAFEICRIIAKIKSKEEVKSSIALLFRTSTNMHLFEEALLNANIKYSIVGSVQFMDRAEIKDAVSYVRFLSNPNDFFAFSRMIQAPKRGIGSATVAKISENASSNIEDKIRGVLDSFTSRTKNKLSEFLAQWERWRSILSKDLSDSKKLRKIMEIIVNESGLYESLESDRKENVDKWLETLDSFEDPESYVNHILWNNLKADDEHDVKLMTVHAAKGLEFDYVFLPVFEDGIFPHSRSFENIEEERRLAYVALTRAKKKLFITYAQSRVFQGRYMNAQPSRFIREMDSKSLQFQSFKHKTLAGKKVYHEEFGYGTIEESGMQCAKVCFGSVSKVVDIKKLVECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHR8</accession>
    <name>A0A5C0UHR8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_02400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="92"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="406"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="529"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="615" mass="69860" checksum="8F7AFA1C5EF78FAA" modified="2019-11-13" version="1">MNIFYLGKKTLRGNYLSFNDSNNEEIKKVQDSFDLNRLEAILALSRVEGIDKLGNIHKFLNDRISAYMQNVTLIDFEKALERIYIALEKKEKICILGDYDVDGITSTVMWMDFFRAYGIEVEYRIPNRSDGYGHDPDVLKSIDCSLFLILDCGSSQDFYGIQKNTANNSKKDICIIDHHQTANDPNVYAFVNPNRADSDIRTQEEYKNLCTAGLCFIFIYKISEMIEERKKVRQNISPKVFMDLVALGTIGDCMKLSGLNRAYVRYGLQIVSLTKRIGLRSLIDNLGLGNIAAGDVAFYICPCINAAGRIHSSGLAVDLLFTKDSVEAERLSKSLISLNTKRKEMEKKALDEALVKVYKEIHKEIKFMDINNNLEPDKQRDSEEEKIPERDDANNEPNVDSKQKSDNESQSVVIVRDKDWHPGLVGIIAGRIKEKENVPVFVFYKIGNEWKGSARSVKGCNIGAVIHESVLNGLATSGGGHDMAGGVAVNDEKFSEWKNWINQKIHKMNLVPEKIINIDAFLNLNGLNMTNVSKITPFGMGNPYPKIILSNVLMLSVMERGNHIMISVKDEKYKRTFWMFNSKEIAKDILENRYYDLILSLSEKKNHNVIDILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHS0</accession>
    <name>A0A5C0UHS0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplX</name>
        <name evidence="6" type="ORF">FZC36_00465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="113" mass="12550" checksum="A729B0A385E311BF" modified="2019-11-13" version="1">MKKNKNFDMNTPKFKIKKGDIVMVISGKNKGSIGPITKMFPKECKALVENINTVKVHQKPSQGQPGSIVEKTMPIHISNLSHVESGKPAKVCYKIDGEEKTLVFKKSGKKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHS8</accession>
    <name>A0A5C0UHS8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="269" mass="31203" checksum="6A57D8A451052B1E" modified="2019-11-13" version="1">MNKIKSLKVASWNVNSVRVRAPLIEKLIKEEDPDVILLQETKCVDADFPREFFQDRSYEHLYISGQKSYNGVAIISKIKADSYSTDLKNNTGSEARYIEAEISGLRIASAYVPCGNKSDEAYEYKKEFLSNINTQMKGSKFIVGGDFNVAINDLDIQTPKKWEGSVLCRDDVREKMHDLQKSNFIDHAKTLEEMYDPSKSINKENSNTKSRDSKMPFTWWDYRRPNEGLRIDYIFTSEMNNECNLETLAEYRWLERPSDHVPLLLEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHT0</accession>
    <name>A0A5C0UHT0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_02505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="151"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="225" mass="25993" checksum="5A050F7568DD8046" modified="2019-11-13" version="1">MFDLTELEKKFKHLNALEKKLGYSFKNIKNLIHAMTHPSFHKSDFEMLEFIGDRVLNLAIANKLWNKKYKSEKEYAEKLATQVNRFSLLKIANIWELDKYILWSGSDIKSILVDACEAVIGAIFIDGGWEKANDLIHSSWPDETMCFEELDPKSVLQQWGHKTAASYKYKTIEKVGPAHKPQFTIQLTVNQYIVTTTSTSKRTAEKQAALEFLKKYTDLIPDQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHU9</accession>
    <name>A0A5C0UHU9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CvpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="176" mass="19712" checksum="79AF5D87D24332D4" modified="2019-11-13" version="1">MDNSKIMDLISLGIVIYSSLFGFLRGFVWEILKIVSILGSTLVSFWAGVSLFGRFNSLSKIWMRYALGFGSGFGIFMIVGSAMLSLVSRVSSYVKKGHMRTVDKFAGFIFGLLRGIMVILLLGFIVSQLDLGMNDMLKDSYVMRILESNNSVITGLRNLLYFSADRFSSFTENFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHV2</accession>
    <name>A0A5C0UHV2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_02230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="234" mass="25138" checksum="8E75B0D00B5DFABF" modified="2019-11-13" version="1">MGKNINNAGSKLKKILEDKKVESVSLKEALDLIKDLKFAKFEESVDVSFNLKKDPKKANQPFKVAIPAPKGTGKKKTIAVFGSDSEIENIKDSGADYLGNDQLVEDFKSGKIDCDICLSSVEGMKYAKKLSRILGPKGKMPNVKLGTISQDLDSLVKSAIKGIIFTGADAQGNLHAGIGKISLGTDSLVENFTALCEKVLESLPKGMDSLNSIFVKTTMSPSVEIDKNSLKGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHV3</accession>
    <name>A0A5C0UHV3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="256" mass="30373" checksum="ED4794F276561F7E" modified="2019-11-13" version="1">MILELKWVEKYSYNNFSFNDSNSSVCKWINSEKIYNQTLLIGPRKSGKRHISFVWLAKLFQNYKDKSIFNHIECDENSSYKKHFDINSFDVELYECMFSDNKTLHLFNNACSTTYEKWDRISPLIIRNNNIYKEEEMFEIFFHANANAIPVLWVFENPEVINEFIPDLSSRLKSINLVSIDTPDLDILKTVMIKRFSDYSLNVSNEFCRFALYRICKSYESVNEFVLKVHELCLQKHRAPTIPFLVENNVLGYDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHW2</accession>
    <name>A0A5C0UHW2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="7">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FZC36_00130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="52"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="180"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="252" mass="27401" checksum="06D8569D1969EAC2" modified="2019-11-13" version="1">MGVANKMSIAYGALNCLLDQGAEVGFSYHPLAAKRAEKIQSESGSSFAIECDVEDPKNIERFFQQVEAQFGKIDFLVHSIAFANTEDINGNYYDVPKDGFLKAMNISCFSFTSAAKYASKIMNENGSMVTMSYYGAEKYIPNYNVMGVAKGALETSVRYLANDLGVEKSIKVNCISAGPIRTLAASAISDFKKLLDWHENNSPIRRNTTITEVGNNVVFLASDLSSGVTGQVIYVDSGYHTIGVKGKDSDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHX0</accession>
    <name>A0A5C0UHX0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name evidence="2" type="ORF">FZC36_02335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="280" mass="32269" checksum="4FB51F07EC7ECC49" modified="2019-11-13" version="1">MENTTKRAMSHELEKILFEEIKVLDQGFVRVIDYMGNDSSIVQAARISYGKGTKTQSSDAGLINYLFKNAHTSVFEMCEIKLHIKAPIFVARQWLRHRTANVNEYSARYSEMEDSFYLPNKEDIKGQDKTNKQARGLELEDSIKQESQDMIHNLNTESYKAYLSLLEKGVARELARGILPTNIYTQFYWKIDLNNLLRFVMLRSSNHSQQEIKAYSDTIKHILKLWTPMVYNAFTNFNQMSLSANAIEVIKKAIKGEKVSREGTSIGKSEWKSLEEAFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHX4</accession>
    <name>A0A5C0UHX4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="8" type="ORF">FZC36_02355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="98"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="188" mass="20891" checksum="0EB3B1631B757710" modified="2019-11-13" version="1">MIKLQARQNFGTLEAQNIRKLGYVPVSIHSNGKSVHGSISFKEVSQLFSEENFMIKKLDLELDGNKYKTIINKVEFHPIHLRPISIDFLDLNPSRLANINVPVSFINKDKSPGIKLGGILNPLVRKVEVKVLTSEIPSAIEIDLTGKNSGDSIKLKDVSIPENLRVMKLEPNTTLATIIAPSKPKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI08</accession>
    <name>A0A5C0UI08_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_01000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="163"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="352" mass="41519" checksum="F97C2C2434C1EA19" modified="2019-11-13" version="1">MKRSNLDVIYNILEKQQYSELLKNKFKDFLFSLFYKECKTYNTVESYFFDIKLSLDYFISQKITLNNKDNTNNKSGKSFQIEKCLSKEIDSADSTCESSYEFCLSDVEKLTSWDFRSFYLYRKNKTNIKSVSQRRLISAWKSFFDFLGLKNILYGLKIKTDKTYPKPVELRNIEKLFEVKEGDWVSFRNRALWSLMYCSGMRISEVIALDIKHWTECKDSMRIVGKGNVERDVPILQFTKDFIDEYLNLHPYRKTQDSPLFFGKSGKRLNPQTAAHTIRRFRISNGISDNLTPHSLRHSFASHVLNNRCSLKDLQNVLGHKNLQTTSQYVEIQDKNLEESFMKIMDEDEDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI16</accession>
    <name>A0A5C0UI16_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FZC36_01050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="entry name" value="PTHR31187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="477" mass="55427" checksum="F34EF228E81B3A59" modified="2019-11-13" version="1">MFFSDIKAKERKRFFTFLSIIVLTLFNSSVLKTLKDSVISSQESGIEVVHYVKLFMVMPFSFLFIFLYEKLNSIYSRQKVTYIIFGLFGLFFFLYGTLIYPLRTYMHPSVSSIRALKESYPYFKWIFVAYGSWTFMFFYLFAELWSAICLNLIFWQLTNHTMTLKQGTYSYVYLSVWGNIGLALGGAATSFLFRSVYFSFGNIFCFLNVLVTSVVIAIIFLYYILYSKILDPKIVENLNVSNTSKKKKLSFYSSIRVVFSSKYLILMMMLVFCYHVSANLIEVTWKACLKLLSGNDSKFASYMGNMHFTVGIVSIILCEIPKYLVKKFSWRFCARLTPMVISVFSGLFFLVLYNDSLYFVRNYGLLIVIICGSMNYILGKIMKYSLFDPTKELAYIPLSSELKDKGKPFIDVFVSRLSKAFSAFIQALFLMIFPDSTQITIANKLLYVVVIFMVVWFLVINRLSEKYEKLISQNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI53</accession>
    <name>A0A5C0UI53_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">serS</name>
        <name evidence="12" type="ORF">FZC36_01995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="164"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="408" mass="46846" checksum="0345411B43CAFEEE" modified="2019-11-13" version="1">MLDIKWIKENPKEFDRNMLLRRESHKSSELISLYEKWKTEVSKIQSMRQNLKQESAEFQGKVDLQKEQAKENIKNIKLNIKESEQIEKEFKKSLDEALLTVPNVLDSEVPEGDSESDNITIRGFGDKIELQKTHDEILSGSLSWHEANMSGSRFVVSSDKLATLERKLANWMMDFNVKNGYKEFSLPYLVLEKALFNSGQLPKFRDDLFRCDDKFLIPTGEVPLVNLGEGKFFLENELPYKVTSLTPCFRKEAGSAGKDTKGMIRLHQFHKAEIVAFCTEKNSDQIQNEMIANVEKILQKLGLSYRLVAICAGDIGFTASKQYDIEVWFAGAKKYREVSSCSNCKTFQSMRMKCKYIDKETKDKKFVHTLNCSSIAVGRILAALLEQYQEKGNAIEISNYILDKLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI59</accession>
    <name>A0A5C0UI59_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="279" mass="32144" checksum="6C835F016566B0DF" modified="2019-11-13" version="1">MQKKKSKLSNMPKEIKINKIKSEVIPACITPFDEHLNIDYASLRNVIQNFSESGIETIALAGTTGEGVTLTKEEKNSLIHFSKTHFPEIKVITCITDFRETDINYARNADCIMFTPQLFIKPSKESFFKYAEKICSFNENIILYNNPSRIGFDASEHYEELYRDFKNIIGIKECADFSEIAKYPKWKWFCGNDENYFACIKNKFNGIISSTANICPKIAVKLENEELWNNSAKQLFSIPNPAAIKLILKQRGIIKTSKMRFAIYEDSKEQEILNHKYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI68</accession>
    <name>A0A5C0UI68_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="325" mass="36038" checksum="00DE142DFC92C24C" modified="2019-11-13" version="1">MVNVKIAIIGATGLVGRKIVSILNERKFPISSLHLLSRSKKEVTIDGKLYKTEISEDFDFNKVDLVFGASSKDSVRKLLGPISDSDAIFIDKSELLRMDKDIPLVVPEVNPHKINSETKVICSPNCVAIAISVILNNLRKKTKIERMFASINESVSGAGTKALNALLNETKESLMSSVIQPQFFEKEIAFNILPQVGEALDDGKSEEEFKITSETHKIMESKFPVNITVVRVPVMVGHSIALHVMCDLEVEDAVKCLKSSDLFSVADEKGKYFTPRQSANTDKILISRVRRANGILSMWVCYDNLRKGAALNAVQIAELLDFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI79</accession>
    <name>A0A5C0UI79_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ORF">FZC36_02190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="156"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="254" mass="28847" checksum="A88BF42AF474DD77" modified="2019-11-13" version="1">MSNKMVLEKDKRFKFVIEYDGNCSEVGWQSQPEKISVQSILSDAFFKLTQERVVFYGAGRTDKGVSAFGQVAHLNMNKSFCLRKLKLGMNFYLIGKGVVITEVEEVDSSFHARFSAKRKEYKYSLLCRPSYSVMKTKAWHIRKPICAELIEESLARLIGVHDFSSFRDSSCQSHNPVKEIYKADCFVNKEDIDITFVGNSFLHHQVRIMIGTVVQVGIGKITLQEFDDIFSSKNRRLAGCTAPANGLSLIEVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-02-10" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI93</accession>
    <name>A0A5C0UI93_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NGN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_02240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="250" mass="28817" checksum="5A8AE3F42599974A" modified="2019-11-13" version="1">MFNFVIKFAFDPGETHLSKLYKFLETKLKELKVEDFLLEIQEKEVMVKNTTKTNFSKIFASALKKFPGIYYTYEDEVALKWYAVNVPSGRENTFSIKIRNIVNGDDNFGEVFLPMVKETAWDKLGNEKVLDKVMYPGYIFVETMHIGRLKNILQSLDSKIKPSILQETLSNDDIEKIKNRKEEDCFLSKKHSYSIGDPVIISAAKFNGLNGIVEEIHEDEPGEELKIAISMFGRCIYARVGFSDVKKIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIF4</accession>
    <name>A0A5C0UIF4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM peptidoglycan-binding domain-containing M23 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="405" mass="45414" checksum="78C3CC67BC6566F4" modified="2019-11-13" version="1">MSNKSAKNDICNIKMLKSRTLRIRSLSVFLLSIFLCSCNESEKVRRIYIVKENETIEEVSEKLNVSKKVLVDLNGIDNEYIQEGQVLRYTPKSSDENDLSLSDKNSDSVNKKNKFNSSKTSELDGKESNDSSKESEGSKALDMQSTDLNGKLNVTEESLKSHKDKNNNNILENESQNINKSDLGLLDEKKSKSKSTTLVERDSDLKASEDSKESVQKLKTPKNDNKKNKIEARLNIDSVNDLVSESELDKEISEEFKNFIPQKVKSKIVEKKKSAPKIVFPMKNGNIDSSAPFSTKHGNVREGVYILGSGDVVSSISGVIKFISKSEKDNNQKGVSGYNSGSTIFIEENRGSDQKYLIMYSGLESVFVRKGEILEKGSVIGSSKRKFFYRVWDGKQYINPSVIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIQ8</accession>
    <name>A0A5C0UIQ8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="100" mass="11558" checksum="7CA97EC39745AA8C" modified="2019-11-13" version="1">MNKKAAEKLNSDHFEVGDTVSAHIPIDKKRTKAFEGLCIKKTPKTALIRKIVNNRGMECSVPLFGNVRIEKHRSHKVRRAVLFYLRKLTGRKAKLKERFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJ73</accession>
    <name>A0A5C0UJ73_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="195" mass="22143" checksum="1A69DC66BCBE90BD" modified="2019-11-13" version="1">MSLVIFLQNPEERIGQNIGPKKRYKLNPAEKATYFFATMFVFFCLYTGILVKRESKQNISELRNLSNVQNAQKNTDSSSNPIHNDQKSINGAYDGNTPNNQGTLIDDGINKNRNTINNEQKTIKLNNPTETENSKNLRNQNNISYKLPNSKSIRTNPVKRNNLAKSTRNVSLKPLGPNKKYNSNITRKSNINKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJA4</accession>
    <name>A0A5C0UJA4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsI</name>
        <name evidence="7" type="ORF">FZC36_00315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="184" mass="20736" checksum="E41B34871E08F0B7" modified="2019-11-13" version="1">MILKTENLEDSVSVEISKNAVESTLESSSEVVKSAVEKKEITSKPEKPILDKIGRSYGTGRRKESVSRVWFKFLEEDSKEENLFTVNGKEINAYFKRSTHSSKATDPISFLKKKFLVKGFAKGGGLSGQADAVRLGLTKAIIKSDPEMHSILKAQGFLTTDARKVERKKPGFRKARRRPQFRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJC1</accession>
    <name>A0A5C0UJC1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rplB</name>
        <name evidence="9" type="ORF">FZC36_00425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="8">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="274" mass="29922" checksum="7E936CDCE2F268BE" modified="2019-11-13" version="1">MNLKVYKPSTPSSRHTKIVDKRSLWSGKPEKSLVKGVKKTGGRNSDGRITSRHIGGGSRKIIRNVEFYPAKLVGLSGTVERIEYDPGRTAFIALVKFSDEKLRYIVAPESVKIGDTIECNEKSPVSPGNIMTLKNVPYGTIVHNVEFFPGQGAKIGRSAGSEVSVLGSDGDHIVLRLKSGEIRKFDSRCFCSIGQVSNLDNKNVSLGKAGRKRWKGIRPSVRGVAMNPVDHPHGGGEGKTSGGRHPVSPWGQNAKGLKTRKKSKKNKMIVRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJD2</accession>
    <name>A0A5C0UJD2_9PROT</name>
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        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsN</name>
        <name evidence="5" type="ORF">FZC36_00475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="101" mass="11675" checksum="A7BB661E5A909F3F" modified="2019-11-13" version="1">MASIGIVNRNKKRVEMEKKYRDRRNKLKSIMKSKTVSMKEKVEAARKLNSLPVKSFSTRTALRCEITGRPRAIVKQFGLCRIKFREFALAGYLPGIKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJI9</accession>
    <name>A0A5C0UJI9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="74" mass="8557" checksum="F5D6EB54FD354D9A" modified="2019-11-13" version="1">MDEKQIMKNLEIIMQESIGKNTDSKSISNALKAIDMMLKYKKNNKKANNISLQNLTEEEIDSMIKQLDVQIKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJS3</accession>
    <name>A0A5C0UJS3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_01270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="394" mass="44379" checksum="B0638CC39998BAE5" modified="2019-11-13" version="1">MTFLILSLGLLLSKFWQETMVISINPLSEVININASYLGKASLFSSLGLTIGALFSGPINDRFGPKRTFPIYLILISILNAILVIYKMNFLLLNLIYFLRSLCIAGCINNIYVAISLIYFGDRLPKMTSMLYMMLFGGSAIIPILYKSLLSYFPVKSIFIVLSFIMVLFAIGIYFITPHKKPVKLNRDLIKKWKNALKNPVFLALSSVSMICIGGFYGLVSVFGSYMVRKGDFLYVIRNFSFFVRFFISLAYIQLIGRVCTFIASTYSSVRLNNKNVKNFLTYGIFLMFVGSILIFHGLYVDKLGIYGVFGLILFCMGSGIAQPATKTSLLNIAKENAGGIQSVVGSFNSIYEAIAYFLVFYFSYPIGSYAYMMLTSALCFIMFLSFKKFKEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJT0</accession>
    <name>A0A5C0UJT0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="595" mass="70384" checksum="D692A07EE4CAF8D5" modified="2019-11-13" version="1">MNVLFNAFLLLTFFIKNISCFYLDIEKKYEPEHTLESRNTLESLREKMPDKNVIGFLRCTKPLEYEITFEVKFNEKDVYLVKANTFISSERSFLSDKISMKLENGLLKLIIDQSHYQLYSGQNEDETFNETSDEMKYLKRTFDFISDKQVKREYKRQEKTRDEKYLKDKQERSLDALCQDSAREMKSIINEENLELNRMYIIFKNPLLDIAESSERKARERIEQEFMEEHVELLRSSKYKEIQTLKQFERLTSMESQIRTEIINKWVSDFTKIDSRKNSNLIITKQEEKKSFLKKLKKLLKNMSTKSRIIYNEIIYSKISKEIKSKAYEELEKSKEKEVNKAYKIIDLEVSKKQKTEGFPEILPKSITKAINNFKELTIAEIEYDYEQKKIETENTNPAHMQEIDSGDLLIIPSDCLMLISTYCDPGSYAALSQVSKVMFIRIYPLAPEQYRRNMLMHSLVSHINQFLSEFKINSKHSTIFSRSIGQTIYKSTQNLSGNYLKIYECKDILGQTINFYIKTLDKDNTTILEKYSIGKTITNNEGLVFLLKPFYKYFNDMLRAAGLIGLLSSEEMDIVDFDLKYSEYELERYSEHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJV1</accession>
    <name>A0A5C0UJV1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="592" mass="68186" checksum="7E36E03439AF060D" modified="2019-11-13" version="1">MKNKLILFALLTNHITSSYELELSNLHKNVQTSVLGHTFLSTKKSINAYLSKTVEEVKELTFEDLQTKISTWIKNMLSDIKETDAKKLELEVTTDTVLKIKENPKNSREILENKILIMTALYESQVILENHSLEDLRYEGISDKPSRELLNKKFKNEIAYLVEFFYRVNEKVKLENEFTCVSKHIRAFSINDKCDVNTMKLKIRFITDHIGKKVPFIYDANCKLGVKEIFLGSFIGTPELWIYNGNVIQEPAIHICELRKYTGIHFVYGESEGLDSATFVSQLLYNDSEKKEFSDLMKKLVEKYKDKIIFSGEIKRYGFPDKDTLFTKITKEMVFDTMKLATFQEDSAQKIILGLINYLQTIDNYHEHESILTEHKIQKKSKKNTCSKKKNKKKILSSKHEIKKTLESEQEEKIVEEVDIDNVETIEESENAIIDNQDVRAVSDTEATRDEDQFTREIKSDSESATEEELAIETNEGDEVASDNRRAIHLSKEEKINLISNALLSKVEGKSIFKKDHMLSIISDWLKHTNLYDKVNKVNIKGSHVSFHINNMYVKFALPHGSSSDGASKNVMGKIAKQISRIKQESEKSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJV6</accession>
    <name>A0A5C0UJV6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_01525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022843385" evidence="2">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="205" mass="20942" checksum="136360DF4BC1DBD8" modified="2019-11-13" version="1">MNMKKFVSFAILGLCCFNAEAGFRSSLKKAAGGAYGAAKGAAKGATKVASSAANVAYQGASYAGHGIYNAGRSAINSQAGQNAISQAKQAATEAGNVAYNSAKQTWDEGNYKNRVFDPNKVSQVVTGVAQYTTTGDSSGLKNTANNFYGRAKDAAHTGYVTGVSNVTGAVGSHVTGKINGMSGYSNEGMHQPSAPPMPKTGSDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK07</accession>
    <name>A0A5C0UK07_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gatB</name>
        <name evidence="12" type="ORF">FZC36_01935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="335"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="485" mass="55006" checksum="D704384BD9A69C94" modified="2019-11-13" version="1">MILDNKENSTKTNQGWKMVIGLEVHAQINTKSKLFSRASTSCEKPNSGVDILELALPGALPVLNKECLYKGITSGLAFGMKINETSSFDRKHYFYPDLPSGYQITQFYRPIAQDGIVKIWDAEGNIKEIRLNRIHLETDAGKSIHKNGKTLIDLNRNGIPLMEIVTEPDISTAEEAACFFRILQATLKAIDTCDGNMEKGQIRADVNVSVHKSGDPLGTRVEVKNINSVRFMKKAINYEFDRQIALLEKGEKINQETRLFDENTFKTSHMRDKEDSSDYRYMPDPDLPCFTVQKEVINSLESSAKLPYDICDKISKLGVKHSDAWTVAENPVLTNLFLDIEENFSTKGKKILFNWLIGDVSAYIKENQNTEINPIYLKNIIEKLESNSISSKVAKEVFIESINKNKNPLEIIKENNLEQTDSIEEVMKVINQVLEENPKELESYKKGKTNLEKFFLGQAMKITKGRINPVLLQTELKKELSKLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK79</accession>
    <name>A0A5C0UK79_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015223">
        <property type="entry name" value="MipZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09140">
        <property type="entry name" value="MipZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="240" mass="27320" checksum="90DB75106746EBAC" modified="2019-11-13" version="1">MKIIVINNIKGGTGKSTITANLISSLIDIGHKVCSIDLDSPQHTLFNYVNNRSEDLPLMECETMDYKGDCNEIKNKIDSLREKYDFVFVDTPGGDFESLKDICMMADIIVTPISDSYLDLDVVLQIKNKQSFMPGCYSKIIWDIKKKKSQDSKNLDWVIVPNKFNVRKTKNQESVYKLLSKASPVLSGRISNFIKDRVVFKELFNKGRTVFDLKKSELTVSRVAAKNEIRMLSKYVLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UKB7</accession>
    <name>A0A5C0UKB7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="192" mass="21989" checksum="A8793294C6F912A1" modified="2019-11-13" version="1">MNITKEQIVDFYKPCGAVKESDQSDLDYNEIRDKEGNLVQRYYSKAGEKEGEETLYEKSVITRRTNYSGNKMNGPMEIYESGNLLMITNYKDDLMHGPVYVFDANGISNKGNYKNGEKSGLFLVFEKGELLKQEIFQKNKLNGFSVTFYPKTGSIMESGMYLEDLKDGQWTVYDPEGKIIKKTYFESGVEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFF3</accession>
    <name>A0A5C0UFF3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-binding factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="90" mass="10816" checksum="0DC1B126DB3C4F79" modified="2019-11-13" version="1">MKPYKRNIRASEHFLDAIREIIWKMFGSICTVTRVKMSKDLKYADIYCNFINEESKDIIETSNKQIMNKIKQSWNSKYIPILRIHEEDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFK0</accession>
    <name>A0A5C0UFK0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="173" mass="19647" checksum="D6C5D5D84855403F" modified="2019-11-13" version="1">MHLSLKKENLVGKFLISSPFLDEKKFKKTLILITECVNSNIIGVAVNKKMSKSECDKTYKDYKIYYGGDLSPGKGLVMYDENIPGVNKVEIMKNIFISNLEEMFSKNIVPKSHIAVMGHFKWNYSSLIEEAKEGNWIPVEGFPSGVIGMAAPSKWYEAYHSINIRPECLCRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFK7</accession>
    <name>A0A5C0UFK7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ros/MucR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041920">
        <property type="entry name" value="ROS/MUCR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008807">
        <property type="entry name" value="ROS_MUCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05443">
        <property type="entry name" value="ROS_MUCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="159" mass="18301" checksum="BA4BCDE1B2958F73" modified="2019-11-13" version="1">MLGEKMSLKFNIDKKDISKQKLLQDSDIKTDLITHAVKLTSSYIKANPGISSDRIVTFLSDIKKTLEEVFEEKKKQNPAVPIGESVFQDHLVCLEDGEKVKVLGPYLKKFDMSFEEYKKKWNLPDSYPSVSPSYSLFRRELALKNKLGHPNKKSKENMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFM1</accession>
    <name>A0A5C0UFM1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_00160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="895" mass="100846" checksum="871B40314B6EDD28" modified="2019-11-13" version="1">MILFLFLICNAFSAAKSVDSNFNPDQGIDSKITRSIQEISKDLSSTENVSKTDSDKKVDQSLKIPGKVQNTKNKNSQLSAQDKPNLSSEKSNAVKSSPKIEVIGNGRTERDFIVGIAKSFIKSMDFTETSKIKNKLLESGYFSDVIVTKKNKNVIQIRVVENPILKSIKYKGSISVEDSMWEVITGLRPKRIVSLKDILIAKARIIRELEALPDSELEEIKIMQKTDKNSIDLIFDIKTRPKKTIDSILFVGNKNIPSGDLYANLEKSSSLFLYVFPRAHVMESEEKQKESLERYAKSKGYFDFRVKSIVCVDINKSRQMTINLEEGKRYKIKSVELNMPNNLKKYFDIKIGQYYEESDIFDRKKKAKCHLYEKQEFSKDIDVKTSQSNGEVEIRFFLTEESSRNVGLINIYGNERTYSEVILRRMRLEPGDKVSERSFAISKAKIASSGFSELADIDVMESEENLSDVKVSFKEADTGKIMASLGLDLGSYFSWNVGFGYQDLNMFGLGKKFNGSFVMKKNKASLNLDLAESYYNSGPFTKSYQLMFGLMDRNHSNYLLARSRSSFPIVFDFGTKADKGSLNFSTLSKELSESGYSDKNDDLEKSKDIGLDKDWSESEEGITFNKPGAEFKRNYSVSLNNLTTDLGVGGTLDYFTLKDTGDLTNTKRGVGIPRFYDKDHRKFDKIKYSVSGHADFTYGISNDNFGLKIHSANELSLGSSIFLKSILSGKLFAEYNDYGVVLSARCGKIFHGSKYSWIDNFKASESGVSGFKEFGPRELISYSTLGGTEMFSFKGEVFGPLLAKKIFEISWFSFFSIGSLCESSIKEKLIPNDLAKKRRWGNVADIVNNKRSLVSSVGTGLIVKFGRSKVRFSINYPVLGRDSSFNAIESFSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFP3</accession>
    <name>A0A5C0UFP3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase F(0) sector subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FZC36_00285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="13">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QEK38878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="73" mass="7407" checksum="E527F8550B841D77" modified="2019-11-13" version="1">MDVSTGKMIAGALALLPLLGVAYGLSNIFSSLFKATAQNPVAKDSMSNMAVIGAGLLESVALLAFVIAILIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFS8</accession>
    <name>A0A5C0UFS8_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="2" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="173" mass="20396" checksum="EE249955A4091307" modified="2019-11-13" version="1">MKFDYGFLKNLNKSCVDEFAKYVEIIFFLRREKPSIWHKMYKANAEETTLSFSKEFNDFYMLAKNNLSWLKFNDFLNNLYKVCKNSREKKVYKFSVASSSGYEILKDFLLSEFKDINFKINLKPSILGGFIIENNYERIDFSCVSKLKKILQNENSLREAKNECAGISSRSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFU9</accession>
    <name>A0A5C0UFU9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">M48 family metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_00805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="118"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="365"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="496" mass="58199" checksum="3474ECB07D9C3332" modified="2019-11-13" version="1">MDMELLMKILLRWFLIKFNYVFRIFKSMRFLLAISILSSCKSSLSSNRLTLDIEFRMFFDNIIRKSNLANKKIQKYKHINKLKKVNISSHDNKDETKEYPSNKLTKQENNFYTPKEQSKNKIRIYGDDSTSINAYVSINHLGSEYMVVHKGLIEKCTAEEAIAVIFHEMGHVKKSHIKQSIFKISKAQNYKLLMPTLLIPGINILGMIVINGIYNDLMMYSQQQEVEADSYALQTLQKLNWTVSGSYKLFKKFAENDKARDYFSSHPSSSNRQKMAFQYLKKEEGKIPDEIISHYKALQSRISKGLYIGGKRIGKPSNEYEKLWEGYLSGRDISKSLVEFLQKLDENSPMYVCSTYIKFLMELRLENYENALQSIQIINQKFSDREVEFCILYTKFHSYKKSKNTAKMKNLEHELLNYKNKDMFDVRIWSLLCSLYDFLGNRSHFYYAKAYNEFVSSGDIYKVNQFLKKALDGLNKNSIAFQECEYLQSVSRKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UFY0</accession>
    <name>A0A5C0UFY0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FZC36_00965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
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            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QEK39006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="103" mass="11383" checksum="2D1FE84B54567BEC" modified="2019-11-13" version="1">MSIEVNNIHRIKPIASYIVVKVLEETKTTSRGILLPNSKESPQKGEIISVGPGKKSESGQLKEIDLKQGQVVVFGEYAGTLIAQDESSKYLLIKEEDVYGTYE</sequence>
</entry>
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    <accession>A0A5C0UFY7</accession>
    <name>A0A5C0UFY7_9PROT</name>
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            <authorList>
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                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="291" mass="34389" checksum="D26F70767C0FFD6B" modified="2019-11-13" version="1">MLENILENAMGVKSMNKFKYSNESTDEHTFISQKPKSTWSDFLFLRLLMIGISIKYLFGTEKVYFLNFIFIITICSFLLFCFDYMKFCDFSLKKIIDIYSLNCYFNNIEVGSSDVDSFPKKITYFNKSDLEESPKEDFKEDYNESESQKNSYKKYLDKGLVNGYEYQKLNIFVVQIFIVRFVRNFLISNVFLKSLVVSLGIFISRKFESEGGFPAGVLFALGLKEFKYKEILIYLGIFIFIFVNIFPMLFGKYVFYTFKELKFINSVWLNDLSVFFLTVYSVLHMIKNLIF</sequence>
</entry>
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                <person name="Kwong W.K."/>
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    <sequence length="221" mass="25157" checksum="657EE453468CD602" modified="2019-11-13" version="1">MVLRLKLSKQGFKAIKVCFIFLFTVFVLGYFTPILCTALILLLFRDEKRVITDPDSCLPPCDGIVESIKKDIALDSVTENEYKDKKWNKIEIKNGITDIHVCRSPIEGTVKHIYYNPGLSGEQNIFYKKRESLIIVISGKTEIIIEHVSQNSLQSVSCYVKTGDLLKIGQKYANQNLGGYVNMYLPVEHELDVLESQKLISAETVVSKLEKLHNDFLKEIQ</sequence>
</entry>
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                <person name="Tashyreva D."/>
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                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
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            </authorList>
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            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
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    </evidence>
    <sequence length="132" mass="15496" checksum="00A3ECAC44F2FEDF" modified="2019-11-13" version="1">MIFRNNIPMKNILNGSVPSMHHRISVMSIKTSTENKLLSNEFCMTGEKFWGYIHSSSIVKKKNNVFDNFFVIISNISEKCLISSGFNWKNRYFQRYSRIQPINQNVGYVYVKDITENGLEQVSFNEQYFSFP</sequence>
</entry>
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                <person name="Tashyreva D."/>
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                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
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    </evidence>
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</entry>
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            <authorList>
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                <person name="Tashyreva D."/>
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                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="652" mass="74790" checksum="C0B0C0B1DA91CC83" modified="2019-11-13" version="1">MFRKNILENLMQKIKSISFRVLKNIALLFNKVVHIFLATKEILNFTMFFMYTLESFLKNIKFRKLCLFLGMVFVVLFENELSLILIWLMIFFSVLKYRSPIFIVIICVIICGLKNFHYTGLGFSYDTKSNLGYLARNYSESFSYIEYSLKTNYARVIFWSSSIITSLSLLLDVKIGKNPIHDIHYMGKNSDVGREESDIVDISSGILCSMFGIMKILSTNDILNTYVGYEIIFAGICLCLAKIQYKHLVSYMKYHLIASLFILLGVGYIYGQSGTMNIKDALSRNVDCSVFMLGLFFKSAILPTGSWVRFYSKIPSSLMFFMSAIITKVPLYSMSVFFSFNPSCFSPNFIVPYLFVFSMIYGAFLAYNSHKTKKILSFHITSQVSVIALLICLESYLFNGLICKDCCEIDSYFLDKNIVSPNVSFVNSYSSFFDHKISICESSLSFFDSILFKFIPKESFMLALRNNFFSLIYTMHHIWTKSTLFLFSEESLFNKNSTVQKDLISHKYSVNKLSTNEFVADFISKFSIFSLMGAPFTFGFLAKSLGMILVCLYGNIFFVLGFAITNLLTYISMEKYMFIKISTFNGSDNFNNVSETEGSLESDKCFDKNIQNCRNIQNSSTGNNDQNNSQKILISFISFMVHLSLILFVFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG45</accession>
    <name>A0A5C0UG45_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplT</name>
        <name evidence="7" type="ORF">FZC36_01085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="116" mass="13746" checksum="22409D923D3E4718" modified="2019-11-13" version="1">MTRIKRGVTKHARHKKILDQTKGYVGRSKNCYRIARNRLEKGLQHAYIDRRKKKRNFRSLWIQRINAAVRSLGFNFSTFKHSLKQNNFDINLKALSEFAIKSPETFDSFVMQVMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG62</accession>
    <name>A0A5C0UG62_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ORF">FZC36_01380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="580"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="589"/>
            <end position="596"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="637"/>
            <end position="641"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="691"/>
            <end position="694"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1081" mass="120934" checksum="13A8024A8F16EEA8" modified="2019-11-13" version="1">MNYTINQGDRKVPVEVRGKNNVAKKDTKNANQLSTKEKEVRDAAVKKIDSLLSKKSEKSEPRYFGGKGSSDNKDSEKRSYSSSEGRRFGGEKRFGDRPGYSNSSRFGGDRRFGDRPSYNRSSEGRPTGNRFSNERSGDSRFSGERRFGDKPGYGDRVGLEKKLGERPSYNRSSDDRSSDNRFSGERKFGDRPSYNNGPGRFGGERRFGDRPGHSSGNRFGDRPSYNRSSDGRSGDSRFGGERKFGDRPSYNNSGKFGDRPSYNRSSDDNRSGERRFGDRPSYNRSSDGRSGDNRFGGERRFGDRPSYNRTSDGRSGENRFSGERKFGDRPSYNNNGPGRFGGERRFGDRPGYSSGNRFGDRPSYNRSSDGRSGYGPRNLSNEENRNRKNVLDRFNKGGNNPSTARRGSSGPGGAKKTEFGQSDIFEKRTVRRNFSTPVKRNYSDRRGDERKSRFRGSDQNSNEKFSHRFLGQIHSADDVDFSSSSYFKKPRDRKKQKDNVIRVAIIPQEGISLIDLSTQIAVRSKDIKKKLEEFGVKNSNEMIDSEVASLIVESFGHKHKIERSEMNIEPEKGELSEHKRSAPVVTIVGHVDHGKTSLLDSLRKTNVTSKEAGGITQSIGASQIFLKDKEGFVTFVDTPGHEAFGSMRARGVKLTDIVVLVVSSDDGIKEQTVEAIDHIKAFNAPLIVCYTKIDKGRKNIDKIRQMLISHDIVVESMGGETLEVEVSAHTGENLDKFLETILMQAEIMDLKSHYECKASGIVIESRLDKHLGPVSSILIKNGKLKLGDAFVVGNTYGKARIMNSVDGKKIKEALPSMPVEIMGLKGVPFSGDELIVVENEKKARAIAEYRENNKDKSKSNDKKEVDILDYFKSEENFEMNFVIKADSFGSLEALEAAVNKIEFEKLNINIVRSGTGDINENDIMIAKSSGSIIIAFNVKAVSGIQKLAKKERVKIKTYSIIYEVLDYINNFAEHVLAPKEEEVSLGMAFIKAIFEKKKLGTIAGCEVEKGVVKLGSFARVIRKGEVIYTGKINSLKQRENDKTEMESGQECGIIIDEYTDYAIGDKIESFIIKKKNNSFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG65</accession>
    <name>A0A5C0UG65_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="216"/>
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        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QEK39096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="268" mass="30209" checksum="D283DE4DF35EEC9A" modified="2019-11-13" version="1">MIYKLKSLRETILNRSVRSFIKSEVSVTIKSLKDAIINSVIWSAMIAVTSGYILQSFGMSKNYGEFQAASLITSAVGFETYRTIFRLLSDIEGEKIILYYFSLPIKSNVVFFRLCVIFALNGVIMSTVTLLVLKAVLWNQINIANINFALFYLVVIVIASLFATFSIFLTAYTPSMQKIGNTLMRVLFPIWFMGGYQFSFAAAKSISNVVACMSLVSPYMYANEAMRGIILSSGEFIPIWKCLTVLVIMTVIFWKIGISKIKRRLDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG73</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">FZC36_01485</name>
    </gene>
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        <name type="scientific">Candidatus Nesciobacter abundans</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
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            <end position="19"/>
        </location>
    </feature>
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    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="78" mass="8813" checksum="E92056AB75901A72" modified="2019-11-13" version="1">MNKKLILLSLFFHILSTNAASIGESGLQQRLRENPELMDTQNSVKLTEFPEKYIKAIEAAKGLKFTELIENPKGSKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UG78</accession>
    <name>A0A5C0UG78_9PROT</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
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            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="197" mass="22412" checksum="9230FE8B5A34F1FA" modified="2019-11-13" version="1">MFDINALIHNYGYWIVFLGSMIEGESVLLTASALAYTGVLSIYKVFALSFVGTCIADQLLYNLGYYIGPGFLEKWKTSRKLFNRLKHIAIKYQNIYILSFRFIYGIRIISPIIIGVVKVDQKKYAILNIVASFIWAFISCLIGYFLGSAVSKMGIFNLKKPYIYLIILGLVGIVILASKLISSYLRKKYIRQGEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGA9</accession>
    <name>A0A5C0UGA9_9PROT</name>
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        <submittedName>
            <fullName evidence="4">SPFH domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">FZC36_01705</name>
    </gene>
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        <name type="scientific">Candidatus Nesciobacter abundans</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="328" mass="36933" checksum="EBB7EAC5FB6D1A69" modified="2019-11-13" version="1">MINNDVFIYVGVFVLVVVFITITSSLFIVEQQKVALIERLGKFSRISGAGLHFLTPFIEKVSGVISLRIKQLDVLVETKTQDNVFIDIMVSVQYKVLPNKVYEAFYTLDNAEKQIQSFVFDVVRARVPLIDLDDVFSKKDEIAISVKDELQEVMNNFGYNIIKTLVTDIKPDSRVKTAMNEINEAQRLRVASMERGEAEKILKVKQAEAEAESKILQGKGMAGQRRAIMDGLRESLDEFQKQIGDADPHDAMTLIMMAQYFDTIKDLGLHSNQNTILIPHSPGGMNDLFNQIRNSIITGNKMSDDMNSNTSEKKSTKKSTSASNFSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGB0</accession>
    <name>A0A5C0UGB0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="11" type="primary">dnaE</name>
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        <name type="scientific">Candidatus Nesciobacter abundans</name>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP043314">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_alpha" evidence="8">
        <location>
            <begin position="311"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_finger" evidence="10">
        <location>
            <begin position="574"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="HHH_6" evidence="9">
        <location>
            <begin position="828"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1142" mass="130635" checksum="99D69B7CFD4FD9AA" modified="2019-11-13" version="1">MYIPLGIKTSYSLLDSTVRINKLVEFLTKNNFLGAGFIDNHNLFGAMEFNEKFINSSLKPITGCEVKLENEKSIMIYCKNSEGYKNLCFLLSKSYENDLKNPFIYWSDLENLMKSKLEIVKSKPEKELSLEKLNLDDKHSKANNSIHCEVDLERNIERNSELGKVDLGLMAIAVPSEICEVNDIESCALKMEKYFNGSWCVGIRDRQENEFLVCKMSDLHKTPVVAIPKVNYIKKDDDEAYEALKCIKNGTYLESGFFNDFYLQTQEELEEIFHDWKEPLENTLLFAKKCSFILEKKKPELPKYTDNENECLREQAIEGIEKKGITKLENSQEYVDRLNFELGVIIKMNFSGYFLIVADFINWAKKNGVSVGPGRGSGAGSLVAYAIGITDVDPLQFGLVFERFLNPGRVSMPDFDVDFCPKGRAKVINYIVNKYGKDHVAHIVTFGSLQSKGVLRDVGRILQIPYPVIDRLCKAIPSIQGFNVTLEKFMENNADLEKQMKSNPNIKKLFDLSLRLEGLFRHASIHAAGIVIGSKPLHEMLPLLFDEHTAVTQFSLNYIETAGLVKFDLLGLTTLTIISKTLDVISDRRSGECDLGDVHSSVGSVSENMLDISKIPLEDDKTLDMLSKGHTVGIFQFESKGMKEVLVGLKPESFKDLIAVISLYRPGPMENIPKFIKGKHKEIKIEYLYSEMEKILESTYGVFVYQEQVLQVARDLAGYSMQEADLLRRAMGKKKPEEMARHQKEFIKRVCENTKSTKQKAEDLFNQIVNFAKYAFPKAHATPYALISYQTAYLKANYTIEFMTASMILEQQNTEKLAELIYETKRMGIKILKPNINKSERDFKVENDTTISFGLSAIKNVSGSCIEEVISKKPFVNMQDFYDRASINKKTMESFIKAGAFDDLERNRAKIFNEFNSEKVKKRKISLFEVIEDDIQKWTEEEEANYEFEVIGSYIDHHPLHKINPNNFGIKWISTRPTKEEDVEAVGLLENLITKKSQRNKIYKIGIVSDPCGMWRFIANDSAELAALHKKMVWISMQDKGKFLSVKNIYPLSEKLKRISRINVKIKSEQDLLNVSKKLKEHIISPSVSKDTVDSYDEIYKKPSGIELMLRFEQQPPLKIGYVNWSDSLMNSIKDIDWEAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGB9</accession>
    <name>A0A5C0UGB9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_01765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="506" mass="56420" checksum="58CFEE3EF68A554E" modified="2019-11-13" version="1">MNKKIFKVCFDMKLDKTISIKKSKKNKCEMLDGNITFFSNEEDFLLIGIELSKHIGIDNYNVNLDSNYLFETETNDLNSNFLSFGDKVKKLYEGLMLGSWKYSGHKTMNNEDSEASLDKSNLAKSGLMEINLSFDLEKSLLEFNNSNTNEFNQTLRDAIYEMNLNPELKKNYLKECLEKITYEIDEVRKICECTNFARELVEMPSNFLTPSIFAEKAKKIEKESENKKLKITIIEEVSGGILEVSKGSLEKPKLIVCEYYGGEGEILGLVGKGVTFDSGGLSLKPAKSMEDMKTDMAGAANVLSIMKLLSDTNSKKNVVAVMPCVENMPSGSALKPGDVISAMSGQTIEVLNTDAEGRLILCDALWYIQEKLNAKTVIDFATLTGSVVVGLGELFAGLFSNDDFLSESLIKSGKRKSEFLCRLPLHKNYDKLIDSDIADMCNIQKPGSGAGSITAAQFLQRFVKKDTKWAHIDIAGTAYTSHKSMINLRKSTGFGVRLMFDFIQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGE8</accession>
    <name>A0A5C0UGE8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FZC36_00340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="8"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022658645" description="Glycerol-3-phosphate dehydrogenase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="11">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="12">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEK38889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="352" mass="39103" checksum="A088B1208CDB75B1" modified="2019-11-13" version="1">MNLMRFYFRRVLLFKIIGNGAFGSAMASAIKRSGFEYVVIDSFSGNVCLNSIEDKKQDNTYNNLNRNKKTDLELNSDNSNKDSYKDFNDYPFLIPAVPSYAVPNIVEKYSSKKDHIIFISKGVLENGLILGEWADKKGIDWSVIAGPHFANEIMKNLPTTSILGSEELIPEVMSFSNMGFMHSKMKKGIQFCGAMKNIIAYGCGVVSGLGLGKNAVASFLNKGFLDLRKLLMEISEEEVIFSPAGIGDLCLTASSDSSRNFKQGFERSASLDLNNVKSYTKTNRDIDSSSNVNASKNINGQILSEAKHSALAMYNRFGDNFVTMKFVSDVLNESLSTQEQIKVQLFENKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGJ7</accession>
    <name>A0A5C0UGJ7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AA_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_kinase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="241" mass="26500" checksum="8A967417AD4E0271" modified="2019-11-13" version="1">MSRNFSADFLKQGVGLVKISGLYFTNQHEGYGLSKNNTQAPREELKEFIDNIPLGKLVFMVGGGNIRRGRDYKGVEKVFNDRIGVLSTVINALDLSSMFKAKSVVYSPICKEDIIRPYDPLKIIDENEKSYSILAGGLGWCGNISTDTAMVIRALELGCNWACKISSSGGVFDKDPKFDKDAQLIKSISYDEAIEFGAFDKSAIAIAKENSLKLVMSSISELQKIISSDLKKENFVGTIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGK3</accession>
    <name>A0A5C0UGK3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="268" mass="31002" checksum="96E9F5B204994BBC" modified="2019-11-13" version="1">MNWSVGRSRKLKKAINQVNQVTIPIYSDNKYIRDYFDFEDVCNEFDNERICVEDSANVLDILSATNTINRSEHMLEGINFYKDLEKRSELFLDLGFGSGDSLMHHLKNSDALILGCEIFKPGIYGAVEKINSILGEVEARKASERTRLFLAFYQDILRKVPNASVDKIFMLFPDPWPKFKHSKRRCYNLPNLDLLLFRSLKTGGKFIFASDIKEIADGMYRMLCDIDFTGGSLARYECKNISEFEYKTTYARKAFSNGRSAYVIEYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGL3</accession>
    <name>A0A5C0UGL3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="120" mass="13659" checksum="51BE6580E6099B66" modified="2019-11-13" version="1">MFLKIIYGSNSIIYDKVSVVGFEDSDGLRCIFDFASDFCSVINSGSVFFISAESDFLVKVGISSISKKDEKITIVSDYVNLLENNKISEIKNQLMESYKTNWDKENWFKENKEKINAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGL5</accession>
    <name>A0A5C0UGL5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FZC36_02165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="166"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QEK39218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="547" mass="63535" checksum="5AE4453BEF2815B8" modified="2019-11-13" version="1">MVQKRGDVIKTSYRNYAANFEKLLSGKIKNSVKKRFITTPIYYVNGNPHIGHLYTSVACDVLSRFYKLFSKVAFSSGTDEHGQKVEREALKRNLEPQKYVDEMQSKFLDLLDRSNVKVDCFVRTTSKDHKENVLKFWNKLVDSGNIYKGSYSGWYSTVDESYYSESEIKDGKSIETGSDVEWLEEEVYFFKLSEWKEKLLEIYSDSNMIFPEERRKEVLGMINSDLPDLCVSRSNFSWGIKLDDQNVVYVWVDALVNYITALDRINSKQDTDCFSIENAIHIIGKDILKFHAIYWPAMLLACKVPLPSKIYAHGWWTVDGQKMSKSLGNVVDPFDLMSKYGADEVRYFLLKEMNFGNDGDFSYKKLEDRINLDLANSIGNLVQRILKFTEKEYGRVPKLDFIDDDKDMAILQEWDKALIKSIEFMDNQSLHSYLDSFISAVFETNKYLEDQSPWKKSADRKRKILSVGCECLKRMSILGAPIMPEKMIEIVKAINIMDHEELEEQPVSDIDISSHLNSYVSNLNNWTFPLNENYLNKDKIFPIFSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGM0</accession>
    <name>A0A5C0UGM0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Site-2 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FZC36_00155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="10">
        <location>
            <begin position="36"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK38857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="352" mass="39717" checksum="EA2D2AAB30945405" modified="2019-11-13" version="1">MLISIFHAFYTNISVFLSNFYVSMISFCIFLSSYLYAILFISILVIAHEFGHFYVALKHGVRAKEFSVGMGWKLFSTRDKNGTIWTFRSIPFGGYVSFYETDINGKTIDNISLIRRITVYLAGPAANLIVAFLAFNLMFVIRGIPKIRFTYKNTEIISINNELPKVSIMKIMRNSSEYESLENRKVGLQTSQGNLVIDIGDLKNNLISNIYYFRGSFINIIRASWKYLADSIRLNLTSIFDLFSGKKVNVSGPIGILHASKGIAKSFSGALEWIAMVSIGLAIFNLMPFVPLDGGRIVHDLLSRYLGKKAAALYERACLVLFYAMIIYVFSKDINKIVSSKIISHKKVGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGN7</accession>
    <name>A0A5C0UGN7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_02270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="415" mass="46274" checksum="B11C3CF7918372FC" modified="2019-11-13" version="1">MNFLCFESNSLSISLMDIKKIYSSFWTLSGSMLEYYDYMLFTYMIPVISANLFGGHFGDSAEFGYALMLIAALFRPLGAMAMGYIGDVFGRKKALFLSIVLISFASMGIGLLPSYQYIGFSTVILLLIFRVLQAMSAGGDLNGSAIFLIEHFGEKRAGLASGVSWAFVVFGMALASLANYVISKPIFQPNGWRWAFIIGGSIGFVGMLARAMIIEGEGFKKTAKQNYSPRSWYPYLSVIGIGAGIGGMYYYSMVYCFNFLKQSYGNQILYYQTLFFVFYAAVVVVSGILTDYFDIKKVMFFSVLALLILAFPCLLLISYGYIILSQMITVCLLGIFVGPSHNLTFQLFPPKYRYRYISLCYGIGTSIVGSATPYLCTKFSQLNYFAPSLWMSFCAFLGMLGVYFAKKSPTIDYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGN8</accession>
    <name>A0A5C0UGN8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 11">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 16" type="primary">dnaA</name>
        <name evidence="16" type="ORF">FZC36_02535</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10 11">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="14">
        <location>
            <begin position="158"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="15">
        <location>
            <begin position="364"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QEK39285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="455" mass="51960" checksum="7FE95C184F260F34" modified="2019-11-13" version="1">MLKDLERNSVNSSEIWERVHEKLNIALGSQTVSNWFKNPDHKVDNSQFSLFLNSRFAVKWINEQYLDLIQDVCSREFGISASVELSPESSLNAATDPKNQESENTNGFNAAQSGINLDMKEYSLPLDPNMTFETFVVGKENEMAYESAYRVVSSDSRSFNPLFIYGKVGLGKTHLMHSMGWSVIKQGNKKVCYISAEQFMVKFINALKRRDMMAFKDDFRSVDMLMIDDFQFLAGKESTQEEFFHTFVYLISQSKQLVISADKPPSELSGIEERLRSRLGSGLVVNVYPATYELRLSILKEKTESKKVDPKVLEFIAEHVTSNVRELSGALNRVFAYFEMFNRPITIEVAKSVLNDFTAKKKITKEDILKKVCVHYSIHESDIMSSSRKKVIVKARQFAMFLCRDMTDSSLPEIGRLFGGKDHTTALYSIRQVEKLSKQDASVMCEIEDIRNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGP5</accession>
    <name>A0A5C0UGP5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mur_ligase_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FZC36_02330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="99"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="573" mass="65665" checksum="7E5313D4928994AA" modified="2019-11-13" version="1">MSGYLILGLGISNLGAVKLLTKLQKKIFIWDDNLELTKLVHKKYPGTIVFDDSYEPEIKFVVLSPGIKSHKFLYDSKIKLNEVDLLFKFNKIRQAIGCTGSFNKTTSVLNISQIMNLHYEKLYISEKEKRKDTKLKETSEKKNNPDKIIHCGNIGISCSSIESDNVIVELSSYQLETIKNAHFDLGIITNIKPHHFDRYDNLKDYRNAKFNLMNMSKKVLLDYELLSDAKQFLKPNLTQDLHSNVKLSKLSKHYESNKPMNQNESTNSKEMLHKVPEILTMSCSETDADFCFKMGKIYENGQEVLQINSSNDSNEINADINTNKNVNYTSESTNITDINLCTYAACRILGLSPNFILDSFAKLNPLEHRREKLAHKSKFIGEIINDSKSTNLICSRHIIKGYTNIIWIAGGKLTRDLKSLHQNQLSINQLSADLHGTDSRKHKEKAEFSEGILSNTETEQAGFSIETFPFKNIKKAYFFGENSSLMHEIFKNEINCEIKKDLNEIFTNIKEIVENQKIAKQQNCENSKINIKKEKQTSLDKINIIFSPGAPSQDMYKNFEQRGRHFKDIFSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGS4</accession>
    <name>A0A5C0UGS4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rho</name>
        <name evidence="10" type="ORF">FZC36_01555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="9">
        <location>
            <begin position="119"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="239"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="492" mass="55315" checksum="CDB8485B7B8952A6" modified="2019-11-13" version="1">MNTKEDIKNPEIDSTSSSINNDDLPTNEIDLNKNINKKSKTKNNQNESKKNTSELNEPKLEENKPVEKKSVKIDLCKLRSKKPMYLAELAESLNININKLQNKDLLVEILRSYSKNGYEIKAYGSLEIINDSFGFIRYSSEDYTASEDDIYVPQNIIFKYSLRPGDNICCTIKVPEKSEKNYSIKTMLSINEEPPKRLLGRSTFESLTSLYPTRKINLEIEDKSSSSSLRALECIVPIGFGQRALIVAPPRTGKTILLQQIANAIHQNHPEAILIILLVGERPEEVTDMRRSVHGEVISSTFDEVASRHVKVAERTLEKAKRLVESKKDVVILLDSITRLARAYNTVLPSSGKVLTGGVDAYALQHPKKFFGSARNLEEGGSLTIIGTALVDTGSRMDDIIYEEFKGTGNADIVLERKSANKRIFPALDISKSGTRKEDLLRNEVELSKMWLFRAVTADMEPTDSLNLLLDKIRSTPNNAEFFKAMNGINKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGT3</accession>
    <name>A0A5C0UGT3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="123" mass="14147" checksum="A5D018ABD55E5149" modified="2019-11-13" version="1">MMALYDNNNPFAKIIRGEIPCDMLLEGTYCVIFHDINPQAKGHLLIVPKGFYTNFEDFLTNADETEILGFFKEVKEFLNKQNIKDGFRIITNQGKDAGQEIEHLHFHLLYGERLGSLKENPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGU1</accession>
    <name>A0A5C0UGU1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_00490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK38917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="129" mass="14665" checksum="CD1117C32A146B68" modified="2019-11-13" version="1">MSRISKAFLRRQSRYRNRIKLAAKKKIASKSNDFTILRLCVSKFSRTIFAQVINDDLGHTVASVSTLSKSFPANEKSYGVKAADWVARQISDKMKSIKYNQIIFDKGGYKMHGIIKTIAEVSRENGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGW9</accession>
    <name>A0A5C0UGW9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="5" type="ORF">FZC36_00460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK38911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="121" mass="12906" checksum="A55FFDEC3D94F5FB" modified="2019-11-13" version="1">MLPKGARLKVADNSGAKEVECIGLPSSKKHGASVGDVIRISVKKANPQAKLVSKGKVCHGVVVSTASHMRQKGGIMSKSDSNFIVLVDEKGEMIGNRVLNPVSRIIKDKYPKIVSLAPEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGX2</accession>
    <name>A0A5C0UGX2_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_00650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="255" mass="29929" checksum="C7E0734F074F23ED" modified="2019-11-13" version="1">MKLQVVESKIRNFSSIGRITSALKTISFIKIKKIKKEFDNIRESCKELNKMVEKRFYSNCSKSEHNYTENEKIKSIRVLFSIDKKFCKDFLFIASSYFKTIEPNQSDFFITFGKYAIEFSKFKNLKRNSVISNLNDSYEVVKEILKKMKTGKYRLFFDFYKNSESKFISQEILKPIKEKKLSCSDENLLYLNLTYQIYLASIENGLMESSSRAMAMSQASDTCDDMKHKLELELNRIRQEKITLEMTEIIGGMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGY1</accession>
    <name>A0A5C0UGY1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="6" type="ORF">FZC36_00700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="166" mass="18994" checksum="88D028DD44DCDCC6" modified="2019-11-13" version="1">MSKEKDEKEIEESENMQGEPSLEKQNSELKEDLARALAEQSNIRKRLEKRSEEVTQFALRRMASSILEIVDNFELACKAAKENPSISEGLNMIQIQILEILKNHKIQQIQTSSGDVFDAEKHEISEEKESNDVESGKVIEVLKNGYQMDGKTLRFARVIVSKKENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGY5</accession>
    <name>A0A5C0UGY5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">xseA</name>
        <name evidence="10" type="ORF">FZC36_01295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="9">
        <location>
            <begin position="75"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="8">
        <location>
            <begin position="182"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="492" mass="55723" checksum="13046C4A562604B1" modified="2019-11-13" version="1">MNSSKGLIDNQNSHSKLNSLNSTKNSLSDAAGSKYGTVSSSSENLSQIKYDKQSTLSTKNTISSDIETSDGVIGVKTLALSIKKLLESSYSKISIKGQVSQPKRSTHLYFSLKEEDAVIDCVCWANIKLKFEPQHDMEIICTGRVSSYPGRSKYQIVVLSVEHLGSSKILEERKEKLRKEGLFDPLRKPKLPKFPRKIGIITSPTGAVLHDMLHRLKDRYPCDVLLWPTAVQGSETVENVVSAIKGFNDKYFNEVDVIIIARGGGSFEDLWSFQDEHIVREISKSKIPIVTAIGHETDTTLSDYASSLRAPTPTASIELIFPDRKNIIREICDLCANKKMILKNTIKRKLSEMMWVRTKRFESVLEPFNTKLQNKTSLLEFSFSHYISKKRNLSKLSVSKPNFSCELSKIQHIHSNLNLIINHMFSKNKSKLDFMLKNLENASYHEILKRGFCRAFSDEKLIKSKKDAPESFSIEFYDGKLSVQKIHSKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH03</accession>
    <name>A0A5C0UH03_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpmE</name>
        <name evidence="9" type="ORF">FZC36_00810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK38977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="100" mass="11303" checksum="8FFF48FC09701BE6" modified="2019-11-13" version="1">MSKNNKSTNKSSKNDKKVVFDPNVKVKAKKSTDSKPVLNEIKVVLSNGEQITIKSTLSNKKEMQVHVDTYSHPAWTGVNKFGIEKDGRVTAFNQKYKDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH07</accession>
    <name>A0A5C0UH07_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RpiB/LacA/LacB family sugar-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="212" mass="24593" checksum="0D6C034AF0728754" modified="2019-11-13" version="1">MSENKSVKMNQPIYILLGCDHRGFELKEKIKQYLIEIQNADQHKYQESARQQAQNEKSESNKINVIYKIVDLGCNGEKCDFTDIVEKMILKWKNLSLEIPQKEIYINEVNDELINENNLHYKHHKANYSVRGILICGSGIGMSIAANRHKMIRAGLCKNIQDVSSAREHNDINVLVIGAENKNDSEKEMVRKFLNHEFSNKLKYINRINKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH22</accession>
    <name>A0A5C0UH22_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">topA</name>
        <name evidence="13" type="ORF">FZC36_00920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Topo_IA"/>
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        <property type="entry name" value="Topo_IA_AS"/>
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        <property type="entry name" value="Topo_IA_cen"/>
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    </dbReference>
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        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
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        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
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        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
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        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13368">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="172"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="143"/>
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    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
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    <feature type="site" description="Interaction with DNA" evidence="10">
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            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
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        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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            <dbReference type="ARBA" id="ARBA00023029"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="QEK38997.1"/>
        </source>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="831" mass="95140" checksum="5D702480FF076016" modified="2019-11-13" version="1">MRLIIVESPTKAVAISGYLKGFENGPYKVIASYGHVRALAKKSGSIDVEKDFKMKWEDVSTASEVIKKIVDEAKKSKEVILATDPDREGEAISWHIVQILRENKVDVKFSRMVFNSITPNEVKNALKNLRSINDELVSAYKARKALDYLVGFNLSPVLWKKLPCRSNQKVQSAGRVQSAALRIIVERENEIVNFESKPYWTISGDFVQETNSFEADLDYYNNEKIEKFSWTEDSVKAAKEVLEKEEYSVSKIDKTEQKRNPLAPFITSTMQQEAASRLDWKPYETMRVAQKLYEGVKVGSAVIGLITYMRTDSVKISDQGIKECRDFISDSFGNNYVSKSVNQYKSRAKNAQEAHEAIRPTKFDFTPEKVQDYLDEKSLKLYRLIWNRSVASQMSHALYDKMTINIESKSSAWKSTGSKLKFDGYQKVYGKEESEEQVIWNCKEGSVSCDEVNINQHETKPPNRFTETGIIKYLEEHGIGRPSTYANILSTLEYRGYVTKNRKTLIPSEIGWLVTGFLKNNFEKFIENDFTSDMEEKLDSIANGKQDLHELLETFWKDFEKYIEKTDDLDPKSVMLDISSTYTKFFFDQDEIPNCPKCSDGKQELKVGKGSAFLSCSNYPDCNWSKSASSKIDSDMILGDDPKTGLPIALKYGPYGYYLQIGQKSDTDFKRIALPKNMKDPGNMNLENALKIVNSDSVLGDDPETGLKINLKHGPYGYYIQIGEKSDEGFKRIPVPKIFRNPENITFEEAIKIRSLPLKMGEYNDHDVHVDIGRFGPHLLYNNVYISIKKRNPFEVTWDDCLEILESPESKKKIDQKSKEKPKKPRKSYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH29</accession>
    <name>A0A5C0UH29_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA</name>
        <name evidence="7" type="ORF">FZC36_01095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="102" mass="11864" checksum="261E88AC1AECD6AC" modified="2019-11-13" version="1">MIKNFDSSTEKEMESNSVSILDFWADWCGPCLNFMPIFEKVAEEFPGVSFYKVNIDEAREFAQKNRIMSIPTIMVLKNGKVVDQHKGSMSEEMFREFVEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH31</accession>
    <name>A0A5C0UH31_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="544" mass="58223" checksum="E0C1183ABAD81D61" modified="2019-11-13" version="1">MSNRILIGSESRSSILKGINDASNIIKKTLGPSGRLALVDEGMSIRFTKDGVSVAKAIDLSDKSESIGVKLVQKVASKTVDTAGDGTTTSVVVFQSLVNNGMELIEAGLSSVEVQSGIRAALSHTEKFLGTITSEIKGDDKKIKQVATISANGEEEIGELISKAIAKIGTDGVIAVDDSKSVDTYLNVVEGMELERGYISSSFVNNQSKQTCELENPYVLIFDSKISNVNALIPVLEKVVAANRSMLIMSEDLEGTALAAIVLNFVRRTMKVAAIKLPGFGDNRKEVSKDIAVMTGGIVISEEAGDKLENVQLEKLGQAKKIIISKDKTTIIEGHGNEDEKQERVSLIKSERENSTSDYDKEKLQERVSKLTNGMAVINVGGATEVEQKERKDRVEDAVLAVKSALESGILPGGGSALAHASRDLEKLIEDSSLSTVEKEAVKAFQKAICAPMLQNIENSGSEKGLVFLNEVQSSSDKNHGYNVISKGYGSMIDLGILDPKKSTESAIKYACSIGIMFLTSGGSIVTLPEDRESNSMPSMDGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH36</accession>
    <name>A0A5C0UH36_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="84" mass="9756" checksum="5CF2A497C6FBE26C" modified="2019-11-13" version="1">MNSKQNKKTLTGTVKKIHRGYRFSILLDLDNKTQIEAELSGRLKNRKIRIVAEDKVVLEFCEDNPSSAKIVFRETPNRIKQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH37</accession>
    <name>A0A5C0UH37_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="232" mass="27437" checksum="86DF5972C855C595" modified="2019-11-13" version="1">MTFMAFIFFFVSNLVFCEYKTSIQDNLDNILSELQTLSDNKIISKEEFISLRNSMLNVKRKVNFLMINSKVKTLKYDSFIETITGFLPTPSASHNMEEYEYKMYLKEAIKAMSKRDFESAKRKFDYLRVNQTYDLAICYYWIGFINFNQNNLDDAIMNFGIFCKIMDQNNKSEFYLKNKSKIYRALMSMMKIYYKKNEFVKAKSLLKKIKHDHLDEIKSVSDKAIVNSVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH43</accession>
    <name>A0A5C0UH43_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rplI</name>
        <name evidence="11" type="ORF">FZC36_00250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L9_C" evidence="10">
        <location>
            <begin position="69"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK38873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="156" mass="17578" checksum="CF1C7CFAEBD51AB5" modified="2019-11-13" version="1">MTSKVINVILTKDIRKLGNSGALKPVKRGYALNHLIPSGSAVRATEQSIKEMEIRKAELEKANEAMRKEALLLKSRVEKIKFSLIRKTSDGYKLYGAITNRDIEEILKKNSINEIRKEDIVVKNAKSIGDFPVTIYIYGEIQATVTLNVFPEEENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH45</accession>
    <name>A0A5C0UH45_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="97" mass="11121" checksum="45A4E9D928FCE470" modified="2019-11-13" version="1">MLSRNFKDEVHRKDRKDSRLRDCSIYKDKPNKRANAMFLLAFFGLFSCLLLLGLMPNITSEVICIISASAGIFGSCLKDAYVFEFGSREDRKSLDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UH60</accession>
    <name>A0A5C0UH60_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="266" mass="29949" checksum="4CD7650B8B9DC989" modified="2019-11-13" version="1">MKLFLDSAEIEEAKLFSKFGVIKGVTTNPKLMSDSFGKIGKQTTNQSNYDISGTSKDAKSSVEERYSEEINHAIEISKITGTKVSVQPSSYDYESIVGFGKLVFKNRNNLILKVPPTFESFEAVRYIRKNLGFIDVNLTLCFSVNQAILGMQLGVQYISIFVGRLEDQNENPFEIIETVKCLIESQQLEEYGYMNSYISENKEQECSLDKSIALEHKNTEIIAASIRSSRHVRESFKSGADIVTTPGKIIRELFNHNLTDKAIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHD1</accession>
    <name>A0A5C0UHD1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FZC36_01540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="458" mass="50512" checksum="A31527EBE64A232F" modified="2019-11-13" version="1">MPISIKMPVLSPTMKKGSLTKWTVKEGQEVKIGDIIAEIETDKSVMEFDSITDGTIAKLLVKNGQENIPVGSIIGWILEEDETIADLEDYIKTNPSENENLESSNEKNNSSNGCLENTKLADNLSSVRSDINVGEINVSDSNDRSDCNSTKPGTDFNTDSLNNSNTSHANRIKISPLAKRLISGKDIDLNNINGTGPNGRIVKEDVVSYLKTKPNQTNSRSAVSSRRNDTNTNCQMFSEHEPKHTKTSLSGMRQVISDRMSFSKQSIPHAYLRLSADISKLKSLKSDLQEDGLKTTINHWILFMTSKTLKKFPSMNSALFVSESESYVKNYENIDLNFAVTIDGGLITPVIRKAEQKTLEEIVSISSELAEKAKSGKLQSHEYQGGTFTISNLGMLGIESFDAVINPPQGAILAVGSGLNNRINLSLSIDHRIIDGYDAALFLRELKQNIENPIRIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHD3</accession>
    <name>A0A5C0UHD3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">FZC36_01735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="176" mass="20466" checksum="8AAF3BC012614C18" modified="2019-11-13" version="1">MSNAEKIIVYLDENELKVYDSVFEFVKNRGYEITMIRIVHEYRSVITRVNIERIDKKPITHEDCSEVGILIDTKLKVDNIKANLEISSPGIDRDLTRLKDFEEHKGKEIKVKTRFPISESKTLIGELMSILPDGIELNKDSQNKRSEENSIYNKVFIPYNTIRKAKLISDAYQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHD8</accession>
    <name>A0A5C0UHD8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA gyrase subunit B</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FZC36_01860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="764" mass="86543" checksum="646178F52AE0EF9C" modified="2019-11-13" version="1">MNNNYSAESIQVLKGLEAVRKRPGMYIGDTDDGSGLHHLVYEIVDNSIDEALAGYCENVSVTICKDGSVSVEDDGRGIPVDTHAGEKMSAAEVIMTQLHAGGKFSSNAYKVSGGLHGVGASVVNALSVWMEVVIWRDSLEHVMRFERGKTVQVLKVNRELKGKESKRTGTKIHFFPDEQIFSNIIFEKIKLFNRFQELVYLNPGVKINLLDERDGSEEKLHDEGGVTSFVKSVAKRKKMVHPEPINIKSKNEEMELSCSMVWTESYYETSLFFTNAIPQKDGGTHMQGFRSGLTRAVQSYIKNSNNKNYQKVSITGEDIREGLACVLSVKVADPKFSSQTKEKLVSSNVRSFVESAVFKDVYDWLEEHPSETKIIIQRIISSSSAREAARKARDMTRKQKNGIDFQVLKKLAGCSEKDPAKCELFIVEGDSAGGSAKQARNRFVQAVLPLRGKILNVEKARFDKMLSSAAITTLISSLGTGIGEDFDVEKIRYHKIIIMTDADVDGKHILSLLLTFFFRYMRAVIDRGYLYIAQPPLYGLKRHGKIVYVRDEKEFLSKLIDMSKDLAIEDFEMEQEKLKLFLKDANEVKNKIVKKSDSWRVMLASKAFDGEVLGVEHVGKMKEYLESKGFNVSVSQSDSIFVIEKEIDGIREDIKIDISNITSDEFRLFNDFTKNWSEFWKEDPVELFDKIIKKARKGIVIQRYKGLGEMNPEDLSETAMKTYQVVKIDSYEESDRICIDLMGEEVEERRCFIERNAEYADLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-10-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHE9</accession>
    <name>A0A5C0UHE9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein assembly factor BamD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bamD</name>
        <name evidence="3" type="ORF">FZC36_01665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="2">
        <location>
            <begin position="81"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="284" mass="33253" checksum="2319F917A2CD8FA1" modified="2019-11-13" version="1">MQIIHILIIFTKCYIFDVYFFKKSRRKINKIIKAILVALFLYTLSSSGLYDLNLEKSAAVKENKKVNQKSSDQKDKVSDLQKIWLNAEDLLKRKKYSQAAEKYLEIEENYPTSSKAKYAILKAAKSFYNAKEYEKSLEAARVLKSIFPIFSGEMDVNSIIIKCLYKKIRDVGRDNSEISEILELIPLSKSNHSEIRSKCINILAYQNFQLGIFYSKKGNPIVSLKYYGKIIKEYSKSDYVQESLFRCAEIFQNIGSKRDKERILKYFEMKYPKSKWYVEAKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHF5</accession>
    <name>A0A5C0UHF5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_01720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="52"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="274" mass="30838" checksum="FE5B61BFA362AE80" modified="2019-11-13" version="1">MLKFDKVFFKYPDENNNKSSKLNENKNHKSNSTKHEIDHKSDYESYESGNEKVLQNSGKKSLEEKDSGESYVLKNVSLEVSKGESLIIEGKSGSGKSTFLNLAGKLETPSEGKILFEGQNLIDFTEHEFRRKISYIFQSHSLWKDFTVLENVKMPLLIKGVSENKATKISKLWLDQVGLSDHLNKSVNAISGGEQQRVGIARAFASSPKLILADEPTGNLDNQTGEKIINLCLSFSKQNNITFICVTHNPNWKNLFDKSYTCSMGKMHLTSSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHF6</accession>
    <name>A0A5C0UHF6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007481">
        <property type="entry name" value="SspB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036760">
        <property type="entry name" value="SspB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04386">
        <property type="entry name" value="SspB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101738">
        <property type="entry name" value="SSF101738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="140" mass="16590" checksum="A5491A7B0E8DE647" modified="2019-11-13" version="1">MIDYKSELNICFRSMVRKLMRSICLEGLKGDQHLYISFVTFHKDVVIPEYLRIKYPKEMILVMQYEFSELQVFKDYFSVKMTFDKEEQISIPFRAITSITDPSENFSVNISPDFEGKEIPESEDEKEKSSNIIFFPETKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHF8</accession>
    <name>A0A5C0UHF8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssb</name>
        <name evidence="7" type="ORF">FZC36_01510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="143" mass="15827" checksum="C4B5F7EBE15D5ADD" modified="2019-11-13" version="1">MLESLMAFSINMVIVSGNVGSDPEIKQMNSGKGKFVTFPIAVEEFWTNKETGEKNSKTSWFKIISFNPYLVELSERKINKGSKVFIKGKLKKSTWTDENNKSMSSINIEPSDISVLGSKANEGTSEGGNDFESSGNEFEDLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHF9</accession>
    <name>A0A5C0UHF9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
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            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="371" mass="44241" checksum="D4231AF5EC910B39" modified="2019-11-13" version="1">MRLYASVITVLLGMFCKNSFCMPQENKTNIQIESNSINTHRKTKENALNIPKYEDYLILLSYQPQTRSYCPTKDSSTTKRRFKRWNFNFFKRKTSCSKKSYKTQNNTNNSNPRFNPISEYKSDFESINQLKEHNISLHSLKNSFPFYSLIFPRKDKGFLAYIYSVSYFVKSRIKDFSCYWKSEYKQAMNVRSLISTDIYGLIKAVHFTKAMLKQHKSFPDIEAVKDNQDLKINQNPEEYSEEFKQNKSDIKNGIVHKTASFEKEEYENEHFSSCYRRSKAEKWLKDAEMWIKAYTEVRNAENHVRSKINENRINNDKTDNDNKTYNDLINKNKINSRMNYRVSKNNHEIKNQSEYTKNDNNKQLKIESRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHG3</accession>
    <name>A0A5C0UHG3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TolC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="437" mass="50660" checksum="6CA7DC4F2B756F44" modified="2019-11-13" version="1">MNKSVKNYNNSKSKLVSKKYSLERSFDFNKLEEVFRGTTEELDSVIRQVATSDIYFSYLKQKMSSEKWENFSEFAKYLPSLDFSYDSSYVGDKLGNHKATLNARLISMDLGFISSIVRMDSKNKLIIEDARYEASKFLLDEVINVLIDLISQKYIISLSKHNVQTSEDLLNAVKARIKIGVMSRSELHSAEANLQKRKTDLFRDKRKYLFLKKKFSNYIKNFKVPSRIGRVPNVESWEKQEAKILKNSHEINKARIARMYNMTTAQKKVFQSVFPTLNISKLLASNSSGADKGIKISLKSKLGFDSYTSSVSHSKTTLYLREFYLNEVRKIKNTALESFLSLENSLEEKTMNKKTLRHERESAKAKRLLFMNDLEQRGRKYSIDEIIYAQNDVNNTFGKLVSSYSKACKAYFTLMHHKGELIEKYFSQNSVFVNKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHG5</accession>
    <name>A0A5C0UHG5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="478" mass="53256" checksum="3ABC20EB7D953FEC" modified="2019-11-13" version="1">MFLKSLLLFTTLVSTSLSSKTYVSKSRQAFNANSGTKFSLKLSTEMESIYSSQDEKPVNYLVSKSKVADETALNNIEIKIRDGLLTEKVDKKPFDNLYFKIGKVVFGLSHENESKLTFGIETKIKLIPENFAVKNLYVYFKQAYGKNDSQDLYICLGSLKGAEDDIAFYSTSLISDKFESFFSSRETLPSPNVISSPVSMTTSGDAAKIYLKNISKISSKDTLKVGLSYAPEVGNMGSSYTNTKINKYSKKTNHVAFATCLEKSVSDHDTMILGANIGSYARHNNEYALFNRNTCANIGIGYKNSSFSAGTSFQYNFSKDVEKYLKTIDFQGLTEGKTKNSEELLLLNHDKSKGNGGSSACFTLRYIFPRGVLHRSEFAFSYLFSSRETEFSIDSQSVLATSHVFCLGFSKPVHKNADAGIRLTINRSQNKADLVEKIYSEVCNGKLNDSERTLNHMKESNGLELAFFLKAKLSKITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-10-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHG7</accession>
    <name>A0A5C0UHG7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">53EXOc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="276" mass="31307" checksum="3CC2A8C8CDAB713D" modified="2019-11-13" version="1">MDLVILDGFSILFRNFFGMSSLYNSEGLPIGGAVGFLNTIFKVMKKYRPDYICIALDSGEKTWRHNLYSDYKSNRKKTPEDLIPQFPIIHEMCETLNLNIFKGGECEADDWIGSISKKYQSNCSNVVVCSCDKDLMQLVENNVFFVNPFKFQKMYEEDVVEKMGVSPNQIPDLFGLTGDASDCIPGVPNVGAKTASSWLNEFKTLEGVIDNLGHLKPLSRRGSLSGNIEQAHLSKTLATLKLDLDLPEIHDLKTNYDKDLLLDLIRKYKMEKHIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHH9</accession>
    <name>A0A5C0UHH9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="243" mass="25888" checksum="C60EC053F89D14A3" modified="2019-11-13" version="1">MFDLTGKRALITGAAGGIGSEVAKTLKNHGADVFLTGTKTEELKEISKPIGASGYFAADLTSYDDLKKMFSEAVKCMGGVDILVHSAGFAQDRLYPAVTNESWQKQMDVNLNSVFQLTQLALSKMRRNGWGRVISMSSVVGCTGNIGQVAYSTSKAALLGMTKTLAREVAKSNITVNAICPGFIDTQMTKELLESNGKILENIPLQRAGTVKEVAAGVIYLASEESAYVTGTSLHINGGMMMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHI3</accession>
    <name>A0A5C0UHI3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">nusA</name>
        <name evidence="9" type="ORF">FZC36_01740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH" evidence="8">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="8">
        <location>
            <begin position="325"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QEK39151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="594" mass="67560" checksum="2BFA62C338A52E65" modified="2019-11-13" version="1">MHTNPKSKKNVKANEEQNIDTRDVLQSITEVSRERGLSEDSVIEMFEDAMRRLLSRANGNVPVSVKINRKAQNIEAYLIKDVVEEPKYKNEVSLEDALKLDPEAEIEGTVNDAIDIEQVQKLLNSRTLAFNARKSLEKNLTVLEKEKEYEYFREKVGEFFLSPVKRREDRYVVLDLIMGEGYLFNSDVIDGEKFRVNQKIKACIKEVKQSVFGIQVLLTRTSPEFLGKLFEEAVPEIQHNIITIKSIARSAGNRSKIAVHSNDPEIDPVGACIGKGNMRIRSVEDQISKEKIDIVRWSENTDVFLVNALGKRIDALRVIKDEDNSEFDIVVRDEDYYKVIGSKGQNIRLIKDLVGCNITIIPESKYSNLKQETIEELAEIGVSEIFAENLYESGIPAYEFLAYATDEEMLEYQSDLSENEMDEIRTKAFDKNKTNQIKTLKEDFESTLDIDLHEKIGFYEACSLSEKEIYENIELVSLSPEELNEILSDYSIEDCAEIIKTFANKPENSQNEDTNEDSISSQNESDTNANDDDKTNKEELSSENTSTPEESDQHETDNSSASVDSEEISSDISEEVSEVSEEAEKSNEKIEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHK7</accession>
    <name>A0A5C0UHK7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="192" mass="23018" checksum="2EC6C3AEC281CF55" modified="2019-11-13" version="1">MKIYGSVFCPFRRYLEIILQEQKVEFTVSESPEDVFFPYIKENGKTYIGLLSTDEVINKIDKNDKPWFFWIITDFFPSLKLIIKQRFFNEFNTNHSSQILEYSKRDMNDFLIKLESIFSDQNWIGKYGPSSSDFLFSSIISYLDYLNEIKWTKYENIKIWYSSIKCRPSFDKVLSYRLPGIKPSPQYKIIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHK9</accession>
    <name>A0A5C0UHK9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="307" mass="33550" checksum="D6BA149B5815439F" modified="2019-11-13" version="1">MNRKTILALSLFTLIGNISAQKKMVSSKRQSVSKYTQSQKKNYIGFGADLDIEFHNMKLKSESIETDVDRVGAVALSKNDAGVYTNSEDIKVETKNAGSLFKGNPFVEYGRKMGNAFIGARFGISLGHTNAYLNDAYTHGAKPGEEDTILNNLKENEMLPVVTENSADADSSAPLNPEVAHNRFNLESYWGLNASILGGYMVNKMVCLYSGLGLKHGAYNAQLILGSNDSDHIESSCHRLGLVLPLGTKIVLSNGLFFNVEGSLGVMFSKNVEMDGKVKEVDHKFKGTLKNEFCGGIKLGIGYKIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHL4</accession>
    <name>A0A5C0UHL4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="3">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapE</name>
        <name evidence="3" type="ORF">FZC36_01210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="171"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="376" mass="42239" checksum="F927EC1EFF5BABA9" modified="2019-11-13" version="1">MNSTLKILSDLVSFKSVTPIGIDCLEYIKNFLDKLGFESEIIKFGNVYNLYSKKDSEGPHICFAGHVDVVPPGDKWDSDPFKLNIHDGKIYGLGVVDMKGSIACFLNVLKNRIKDINSSVSVLLTTDEEGLAVDGLAKCVSWLKERNQVFDLFLLGEPSCIENTGDSIKSGRRGSLTSQVRVLGNKGHIAYPEHACSITSAALEIMEFSNNKSIGYEYEDFPKSVVQVTHFRTPERVENLLPGECFIDFGIRFNPSLTPNSIIEMFENKFLEISNKYKLEIISQWTKHGNPFFVRDKNIKDFIRESVINELGISPRFNADGATSDGRFLIELAPVIEIGLEESQAHKTNEHTTLENIMNLERVFDSIVSNFHKINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHL9</accession>
    <name>A0A5C0UHL9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="316" mass="36370" checksum="52F931EFED734AFB" modified="2019-11-13" version="1">MIRKMNSVFFVFVLSVLFGKTCFSDSKSKESLLDKGSQYKSKLNKSKVLAVVVGKEITYSEVIKFINANKSLSEQFLKASQDSDVKKVSEVIEKVLNLIIKQKIMKFIAENKGYDKDDKYKKEFIRANNQVKMKLFQESVLKEVRKDDLELKKLYNSIKNELVNERIIGMLLISRTKDDANSVIKAINHDAKSKKEPFEKIFEDNLKKYSIESDNKNVSYVEKLVTQLDYDLGTLASKSISNLNSGSITQTPFAISGKNNKHNGLWGVFYLKSKQKKQISYDESMILLQTLLFSKKMNQIVSEHDEFKKVKKYNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHM9</accession>
    <name>A0A5C0UHM9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsB</name>
        <name evidence="5" type="ORF">FZC36_02045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QEK39200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="366" mass="41974" checksum="2A7973372813F568" modified="2019-11-13" version="1">MDIQKQENLDSEKEVEKETESKDSESEEAESSKNIEEIIKFNVFDLKDHAFHFGHNTKKLNPKMDSYVFGTVGNMHVIDISKTVPLFKDALSFLRKITCNGGRVLFVGTKYQSKEVVKKAAEDCGQFYMNHRWPGGLMTNWNTVSVSIQGMKDLEKKIEEGFFKKYKKHEQSKINKKLFNLKRMFSGIKDMHGLPNAIVVTSWKEENIAIREAIKLRIPVVALMDTDADPASIDYPVPGNDDAMKSIEFFSSLCASACLLGIHDEQIKISEKSKEVESKKRRNPREFNRDYRKESFRPRERRDAFETKFVAKKTEPEFDSKISVEKKNIPSNDSKIDEKKLSDDSVSSIKVDKVESKSKDSDSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHN1</accession>
    <name>A0A5C0UHN1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_00125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK38852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="97" mass="11442" checksum="9FCB7A511F292796" modified="2019-11-13" version="1">MRKYFTKTLGSSLAKVLDPMYGNDPVISSLRKNWSNISKEQDLLPYHYCLKTKTLFLRVEKNQNLISFQYKSQELIEPINFYLGFVAVKYIKINQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHP4</accession>
    <name>A0A5C0UHP4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APC family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="422" mass="45067" checksum="9C173C8FDCD4989A" modified="2019-11-13" version="1">MNSNKEAGMGIIGATSISVGTMVSSGILIISSSIAIYGGWGLLGWISSAFCAVLLGYSFSQMSRSEDGKKGIPVYVSKAFKSCGSYLGFQTSWDHWSGLCMGCSAVSIAFATHFVELFPFHVSKAGQAFLAISLLWLLILGNCRSSVFSVGMITAIAILKVIIFSSIFLFSIPNISLDKIMIPSTVNVSSLQSVFKSMPLALFAFLGLESATSSYESVKNPERTVPLATILGVIIAASLFIGMHIAVMVTLPQDLQISSAKPVYDTASILMGKFGSFIVLFIAVLGLLGGVNGLVFISSYIMFSSASSGWVSARINSVNKNNFPVPSSLLTGALVTATVLSYYYGLLSMHVLINLTSFMLIKVYIAGVLAHYIHSRGLSLFLINMFSCVILLLGCSLEAVLYGSLISALGLIFYLFRPSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHP6</accession>
    <name>A0A5C0UHP6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="70"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="414" mass="48097" checksum="42DDA1DBC52A8F1C" modified="2019-11-13" version="1">MGSMNILNAPVYSLNYYNIDELLKRENQTESENNIDTNDTQIENAKECEANLKEVNTNDISNDDIKNINITFLQNKSELLQACQFIKTIIENQTDLVVAFDTEFYRRKTYWPILCLIQIRIKDFVFIIDCQEISIKGTFLEEIFSNEDIVKVCHACEQDIAILQSENIEINNCFDSQVGAMFVKFGHAISYQDLIDKILNVKIKKEFQDSNWNLRPIPQHLIEYAAKDVIYLYDCFTKLKKTLNSLGRFSWAMSETERKINTRGKNKTRLHKWRDTIAEEKNIPPSWLIDNKVMHSLCCLSNPCLDSVKKLLPKKLHTDLPHVLEILKAMPKNKSNIDITKSSVISLVVRIISNEELIPPSLICDSETIRYISCHMKVPEHLTGWRYEIFGKKIETFLKGKSKIGMKYNRLVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHP7</accession>
    <name>A0A5C0UHP7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="153"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="290" mass="33537" checksum="AA59F8F3E696EF97" modified="2019-11-13" version="1">MYEKIKSRIKLLSYPLMSVVASSLLFSIMKTISRDKIPTEQFMLIRLLISSLFFIPMFLKVKSIKTKINKLHFLRAIVLFSSMIMTYEGYRNIPFVTSSALGMTEPIFIFIFSWAFFRNKISYQKVLGILFGYIGVLVTLYPFDLSINTFYSVILLLANVLSAISMILMKKSHNKDAPEVVLFYSYFYLTMFSIIWNLHGLFFRDDFILMDFVYLYENIWRVVSVCSLAAVNTYAIIWSIKKLDPISYSSVQYLKVVFSVIIGWVFLGESLVLNQILGSLIIAISASIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHQ0</accession>
    <name>A0A5C0UHQ0_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplJ</name>
        <name evidence="4" type="ORF">FZC36_02225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="166" mass="18132" checksum="FE3B4EA9EA08B955" modified="2019-11-13" version="1">MNTSIKKKLIDDIKKIKLENDFLILTEQSCVSISDLDEIKHELGDGVEIKFVKNSLAKIAIENEEFSSFMKKSNFLVYGKSDPIESMCKVIKASKSSDSVNVKAALIQGDVFDKAGISAISKYKTKNALQATLVGAISSSCSGMVRCMSSLQSSIVRILSEKIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHQ6</accession>
    <name>A0A5C0UHQ6_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FZC36_00355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1604HC</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QEK38892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="229" mass="25663" checksum="909AE25C4BB39F6D" modified="2019-11-13" version="1">MRFREDNVSVQSGLSDYFAAVYKFLGVGFAFTGALAFCVSSFLSNRSFAMVSIISIPAWIIMSLYFRKVNIRSSYSEISLMYWSYCSVMGISSAYIFKVFTSSSIVSMFFLTASIFLVVSYYGASTKTDLSSYLSLAFYTFFAVSIYSLFAYFVFGSTSSHILLISLSTFVSVVSIAFTSQNLVNIYYSNQVSDEDLNKAAILSSLVLLMDVIIILRNLLYLFGDRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHR2</accession>
    <name>A0A5C0UHR2_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="184" mass="20866" checksum="C73A54ABD780084C" modified="2019-11-13" version="1">MSNLVIVLVGPSGSGKTSLSCMLVDFGFYKPITCTTRSKRDSEKHGVDYFFLSEYEFLQRKELGKLADWDNIFGCWYGIEKSQVEDINKPIILAASYKGVENLKESTNKKVISVFLNPPSKNEIECRINDRDGSVCKDNLKKRMTSFDSEMENMSKCDYVVSTDQAIEKSLEDILCIHSKFGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHS3</accession>
    <name>A0A5C0UHS3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="256" mass="28880" checksum="04B5F5787242AD9A" modified="2019-11-13" version="1">MNFIKNRLSFKGFDPFSLNGNLYSVVINTEEGLLEGRYFESLKENRQPKSVALVLHPDPKKNGSMNNKVVKSMFNAFAALGFDVLRFNFRGVGKSKGKISKDEDQNLKDALKCMDWLISKHEEICNAWIAGFAFGGFIGMKAVMRRPDITGFVLASPTAETSSLNMLTPCPDGIVVAGGKDTFSEENHAYELSKALLNQSNSEIELEYLPESDHYFSNHEDLLRQKIESFVKKRIRTPSEIITVKRKRKKQSKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHU1</accession>
    <name>A0A5C0UHU1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="194" mass="22809" checksum="C873C359BBD4E522" modified="2019-11-13" version="1">MFRCFGNKNKVFGDYHDVEWGKPIYDDQVLFEMLILEGAHAGLSWEIILMKRDAYREAFHFFDPIKVSEMSDEELEKNMENKGIVRNRLKIFSARKNAIAFLKIVEEYKSFSNYIWGFVNNKPINNAWKEYSEVPSVSEEGDLLSKDLKKRGMTFVGPRIIYAYMQSIGMVNDHLTKCFRYDQVIKMQNDAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHU3</accession>
    <name>A0A5C0UHU3_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="7" type="ORF">FZC36_00620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="416" mass="47798" checksum="2B107715AF8E7B14" modified="2019-11-13" version="1">MNILNNELENDKAIKKNNNKNSDKAKNISDNQKNVNDSNKNNTSKNNTSNSVHSENINAIFSKIEKYINLLQDNLKKLDLENKLLELSKEVENPNLWDDKEKAQQILKEHSQTNEMVGSIKHFSEQYINIKEMTQIPEFMEDAAIESNELLEQLKPFYVNLLFSEQVDKLDCFVSLNSGAGGTEAQDWTEMLMRMYLRFFEKNNFKAEILHEQKGEEAGVKSAEIKVSSNENSFPYGWTKGESGVHRLVRISPFDSNSRRHTSFASVWVTPVINQEINIEIEDKDIRIDTYRASGAGGQHVNKTDSAVRITHIESGIVVQCQNDRSQHRNKAEAMQMLKSKLYAHEKEKAEKEASENSAKKKDNSWGSQIRSYVMHPYRMVKDLRTGHESGQVEKIMDGDIKEFLVKYLEKSSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHV5</accession>
    <name>A0A5C0UHV5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK38952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="474" mass="53805" checksum="B2502700665D82F7" modified="2019-11-13" version="1">MKKIFLLTQIIAMNVFAMSGGEEIGCMPSSPVQVPGQAVEPAAPSSATPVNDGEDLKLDSGQAGQISEPVVSSTGTQTELNLEPDHAEHLKKVFQGGLEGLGTQFFVQHKEEILGFIDSLKYKSKEEQESAKQSYQNMKEILKTNPYRAGHDSDSYDFYVEKATVLIKELFKVEGGDLTDASVGKLLDVKDYELMKAYIENAMNKSIGVEFFEGVDLNSDVFRVMEDSLKHERTKIIESIFSHFCEYVLGSEFGIGRVRSCAIAVQSRIQDLLQGSISNYEKKIESIKSKIANLEKEKTTLKTDKADLETKISSAKKKRDLNIINFFNPKLKAVKTKINNLTNKIEKLQKDLNGIPCLNMDKFHPRTFDNRDGTIAHYLKILRKNIRVEYLDKALVIEDNGDMSRGYFRIFSHLANMAKHGINPYEYALMSEASEIEKQGLEIDKKNTEMSDLESRYYRLVKRSRRKQEYKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHW5</accession>
    <name>A0A5C0UHW5_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ORF">FZC36_02285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="230" mass="26593" checksum="727C45F808592C94" modified="2019-11-13" version="1">MMKLNHVSFIMDGNRRWERASISEKKASGHEMGLLNMMEIIKYCSGKIDEISFFTFSSDNWNRSIKEIYKIMKLASKYSSLLIEECASMNIRCKFIGDLKNLPDFVYEEVIDIERKTKNNTGMKLYIAINYSGRKAILEACKSSFYKHIKSGKSSIDMTESCFSSEVSPFSNDPDICIRTGGGKRISDFLLWNFSYTEFFFEEKLWPDFGIKDFEKIISKCSSIRKNLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UHW9</accession>
    <name>A0A5C0UHW9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl-ACP synthase 3</fullName>
            <ecNumber evidence="4">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FZC36_01880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.180" evidence="4"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="228"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QEK39173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="309" mass="33925" checksum="7A2774571823706E" modified="2019-11-13" version="1">MNGMLIKDCGIFVPSNCVSNFDLQKKLDTSDEWIKTRTGISSRFIAEKETTYSMAYESAKNLNLGNVKIILCATSTPDCNFPTCSSYVHGKLGLGKDVMCFDIHDACNGFVQAFTTAMVFLQNMPEDSEALIIGSEKMSSILDWNDRSTAVLFGDGAGAVLVNNKFGKLLKYSSYSKPSFDSLNVENTTTKINDKEFGNGSIKMNGQDVFKNACSSMREDVINIVKESGEVDWFIPHQANLRILKKVSENLSGIKNLVYNGDKYGNTSAASIPLALYDVFKEGKLSSGQKLLFTGFAAGFRWGSVLVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UI40</accession>
    <name>A0A5C0UI40_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lipB</name>
        <name evidence="11" type="ORF">FZC36_01205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="36"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK39052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="232" mass="26813" checksum="B873F298348E3EFA" modified="2019-11-13" version="1">MNEMKHRKNITIYKKIFSVTYEESMLIMNKHMDIVHKDGSMVFFLIFNYLPVITLGVNEKELSESFIKTISEKNISYYKSSRGGKITYHDKGQFTCYPIINLDYLGVSPANYVVRLQEWMNGSIGSLGVESKKHAIGVWVKDCIWKKVGFIGVKISRKITSHGFSINLNANLDAFNMFIPCGMESCVVGNLRDVKCKSMLNEAINRNCLSEKSNNLYKFFYKKLDCFFDKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIA0</accession>
    <name>A0A5C0UIA0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_01640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="416" mass="47695" checksum="2DCFBD77C0E0928D" modified="2019-11-13" version="1">MKNKYISRNTNIMYINNVKKFLRPKGFSMLEMAIVLVIFGSLSSIMFSSMQKYVKWQRSEVTKSNMEKILKSLGTFVSSRGRLPYPSTPSNKFPDPDNPVTVAPGFEYPWPKNDKEWGNIYLYSGIVPFKTLQIPEHMAKDGNGRYFTYVMDTTLGGRTYVESVSPNDDRIKYEYDSDDKDIKISSFCFVRHYGDPTEITKGEITKGVGDSGYFKHIGLNFRASLVDLVHWREKISLIEDKTVYAYQLMYPEYIPQNNLATKYFISEMYQHDNDLYRQHHRPYVLNKAFSAKMSSSHKGLVVRDTIAVVLISHGDSGGWITPNGTRQPLKGDVSRGKRCNSKHNGSFFETDIETKKDKSKIFDDTVLFVSRFNFAALYGGFLCESLSSSQRHVPYIPAPHIADKIAKKQNLTEHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIA1</accession>
    <name>A0A5C0UIA1_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Replicative DNA helicase</fullName>
            <ecNumber evidence="4 13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FZC36_00245</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 13"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="14">
        <location>
            <begin position="171"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QEK39321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="450" mass="50931" checksum="68E3C5F360F1F331" modified="2019-11-13" version="1">MPNAVEAERSLLAALLHDNLLFDNISDFLKPEHFFEPLHRKIFEAFLFCINKGQLANSITLWPFFVDDELIKEYGGKEYLDTLSSYIVSLDYTKDYAQQIYDRYLRRKIILVGESMVSQAYKMDINNGALSQIENAESGLFKLASTSITKENRFSDAVGLAMKNAELAFKRSDHLVGVPSGFKSIDRYLGGLHKSDLLILAARPSMGKTAFVTNIAFQSAQLGNKVLFFSLEMSSEQLALRILGHESMIPSDKIRRGAVSDKDISKLSTISKKISNLSLFIDDTPALSIAGLRTRARRLKRQESINLIIIDYLQLMSSGGNHENRVQELSTITRSLKALAKDLDVPIIALSQLSRAVEQREDKRPQLSDLRESGTIEQDADVVMFVYREAYYESRKKPAEGSEKLEAWQARMDKIYNLADIIVAKQRHGPIRNIQMGFEESFTKFYDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIC4</accession>
    <name>A0A5C0UIC4_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="169" mass="19493" checksum="B1A71C1FA282A7DF" modified="2019-11-13" version="1">MIKTVPLVQKVIGKINHDIISPIAALQIDLEENNIENAKKAFSNLLKSINVFRAVASESLKWESAKQISYENMDNIKWNVDSFPKGHFLSNITILLAFILHKKKQNREINISDKKIETHFEIQNVELDALSLKQESQCSYNTYFYLIGLFCKELNYNLSFSSKHICIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIE7</accession>
    <name>A0A5C0UIE7_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glmS</name>
        <name evidence="10" type="ORF">FZC36_02525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="9">
        <location>
            <begin position="259"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="9">
        <location>
            <begin position="425"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="575" mass="64217" checksum="F3D998AC9D2B4395" modified="2019-11-13" version="1">MCGLIGIVHKTENVSDSLFQGLKILQYRGYDSCGMCIVDESEFDVYKELGSVSNLEKYLKNMNGKIGIGHTRWATHGSRSIRNSQPFVYMNIALVHNGIIENHLEIKESSTDYEWKTETDTEVLLKMAYDYLQKFNNDWDLVLQKICETLEGSFAVSFLDLNDQNKIYFVRKGLSPISISVGKDYACVSSDCSALSGIADHVFDLEDGQYGYVAPNDIHVLPNFNNKKREIIKIDNNDRSQQTWYMSEFYSQPVVLMNVLKSINNFKWPEMDTPEYIHLLGCGSAYYASCVGKHWIEKIAKIPVNACIASEWVNNINSGLVGLVSQSGETADTIAALRRAKKDKKTIGFINSMGSAIAREVDYLIPTFAGHEISVASTKAMTGQMLSLFIWTSKLAGVDRTTELYDLFKEMNSFLEIIPKLAGPVSAACSNKDNLIILARGNLVPITKEASLKIKELAYIHSEGMSLSELKHGPLALVDSGKILIVMAPSSSPFWTKILSSIEEINTRGGKVVVLTDKPEIFTHLYMTVKMPYVEDDLAPFVYILPFQWLAYDLALSKGVSVDNPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIG5</accession>
    <name>A0A5C0UIG5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="249" mass="29364" checksum="46A27842A04635E0" modified="2019-11-13" version="1">MGARGDRSTKEKKEKAKEVEQQQETIIDEEPVDPDIGSICQIYDEKWGETVRNVNAGTYQKLMTLTNFGTIEELEIEEELSEPYTIKGKCFFWEEIYGDVVGMEPKVTLATEGKTRYWHGVITEWIEGGTDLKDERYYYEFEMRPKLWYRMQSRQNKIHVSDKGMRVKELASKLIEDAMQNNKNTKVKFEQKYDVNFAKVKSAQNNPNEPLIEYAVQYEETTYGFFQRLLSNHGIFYYYKVEDNYSCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIG9</accession>
    <name>A0A5C0UIG9_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="238" mass="27330" checksum="0DC24074B05C8418" modified="2019-11-13" version="1">MVKINLLSGQKIIGRSIKCFELVKELCLSSDILGFVSCSEGDKKVYDLHSEIPEGEEVKPIRRTDKEALHMLRHDIAHVLAQALSDLFDGVQYGKQYFDEESIFGFDFISEKKVSESDFPAIEFRMSQIIERKDSILREIWSKSKSLREFKNDSFKVDIVKNCKKESLMLYSHGGYIDICGGPRTTNNDFLGHNFEILGIGESSWLYDGSIKMQRIYGTYWPTEADLKNYLSQKKQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UII4</accession>
    <name>A0A5C0UII4_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Elongation factor G</fullName>
            <shortName evidence="8">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">fusA</name>
        <name evidence="10" type="ORF">FZC36_00400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QEK39323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="704" mass="78153" checksum="34C908A1701944C9" modified="2019-11-13" version="1">MNKSASFDLNFYRNIGIIAHIDAGKTTTTERILYYTGKTHKIGEVHEGQATMDFMVQEQERGITIGSAATNCSWTKDENLYNVNIIDTPGHVDFTVEVERSLRVLDGAVVVFDGVAGVEPQSETVWIQANKHRVPRICFVNKMDRSGADFYRCVSMIEDRLDGKPLVLNIPIGCESDFKGIIDLVSMKSVIWQGDDLGASFVVGEIPSDLVDKANEWRDSLTEEIRSCLLDEINDENEELMMSYIEGEKEIPLNLLKDMIRKGTLAAKFFPTLCGSSFKNKGVQTLLDAVADYLPSPLDLTEIKGTNPKTDEEIVRKHNIDDHFSGLAFKITCDKYVGTLTYFRVYSGTLKVGDSYLNSTSGKKGKIGRMLLLHANSREDIKEAKAGDVVALCGIDATTGDTLCDPSNPILLESIEFPEPVMSLSLEPESKAEIDKLSKALESLKKEDPSFQVTTNIETQQTLIHGMGELQLDVIADRLKREFKVGVKVGAPEVSYREKYRKPVEINYQHKKQSGGAGQFAYVEMEFHPLESGSDFVFESKIKEGAIPREYIPGVEKGVRSAMTTGYYGYPMVDFKAVLVDGSYHDVDSSVYAFDFAAREAFRKSVSGGENSVLLEPLMDVEITSPEDYMGTIIGDVSGKRGEIKSTDSIGKITVIKCFIPLSEMFGYIGHLRQISNGRASFSMKFSKYSEAPSHIAEKVKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIK1</accession>
    <name>A0A5C0UIK1_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="219" mass="24744" checksum="6241B1D720AE5ECD" modified="2019-11-13" version="1">MLKLNEIINLKDYKCLVGLGNIGKEYASTRHNLGFVFLDVMKEKFYSSDFKSNRNYSISSLEITINEVHENIAQEKNSISSEPKSIKNNFTKNSDQNNFPKVQKKHHIDFIKPSTYMNSSGLAVLSYMKNKNVKPEEVLVVHDDLETDEYEIKIKHGGGTAGHKGLKSITSAIGSEYSRVKVGIGHPGHGVAEFVLKAIKMDKWNIAIERWIDSNIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UIM3</accession>
    <name>A0A5C0UIM3_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FZC36_02515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="74"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QEK39282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="219" mass="25403" checksum="4EB39EFB3C1330B7" modified="2019-11-13" version="1">MVVKLLRAIKSYFFIFVMYTYAVIFFIISLPFLFSEKMVYKSVKIWAKSFLFIGRVFGISSEIIDLHKLKPGPKIICCNHQSYYEIIMLLSVLERPVFIMKKSIMKVPLFSIYMKKMNMIAIDRATYNFGWMDKAKDAFKEGKTLVIFPEGTRVPIGKEVPYKKGAFKLAKEVGMNIVPAKTNSAECWEGPGFIKKGYVYLRFFDEISPDPELLRKYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJ83</accession>
    <name>A0A5C0UJ83_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rnhA</name>
        <name evidence="7" type="ORF">FZC36_00200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK38864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="142" mass="16071" checksum="7F460BED031BBACE" modified="2019-11-13" version="1">MLITDGSCLGNPGKGGWAFILKLGDTVISKSGNEKQTTNNRMELVALIRGLEEYMKVSSSSDLEVILDSNYVLKGITDWIKNWKKNGWKNSQKQDVKNKDLWLELDSFMDKLNIKFTWVKGHSGHEIHDKVDVMAREAASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJF0</accession>
    <name>A0A5C0UJF0_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK38934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="463" mass="52418" checksum="1A6015C751321FDB" modified="2019-11-13" version="1">MNVKKYITLLALCNMINAMPGEIHSMESGDLSSSEKYETMTAVSVSSTGTMMSSAHININAWLDKIETEKDKHICMEIAQIAKCKLQNMHCKLTMTRQLLETQQQAVLNLSDMNRDLRSSNKALNDTVSESLKKERESYAELSKEKDKRFNEKEISNQELLSEKEKLAFAIKELADKRARLECSGVAIEKAESSLEKLEKNLNSKELELESVKSEKQEAVLSLVKESTSKECNEKHNTERILHLNKLLEEAKCTIKNLQEDSEKSHNKSLSQAMEISSLKEVVQNLKSAESSKDTEIEKLREKVNALESKLENALEFKVENAKLESEIKNSDRSMRRKDEDLNGALDQLSFYRAILKEASRPDAALVGDKVASIFKESSCSVKKELATEFIDAFDLKLDTKDKESAWNKLLSIMIISIKLNEAMGNNIVGKQLYLKEVLNANTGITFIANKKPDQRLHIKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJJ8</accession>
    <name>A0A5C0UJJ8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FZC36_00850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="194"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="854"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1140"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1140"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QEK38984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="1226" mass="136725" checksum="C5A344D75BE007D1" modified="2019-11-13" version="1">MYFSRCFTKKGPYEGIKFVERSSEIRDLSGKLIKSFEKIIVPENWSQTAVDIFAQKYCRKAGVAKILKRIPEEGVPEWLWKSEPDLEAMYGIEEKFGAETDARNVFNRIVGTWTYWGWKYKYFNSESDAKTFYDELCNMVALQKAAPNSPQWFNTGMHWGYGIEGGAQGHYYVDPSTLEIKKSKSAYERPQPHACFIQSVSDDLVNEGGIMDLWVRESRIFKYGSGSGTNFSILRAANESLSSGGVSSGMLSFLKVGDSVAGAIKSGGANRRSAKMVTVDVEHPDIESYVKWKTEEEDKVVFLSVGSKIINEAIKEINLSCDSFDFDKINLDNISDDVSINLDSLNDFCKTYDGNKNDLHLSDANLSDENIESDDEKSNQENNIRKLKFNPKVNKRLGKALRKAEKTGVPFGYLDRILKLLEQGVENVSAKILTTEFESEAYASVSGQNSNNSVRVTNDFMRKVENDEDFDLVYRTSRGIAKTCKARSIWSEISKSAWLCADPGLQYDTTINEWHTCPQSGRINASNPCSEYMFLDDTACNLASINLLKFYKHNEGKWSFESDEFSYAVRIWTLVLEISITMAQYPSKIIAEKSFDFRTLGLGYANLGALMMQSGIPYDSEEGRALAAYVTAIMHGESYKTSAEIAKELGAFAKYDKNKDSMMRVIKNHRAALYGHGYEDIEINPISLDWDKCPIKEKKKVLDLWDEVIDLGNKYGFRNSQVTLLAPTGTIGLLMDCDTLGIEPDFALVKHKKLSGGGYFKIINNSIKPALKSLDYSDSDINKIMNYIIGCSSLEDSPYINHKTLTEKGFDKSDIGKLEKALANSFSISQACSKWTMGDDFCKRLGIEGNNILAELGFSDEEMGACSEYACGTSSIVGCPYMKESDLAVFDCATHGERFVSWEGHVKMIASVQPFLSGAVSKTINMPNNANISDCAEAYSLAWKIGVKAIALYRDGSKLSQALNLTGSSSTYLDDEELSNEEDTLKSVTNEEKDTKLERGYKEKIPYKRNGYTQKINISGGYSFYHTTGENEKGELREIFTSGMGTEGASFRSLMSCFSKAISIGLQYGVPLKEFVSAFKFTKFEPSGIINGHDEINFADSLIDYIFRDLESRYGKNNVSKDFQHNVSLKSNDASAFKGNGSINVNNSQSKPQKSNNLNQSDIKNKNDLSGDEKGSGFDAKQTVNKAEQTKLGYTGDMCAHCKEFSMRRVGTCLQCDKCGSTSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJK7</accession>
    <name>A0A5C0UJK7_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FZC36_00905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK38994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QEK38994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="175" mass="19809" checksum="E7BDA807F2DB2559" modified="2019-11-13" version="1">MIFEFIFFMIGSIPSGRLISFLFRKEDLRFAGSGNIGTSNAWRVNGKMVGSLTGIFDVLKGLSVIFSGSIFYYGMFVVLGNMFAPWSGGKGMAVFFGICLAFFGKIAFIFIFTWAFCVWIGFRPAHSSYISLLLVNLYFVLCVGKCISFLLIISLIILMRHLLWNKNFYNKDKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJM9</accession>
    <name>A0A5C0UJM9_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accA</name>
        <name evidence="13" type="ORF">FZC36_01010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEK39014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="321" mass="35450" checksum="56147B9B3D74FB59" modified="2019-11-13" version="1">MSIFYQLDFESDIREIEQKIVELKESTNCGKSKVLNEISVLEEKRDKKLEKIYANLTPWQKVQIARHPDRPKGFYYINAITEDFFELSGDRCKGNDRAIVAGIAKFRGRKIMIAAQEKGHDSKTMTEHNFGMPLPEGYRKLVRVMKLANELNLPFVSLVDTAGASPGIEAEEGGQGHAIASAISASFELEVPNVSVIIGEGGSGGAVALACANSIIMNEHSIYSTISPEGCSAILWKNKDSKKKAAEMQKLTAQDLLSFGLIDKIIDEPLGGAHRNKDKMCDRVANCIEEELDLLSGKPSSFVKASRAEKFKNIHKKYGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UJZ5</accession>
    <name>A0A5C0UJZ5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_01815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="222" mass="25110" checksum="56F2A97B1FA5165A" modified="2019-11-13" version="1">MISNCRIVILSFLFVFVELKSVSISVEGGAGSLLDFTVYGRDKAIYDRKQVYIKNKSYFNEFIRGQINIDLFESISKRFIFKLYIGLASTIRQVHLSAKSIENDPEGNYTESDSEDLMLSDIKPIRYIAPFFGYSIGTELSNKICVGLLAKMGFVDFKNMKWKSGAPIKRKTLDLSEVVTVYMFAGAFLSTKLTKRINVLASFEVANNKNKQITLSTEVKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK24</accession>
    <name>A0A5C0UK24_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FZC36_02070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QEK39204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="485" mass="53846" checksum="BB6E7BEAFA99FEF8" modified="2019-11-13" version="1">MKSLNKNTIAVIGAGPVGISAAVHLKIRGLNPIVFEKGSSVGHAMKEWGHVRVFTPWKYVMDKEVVNLLGKTDWKHPDKEYIPTGNEIVEEYLYPASKIPELKNRIIYGAEVIAVSKSKSSKSSSNNRDEKSFTIHYKSENGSHYVTEVNGVIDASGTWGTPNPIGADGLPVIGEIENKEYISYGIPDILLKNRNLYEGKRVLVLGSGHSAINVVLDILSLKNKNLDTKLIWGLRNNKLDKLLGGGINDELPARGALGQAAKKAISEGSLDLMAPFEVKEIERKYSRNRSGFNGEFIKREPELKVKSEFDGKKIVLTVDRIIVAAGFRPNLDMLRELRLDLDTIVEAPKTLAPMIDPNLHSCGTVKPHGVDELSHPDKNFFIVGMKAYGRAPTFLMLTGYEQVRSIADELAGNHEAAREVQLKLPETGVCNSNSKNIYYEKALDKKNLDDHDKIEYQDYRLSLRSKRSSCCGADKEESKTNHSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK43</accession>
    <name>A0A5C0UK43_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radC</name>
        <name evidence="8" type="ORF">FZC36_02195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="102"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="224" mass="25605" checksum="7FB6D8D91A65C02C" modified="2019-11-13" version="1">MVNDNSGHRQRLRERFLNSDTSKFSDYELVEILLQISQPRKDIKPVAKSLINAFKSFSAVVCSEKERLSQIKGMGPISIALFKSIHESICRILKEEITKNPILNTGEKVVEYCKARMAYLSAEEFRILFLNKKNMLISDEVQQRGTLDHAPIYPREIVKRCLELGASAIIMVHNHPSGNCNPSKADISSTYQVRDIAKMMNIFLHDHIIVSRNGCFSMREHNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UK95</accession>
    <name>A0A5C0UK95_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FZC36_02530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1604HC</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QEK39284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="485" mass="52932" checksum="C749E0396116166C" modified="2019-11-13" version="1">MYSEDYKAFKSINAIILAAGKSSRFKLGSKILMNLCGKRIIDYVIDIVHDLNNLPVSEEDIGAINSDSEENVLNEKHDKHIQGDLDHNSGTKNHDVISNEKTTNLKSEVIVVVNDEFDKNELNGVSYCIQKKQLGTGHAVQSSLDLIDNFEPIVILLGDSPLVSHGDINKALHAMKNGNDVALGGFRKDLYSSLPNQYGRIIIEKGVVESIKEAKVFPKETEFFNAGWFVFRNKNIAERLLSKIQDTNGEYYLTECVEIANKIGLKVGMIETNFVTGINTLGEYSLAVESLQRKWKEEAIDRGVCFLDPSSVTLSFDTKIDTNVIIEPHVVLGTGVCIKKNARIKSFTVIENSTINESCTVGPFANLRAGTILMENSSVGSFVETKKCFLGKGSKAKHLCYLGDVKIEKNVNVGAGAVFCNYDGKDKHSSTVGESAFLGGNTTYVSPVSIGARSVIGAGSVITKDVSDGSTCVARAGQKELTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UKA8</accession>
    <name>A0A5C0UKA8_9PROT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease III</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nth</name>
        <name evidence="8" type="ORF">FZC36_02580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1604HC</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="58"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QEK39294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="230" mass="25919" checksum="513DC02915606F95" modified="2019-11-13" version="1">MTSLKKKSNTLDKPNLTEEANILKRSSVVFEKLSESKLPETIALNYENHYTLLVAVILSAQSKDEQVNKITPNLFKVASTPSGMIELGLEKLIDLVKSIGLYRNKSKNIIEASKILAEKYNSIVPDTMEELIELPGVGRKTANVILNFAFKKPTMPVDTHVLRVSRRLGLTKEKTPEKVERDLLKIVPEKLNLEAHNLLVWHGRNVCQAKKPDCKNCCLKDICESEDKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5C0UGZ5</accession>
    <name>A0A5C0UGZ5_9PROT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alanine racemase</fullName>
            <ecNumber evidence="7">5.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">FZC36_00935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nesciobacter abundans</name>
        <dbReference type="NCBI Taxonomy" id="2601668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Alphaproteobacteria</taxon>
            <taxon>Holosporales</taxon>
            <taxon>Holosporaceae</taxon>
            <taxon>Candidatus Nesciobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <title>Highly reduced genomes of protist endosymbionts show evolutionary convergence.</title>
            <authorList>
                <person name="George E."/>
                <person name="Husnik F."/>
                <person name="Tashyreva D."/>
                <person name="Prokopchuk G."/>
                <person name="Horak A."/>
                <person name="Kwong W.K."/>
                <person name="Lukes J."/>
                <person name="Keeling P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1604HC</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP043314">
        <property type="protein sequence ID" value="QEK39000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000324924">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="241"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QEK39000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000324924"/>
        </source>
    </evidence>
    <sequence length="367" mass="41999" checksum="60EA5A34DA2FB66F" modified="2019-11-13" version="1">MYNKPFLKINLSNLVKNYLNLSKDIKCAAVIKCNAYGLGAKEIYEHLRKNTNCKDFFVNSVEEADEILSTALSGHNNIYILSGYTKYQLDHVFDKGFIPVCFSVEQIRDWNDHCEKVKKNKPIVVQLETGMNRLGISLQELENVTDITRVKFFMQHLSHGYDLESDQNQSQIEKTNHFKELINEKFNQLANETKFSTNTLFSLSSSCGLLLGREFHGNMIRLGRFLYGFNEDCADLKLENVAELFAKVIKINHVKKDCGVGYDHKHITEKDSKVGILNIGYGDGYIVGNSYGFLNGKYCKILSVSMDYTMIDLTDLDLKDKDLLFANIELLGKNITAEKLKHWNNKKAQGTEILTTIGRRVDRIYLK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>